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Items: 35


Macrophages assemble! But do they need IL-4R during schistosomiasis?

Rückerl D, Cook PC.

Eur J Immunol. 2019 Jul;49(7):996-1000. doi: 10.1002/eji.201948158.


Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice.

Toor IS, Rückerl D, Mair I, Thomson A, Rossi AG, Newby DE, Allen JE, Gray GA.

Clin Exp Immunol. 2019 May 23. doi: 10.1111/cei.13330. [Epub ahead of print]


Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

Sutherland TE, Rückerl D, Logan N, Duncan S, Wynn TA, Allen JE.

PLoS Pathog. 2018 Nov 30;14(11):e1007423. doi: 10.1371/journal.ppat.1007423. eCollection 2018 Nov.


Characterizing Activation, Proliferation, and Ontogeny of Murine Macrophages in Parasitic Helminth Infections.

Rückerl D.

Methods Mol Biol. 2018;1784:225-241. doi: 10.1007/978-1-4939-7837-3_21.


Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.

Crittenden S, Cheyne A, Adams A, Forster T, Robb CT, Felton J, Ho GT, Ruckerl D, Rossi AG, Anderton SM, Ghazal P, Satsangi J, Howie SE, Yao C.

Immunol Cell Biol. 2018 Nov;96(10):1049-1059. doi: 10.1111/imcb.12167. Epub 2018 Jul 10.


The M2 triangle: gp130 binding cytokines drive macrophages to promote tumor growth.

Rückerl D, Seoane PI.

Immunol Cell Biol. 2018 Mar;96(3):243-245. doi: 10.1111/imcb.12016. Epub 2018 Feb 28. No abstract available.


The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.

Czimmerer Z, Daniel B, Horvath A, Rückerl D, Nagy G, Kiss M, Peloquin M, Budai MM, Cuaranta-Monroy I, Simandi Z, Steiner L, Nagy B Jr, Poliska S, Banko C, Bacso Z, Schulman IG, Sauer S, Deleuze JF, Allen JE, Benko S, Nagy L.

Immunity. 2018 Jan 16;48(1):75-90.e6. doi: 10.1016/j.immuni.2017.12.010.


Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection.

Campbell SM, Knipper JA, Ruckerl D, Finlay CM, Logan N, Minutti CM, Mack M, Jenkins SJ, Taylor MD, Allen JE.

Elife. 2018 Jan 4;7. pii: e30947. doi: 10.7554/eLife.30947.


Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.

Front Immunol. 2017 Nov 10;8:1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.


The Silent Undertakers: Macrophages Programmed for Efferocytosis.

Allen JE, Rückerl D.

Immunity. 2017 Nov 21;47(5):810-812. doi: 10.1016/j.immuni.2017.10.010.


Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.

Pelly VS, Coomes SM, Kannan Y, Gialitakis M, Entwistle LJ, Perez-Lloret J, Czieso S, Okoye IS, Rückerl D, Allen JE, Brombacher F, Wilson MS.

J Exp Med. 2017 Jun 5;214(6):1809-1826. doi: 10.1084/jem.20161104. Epub 2017 May 15.


Macrophage origin limits functional plasticity in helminth-bacterial co-infection.

Rückerl D, Campbell SM, Duncan S, Sutherland TE, Jenkins SJ, Hewitson JP, Barr TA, Jackson-Jones LH, Maizels RM, Allen JE.

PLoS Pathog. 2017 Mar 23;13(3):e1006233. doi: 10.1371/journal.ppat.1006233. eCollection 2017 Mar.


Particles from the Echinococcus granulosus laminated layer inhibit IL-4 and growth factor-driven Akt phosphorylation and proliferative responses in macrophages.

Seoane PI, Rückerl D, Casaravilla C, Barrios AA, Pittini Á, MacDonald AS, Allen JE, Díaz A.

Sci Rep. 2016 Dec 14;6:39204. doi: 10.1038/srep39204.


IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.

Jackson-Jones LH, Rückerl D, Svedberg F, Duncan S, Maizels RM, Sutherland TE, Jenkins SJ, McSorley HJ, Bénézech C, MacDonald AS, Allen JE.

Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.


The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p.

Czimmerer Z, Varga T, Kiss M, Vázquez CO, Doan-Xuan QM, Rückerl D, Tattikota SG, Yan X, Nagy ZS, Daniel B, Poliska S, Horvath A, Nagy G, Varallyay E, Poy MN, Allen JE, Bacso Z, Abreu-Goodger C, Nagy L.

Genome Med. 2016 May 31;8(1):63. doi: 10.1186/s13073-016-0315-y.


IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection.

Pelly VS, Kannan Y, Coomes SM, Entwistle LJ, Rückerl D, Seddon B, MacDonald AS, McKenzie A, Wilson MS.

Mucosal Immunol. 2016 Nov;9(6):1407-1417. doi: 10.1038/mi.2016.4. Epub 2016 Feb 17.


IL-17 and neutrophils: unexpected players in the type 2 immune response.

Allen JE, Sutherland TE, Rückerl D.

Curr Opin Immunol. 2015 Jun;34:99-106. doi: 10.1016/j.coi.2015.03.001. Epub 2015 Mar 18. Review.


Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma.

Ford CA, Petrova S, Pound JD, Voss JJ, Melville L, Paterson M, Farnworth SL, Gallimore AM, Cuff S, Wheadon H, Dobbin E, Ogden CA, Dumitriu IE, Dunbar DR, Murray PG, Ruckerl D, Allen JE, Hume DA, van Rooijen N, Goodlad JR, Freeman TC, Gregory CD.

Curr Biol. 2015 Mar 2;25(5):577-88. doi: 10.1016/j.cub.2014.12.059. Epub 2015 Feb 19.


The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2' phenotype in response to Th2 immunologic challenge.

Mylonas KJ, Jenkins SJ, Castellan RF, Ruckerl D, McGregor K, Phythian-Adams AT, Hewitson JP, Campbell SM, MacDonald AS, Allen JE, Gray GA.

Immunobiology. 2015 Jul;220(7):924-33. doi: 10.1016/j.imbio.2015.01.013. Epub 2015 Feb 7.


Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.

Sutherland TE, Logan N, Rückerl D, Humbles AA, Allan SM, Papayannopoulos V, Stockinger B, Maizels RM, Allen JE.

Nat Immunol. 2014 Dec;15(12):1116-25. doi: 10.1038/ni.3023. Epub 2014 Oct 19.


Macrophage proliferation, provenance, and plasticity in macroparasite infection.

Rückerl D, Allen JE.

Immunol Rev. 2014 Nov;262(1):113-33. doi: 10.1111/imr.12221. Review.


Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus.

Casaravilla C, Pittini A, Rückerl D, Seoane PI, Jenkins SJ, MacDonald AS, Ferreira AM, Allen JE, Díaz A.

Infect Immun. 2014 Aug;82(8):3164-76. doi: 10.1128/IAI.01959-14. Epub 2014 May 19.


Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

Gundra UM, Girgis NM, Ruckerl D, Jenkins S, Ward LN, Kurtz ZD, Wiens KE, Tang MS, Basu-Roy U, Mansukhani A, Allen JE, Loke P.

Blood. 2014 May 15;123(20):e110-22. doi: 10.1182/blood-2013-08-520619. Epub 2014 Apr 2.


The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo.

Hewitson JP, Rückerl D, Harcus Y, Murray J, Webb LM, Babayan SA, Allen JE, Kurniawan A, Maizels RM.

PLoS Pathog. 2014 Feb 27;10(2):e1003930. doi: 10.1371/journal.ppat.1003930. eCollection 2014 Feb. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004133.


IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.

Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE.

J Exp Med. 2013 Oct 21;210(11):2477-91. doi: 10.1084/jem.20121999. Epub 2013 Oct 7.


The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics.

Thomas GD, Rückerl D, Maskrey BH, Whitfield PD, Blaxter ML, Allen JE.

Blood. 2012 Dec 13;120(25):e93-e104. doi: 10.1182/blood-2012-07-442640. Epub 2012 Oct 16.


Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

Rückerl D, Jenkins SJ, Laqtom NN, Gallagher IJ, Sutherland TE, Duncan S, Buck AH, Allen JE.

Blood. 2012 Sep 13;120(11):2307-16. doi: 10.1182/blood-2012-02-408252. Epub 2012 Aug 1.


Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function.

Whyte CS, Bishop ET, Rückerl D, Gaspar-Pereira S, Barker RN, Allen JE, Rees AJ, Wilson HM.

J Leukoc Biol. 2011 Nov;90(5):845-54. doi: 10.1189/jlb.1110644. Epub 2011 May 31.


Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation.

Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N, MacDonald AS, Allen JE.

Science. 2011 Jun 10;332(6035):1284-8. doi: 10.1126/science.1204351. Epub 2011 May 12.


DAP10 contributes to CD8(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection.

Hessmann M, Rausch A, Rückerl D, Adams PS, Simon M, Gilfillan S, Colonna M, Ehlers S, Hölscher C.

Immunobiology. 2011 May;216(5):639-47. doi: 10.1016/j.imbio.2010.09.010. Epub 2010 Sep 24.


Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice.

Nigg AP, Zahn S, Rückerl D, Hölscher C, Yoshimoto T, Ehrchen JM, Wölbing F, Udey MC, von Stebut E.

J Immunol. 2007 Jun 1;178(11):7251-8.


Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.

Höpner S, Dickhaut K, Hofstätter M, Krämer H, Rückerl D, Söderhäll JA, Gupta S, Marin-Esteban V, Kühne R, Freund C, Jung G, Falk K, Rötzschke O.

J Biol Chem. 2006 Dec 15;281(50):38535-42. Epub 2006 Sep 27.


Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1.

Rückerl D, Hessmann M, Yoshimoto T, Ehlers S, Hölscher C.

Immunobiology. 2006;211(6-8):427-36. Epub 2006 Jul 5.


The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis.

Hölscher C, Hölscher A, Rückerl D, Yoshimoto T, Yoshida H, Mak T, Saris C, Ehlers S.

J Immunol. 2005 Mar 15;174(6):3534-44.


Reduction of tamoxifen resistance in human breast carcinomas by tamoxifen-containing liposomes in vivo.

Zeisig R, Rückerl D, Fichtner I.

Anticancer Drugs. 2004 Aug;15(7):707-14.


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