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p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.

Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM.

Science. 2019 Dec 13;366(6471). pii: eaaw2106. doi: 10.1126/science.aaw2106.


E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family.

Hsu J, Arand J, Chaikovsky A, Mooney NA, Demeter J, Brison CM, Oliverio R, Vogel H, Rubin SM, Jackson PK, Sage J.

Nat Commun. 2019 Jul 3;10(1):2939. doi: 10.1038/s41467-019-10901-x.


Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH.

Mol Cell. 2019 Aug 8;75(3):483-497.e9. doi: 10.1016/j.molcel.2019.06.002. Epub 2019 Jun 25.


An order-to-disorder structural switch activates the FoxM1 transcription factor.

Marceau AH, Brison CM, Nerli S, Arsenault HE, McShan AC, Chen E, Lee HW, Benanti JA, Sgourakis NG, Rubin SM.

Elife. 2019 May 28;8. pii: e46131. doi: 10.7554/eLife.46131.


Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets.

Rubin SM, Sage J.

Nature. 2019 May;569(7756):343-344. doi: 10.1038/d41586-019-01319-y. No abstract available.


Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.

Topacio BR, Zatulovskiy E, Cristea S, Xie S, Tambo CS, Rubin SM, Sage J, Kõivomägi M, Skotheim JM.

Mol Cell. 2019 May 16;74(4):758-770.e4. doi: 10.1016/j.molcel.2019.03.020. Epub 2019 Apr 11.


Structural mechanism of Myb-MuvB assembly.

Guiley KZ, Iness AN, Saini S, Tripathi S, Lipsick JS, Litovchick L, Rubin SM.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10016-10021. doi: 10.1073/pnas.1808136115. Epub 2018 Sep 17.


The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb.

Iness AN, Felthousen J, Ananthapadmanabhan V, Sesay F, Saini S, Guiley KZ, Rubin SM, Dozmorov M, Litovchick L.

Oncogene. 2019 Feb;38(7):1080-1092. doi: 10.1038/s41388-018-0490-y. Epub 2018 Sep 11.


Correction to: Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site.

Tomsho KS, Basra K, Rubin SM, Miller CB, Juang R, Broude S, Martinez A, Hornbuckle KC, Heiger-Bernays W, Scammell MK.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16401. doi: 10.1007/s11356-017-0765-9.


Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site.

Tomsho KS, Basra K, Rubin SM, Miller CB, Juang R, Broude S, Martinez A, Hornbuckle KC, Heiger-Bernays W, Scammell MK.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16389-16400. doi: 10.1007/s11356-017-0286-6. Epub 2017 Oct 27. Erratum in: Environ Sci Pollut Res Int. 2017 Nov 29;:.


Heavy metal in cancer: The cell cycle jams with arsenic.

Barrett AK, Rubin SM.

Cell Cycle. 2017 Sep 17;16(18):1641-1642. doi: 10.1080/15384101.2017.1360653. Epub 2017 Aug 18. No abstract available.


Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.

McGrath DA, Fifield BA, Marceau AH, Tripathi S, Porter LA, Rubin SM.

EMBO J. 2017 Aug 1;36(15):2251-2262. doi: 10.15252/embj.201796905. Epub 2017 Jun 30.


Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family.

Liban TJ, Medina EM, Tripathi S, Sengupta S, Henry RW, Buchler NE, Rubin SM.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4942-4947. doi: 10.1073/pnas.1619170114. Epub 2017 Apr 24.


Are Preferences for Aggressive Medical Treatment Associated with Healthcare Utilization in the Very Old?

Albert SM, Lunney JR, Ye L, Boudreau R, Ives D, Satterfield S, Kaplan CM, Waters T, Ayonayon HN, Rubin SM, Newman AB, Harris T.

J Palliat Med. 2017 Mar 23. doi: 10.1089/jpm.2016.0284. [Epub ahead of print]


An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.

Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA.

Mol Cell. 2016 Dec 15;64(6):1074-1087. doi: 10.1016/j.molcel.2016.10.021. Epub 2016 Nov 23.


Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.

Liban TJ, Thwaites MJ, Dick FA, Rubin SM.

J Mol Biol. 2016 Oct 9;428(20):3960-3971. doi: 10.1016/j.jmb.2016.08.017. Epub 2016 Aug 25.


Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters.

Marceau AH, Felthousen JG, Goetsch PD, Iness AN, Lee HW, Tripathi SM, Strome S, Litovchick L, Rubin SM.

Nat Commun. 2016 Jul 28;7:12301. doi: 10.1038/ncomms12301.


Symptom Burden and End-of-Life Treatment Preferences in the Very Old.

Albert SM, Lunney JR, Ye L, Boudreau R, Ives D, Satterfield S, Ayonayon HN, Rubin SM, Newman AB, Harris T; Health ABC Study.

J Pain Symptom Manage. 2016 Sep;52(3):404-11. doi: 10.1016/j.jpainsymman.2016.03.009. Epub 2016 Jun 3.


Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia.

Kaup AR, Byers AL, Falvey C, Simonsick EM, Satterfield S, Ayonayon HN, Smagula SF, Rubin SM, Yaffe K.

JAMA Psychiatry. 2016 May 1;73(5):525-31. doi: 10.1001/jamapsychiatry.2016.0004.


Association of Hearing Impairment and Anxiety in Older Adults.

Contrera KJ, Betz J, Deal J, Choi JS, Ayonayon HN, Harris T, Helzner E, Martin KR, Mehta K, Pratt S, Rubin SM, Satterfield S, Yaffe K, Simonsick EM, Lin FR; Health ABC Study.

J Aging Health. 2017 Feb;29(1):172-184. doi: 10.1177/0898264316634571. Epub 2016 Jul 8.


Association of Hearing Impairment and Emotional Vitality in Older Adults.

Contrera KJ, Betz J, Deal JA, Choi JS, Ayonayon HN, Harris T, Helzner E, Martin KR, Mehta K, Pratt S, Rubin SM, Satterfield S, Yaffe K, Garcia M, Simonsick EM, Lin FR; Health ABC Study.

J Gerontol B Psychol Sci Soc Sci. 2016 May;71(3):400-4. doi: 10.1093/geronb/gbw005. Epub 2016 Feb 16.


A Strategy for Direct Chemical Activation of the Retinoblastoma Protein.

Pye CR, Bray WM, Brown ER, Burke JR, Lokey RS, Rubin SM.

ACS Chem Biol. 2016 May 20;11(5):1192-7. doi: 10.1021/acschembio.6b00011. Epub 2016 Feb 11.


Structural basis of template-boundary definition in Tetrahymena telomerase.

Jansson LI, Akiyama BM, Ooms A, Lu C, Rubin SM, Stone MD.

Nat Struct Mol Biol. 2015 Nov;22(11):883-8. doi: 10.1038/nsmb.3101. Epub 2015 Oct 5.


Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study.

Izano M, Wei EK, Tai C, Swede H, Gregorich S, Harris TB, Klepin H, Satterfield S, Murphy R, Newman AB, Rubin SM, Braithwaite D; Health ABC study.

Int J Cancer. 2016 Mar 1;138(5):1118-28. doi: 10.1002/ijc.29868. Epub 2015 Oct 19.


Gait Speed Predicts Incident Disability: A Pooled Analysis.

Perera S, Patel KV, Rosano C, Rubin SM, Satterfield S, Harris T, Ensrud K, Orwoll E, Lee CG, Chandler JM, Newman AB, Cauley JA, Guralnik JM, Ferrucci L, Studenski SA.

J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):63-71. doi: 10.1093/gerona/glv126. Epub 2015 Aug 22.


Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study.

Murphy RA, Hagaman AK, Reinders I, Steeves JA, Newman AB, Rubin SM, Satterfield S, Kritchevsky SB, Yaffe K, Ayonayon HN, Nagin DS, Simonsick EM, Penninx BW, Harris TB; Health ABC Study.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):228-35. doi: 10.1093/gerona/glv139. Epub 2015 Aug 13.


Structural mechanisms of DREAM complex assembly and regulation.

Guiley KZ, Liban TJ, Felthousen JG, Ramanan P, Litovchick L, Rubin SM.

Genes Dev. 2015 May 1;29(9):961-74. doi: 10.1101/gad.257568.114. Epub 2015 Apr 27.


Migraines in women.

Rubin SM.

Dis Mon. 2015 Jun;61(6):229-32. doi: 10.1016/j.disamonth.2015.03.005. Epub 2015 Apr 15. Review. No abstract available.


Perceptions of very old adults about informed care in medical encounters.

Hoffelder Wynne J, Lunney J, Ives D, Newman AB, Satterfield S, Garcia M, Harris T, Ayonayon HN, Rubin SM, Albert SM.

J Am Geriatr Soc. 2015 Mar;63(3):612-4. doi: 10.1111/jgs.13291. No abstract available.


Association between sleep duration and mortality is mediated by markers of inflammation and health in older adults: the Health, Aging and Body Composition Study.

Hall MH, Smagula SF, Boudreau RM, Ayonayon HN, Goldman SE, Harris TB, Naydeck BL, Rubin SM, Samuelsson L, Satterfield S, Stone KL, Visser M, Newman AB.

Sleep. 2015 Feb 1;38(2):189-95. doi: 10.5665/sleep.4394.


Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the health, aging, and body composition study.

Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK.

J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):757-63. doi: 10.1093/gerona/glu184. Epub 2014 Oct 18.


Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting.

Rubin SM, Sage J.

Cell Div. 2013 Nov 21;8(1):13. doi: 10.1186/1747-1028-8-13.


Cks confers specificity to phosphorylation-dependent CDK signaling pathways.

McGrath DA, Balog ER, Kõivomägi M, Lucena R, Mai MV, Hirschi A, Kellogg DR, Loog M, Rubin SM.

Nat Struct Mol Biol. 2013 Dec;20(12):1407-14. doi: 10.1038/nsmb.2707. Epub 2013 Nov 3.


Multisite phosphorylation networks as signal processors for Cdk1.

Kõivomägi M, Ord M, Iofik A, Valk E, Venta R, Faustova I, Kivi R, Balog ER, Rubin SM, Loog M.

Nat Struct Mol Biol. 2013 Dec;20(12):1415-24. doi: 10.1038/nsmb.2706. Epub 2013 Nov 3.


Older adults with limited literacy are at increased risk for likely dementia.

Kaup AR, Simonsick EM, Harris TB, Satterfield S, Metti AL, Ayonayon HN, Rubin SM, Yaffe K.

J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):900-6. doi: 10.1093/gerona/glt176. Epub 2013 Oct 24.


Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain.

Burke JR, Liban TJ, Restrepo T, Lee HW, Rubin SM.

J Mol Biol. 2014 Jan 9;426(1):245-55. doi: 10.1016/j.jmb.2013.09.031. Epub 2013 Oct 5.


Management of cognition and fatigue.

Rubin SM.

Dis Mon. 2013 Jul;59(7):269-72. doi: 10.1016/j.disamonth.2013.03.014. Review. No abstract available.


Management of multiple sclerosis: an overview.

Rubin SM.

Dis Mon. 2013 Jul;59(7):253-60. doi: 10.1016/j.disamonth.2013.03.012. Review. No abstract available.


Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions.

Shi T, Bunker RD, Mattarocci S, Ribeyre C, Faty M, Gut H, Scrima A, Rass U, Rubin SM, Shore D, Thomä NH.

Cell. 2013 Jun 6;153(6):1340-53. doi: 10.1016/j.cell.2013.05.007.


A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.

Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP.

Mol Cell. 2013 Apr 25;50(2):250-60. doi: 10.1016/j.molcel.2013.04.003.


Molecular mechanisms underlying RB protein function.

Dick FA, Rubin SM.

Nat Rev Mol Cell Biol. 2013 May;14(5):297-306. doi: 10.1038/nrm3567. Epub 2013 Apr 18. Review.


Unhealthy lifestyles do not mediate the relationship between socioeconomic status and incident depressive symptoms: the Health ABC study.

Groffen DA, Koster A, Bosma H, van den Akker M, Kempen GI, van Eijk JT, van Gool CH, Penninx BW, Harris TB, Rubin SM, Pahor M, Schulz R, Simonsick EM, Perry SE, Ayonayon HN, Kritchevsky SB; Health ABC study.

Am J Geriatr Psychiatry. 2013 Jul;21(7):664-74. doi: 10.1016/j.jagp.2013.01.004. Epub 2013 Feb 6.


Deciphering the retinoblastoma protein phosphorylation code.

Rubin SM.

Trends Biochem Sci. 2013 Jan;38(1):12-9. doi: 10.1016/j.tibs.2012.10.007. Epub 2012 Dec 3. Review.


25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study.

Kritchevsky SB, Tooze JA, Neiberg RH, Schwartz GG, Hausman DB, Johnson MA, Bauer DC, Cauley JA, Shea MK, Cawthon PM, Harris TB, Rubin SM, Tylavsky FA, Houston DK; Health ABC Study.

J Clin Endocrinol Metab. 2012 Nov;97(11):4156-65. doi: 10.1210/jc.2012-1551. Epub 2012 Aug 31.


An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.

Hegnauer AM, Hustedt N, Shimada K, Pike BL, Vogel M, Amsler P, Rubin SM, van Leeuwen F, Guénolé A, van Attikum H, Thomä NH, Gasser SM.

EMBO J. 2012 Sep 12;31(18):3768-83. doi: 10.1038/emboj.2012.195. Epub 2012 Jul 20.


Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.

Burke JR, Hura GL, Rubin SM.

Genes Dev. 2012 Jun 1;26(11):1156-66. doi: 10.1101/gad.189837.112. Epub 2012 May 8.


Patterns of mortality among Wisconsin Uniroyal tire manufacturing workers.

Rubin SM, Clapp R.

New Solut. 2011;21(4):603-20. doi: 10.2190/NS.21.4.h.


Racial differences in mortality in older adults: factors beyond socioeconomic status.

Thorpe RJ Jr, Koster A, Bosma H, Harris TB, Simonsick EM, van Eijk JT, Kempen GI, Newman AB, Satterfield S, Rubin SM, Kritchevsky SB; Health ABC Study.

Ann Behav Med. 2012 Feb;43(1):29-38. doi: 10.1007/s12160-011-9335-4.


Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M.

Nature. 2011 Oct 12;480(7375):128-31. doi: 10.1038/nature10560.


The structure of a monomeric mutant Cks protein reveals multiple functions for a conserved hinge-region proline.

Balog ER, Saetern OC, Finch W, Hoeft CO, Thai V, Harvey SL, Kellogg DR, Rubin SM.

J Mol Biol. 2011 Aug 19;411(3):520-8. doi: 10.1016/j.jmb.2011.05.045. Epub 2011 Jun 17.


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