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Items: 1 to 50 of 166

1.

The mycobacterial cell envelope - a moving target.

Dulberger CL, Rubin EJ, Boutte CC.

Nat Rev Microbiol. 2019 Nov 14. doi: 10.1038/s41579-019-0273-7. [Epub ahead of print] Review.

PMID:
31728063
2.

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.

Ruetz M, Campanello GC, Purchal M, Shen H, McDevitt L, Gouda H, Wakabayashi S, Zhu J, Rubin EJ, Warncke K, Mootha VK, Koutmos M, Banerjee R.

Science. 2019 Nov 1;366(6465):589-593. doi: 10.1126/science.aay0934.

PMID:
31672889
3.

Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis.

Poce G, Consalvi S, Venditti G, Alfonso S, Desideri N, Fernandez-Menendez R, Bates RH, Ballell L, Barros Aguirre D, Rullas J, De Logu A, Gardner M, Ioerger TR, Rubin EJ, Biava M.

ACS Med Chem Lett. 2019 Sep 18;10(10):1423-1429. doi: 10.1021/acsmedchemlett.9b00204. eCollection 2019 Oct 10.

PMID:
31620228
4.

Changing Principals, Keeping Principles.

Rubin EJ.

N Engl J Med. 2019 Sep 12;381(11):1069-1070. doi: 10.1056/NEJMe1911103. No abstract available.

PMID:
31509679
5.

Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB.

Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19.

PMID:
31427817
6.

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

Dragset MS, Ioerger TR, Zhang YJ, Mærk M, Ginbot Z, Sacchettini JC, Flo TH, Rubin EJ, Steigedal M.

Sci Rep. 2019 Aug 6;9(1):11394. doi: 10.1038/s41598-019-47905-y.

7.

Correction for Mir et al., "Mycobacterial Gene cuvA Is Required for Optimal Nutrient Utilization and Virulence".

Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN.

Infect Immun. 2019 Jul 23;87(8). pii: e00414-19. doi: 10.1128/IAI.00414-19. Print 2019 Aug. No abstract available.

8.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT.

Nature. 2019 Jul;571(7763):72-78. doi: 10.1038/s41586-019-1315-z. Epub 2019 Jun 19.

PMID:
31217586
9.

Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase.

Wu KJ, Boutte CC, Ioerger TR, Rubin EJ.

Cell Rep. 2019 May 21;27(8):2468-2479.e3. doi: 10.1016/j.celrep.2018.12.063.

10.

The Dream of a Mycobacterium.

Baranowski C, Rego EH, Rubin EJ.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0008-2018. Review.

PMID:
31025625
11.

Cell Wall Hydrolytic Enzymes Enhance Antimicrobial Drug Activity Against Mycobacterium.

Gustine JN, Au MB, Haserick JR, Hett EC, Rubin EJ, Gibson FC 3rd, Deng LL.

Curr Microbiol. 2019 Apr;76(4):398-409. doi: 10.1007/s00284-018-1620-z. Epub 2019 Jan 2.

PMID:
30603964
12.

Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes.

Landeta C, McPartland L, Tran NQ, Meehan BM, Zhang Y, Tanweer Z, Wakabayashi S, Rock J, Kim T, Balasubramanian D, Audette R, Toosky M, Pinkham J, Rubin EJ, Lory S, Pier G, Boyd D, Beckwith J.

Mol Microbiol. 2019 Apr;111(4):918-937. doi: 10.1111/mmi.14185. Epub 2019 Mar 18.

PMID:
30556355
13.

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape.

Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney JD, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH.

Elife. 2018 Oct 16;7. pii: e37516. doi: 10.7554/eLife.37516.

14.

Of MICs and Men.

Rubin EJ.

N Engl J Med. 2018 Aug 30;379(9):882-883. doi: 10.1056/NEJMe1808564. No abstract available.

PMID:
30157402
15.

Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation.

Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B.

Elife. 2018 Aug 28;7. pii: e36782. doi: 10.7554/eLife.36782.

16.

Enterotoxigenic E. coli virulence gene regulation in human infections.

Crofts AA, Giovanetti SM, Rubin EJ, Poly FM, Gutiérrez RL, Talaat KR, Porter CK, Riddle MS, DeNearing B, Brubaker J, Maciel M Jr, Alcala AN, Chakraborty S, Prouty MG, Savarino SJ, Davies BW, Trent MS.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8968-E8976. doi: 10.1073/pnas.1808982115. Epub 2018 Aug 20.

17.

Misunderstanding the goals of animal research.

Rubin EJ, Fortune SM.

BMJ. 2018 Feb 21;360:k759. doi: 10.1136/bmj.k759. No abstract available.

PMID:
29467126
18.

TB diagnosis from the Dark Ages to fluorescence.

Rubin EJ.

Nat Microbiol. 2018 Mar;3(3):268-269. doi: 10.1038/s41564-018-0118-6. No abstract available.

PMID:
29463926
19.

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1002-E1011. doi: 10.1073/pnas.1713195115. Epub 2018 Jan 17.

20.

Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis.

Wu KJ, Zhang J, Baranowski C, Leung V, Rego EH, Morita YS, Rubin EJ, Boutte CC.

J Bacteriol. 2018 Feb 23;200(6). pii: e00649-17. doi: 10.1128/JB.00649-17. Print 2018 Mar 15.

21.

Tuberculosis: Just the FAQs.

Guinn KM, Rubin EJ.

MBio. 2017 Dec 19;8(6). pii: e01910-17. doi: 10.1128/mBio.01910-17. Review.

22.

Towards the use of breath for detecting mycobacterial infection: a case study in a murine model.

Franchina FA, Mellors TR, Aliyeva M, Wagner J, Daphtary N, Lundblad LKA, Fortune SM, Rubin EJ, Hill JE.

J Breath Res. 2018 Feb 7;12(2):026008. doi: 10.1088/1752-7163/aaa016.

PMID:
29219122
23.

An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):348-353. doi: 10.1002/anie.201709365. Epub 2017 Dec 5.

24.

We Can Do Better - Improving Outcomes in the Midst of an Emergency.

Baden LR, Rubin EJ, Morrissey S, Farrar JJ, Drazen JM.

N Engl J Med. 2017 Oct 12;377(15):1482-1484. doi: 10.1056/NEJMe1712330. No abstract available.

25.

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS.

Nat Commun. 2017 Sep 19;8(1):588. doi: 10.1038/s41467-017-00721-2.

26.

Draft Genome Sequence of Mycobacterium avium 11.

Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Chien JY, Hsueh PR, Dick T.

Genome Announc. 2017 Aug 10;5(32). pii: e00766-17. doi: 10.1128/genomeA.00766-17.

27.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

28.

Reviving a Drug for Tuberculosis?

Rubin EJ.

N Engl J Med. 2017 Jun 8;376(23):2292-2294. doi: 10.1056/NEJMcibr1703502. No abstract available.

PMID:
28591540
29.

Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity.

Rego EH, Audette RE, Rubin EJ.

Nature. 2017 Jun 1;546(7656):153-157. doi: 10.1038/nature22361. Epub 2017 May 31.

30.

Draft Genome Sequence of Mycobacterium abscessus Bamboo.

Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Dick T.

Genome Announc. 2017 May 18;5(20). pii: e00388-17. doi: 10.1128/genomeA.00388-17.

31.

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.

Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM.

Nat Microbiol. 2017 Feb 6;2:16274. doi: 10.1038/nmicrobiol.2016.274.

32.

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR.

MBio. 2017 Jan 17;8(1). pii: e02133-16. doi: 10.1128/mBio.02133-16.

33.

Next-Generation High-Throughput Functional Annotation of Microbial Genomes.

Baric RS, Crosson S, Damania B, Miller SI, Rubin EJ.

MBio. 2016 Oct 4;7(5). pii: e01245-16. doi: 10.1128/mBio.01245-16.

34.

Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?

Baranowski C, Rubin EJ.

J Med Chem. 2016 Jul 14;59(13):6025-6. doi: 10.1021/acs.jmedchem.6b00875. Epub 2016 Jun 20.

PMID:
27322073
35.

A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis.

Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ.

Elife. 2016 Jun 15;5. pii: e14590. doi: 10.7554/eLife.14590.

36.

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.

Filippova EV, Kieser KJ, Luan CH, Wawrzak Z, Kiryukhina O, Rubin EJ, Anderson WF.

FEBS J. 2016 Jun;283(12):2206-18. doi: 10.1111/febs.13738. Epub 2016 May 25.

37.

Inflammatory signaling in human tuberculosis granulomas is spatially organized.

Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE 3rd, Mann M, Dartois V, Rubin EJ.

Nat Med. 2016 May;22(5):531-8. doi: 10.1038/nm.4073. Epub 2016 Apr 4.

38.

Leveraging Advances in Tuberculosis Diagnosis and Treatment to Address Nontuberculous Mycobacterial Disease.

Raju RM, Raju SM, Zhao Y, Rubin EJ.

Emerg Infect Dis. 2016 Mar;22(3):365-9. doi: 10.3201/eid2203.151643.

39.

Zika Virus and Microcephaly.

Rubin EJ, Greene MF, Baden LR.

N Engl J Med. 2016 Mar 10;374(10):984-5. doi: 10.1056/NEJMe1601862. Epub 2016 Feb 10. No abstract available.

40.

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ.

PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351. eCollection 2016 Jan.

41.

Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility.

Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13087-92. doi: 10.1073/pnas.1514135112. Epub 2015 Oct 5.

42.

Benzoic Acid-Inducible Gene Expression in Mycobacteria.

Dragset MS, Barczak AK, Kannan N, Mærk M, Flo TH, Valla S, Rubin EJ, Steigedal M.

PLoS One. 2015 Sep 8;10(9):e0134544. doi: 10.1371/journal.pone.0134544. eCollection 2015.

43.

Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria.

Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ.

PLoS Pathog. 2015 Jun 26;11(6):e1005010. doi: 10.1371/journal.ppat.1005010. eCollection 2015 Jun.

44.

Genetic Strategies for Identifying New Drug Targets.

Trauner A, Sassetti CM, Rubin EJ.

Microbiol Spectr. 2014 Aug;2(4):MGM2-0030-2013. doi: 10.1128/microbiolspec.MGM2-0030-2013. Review.

PMID:
26104208
45.

Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.

Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, Dick T.

MBio. 2015 May 5;6(3):e00253-15. doi: 10.1128/mBio.00253-15.

46.

Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB.

PLoS Pathog. 2015 Mar 27;11(3):e1004792. doi: 10.1371/journal.ppat.1004792. eCollection 2015 Mar.

47.

Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.

Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL.

J Biol Chem. 2015 Apr 24;290(17):11008-20. doi: 10.1074/jbc.M114.625640. Epub 2015 Mar 10.

48.

New insights into TB physiology suggest untapped therapeutic opportunities.

Baer CE, Rubin EJ, Sassetti CM.

Immunol Rev. 2015 Mar;264(1):327-43. doi: 10.1111/imr.12267. Review.

49.

Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria.

Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, Boyd D.

Nat Chem Biol. 2015 Apr;11(4):292-8. doi: 10.1038/nchembio.1752. Epub 2015 Feb 16.

50.

The HIV-positive transplant donor--change born of necessity.

Ingelfinger JR, Rubin EJ.

N Engl J Med. 2015 Feb 12;372(7):663-5. doi: 10.1056/NEJMe1500221. No abstract available.

PMID:
25671260

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