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Items: 24

1.

Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction.

Friedfeld MR, Zhong H, Ruck RT, Shevlin M, Chirik PJ.

Science. 2018 May 25;360(6391):888-893. doi: 10.1126/science.aar6117.

PMID:
29798879
2.

Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.

Yu W, Tong L, Selyutin O, Chen L, Hu B, Zhong B, Hao J, Ji T, Zan S, Yin J, Ruck RT, Curry S, McMonagle P, Agrawal S, Rokosz L, Carr D, Ingravallo P, Bystol K, Lahser F, Liu R, Chen S, Feng KI, Cartwright M, Asante-Appiah E, Kozlowski JA.

J Med Chem. 2018 May 10;61(9):3984-4003. doi: 10.1021/acs.jmedchem.7b01927. Epub 2018 May 1.

PMID:
29681153
3.

Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis.

Twilton J, Christensen M, DiRocco DA, Ruck RT, Davies IW, MacMillan DWC.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5369-5373. doi: 10.1002/anie.201800749. Epub 2018 Apr 6.

PMID:
29490112
4.

Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir.

Xu F, Zhong YL, Li H, Qi J, Desmond R, Song ZJ, Park J, Wang T, Truppo M, Humphrey GR, Ruck RT.

Org Lett. 2017 Nov 3;19(21):5880-5883. doi: 10.1021/acs.orglett.7b02867.

PMID:
29052413
5.

Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir.

Chung CK, Liu Z, Lexa KW, Andreani T, Xu Y, Ji Y, DiRocco DA, Humphrey GR, Ruck RT.

J Am Chem Soc. 2017 Aug 9;139(31):10637-10640. doi: 10.1021/jacs.7b05806. Epub 2017 Jul 25.

PMID:
28737937
6.

A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions.

Ji Y, Li H, Hyde AM, Chen Q, Belyk KM, Lexa KW, Yin J, Sherer EC, Williamson RT, Brunskill A, Ren S, Campeau LC, Davies IW, Ruck RT.

Chem Sci. 2017 Apr 1;8(4):2841-2851. doi: 10.1039/c6sc05472b. Epub 2017 Jan 19.

7.

The protecting-group free selective 3'-functionalization of nucleosides.

McCabe Dunn JM, Reibarkh M, Sherer EC, Orr RK, Ruck RT, Simmons B, Bellomo A.

Chem Sci. 2017 Apr 1;8(4):2804-2810. doi: 10.1039/c6sc05081f. Epub 2017 Jan 18.

8.

A multifunctional catalyst that stereoselectively assembles prodrugs.

DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW.

Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936.

PMID:
28450641
9.

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.

Tong L, Yu W, Chen L, Selyutin O, Dwyer MP, Nair AG, Mazzola R, Kim JH, Sha D, Yin J, Ruck RT, Davies IW, Hu B, Zhong B, Hao J, Ji T, Zan S, Liu R, Agrawal S, Xia E, Curry S, McMonagle P, Bystol K, Lahser F, Carr D, Rokosz L, Ingravallo P, Chen S, Feng KI, Cartwright M, Asante-Appiah E, Kozlowski JA.

J Med Chem. 2017 Jan 12;60(1):290-306. doi: 10.1021/acs.jmedchem.6b01310. Epub 2016 Nov 15.

10.

Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.

Tong L, Yu W, Coburn CA, Chen L, Selyutin O, Zeng Q, Dwyer MP, Nair AG, Shankar BB, Kim SH, Yang DY, Rosenblum SB, Ruck RT, Davies IW, Hu B, Zhong B, Hao J, Ji T, Zan S, Liu R, Agrawal S, Carr D, Curry S, McMonagle P, Bystol K, Lahser F, Ingravallo P, Chen S, Asante-Appiah E, Kozlowski JA.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5354-5360. doi: 10.1016/j.bmcl.2016.08.097. Epub 2016 Sep 2.

PMID:
27680588
11.

Solution to the C3-Arylation of Indazoles: Development of a Scalable Method.

Basu K, Poirier M, Ruck RT.

Org Lett. 2016 Jul 1;18(13):3218-21. doi: 10.1021/acs.orglett.6b01456. Epub 2016 Jun 23.

PMID:
27336404
12.

A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C.

Chung CK, Cleator E, Dumas AM, Hicks JD, Humphrey GR, Maligres PE, Nolting AF, Rivera N, Ruck RT, Shevlin M.

Org Lett. 2016 Mar 18;18(6):1394-7. doi: 10.1021/acs.orglett.6b00331. Epub 2016 Mar 7.

PMID:
26950496
13.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Neelamkavil SF, Agrawal S, Bara T, Bennett C, Bhat S, Biswas D, Brockunier L, Buist N, Burnette D, Cartwright M, Chackalamannil S, Chase R, Chelliah M, Chen A, Clasby M, Colandrea VJ, Davies IW, Eagen K, Guo Z, Han Y, Howe J, Jayne C, Josien H, Kargman S, Marcantonio K, Miao S, Miller R, Nolting A, Pinto P, Rajagopalan M, Ruck RT, Shah U, Soriano A, Sperbeck D, Velazquez F, Wu J, Xia Y, Venkatraman S.

ACS Med Chem Lett. 2015 Dec 22;7(1):111-6. doi: 10.1021/acsmedchemlett.5b00425. eCollection 2016 Jan 14.

14.

Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates.

Christensen M, Nolting A, Shevlin M, Weisel M, Maligres PE, Lee J, Orr RK, Plummer CW, Tudge MT, Campeau LC, Ruck RT.

J Org Chem. 2016 Feb 5;81(3):824-30. doi: 10.1021/acs.joc.5b02296. Epub 2016 Jan 25.

PMID:
26743694
15.

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.

He S, Ye Z, Truong Q, Shah S, Du W, Guo L, Dobbelaar PH, Lai Z, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Pasternak A, Feng Z, deJesus R, Yang L, Reibarkh M, Bradley SA, Holmes MA, Ball RG, Ruck RT, Huffman MA, Wong F, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2012 May 7;3(6):484-9. doi: 10.1021/ml300063m. eCollection 2012 Jun 14.

16.

Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors.

Bellomo A, Celebi-Olcum N, Bu X, Rivera N, Ruck RT, Welch CJ, Houk KN, Dreher SD.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6912-5. doi: 10.1002/anie.201201720. Epub 2012 Jun 11.

PMID:
22689502
17.

A concise synthesis of a β-lactamase inhibitor.

Mangion IK, Ruck RT, Rivera N, Huffman MA, Shevlin M.

Org Lett. 2011 Oct 21;13(20):5480-3. doi: 10.1021/ol202195n. Epub 2011 Sep 15.

PMID:
21916523
18.

Palladium-catalyzed tandem Heck reaction/C-H functionalization--preparation of spiro-indane-oxindoles.

Ruck RT, Huffman MA, Kim MM, Shevlin M, Kandur WV, Davies IW.

Angew Chem Int Ed Engl. 2008;47(25):4711-4. doi: 10.1002/anie.200800549. No abstract available.

PMID:
18491340
19.
20.

Synthetic and Mechanistic Studies of Strained Heterocycle Opening Reactions Mediated by Zirconium(IV) Imido Complexes.

Blum SA, Rivera VA, Ruck RT, Michael FE, Bergman RG.

Organometallics. 2005 Mar 28;24(7):1647-1659.

21.

Zirconium-mediated conversion of amides to nitriles: a surprising additive effect.

Ruck RT, Bergman RG.

Angew Chem Int Ed Engl. 2004 Oct 11;43(40):5375-7. No abstract available.

22.

Carboamination: additions of imine C=N bonds across alkynes catalyzed by imidozirconium complexes.

Ruck RT, Zuckerman RL, Krska SW, Bergman RG.

Angew Chem Int Ed Engl. 2004 Oct 11;43(40):5372-4. No abstract available.

23.

Asymmetric hetero-ene reactions of trimethylsilyl enol ethers catalyzed by tridentate Schiff base chromium(III) complexes.

Ruck RT, Jacobsen EN.

Angew Chem Int Ed Engl. 2003 Oct 13;42(39):4771-4. No abstract available.

PMID:
14562344
24.

Asymmetric catalysis of hetero-ene reactions with tridentate Schiff base chromium(III) complexes.

Ruck RT, Jacobsen EN.

J Am Chem Soc. 2002 Mar 27;124(12):2882-3.

PMID:
11902873

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