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ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity.

Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP, Kros CJ.

JCI Insight. 2019 Aug 8;4(15). pii: 126764. doi: 10.1172/jci.insight.126764. eCollection 2019 Aug 8.


The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death.

Stawicki TM, Linbo T, Hernandez L, Parkinson L, Bellefeuille D, Rubel EW, Raible DW.

Biol Open. 2019 Jan 14;8(1). pii: bio038745. doi: 10.1242/bio.038745.


Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish.

Bhandiwad AA, Raible DW, Rubel EW, Sisneros JA.

J Assoc Res Otolaryngol. 2018 Dec;19(6):741-752. doi: 10.1007/s10162-018-00685-0. Epub 2018 Sep 6.


De novo sequencing and initial annotation of the Mongolian gerbil (Meriones unguiculatus) genome.

Zorio DAR, Monsma S, Sanes DH, Golding NL, Rubel EW, Wang Y.

Genomics. 2019 May;111(3):441-449. doi: 10.1016/j.ygeno.2018.03.001. Epub 2018 Mar 8.


Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.

Chowdhury S, Owens KN, Herr RJ, Jiang Q, Chen X, Johnson G, Groppi VE, Raible DW, Rubel EW, Simon JA.

J Med Chem. 2018 Jan 11;61(1):84-97. doi: 10.1021/acs.jmedchem.7b00932. Epub 2017 Oct 27.


Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein.

Sakano H, Zorio DAR, Wang X, Ting YS, Noble WS, MacCoss MJ, Rubel EW, Wang Y.

J Comp Neurol. 2017 Oct 15;525(15):3341-3359. doi: 10.1002/cne.24281. Epub 2017 Jul 24.


Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells.

Hailey DW, Esterberg R, Linbo TH, Rubel EW, Raible DW.

J Clin Invest. 2017 Feb 1;127(2):472-486. doi: 10.1172/JCI85052. Epub 2016 Dec 19.


Maintenance of neuronal size gradient in MNTB requires sound-evoked activity.

Weatherstone JH, Kopp-Scheinpflug C, Pilati N, Wang Y, Forsythe ID, Rubel EW, Tempel BL.

J Neurophysiol. 2017 Feb 1;117(2):756-766. doi: 10.1152/jn.00528.2016. Epub 2016 Nov 23.


Glial Cell Contributions to Auditory Brainstem Development.

Cramer KS, Rubel EW.

Front Neural Circuits. 2016 Oct 21;10:83. eCollection 2016. Review.


Cellular distribution of the fragile X mental retardation protein in the mouse brain.

Zorio DA, Jackson CM, Liu Y, Rubel EW, Wang Y.

J Comp Neurol. 2017 Mar 1;525(4):818-849. doi: 10.1002/cne.24100. Epub 2016 Sep 16.


Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death.

Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW.

J Clin Invest. 2016 Sep 1;126(9):3556-66. doi: 10.1172/JCI84939. Epub 2016 Aug 8.


Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.

Stawicki TM, Hernandez L, Esterberg R, Linbo T, Owens KN, Shah AN, Thapa N, Roberts B, Moens CB, Rubel EW, Raible DW.

G3 (Bethesda). 2016 Jul 7;6(7):2225-35. doi: 10.1534/g3.116.030080.


Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells.

Suli A, Pujol R, Cunningham DE, Hailey DW, Prendergast A, Rubel EW, Raible DW.

J Cell Sci. 2016 Jun 1;129(11):2250-60. doi: 10.1242/jcs.182592. Epub 2016 Apr 21.


Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion.

Kaur T, Zamani D, Tong L, Rubel EW, Ohlemiller KK, Hirose K, Warchol ME.

J Neurosci. 2015 Nov 11;35(45):15050-61. doi: 10.1523/JNEUROSCI.2325-15.2015.


Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem.

Seidl AH, Rubel EW.

Glia. 2016 Apr;64(4):487-94. doi: 10.1002/glia.22941. Epub 2015 Nov 10.


Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons.

Tong L, Strong MK, Kaur T, Juiz JM, Oesterle EC, Hume C, Warchol ME, Palmiter RD, Rubel EW.

J Neurosci. 2015 May 20;35(20):7878-91. doi: 10.1523/JNEUROSCI.2179-14.2015.


Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle.

Kaur T, Hirose K, Rubel EW, Warchol ME.

Front Cell Neurosci. 2015 Apr 22;9:150. doi: 10.3389/fncel.2015.00150. eCollection 2015.


Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death.

Stawicki TM, Esterberg R, Hailey DW, Raible DW, Rubel EW.

Front Cell Neurosci. 2015 Feb 18;9:46. doi: 10.3389/fncel.2015.00046. eCollection 2015. Review.


Seasonal plasticity of precise spike timing in the avian auditory system.

Caras ML, Sen K, Rubel EW, Brenowitz EA.

J Neurosci. 2015 Feb 25;35(8):3431-45. doi: 10.1523/JNEUROSCI.3407-14.2015.


Identification of small molecule inhibitors of cisplatin-induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

Thomas AJ, Wu P, Raible DW, Rubel EW, Simon JA, Ou HC.

Otol Neurotol. 2015 Mar;36(3):519-25. doi: 10.1097/MAO.0000000000000487.


ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage.

Esterberg R, Hailey DW, Rubel EW, Raible DW.

J Neurosci. 2014 Jul 16;34(29):9703-19. doi: 10.1523/JNEUROSCI.0281-14.2014.


The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.

Stawicki TM, Owens KN, Linbo T, Reinhart KE, Rubel EW, Raible DW.

Dis Model Mech. 2014 Jul;7(7):847-56. doi: 10.1242/dmm.016576.


Differential conduction velocity regulation in ipsilateral and contralateral collaterals innervating brainstem coincidence detector neurons.

Seidl AH, Rubel EW, BarrĂ­a A.

J Neurosci. 2014 Apr 2;34(14):4914-9. doi: 10.1523/JNEUROSCI.5460-13.2014.


Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.

Cox BC, Chai R, Lenoir A, Liu Z, Zhang L, Nguyen DH, Chalasani K, Steigelman KA, Fang J, Rubel EW, Cheng AG, Zuo J.

Development. 2014 Feb;141(4):816-29. doi: 10.1242/dev.103036. Erratum in: Development. 2014 Apr;141(7):1599. Rubel, Edwin W [added].


Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: a comparative study in the alligator, chicken, gerbil, and human.

Wang Y, Sakano H, Beebe K, Brown MR, de Laat R, Bothwell M, Kulesza RJ Jr, Rubel EW.

J Comp Neurol. 2014 Jun 15;522(9):2107-28. doi: 10.1002/cne.23520.


Fish in a Dish: Drug Discovery for Hearing Habilitation.

Esterberg R, Coffin AB, Ou H, Simon JA, Raible DW, Rubel EW.

Drug Discov Today Dis Models. 2013;10(1). doi: 10.1016/j.ddmod.2012.02.001.


Auditory sensitivity of larval zebrafish (Danio rerio) measured using a behavioral prepulse inhibition assay.

Bhandiwad AA, Zeddies DG, Raible DW, Rubel EW, Sisneros JA.

J Exp Biol. 2013 Sep 15;216(Pt 18):3504-13. doi: 10.1242/jeb.087635.


Osteopontin does not mitigate cisplatin ototoxicity or nephrotoxicity in adult mice.

Schmitt NC, Rubel EW.

Otolaryngol Head Neck Surg. 2013 Oct;149(4):614-20. doi: 10.1177/0194599813498218. Epub 2013 Jul 24.


Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line.

Coffin AB, Rubel EW, Raible DW.

J Assoc Res Otolaryngol. 2013 Oct;14(5):645-59. doi: 10.1007/s10162-013-0404-1. Epub 2013 Jul 3.


Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death.

Esterberg R, Hailey DW, Coffin AB, Raible DW, Rubel EW.

J Neurosci. 2013 Apr 24;33(17):7513-25. doi: 10.1523/JNEUROSCI.4559-12.2013.


Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience.

Mahrt EJ, Perkel DJ, Tong L, Rubel EW, Portfors CV.

J Neurosci. 2013 Mar 27;33(13):5573-83. doi: 10.1523/JNEUROSCI.5054-12.2013.


Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.

Thomas AJ, Hailey DW, Stawicki TM, Wu P, Coffin AB, Rubel EW, Raible DW, Simon JA, Ou HC.

J Neurosci. 2013 Mar 6;33(10):4405-14. doi: 10.1523/JNEUROSCI.3940-12.2013.


Profiling drug-induced cell death pathways in the zebrafish lateral line.

Coffin AB, Williamson KL, Mamiya A, Raible DW, Rubel EW.

Apoptosis. 2013 Apr;18(4):393-408. doi: 10.1007/s10495-013-0816-8.


A brief history of hair cell regeneration research and speculations on the future.

Rubel EW, Furrer SA, Stone JS.

Hear Res. 2013 Mar;297:42-51. doi: 10.1016/j.heares.2012.12.014. Epub 2013 Jan 12. Review.


Pre-target axon sorting in the avian auditory brainstem.

Kashima DT, Rubel EW, Seidl AH.

J Comp Neurol. 2013 Jul 1;521(10):2310-20. doi: 10.1002/cne.23287.


Estradiol selectively enhances auditory function in avian forebrain neurons.

Caras ML, O'Brien M, Brenowitz EA, Rubel EW.

J Neurosci. 2012 Dec 5;32(49):17597-611. doi: 10.1523/JNEUROSCI.3938-12.2012.


Estimating relative abundances of proteins from shotgun proteomics data.

McIlwain S, Mathews M, Bereman MS, Rubel EW, MacCoss MJ, Noble WS.

BMC Bioinformatics. 2012 Nov 19;13:308. doi: 10.1186/1471-2105-13-308.


Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin.

Golub JS, Tong L, Ngyuen TB, Hume CR, Palmiter RD, Rubel EW, Stone JS.

J Neurosci. 2012 Oct 24;32(43):15093-105. doi: 10.1523/JNEUROSCI.1709-12.2012.


Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone.

Hailey DW, Roberts B, Owens KN, Stewart AK, Linbo T, Pujol R, Alper SL, Rubel EW, Raible DW.

PLoS Genet. 2012;8(10):e1002971. doi: 10.1371/journal.pgen.1002971. Epub 2012 Oct 11.


Quinoline ring derivatives protect against aminoglycoside-induced hair cell death in the zebrafish lateral line.

Ou HC, Keating S, Wu P, Simon JA, Raible DW, Rubel EW.

J Assoc Res Otolaryngol. 2012 Dec;13(6):759-70. doi: 10.1007/s10162-012-0353-0. Epub 2012 Oct 10.


TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis.

Schecterson LC, Sanchez JT, Rubel EW, Bothwell M.

J Neurosci. 2012 Oct 3;32(40):14000-9. doi: 10.1523/JNEUROSCI.2274-12.2012.


Afferent regulation of chicken auditory brainstem neurons: rapid changes in phosphorylation of elongation factor 2.

McBride EG, Rubel EW, Wang Y.

J Comp Neurol. 2013 Apr 1;521(5):1165-83. doi: 10.1002/cne.23227.


Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin.

Vlasits AL, Simon JA, Raible DW, Rubel EW, Owens KN.

Hear Res. 2012 Dec;294(1-2):153-65. doi: 10.1016/j.heares.2012.08.002. Epub 2012 Aug 31.


In vivo reversible regulation of dendritic patterning by afferent input in bipolar auditory neurons.

Wang Y, Rubel EW.

J Neurosci. 2012 Aug 15;32(33):11495-504. doi: 10.1523/JNEUROSCI.1737-12.2012.


Control of neuronal excitability by NMDA-type glutamate receptors in early developing binaural auditory neurons.

Sanchez JT, Seidl AH, Rubel EW, Barria A.

J Physiol. 2012 Oct 1;590(19):4801-18. doi: 10.1113/jphysiol.2012.228734. Epub 2012 Jul 23.


Transgenic quail as a model for research in the avian nervous system: a comparative study of the auditory brainstem.

Seidl AH, Sanchez JT, Schecterson L, Tabor KM, Wang Y, Kashima DT, Poynter G, Huss D, Fraser SE, Lansford R, Rubel EW.

J Comp Neurol. 2013 Jan 1;521(1):5-23. doi: 10.1002/cne.23187.


Identification of modulators of hair cell regeneration in the zebrafish lateral line.

Namdaran P, Reinhart KE, Owens KN, Raible DW, Rubel EW.

J Neurosci. 2012 Mar 7;32(10):3516-28. doi: 10.1523/JNEUROSCI.3905-11.2012.


Rheotaxis in larval zebrafish is mediated by lateral line mechanosensory hair cells.

Suli A, Watson GM, Rubel EW, Raible DW.

PLoS One. 2012;7(2):e29727. doi: 10.1371/journal.pone.0029727. Epub 2012 Feb 16.


Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.

Ou H, Simon JA, Rubel EW, Raible DW.

Hear Res. 2012 Jun;288(1-2):58-66. doi: 10.1016/j.heares.2012.01.009. Epub 2012 Jan 31. Review.

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