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Items: 1 to 50 of 103

1.

Angiogenic gene therapy for refractory angina.

Rubanyi GM.

Expert Opin Biol Ther. 2016;16(3):303-15. doi: 10.1517/14712598.2016.1122753. Epub 2015 Dec 14. Review.

PMID:
26581236
2.

Identifying and overcoming obstacles in angiogenic gene therapy for myocardial ischemia.

Rubanyi GM.

J Cardiovasc Pharmacol. 2014 Aug;64(2):109-19. doi: 10.1097/FJC.0000000000000107. Review.

PMID:
24736636
3.
4.

Ischemia-reperfusion increases transfection efficiency of intracoronary adenovirus type 5 in pig heart in situ.

Shi W, Schmarkey LS, Jiang R, Bone CC, Condit ME, Dillehay DL, Engler RL, Rubanyi GM, Vinten-Johansen J.

Hum Gene Ther Methods. 2012 Jun;23(3):204-12. doi: 10.1089/hgtb.2012.048. Epub 2012 Jul 20.

5.

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension.

Zhang LN, Vincelette J, Chen D, Gless RD, Anandan SK, Rubanyi GM, Webb HK, MacIntyre DE, Wang YX.

Eur J Pharmacol. 2011 Mar 1;654(1):68-74. doi: 10.1016/j.ejphar.2010.12.016. Epub 2010 Dec 25.

PMID:
21187082
6.

The discovery of endothelin: the power of bioassay and the role of serendipity in the discovery of endothelium-derived vasocative substances.

Rubanyi GM.

Pharmacol Res. 2011 Jun;63(6):448-54. doi: 10.1016/j.phrs.2010.08.004. Epub 2010 Sep 8. Review.

PMID:
20813186
7.

Directed evolution generates a novel oncolytic virus for the treatment of colon cancer.

Kuhn I, Harden P, Bauzon M, Chartier C, Nye J, Thorne S, Reid T, Ni S, Lieber A, Fisher K, Seymour L, Rubanyi GM, Harkins RN, Hermiston TW.

PLoS One. 2008 Jun 18;3(6):e2409. doi: 10.1371/journal.pone.0002409.

8.

Regulated expression of the interferon-beta gene in mice.

Harkins RN, Szymanski P, Petry H, Brooks A, Qian HS, Schaefer C, Kretschmer PJ, Orme A, Wang P, Rubanyi GM, Hermiston TW.

Gene Ther. 2008 Jan;15(1):1-11. Epub 2007 Jul 19.

PMID:
17637794
9.

Development and validation of a robust and versatile one-plasmid regulated gene expression system.

Szymanski P, Kretschmer PJ, Bauzon M, Jin F, Qian HS, Rubanyi GM, Harkins RN, Hermiston TW.

Mol Ther. 2007 Jul;15(7):1340-7. Epub 2007 May 1.

10.

Mx1 and IP-10: biomarkers to measure IFN-beta activity in mice following gene-based delivery.

Petry H, Cashion L, Szymanski P, Ast O, Orme A, Gross C, Bauzon M, Brooks A, Schaefer C, Gibson H, Qian H, Rubanyi GM, Harkins RN.

J Interferon Cytokine Res. 2006 Oct;26(10):699-705.

PMID:
17032164
11.

Gene-based delivery of IFN-beta is efficacious in a murine model of experimental allergic encephalomyelitis.

Schaefer C, Hidalgo TR, Cashion L, Petry H, Brooks A, Szymanski P, Qian HS, Gross C, Wang P, Liu P, Goldman C, Rubanyi GM, Harkins RN.

J Interferon Cytokine Res. 2006 Jul;26(7):449-54.

PMID:
16800783
12.

Age-dependent acceleration of ischemic injury in endothelial nitric oxide synthase-deficient mice: potential role of impaired VEGF receptor 2 expression.

Qian HS, de Resende MM, Beausejour C, Huw LY, Liu P, Rubanyi GM, Kauser K.

J Cardiovasc Pharmacol. 2006 Apr;47(4):587-93.

PMID:
16680073
13.

Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene.

Qian HS, Liu P, Huw LY, Orme A, Halks-Miller M, Hill SM, Jin F, Kretschmer P, Blasko E, Cashion L, Szymanski P, Vergona R, Harkins R, Yu J, Sessa WC, Dole WP, Rubanyi GM, Kauser K.

Gene Ther. 2006 Sep;13(18):1342-50. Epub 2006 Apr 27.

PMID:
16642030
14.

Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice.

Fitch RM, Rutledge JC, Wang YX, Powers AF, Tseng JL, Clary T, Rubanyi GM.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1190-8. Epub 2005 Nov 4.

15.

Arteriogenic gene therapy in patients with unreconstructable critical limb ischemia: a randomized, placebo-controlled clinical trial of adenovirus 5-delivered fibroblast growth factor-4.

Matyas L, Schulte KL, Dormandy JA, Norgren L, Sowade O, Grötzbach G, Palmer-Kazen U, Rubanyi GM, Wahlberg E.

Hum Gene Ther. 2005 Oct;16(10):1202-11.

PMID:
16218781
16.

Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.

Yu J, deMuinck ED, Zhuang Z, Drinane M, Kauser K, Rubanyi GM, Qian HS, Murata T, Escalante B, Sessa WC.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10999-1004. Epub 2005 Jul 25.

17.
18.
19.

Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data.

Gao MH, Lai NC, McKirnan MD, Roth DA, Rubanyi GM, Dalton N, Roth DM, Hammond HK.

Hum Gene Ther. 2004 Jun;15(6):574-87.

PMID:
15212716
20.
21.

Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle.

Brooks AR, Harkins RN, Wang P, Qian HS, Liu P, Rubanyi GM.

J Gene Med. 2004 Apr;6(4):395-404.

PMID:
15079814
22.

Angiogenic gene therapy with adenovirus 5 fibroblast growth factor-4 (Ad5FGF-4): a new option for the treatment of coronary artery disease.

Grines C, Rubanyi GM, Kleiman NS, Marrott P, Watkins MW.

Am J Cardiol. 2003 Nov 7;92(9B):24N-31N. Review.

PMID:
14615023
23.

Gene therapy for coronary artery disease: preclinical and initial clinical results with intracoronary administration of Ad5FGF-4.

Watkins MW, Rubanyi GM.

Ernst Schering Res Found Workshop. 2003;(43):61-78. Review. No abstract available.

PMID:
12894451
24.

Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model.

Rissanen TT, Markkanen JE, Arve K, Rutanen J, Kettunen MI, Vajanto I, Jauhiainen S, Cashion L, Gruchala M, Närvänen O, Taipale P, Kauppinen RA, Rubanyi GM, Ylä-Herttuala S.

FASEB J. 2003 Jan;17(1):100-2. Epub 2002 Nov 15.

PMID:
12475908
25.

Effect of estrogen on endothelial function and angiogenesis.

Rubanyi GM, Johns A, Kauser K.

Vascul Pharmacol. 2002 Feb;38(2):89-98. Review.

PMID:
12379955
26.

Role of estrogen receptors in the vascular system.

Rubanyi GM, Kauser K, Johns A.

Vascul Pharmacol. 2002 Feb;38(2):81-8. Review.

PMID:
12379954
27.
28.
29.

The future of human gene therapy.

Rubanyi GM.

Mol Aspects Med. 2001 Jun;22(3):113-42. Review.

PMID:
11470139
30.

Estrogen inhibits mechanical strain-induced mitogenesis in human vascular smooth muscle cells via down-regulation of Sp-1.

Ling S, Deng G, Ives HE, Chatterjee K, Rubanyi GM, Komesaroff PA, Sudhir K.

Cardiovasc Res. 2001 Apr;50(1):108-14.

PMID:
11282083
31.
32.

Changes of endothelial nitric oxide synthase level and activity during endothelial cell proliferation.

Zöllner S, Aberle S, Harvey SE, Polokoff MA, Rubanyi GM.

Endothelium. 2000;7(3):169-84.

PMID:
10912911
33.
34.

Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice.

Kauser K, da Cunha V, Fitch R, Mallari C, Rubanyi GM.

Am J Physiol Heart Circ Physiol. 2000 May;278(5):H1679-85.

35.

Identification of selective estrogen receptor modulators by their gene expression fingerprints.

Zajchowski DA, Kauser K, Zhu D, Webster L, Aberle S, White FA 3rd, Liu HL, Humm R, MacRobbie J, Ponte P, Hegele-Hartung C, Knauthe R, Fritzemeier KH, Vergona R, Rubanyi GM.

J Biol Chem. 2000 May 26;275(21):15885-94.

36.

Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice.

Wang YX, Halks-Miller M, Vergona R, Sullivan ME, Fitch R, Mallari C, Martin-McNulty B, da Cunha V, Freay A, Rubanyi GM, Kauser K.

Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H428-34.

37.

Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiol.

Tse J, Martin-McNaulty B, Halks-Miller M, Kauser K, DelVecchio V, Vergona R, Sullivan ME, Rubanyi GM.

Atherosclerosis. 1999 Jun;144(2):303-13.

PMID:
10407491
38.

Effect of 17beta-estradiol in hypercholesterolemic rabbits with severe endothelial dysfunction.

Nascimento CA, Kauser K, Rubanyi GM.

Am J Physiol. 1999 May;276(5):H1788-94. doi: 10.1152/ajpheart.1999.276.5.H1788.

PMID:
10330264
39.

Nitric oxide and circulatory shock.

Rubanyi GM.

Adv Exp Med Biol. 1998;454:165-72. Review. No abstract available.

PMID:
9889889
40.

Differential effects of IFN-beta1b on the proliferation of human vascular smooth muscle and endothelial cells.

Mintzer RJ, Croze E, Rubanyi GM, Johns A.

J Interferon Cytokine Res. 1998 Nov;18(11):939-45.

PMID:
9858315
41.

Expression of interleukin-6 in atherosclerotic lesions of male ApoE-knockout mice: inhibition by 17beta-estradiol.

Sukovich DA, Kauser K, Shirley FD, DelVecchio V, Halks-Miller M, Rubanyi GM.

Arterioscler Thromb Vasc Biol. 1998 Sep;18(9):1498-505.

PMID:
9743240
42.

Effect of 17beta-oestradiol on cytokine-induced nitric oxide production in rat isolated aorta.

Kauser K, Sonnenberg D, Diel P, Rubanyi GM.

Br J Pharmacol. 1998 Mar;123(6):1089-96.

43.

Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man.

Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, Malloy MJ, Korach KS, Rubanyi GM.

Circulation. 1997 Nov 18;96(10):3774-7.

PMID:
9396482
44.
45.

Nitroxides increase the detectable amount of nitric oxide released from endothelial cells.

Zöllner S, Haseloff RF, Kirilyuk IA, Blasig IE, Rubanyi GM.

J Biol Chem. 1997 Sep 12;272(37):23076-80.

46.
47.

Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice.

Johnson BD, Zheng W, Korach KS, Scheuer T, Catterall WA, Rubanyi GM.

J Gen Physiol. 1997 Aug;110(2):135-40.

48.

17 beta-Estradiol attenuates endotoxin-induced excessive nitric oxide production in ovariectomized rats in vivo.

Kauser K, Sonnenberg D, Tse J, Rubanyi GM.

Am J Physiol. 1997 Jul;273(1 Pt 2):H506-9.

PMID:
9249525
49.

Quantitative measurement for endothelial constitutive nitric oxide synthase in cultured human endothelial cells.

Aberle S, Young TA, Medberry P, Parkinson J, Rubanyi GM, Kauser K.

Nitric Oxide. 1997 Jun;1(3):226-33.

PMID:
9704584
50.

Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption.

Rubanyi GM, Freay AD, Kauser K, Sukovich D, Burton G, Lubahn DB, Couse JF, Curtis SW, Korach KS.

J Clin Invest. 1997 May 15;99(10):2429-37.

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