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Items: 1 to 50 of 59

1.

Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest.

Mokhtari Brikci-Nigassa N, Nauton L, Moreau P, Mongin O, Duval RE, Picot L, Thiéry V, Souab M, Baratte B, Ruchaud S, Bach S, Le Guevel R, Bentabed-Ababsa G, Erb W, Roisnel T, Dorcet V, Mongin F.

Bioorg Chem. 2020 Jan;94:103347. doi: 10.1016/j.bioorg.2019.103347. Epub 2019 Oct 10.

PMID:
31810757
2.

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3).

Lassagne F, Duguépéroux C, Roca C, Perez C, Martinez A, Baratte B, Robert T, Ruchaud S, Bach S, Erb W, Roisnel T, Mongin F.

Org Biomol Chem. 2019 Dec 18;18(1):154-162. doi: 10.1039/c9ob02002k.

PMID:
31803883
3.

Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents.

Nascimento da Cruz AC, Brondani DJ, I Talo de Santana T, Oliveira da Silva L, da Oliveira Borba EF, de Faria AR, Ferreira Cavalcanti de Albuquerque J, Piessard S, Matos Ximenes R, Baratte B, Bach S, Ruchaud S, Bezerra Mendonça Junior FJ, Bazin MA, Montenegro Rabello M, Hernandes MZ, Marchand P, Gonçalves da Silva T.

Pharmaceuticals (Basel). 2019 Nov 17;12(4). pii: E169. doi: 10.3390/ph12040169.

4.

Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.

Papini D, Fant X, Ogawa H, Desban N, Samejima K, Feizbakhsh O, Askin B, Ly T, Earnshaw WC, Ruchaud S.

J Cell Sci. 2019 Nov 6;132(21). pii: jcs234401. doi: 10.1242/jcs.234401.

5.

Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi.

Nguyen TN, Feizbakhsh O, Sfecci E, Baratte B, Delehouzé C, Garcia A, Moulin C, Colas P, Ruchaud S, Mehiri M, Bach S.

Mar Drugs. 2019 Oct 9;17(10). pii: E569. doi: 10.3390/md17100569.

6.

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies.

Zeinyeh W, Esvan YJ, Josselin B, Baratte B, Bach S, Nauton L, Théry V, Ruchaud S, Anizon F, Giraud F, Moreau P.

Bioorg Med Chem. 2019 May 15;27(10):2083-2089. doi: 10.1016/j.bmc.2019.04.005. Epub 2019 Apr 4.

PMID:
30967303
7.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY.

Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.

8.

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

Tazarki H, Zeinyeh W, Esvan YJ, Knapp S, Chatterjee D, Schröder M, Joerger AC, Khiari J, Josselin B, Baratte B, Bach S, Ruchaud S, Anizon F, Giraud F, Moreau P.

Eur J Med Chem. 2019 Mar 15;166:304-317. doi: 10.1016/j.ejmech.2019.01.052. Epub 2019 Jan 26.

PMID:
30731399
9.

Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides.

Motuhi SE, Feizbakhsh O, Foll-Josselin B, Baratte B, Delehouzé C, Cousseau A, Fant X, Bulinski JC, Payri CE, Ruchaud S, Mehiri M, Bach S.

Mar Drugs. 2019 Feb 1;17(2). pii: E93. doi: 10.3390/md17020093.

10.

The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases.

Masłyk M, Janeczko M, Martyna A, Czernik S, Tokarska-Rodak M, Chwedczuk M, Foll-Josselin B, Ruchaud S, Bach S, Demchuk OM, Kubiński K.

Molecules. 2019 Jan 2;24(1). pii: E153. doi: 10.3390/molecules24010153.

11.

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines.

Lassagne F, Langlais T, Caytan E, Limanton E, Paquin L, Boullard M, Courtel C, Curbet I, Gédéon C, Lebreton J, Picot L, Thiéry V, Souab M, Baratte B, Ruchaud S, Bach S, Roisnel T, Mongin F.

Molecules. 2018 Nov 13;23(11). pii: E2961. doi: 10.3390/molecules23112961.

12.

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.

Winfield HJ, Cahill MM, O'Shea KD, Pierce LT, Robert T, Ruchaud S, Bach S, Marchand P, McCarthy FO.

Bioorg Med Chem. 2018 Aug 7;26(14):4209-4224. doi: 10.1016/j.bmc.2018.07.012. Epub 2018 Jul 9.

PMID:
30026041
13.

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.

Dao VH, Ourliac-Garnier I, Bazin MA, Jacquot C, Baratte B, Ruchaud S, Bach S, Grovel O, Le Pape P, Marchand P.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2250-2255. doi: 10.1016/j.bmcl.2018.05.044. Epub 2018 May 23.

PMID:
29853332
14.

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.

Oyallon B, Brachet-Botineau M, Logé C, Bonnet P, Souab M, Robert T, Ruchaud S, Bach S, Berthelot P, Gouilleux F, Viaud-Massuard MC, Denevault-Sabourin C.

Eur J Med Chem. 2018 Jun 25;154:101-109. doi: 10.1016/j.ejmech.2018.04.056. Epub 2018 May 11.

PMID:
29778892
15.

Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129.

Navarri M, Jégou C, Bondon A, Pottier S, Bach S, Baratte B, Ruchaud S, Barbier G, Burgaud G, Fleury Y.

Mar Drugs. 2017 Apr 7;15(4). pii: E111. doi: 10.3390/md15040111.

16.

Synthesis, Docking Study and Kinase Inhibitory Activity of a Number of New Substituted Pyrazolo[3,4-c]pyridines.

Sklepari M, Lougiakis N, Papastathopoulos A, Pouli N, Marakos P, Myrianthopoulos V, Robert T, Bach S, Mikros E, Ruchaud S.

Chem Pharm Bull (Tokyo). 2017;65(1):66-81. doi: 10.1248/cpb.c16-00704.

17.

Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme.

Daniilides K, Lougiakis N, Evangelidis T, Kostakis IK, Pouli N, Marakos P, Mikros E, Skaltsounis AL, Bach S, Baratte B, Ruchaud S, Karamani V, Papafotika A, Christoforidis S, Argyros O, Kouvari E, Tamvakopoulos C.

Anticancer Agents Med Chem. 2017;17(7):990-1002. doi: 10.2174/1871520616666161207143450.

PMID:
27928955
18.

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.

Lawson M, Rodrigo J, Baratte B, Robert T, Delehouzé C, Lozach O, Ruchaud S, Bach S, Brion JD, Alami M, Hamze A.

Eur J Med Chem. 2016 Nov 10;123:105-114. doi: 10.1016/j.ejmech.2016.07.040. Epub 2016 Jul 21.

PMID:
27474927
19.

Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines.

Bazin MA, Rousseau B, Marhadour S, Tomasoni C, Evenou P, Piessard S, Vaisberg AJ, Ruchaud S, Bach S, Roussakis C, Marchand P.

Anticancer Res. 2016 Apr;36(4):1621-30.

PMID:
27069139
20.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.

Ouach A, Boulahjar R, Vala C, Bourg S, Bonnet P, Guguen-Guillouzo C, Ravache M, Le Guevel R, Lozach O, Lazar S, Troin Y, Meijer L, Ruchaud S, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2016 Jun 10;115:311-25. doi: 10.1016/j.ejmech.2016.02.072. Epub 2016 Mar 2.

PMID:
27019296
21.

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

Durieu E, Prina E, Leclercq O, Oumata N, Gaboriaud-Kolar N, Vougogiannopoulou K, Aulner N, Defontaine A, No JH, Ruchaud S, Skaltsounis AL, Galons H, Späth GF, Meijer L, Rachidi N.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2822-33. doi: 10.1128/AAC.00021-16. Print 2016 May.

22.

Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.

Moine E, Dimier-Poisson I, Enguehard-Gueiffier C, Logé C, Pénichon M, Moiré N, Delehouzé C, Foll-Josselin B, Ruchaud S, Bach S, Gueiffier A, Debierre-Grockiego F, Denevault-Sabourin C.

Eur J Med Chem. 2015 Nov 13;105:80-105. doi: 10.1016/j.ejmech.2015.10.004. Epub 2015 Oct 9.

PMID:
26479029
23.

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

Marchand P, Bazin MA, Pagniez F, Rivière G, Bodero L, Marhadour S, Nourrisson MR, Picot C, Ruchaud S, Bach S, Baratte B, Sauvain M, Pareja DC, Vaisberg AJ, Le Pape P.

Eur J Med Chem. 2015 Oct 20;103:381-95. doi: 10.1016/j.ejmech.2015.09.002. Epub 2015 Sep 9.

PMID:
26383125
24.

Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases.

Dago CD, Ambeu CN, Coulibaly WK, Békro YA, Mamyrbékova J, Defontaine A, Baratte B, Bach S, Ruchaud S, Guével RL, Ravache M, Corlu A, Bazureau JP.

Molecules. 2015 Jul 8;20(7):12412-35. doi: 10.3390/molecules200712412.

25.

Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell-based assays.

Kernéis S, Swift LH, Lewis CW, Bruyère C, Oumata N, Colas P, Ruchaud S, Bain J, Golsteyn RM.

Nat Prod Res. 2015;29(11):1026-34. doi: 10.1080/14786419.2014.979423. Epub 2014 Nov 25.

PMID:
25423141
26.

Bioprospecting marine plankton.

Abida H, Ruchaud S, Rios L, Humeau A, Probert I, De Vargas C, Bach S, Bowler C.

Mar Drugs. 2013 Nov 14;11(11):4594-611. doi: 10.3390/md11114594. Review.

27.

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.

Marhadour S, Marchand P, Pagniez F, Bazin MA, Picot C, Lozach O, Ruchaud S, Antoine M, Meijer L, Rachidi N, Le Pape P.

Eur J Med Chem. 2012 Dec;58:543-56. doi: 10.1016/j.ejmech.2012.10.048. Epub 2012 Nov 2.

PMID:
23164660
28.

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors.

Bruel A, Logé C, Tauzia ML, Ravache M, Le Guevel R, Guillouzo C, Lohier JF, Oliveira Santos JS, Lozach O, Meijer L, Ruchaud S, Bénédetti H, Robert JM.

Eur J Med Chem. 2012 Nov;57:225-33. doi: 10.1016/j.ejmech.2012.09.001. Epub 2012 Sep 10.

PMID:
23063566
29.

An emerging function of survivin's BIR domain phosphorylation in the control of cell division and cell death.

Fant X, Ruchaud S.

Cell Cycle. 2011 Mar 15;10(6):876-7. Epub 2011 Mar 15. No abstract available.

PMID:
21350336
30.

Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function.

Fant X, Samejima K, Carvalho A, Ogawa H, Xu Z, Yue Z, Earnshaw WC, Ruchaud S.

Biochem Soc Trans. 2010 Dec;38(6):1655-9. doi: 10.1042/BST0381655.

31.

SUMOylation modulates the function of Aurora-B kinase.

Fernández-Miranda G, Pérez de Castro I, Carmena M, Aguirre-Portolés C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M.

J Cell Sci. 2010 Aug 15;123(Pt 16):2823-33. doi: 10.1242/jcs.065565. Epub 2010 Jul 27.

32.

INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.

Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K.

J Cell Biol. 2009 Nov 30;187(5):637-53. doi: 10.1083/jcb.200906053. Erratum in: J Cell Biol. 2010 Feb 22;188(4):611.

33.

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.

Carmena M, Ruchaud S, Earnshaw WC.

Curr Opin Cell Biol. 2009 Dec;21(6):796-805. doi: 10.1016/j.ceb.2009.09.008. Review.

34.

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex.

Zhou L, Li J, George R, Ruchaud S, Zhou HG, Ladbury JE, Earnshaw WC, Yuan X.

Biochemistry. 2009 Feb 17;48(6):1156-61. doi: 10.1021/bi801298j.

35.

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.

Yue Z, Carvalho A, Xu Z, Yuan X, Cardinale S, Ribeiro S, Lai F, Ogawa H, Gudmundsdottir E, Gassmann R, Morrison CG, Ruchaud S, Earnshaw WC.

J Cell Biol. 2008 Oct 20;183(2):279-96. doi: 10.1083/jcb.200806118.

36.

Apoptosis-associated caspase activation assays.

Kaufmann SH, Lee SH, Meng XW, Loegering DA, Kottke TJ, Henzing AJ, Ruchaud S, Samejima K, Earnshaw WC.

Methods. 2008 Mar;44(3):262-72. doi: 10.1016/j.ymeth.2007.11.005. Review.

PMID:
18314058
37.

A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes.

Samejima K, Ogawa H, Cooke CA, Hudson DF, Macisaac F, Ribeiro SA, Vagnarelli P, Cardinale S, Kerr A, Lai F, Ruchaud S, Yue Z, Earnshaw WC.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2457-62. doi: 10.1073/pnas.0712083105. Epub 2008 Feb 8. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5650. Hudson, Damien [Hudson, Damien F].

38.

The chromosomal passenger complex: one for all and all for one.

Ruchaud S, Carmena M, Earnshaw WC.

Cell. 2007 Oct 19;131(2):230-1.

39.

Chromosomal passengers: conducting cell division.

Ruchaud S, Carmena M, Earnshaw WC.

Nat Rev Mol Cell Biol. 2007 Oct;8(10):798-812. Review.

PMID:
17848966
40.

Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.

Faragher AJ, Sun XM, Butterworth M, Harper N, Mulheran M, Ruchaud S, Earnshaw WC, Cohen GM.

Mol Biol Cell. 2007 Apr;18(4):1337-47. Epub 2007 Feb 7.

41.

Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome.

Rodríguez-Bayona B, Ruchaud S, Rodríguez C, Linares M, Astola A, Ortiz M, Earnshaw WC, Valdivia MM.

J Autoimmune Dis. 2007 Jan 12;4:1. doi: 10.1186/1740-2557-4-1.

42.

Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis.

Loegering DA, Ruchaud S, Earnshaw WC, Kaufmann SH.

Cell Death Differ. 2006 Feb;13(2):346-7. No abstract available.

43.

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC.

J Cell Biol. 2004 Jul 19;166(2):179-91. Epub 2004 Jul 12.

44.

Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.

Korfali N, Ruchaud S, Loegering D, Bernard D, Dingwall C, Kaufmann SH, Earnshaw WC.

J Biol Chem. 2004 Jan 9;279(2):1030-9. Epub 2003 Oct 28.

45.

Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'.

Hudson DF, Morrison C, Ruchaud S, Earnshaw WC.

Trends Cell Biol. 2002 Jun;12(6):281-7. Review.

PMID:
12074888
46.

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

Ruchaud S, Korfali N, Villa P, Kottke TJ, Dingwall C, Kaufmann SH, Earnshaw WC.

EMBO J. 2002 Apr 15;21(8):1967-77.

47.

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells.

Kottke TJ, Blajeski AL, Meng XW, Svingen PA, Ruchaud S, Mesner PW Jr, Boerner SA, Samejima K, Henriquez NV, Chilcote TJ, Lord J, Salmon M, Earnshaw WC, Kaufmann SH.

J Biol Chem. 2002 Jan 4;277(1):804-15. Epub 2001 Oct 24.

48.

Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-induced apoptosis to granulocytic differentiation.

Séité P, Ruchaud S, Hillion J, Gendron MC, Bruland O, Ségal-Bendirdjian E, Doskeland SO, Lillehaug JR, Lanotte M.

Cell Death Differ. 2000 Nov;7(11):1081-9.

49.

RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.

Benoit G, Altucci L, Flexor M, Ruchaud S, Lillehaug J, Raffelsberger W, Gronemeyer H, Lanotte M.

EMBO J. 1999 Dec 15;18(24):7011-8.

50.

A dynamic connection between centromeres and ND10 proteins.

Everett RD, Earnshaw WC, Pluta AF, Sternsdorf T, Ainsztein AM, Carmena M, Ruchaud S, Hsu WL, Orr A.

J Cell Sci. 1999 Oct;112 ( Pt 20):3443-54.

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