Molecules Produced by Probiotics and Intestinal Microorganisms with Immunomodulatory Activity.

Delgado S, Sánchez B, Margolles A, Ruas-Madiedo P, Ruiz L.

Nutrients. 2020 Feb 1;12(2). pii: E391. doi: 10.3390/nu12020391. Review.


In Vitro Evaluation of Different Prebiotics on the Modulation of Gut Microbiota Composition and Function in Morbid Obese and Normal-Weight Subjects.

Nogacka AM, Salazar N, Arboleya S, Ruas-Madiedo P, Mancabelli L, Suarez A, Martinez-Faedo C, Ventura M, Tochio T, Hirano K, Endo A, G de Los Reyes-Gavilán C, Gueimonde M.

Int J Mol Sci. 2020 Jan 30;21(3). pii: E906. doi: 10.3390/ijms21030906.


Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice.

Salazar N, Neyrinck AM, Bindels LB, Druart C, Ruas-Madiedo P, Cani PD, de Los Reyes-Gavilán CG, Delzenne NM.

Front Microbiol. 2019 Aug 7;10:1809. doi: 10.3389/fmicb.2019.01809. eCollection 2019.


Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.

Castro-Bravo N, Margolles A, Wells JM, Ruas-Madiedo P.

Anaerobe. 2019 Apr;56:98-101. doi: 10.1016/j.anaerobe.2019.02.014. Epub 2019 Feb 20.


The biogenic amines putrescine and cadaverine show in vitro cytotoxicity at concentrations that can be found in foods.

Del Rio B, Redruello B, Linares DM, Ladero V, Ruas-Madiedo P, Fernandez M, Martin MC, Alvarez MA.

Sci Rep. 2019 Jan 15;9(1):120. doi: 10.1038/s41598-018-36239-w.


Interactions of Surface Exopolysaccharides From Bifidobacterium and Lactobacillus Within the Intestinal Environment.

Castro-Bravo N, Wells JM, Margolles A, Ruas-Madiedo P.

Front Microbiol. 2018 Oct 11;9:2426. doi: 10.3389/fmicb.2018.02426. eCollection 2018. Review.


Spermine and spermidine are cytotoxic towards intestinal cell cultures, but are they a health hazard at concentrations found in foods?

Del Rio B, Redruello B, Linares DM, Ladero V, Ruas-Madiedo P, Fernandez M, Martin MC, Alvarez MA.

Food Chem. 2018 Dec 15;269:321-326. doi: 10.1016/j.foodchem.2018.06.148. Epub 2018 Jul 2.


Real-time monitoring of HT29 epithelial cells as an in vitro model for assessing functional differences among intestinal microbiotas from different human population groups.

Nogacka AM, Ruas-Madiedo P, Gómez E, Solís G, Fernández N, Suárez M, Suárez A, Salazar N, de Los Reyes-Gavilán CG, Gueimonde M.

J Microbiol Methods. 2018 Sep;152:210-216. doi: 10.1016/j.mimet.2018.07.003. Epub 2018 Jul 10.


Extraction of the same novel homoglycan mixture from two different strains of Bifidobacterium animalis and three strains of Bifidobacterium breve.

Alhudhud M, Sadiq S, Ngo HN, Hidalgo-Cantabrana C, Ruas-Madiedo P, van Sinderen D, Humphreys PN, Laws AP.

Benef Microbes. 2018 Jun 15;9(4):663-674. doi: 10.3920/BM2017.0145. Epub 2018 Apr 26.


Probiotics for Prevention and Treatment of Clostridium difficile Infection.

Valdés-Varela L, Gueimonde M, Ruas-Madiedo P.

Adv Exp Med Biol. 2018;1050:161-176. doi: 10.1007/978-3-319-72799-8_10. Review.


Bifidobacteria and Their Molecular Communication with the Immune System.

Ruiz L, Delgado S, Ruas-Madiedo P, Sánchez B, Margolles A.

Front Microbiol. 2017 Dec 4;8:2345. doi: 10.3389/fmicb.2017.02345. eCollection 2017. Review.


Real-Time Assessment of Staphylococcus aureus Biofilm Disruption by Phage-Derived Proteins.

Gutiérrez D, Fernández L, Martínez B, Ruas-Madiedo P, García P, Rodríguez A.

Front Microbiol. 2017 Aug 24;8:1632. doi: 10.3389/fmicb.2017.01632. eCollection 2017.


Rheology and bioactivity of high molecular weight dextrans synthesised by lactic acid bacteria.

Zarour K, Llamas MG, Prieto A, Rúas-Madiedo P, Dueñas MT, de Palencia PF, Aznar R, Kihal M, López P.

Carbohydr Polym. 2017 Oct 15;174:646-657. doi: 10.1016/j.carbpol.2017.06.113. Epub 2017 Jun 29.


Chemical and biological properties of the novel exopolysaccharide produced by a probiotic strain of Bifidobacterium longum.

Inturri R, Molinaro A, Di Lorenzo F, Blandino G, Tomasello B, Hidalgo-Cantabrana C, De Castro C, Ruas-Madiedo P.

Carbohydr Polym. 2017 Oct 15;174:1172-1180. doi: 10.1016/j.carbpol.2017.07.039. Epub 2017 Jul 19.


Bacterial diversity of the Colombian fermented milk "Suero Costeño" assessed by culturing and high-throughput sequencing and DGGE analysis of 16S rRNA gene amplicons.

Motato KE, Milani C, Ventura M, Valencia FE, Ruas-Madiedo P, Delgado S.

Food Microbiol. 2017 Dec;68:129-136. doi: 10.1016/j.fm.2017.07.011. Epub 2017 Jul 18.


Gene Replacement and Fluorescent Labeling to Study the Functional Role of Exopolysaccharides in Bifidobacterium animalis subsp. lactis.

Castro-Bravo N, Hidalgo-Cantabrana C, Rodriguez-Carvajal MA, Ruas-Madiedo P, Margolles A.

Front Microbiol. 2017 Jul 25;8:1405. doi: 10.3389/fmicb.2017.01405. eCollection 2017.


Bifidobacteria and Their Health-Promoting Effects.

Hidalgo-Cantabrana C, Delgado S, Ruiz L, Ruas-Madiedo P, Sánchez B, Margolles A.

Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.BAD-0010-2016. Review.


Complete Genome Sequence of Bifidobacterium longum W11 (LMG P-21586), Used as a Probiotic Strain.

Inturri R, Ventura M, Ruas-Madiedo P, Lugli GA, Blandino G.

Genome Announc. 2017 Mar 9;5(10). pii: e01659-16. doi: 10.1128/genomeA.01659-16.


In vitro fermentation of different fructo-oligosaccharides by Bifidobacterium strains for the selection of synbiotic combinations.

Valdés-Varela L, Ruas-Madiedo P, Gueimonde M.

Int J Food Microbiol. 2017 Feb 2;242:19-23. doi: 10.1016/j.ijfoodmicro.2016.11.011. Epub 2016 Nov 12.


Susceptibility of lactic acid bacteria, bifidobacteria and other bacteria of intestinal origin to chemotherapeutic agents.

Flórez AB, Sierra M, Ruas-Madiedo P, Mayo B.

Int J Antimicrob Agents. 2016 Nov;48(5):547-550. doi: 10.1016/j.ijantimicag.2016.07.011. Epub 2016 Aug 18.


Bioactive compounds from regular diet and faecal microbial metabolites.

Fernández-Navarro T, Salazar N, Gutiérrez-Díaz I, Sánchez B, Rúas-Madiedo P, de Los Reyes-Gavilán CG, Margolles A, Gueimonde M, González S.

Eur J Nutr. 2018 Mar;57(2):487-497. doi: 10.1007/s00394-016-1332-8. Epub 2016 Oct 15.


The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture.

Del Rio B, Redruello B, Linares DM, Ladero V, Fernandez M, Martin MC, Ruas-Madiedo P, Alvarez MA.

Food Chem. 2017 Mar 1;218:249-255. doi: 10.1016/j.foodchem.2016.09.046. Epub 2016 Sep 8.


Monitoring in Real Time the Formation and Removal of Biofilms from Clinical Related Pathogens Using an Impedance-Based Technology.

Gutiérrez D, Hidalgo-Cantabrana C, Rodríguez A, García P, Ruas-Madiedo P.

PLoS One. 2016 Oct 3;11(10):e0163966. doi: 10.1371/journal.pone.0163966. eCollection 2016.


Proteinaceous Molecules Mediating Bifidobacterium-Host Interactions.

Ruiz L, Delgado S, Ruas-Madiedo P, Margolles A, Sánchez B.

Front Microbiol. 2016 Aug 3;7:1193. doi: 10.3389/fmicb.2016.01193. eCollection 2016. Review.


Bacteroides fragilis metabolises exopolysaccharides produced by bifidobacteria.

Rios-Covian D, Cuesta I, Alvarez-Buylla JR, Ruas-Madiedo P, Gueimonde M, de Los Reyes-Gavilán CG.

BMC Microbiol. 2016 Jul 15;16(1):150. doi: 10.1186/s12866-016-0773-9.


Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model.

Hidalgo-Cantabrana C, Algieri F, Rodriguez-Nogales A, Vezza T, Martínez-Camblor P, Margolles A, Ruas-Madiedo P, Gálvez J.

Front Microbiol. 2016 Jun 9;7:868. doi: 10.3389/fmicb.2016.00868. eCollection 2016.


Effect of Bifidobacterium upon Clostridium difficile Growth and Toxicity When Co-cultured in Different Prebiotic Substrates.

Valdés-Varela L, Hernández-Barranco AM, Ruas-Madiedo P, Gueimonde M.

Front Microbiol. 2016 May 18;7:738. doi: 10.3389/fmicb.2016.00738. eCollection 2016.


Screening of Bifidobacteria and Lactobacilli Able to Antagonize the Cytotoxic Effect of Clostridium difficile upon Intestinal Epithelial HT29 Monolayer.

Valdés-Varela L, Alonso-Guervos M, García-Suárez O, Gueimonde M, Ruas-Madiedo P.

Front Microbiol. 2016 Apr 22;7:577. doi: 10.3389/fmicb.2016.00577. eCollection 2016.


EPS-SJ Exopolisaccharide Produced by the Strain Lactobacillus paracasei subsp. paracasei BGSJ2-8 Is Involved in Adhesion to Epithelial Intestinal Cells and Decrease on E. coli Association to Caco-2 Cells.

Živković M, Miljković MS, Ruas-Madiedo P, Markelić MB, Veljović K, Tolinački M, Soković S, Korać A, Golić N.

Front Microbiol. 2016 Mar 9;7:286. doi: 10.3389/fmicb.2016.00286. eCollection 2016.


Modulation of the eps-ome transcription of bifidobacteria through simulation of human intestinal environment.

Ferrario C, Milani C, Mancabelli L, Lugli GA, Duranti S, Mangifesta M, Viappiani A, Turroni F, Margolles A, Ruas-Madiedo P, van Sinderen D, Ventura M.

FEMS Microbiol Ecol. 2016 Apr;92(4):fiw056. doi: 10.1093/femsec/fiw056. Epub 2016 Mar 8.


Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health.

Ríos-Covián D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilán CG, Salazar N.

Front Microbiol. 2016 Feb 17;7:185. doi: 10.3389/fmicb.2016.00185. eCollection 2016. Review.


Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine.

Linares DM, del Rio B, Redruello B, Ladero V, Martin MC, Fernandez M, Ruas-Madiedo P, Alvarez MA.

Food Chem. 2016 Apr 15;197(Pt A):658-63. doi: 10.1016/j.foodchem.2015.11.013. Epub 2015 Nov 9.


Monitoring in real time the cytotoxic effect of Clostridium difficile upon the intestinal epithelial cell line HT29.

Valdés L, Gueimonde M, Ruas-Madiedo P.

J Microbiol Methods. 2015 Dec;119:66-73. doi: 10.1016/j.mimet.2015.09.022. Epub 2015 Oct 5.


A single mutation in the gene responsible for the mucoid phenotype of Bifidobacterium animalis subsp. lactis confers surface and functional characteristics.

Hidalgo-Cantabrana C, Sánchez B, Álvarez-Martín P, López P, Martínez-Álvarez N, Delley M, Martí M, Varela E, Suárez A, Antolín M, Guarner F, Berger B, Ruas-Madiedo P, Margolles A.

Appl Environ Microbiol. 2015 Dec;81(23):7960-8. doi: 10.1128/AEM.02095-15. Epub 2015 Sep 11.


Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX.

Zivkovic M, Hidalgo-Cantabrana C, Kojic M, Gueimonde M, Golic N, Ruas-Madiedo P.

Food Res Int. 2015 Aug;74:199-207. doi: 10.1016/j.foodres.2015.05.012. Epub 2015 May 12.


The relationship between phenolic compounds from diet and microbiota: impact on human health.

Valdés L, Cuervo A, Salazar N, Ruas-Madiedo P, Gueimonde M, González S.

Food Funct. 2015 Aug;6(8):2424-39. doi: 10.1039/c5fo00322a. Epub 2015 Jun 11. Review.


Probiotic potential of selected lactic acid bacteria strains isolated from Brazilian kefir grains.

Leite AM, Miguel MA, Peixoto RS, Ruas-Madiedo P, Paschoalin VM, Mayo B, Delgado S.

J Dairy Sci. 2015 Jun;98(6):3622-32. doi: 10.3168/jds.2014-9265. Epub 2015 Apr 1.


The effects of Bifidobacterium breve on immune mediators and proteome of HT29 cells monolayers.

Sánchez B, González-Rodríguez I, Arboleya S, López P, Suárez A, Ruas-Madiedo P, Margolles A, Gueimonde M.

Biomed Res Int. 2015;2015:479140. doi: 10.1155/2015/479140. Epub 2015 Feb 22.


Red wine consumption is associated with fecal microbiota and malondialdehyde in a human population.

Cuervo A, Reyes-Gavilán CG, Ruas-Madiedo P, Lopez P, Suarez A, Gueimonde M, González S.

J Am Coll Nutr. 2015;34(2):135-41. doi: 10.1080/07315724.2014.904763. Epub 2015 Mar 4.


Exopolysaccharides Produced by Lactic Acid Bacteria and Bifidobacteria as Fermentable Substrates by the Intestinal Microbiota.

Salazar N, Gueimonde M, de Los Reyes-Gavilán CG, Ruas-Madiedo P.

Crit Rev Food Sci Nutr. 2016 Jul 3;56(9):1440-53. doi: 10.1080/10408398.2013.770728. Review.


[Prebiotics: concept, properties and beneficial effects].

Corzo N, Alonso JL, Azpiroz F, Calvo MA, Cirici M, Leis R, Lombó F, Mateos-Aparicio I, Plou FJ, Ruas-Madiedo P, Rúperez P, Redondo-Cuenca A, Sanz ML, Clemente A.

Nutr Hosp. 2015 Feb 7;31 Suppl 1:99-118. doi: 10.3305/nh.2015.31.sup1.8715. Review. Spanish.


[Irritable Bowel Syndrome; gut microbiota and probiotic therapy].

Tojo González R, Suarez Gonzalez A, Rúas Madiedo P, Mancebo Mata A, Pipa Muñiz M, Barreiro Alonso E, Roman Llorente FJ, Moro Villar MC, Arce González MM, Villegas Diaz MF, Mosquera Sierra E, Ruiz Ruiz M.

Nutr Hosp. 2015 Feb 7;31 Suppl 1:83-8. doi: 10.3305/nh.2015.31.sup1.8713. Review. Spanish.


Degenerate PCR primers for detecting putative priming glycosyltransferase genes in Bifidobacterium strains.

Hidalgo-Cantabrana C, Ordoñez I, Ruas-Madiedo P, Margolles A.

Benef Microbes. 2015;6(4):553-62. doi: 10.3920/BM2014.0046. Epub 2015 Feb 12.


Probiotic and technological properties of Lactobacillus spp. strains from the human stomach in the search for potential candidates against gastric microbial dysbiosis.

Delgado S, Leite AM, Ruas-Madiedo P, Mayo B.

Front Microbiol. 2015 Jan 14;5:766. doi: 10.3389/fmicb.2014.00766. eCollection 2014.


Exopolysaccharide production and ropy phenotype are determined by two gene clusters in putative probiotic strain Lactobacillus paraplantarum BGCG11.

Zivkovic M, Miljkovic M, Ruas-Madiedo P, Strahinic I, Tolinacki M, Golic N, Kojic M.

Appl Environ Microbiol. 2015 Feb;81(4):1387-96.


Potentially probiotic and bioprotective lactic acid bacteria starter cultures antagonise the Listeria monocytogenes adhesion to HT29 colonocyte-like cells.

Garriga M, Rubio R, Aymerich T, Ruas-Madiedo P.

Benef Microbes. 2015;6(3):337-43. doi: 10.3920/BM2014.0056.


Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis.

Tojo R, Suárez A, Clemente MG, de los Reyes-Gavilán CG, Margolles A, Gueimonde M, Ruas-Madiedo P.

World J Gastroenterol. 2014 Nov 7;20(41):15163-76. doi: 10.3748/wjg.v20.i41.15163. Review.


Effective removal of staphylococcal biofilms by the endolysin LysH5.

Gutiérrez D, Ruas-Madiedo P, Martínez B, Rodríguez A, García P.

PLoS One. 2014 Sep 9;9(9):e107307. doi: 10.1371/journal.pone.0107307. eCollection 2014.


Immune modulating capability of two exopolysaccharide-producing Bifidobacterium strains in a Wistar rat model.

Salazar N, López P, Garrido P, Moran J, Cabello E, Gueimonde M, Suárez A, González C, de los Reyes-Gavilán CG, Ruas-Madiedo P.

Biomed Res Int. 2014;2014:106290. doi: 10.1155/2014/106290. Epub 2014 May 29.


Pilot study of diet and microbiota: interactive associations of fibers and polyphenols with human intestinal bacteria.

Cuervo A, Valdés L, Salazar N, de los Reyes-Gavilán CG, Ruas-Madiedo P, Gueimonde M, González S.

J Agric Food Chem. 2014 Jun 11;62(23):5330-6. doi: 10.1021/jf501546a. Epub 2014 May 30.


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