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Items: 1 to 50 of 113

1.

Oxysterols and Gastrointestinal Cancers Around the Clock.

Kovač U, Skubic C, Bohinc L, Rozman D, Režen T.

Front Endocrinol (Lausanne). 2019 Jul 17;10:483. doi: 10.3389/fendo.2019.00483. eCollection 2019. Review.

2.

The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2nd Trimester Lipid Levels and Preterm Birth.

Kovac U, Jasper EA, Smith CJ, Baer RJ, Bedell B, Donovan BM, Weathers N, Prosenc Zmrzljak U, Jelliffe-Pawlowski LL, Rozman D, Ryckman KK.

Front Genet. 2019 Jun 13;10:540. doi: 10.3389/fgene.2019.00540. eCollection 2019.

3.

Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis.

Marbach-Breitrück E, Matz-Soja M, Abraham U, Schmidt-Heck W, Sales S, Rennert C, Kern M, Aleithe S, Spormann L, Thiel C, Gerlini R, Arnold K, Klöting N, Guthke R, Rozman D, Teperino R, Shevchenko A, Kramer A, Gebhardt R.

J Hepatol. 2019 Jun;70(6):1192-1202. doi: 10.1016/j.jhep.2019.01.022. Epub 2019 Feb 1.

PMID:
30711403
4.

Computational Modelling of Liver Metabolism and its Applications in Research and the Clinics.

Cvitanović Tomaš T, Moškon M, Mraz M, Rozman D.

Acta Chim Slov. 2018 Jun;65(2):253-265. doi: 10.17344/acsi.2018.4461.

PMID:
29993093
5.

Personalized therapy when tackling nonalcoholic fatty liver disease: a focus on sex, genes, and drugs.

Skubic C, Drakulić Ž, Rozman D.

Expert Opin Drug Metab Toxicol. 2018 Aug;14(8):831-841. doi: 10.1080/17425255.2018.1492552. Epub 2018 Jul 3. Review.

PMID:
29969922
6.

Meta-Analysis and Experimental Validation Identified FREM2 and SPRY1 as New Glioblastoma Marker Candidates.

Vidak M, Jovcevska I, Samec N, Zottel A, Liovic M, Rozman D, Dzeroski S, Juvan P, Komel R.

Int J Mol Sci. 2018 May 4;19(5). pii: E1369. doi: 10.3390/ijms19051369.

7.

LiverSex Computational Model: Sexual Aspects in Hepatic Metabolism and Abnormalities.

Cvitanović Tomaš T, Urlep Ž, Moškon M, Mraz M, Rozman D.

Front Physiol. 2018 Apr 12;9:360. doi: 10.3389/fphys.2018.00360. eCollection 2018.

8.

Lactobacillus fermentum L930BB and Bifidobacterium animalis subsp. animalis IM386 initiate signalling pathways involved in intestinal epithelial barrier protection.

Paveljšek D, Juvan P, Košir R, Rozman D, Hacin B, Ivičak-Kocjan K, Rogelj I.

Benef Microbes. 2018 Apr 25;9(3):515-525. doi: 10.3920/BM2017.0107. Epub 2018 Apr 10.

PMID:
29633647
9.

Community effort endorsing multiscale modelling, multiscale data science and multiscale computing for systems medicine.

Zanin M, Chorbev I, Stres B, Stalidzans E, Vera J, Tieri P, Castiglione F, Groen D, Zheng H, Baumbach J, Schmid JA, Basilio J, Klimek P, Debeljak N, Rozman D, Schmidt HHHW.

Brief Bioinform. 2019 May 21;20(3):1057-1062. doi: 10.1093/bib/bbx160.

10.

Interaction of PER2 with the Constitutive Androstane Receptor Possibly Links Circadian Rhythms to Metabolism.

Martini T, Stojan J, Rozman D, Prosenc Zmrzljak U.

Acta Chim Slov. 2017 Sep;64(3):571-576.

PMID:
28862300
11.

Computational modelling of genome-scale metabolic networks and its application to CHO cell cultures.

Rejc Ž, Magdevska L, Tršelič T, Osolin T, Vodopivec R, Mraz J, Pavliha E, Zimic N, Cvitanović T, Rozman D, Moškon M, Mraz M.

Comput Biol Med. 2017 Sep 1;88:150-160. doi: 10.1016/j.compbiomed.2017.07.005. Epub 2017 Jul 8. Review.

PMID:
28732234
12.

Evaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner.

Režen T, Ogris I, Sever M, Merzel F, Golic Grdadolnik S, Rozman D.

Front Pharmacol. 2017 Jun 30;8:417. doi: 10.3389/fphar.2017.00417. eCollection 2017.

13.

Rosuvastatin and Atorvastatin Are Ligands of the Human Constitutive Androstane Receptor/Retinoid X Receptor α Complex.

Režen T, Hafner M, Kortagere S, Ekins S, Hodnik V, Rozman D.

Drug Metab Dispos. 2017 Aug;45(8):974-976. doi: 10.1124/dmd.117.075523. Epub 2017 May 23.

PMID:
28536098
14.

Large-scale computational models of liver metabolism: How far from the clinics?

Cvitanović T, Reichert MC, Moškon M, Mraz M, Lammert F, Rozman D.

Hepatology. 2017 Oct;66(4):1323-1334. doi: 10.1002/hep.29268. Epub 2017 Aug 30. Review.

PMID:
28520105
15.

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.

Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanai Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI.

Sci Rep. 2017 Feb 2;7:41912. doi: 10.1038/srep41912.

16.

Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling.

Urlep Ž, Lorbek G, Perše M, Jeruc J, Juvan P, Matz-Soja M, Gebhardt R, Björkhem I, Hall JA, Bonneau R, Littman DR, Rozman D.

Sci Rep. 2017 Jan 18;7:40775. doi: 10.1038/srep40775.

17.

Targeting Signalling Pathways in Hepatocellular Carcinoma.

Blagotinsek K, Rozman D.

Curr Pharm Des. 2017;23(1):170-175. doi: 10.2174/1381612822666161006160005. Review.

PMID:
27719638
18.

Mouse genotypes drive the liver and adrenal gland clocks.

Košir R, Prosenc Zmrzljak U, Korenčič A, Juvan P, Ačimovič J, Rozman D.

Sci Rep. 2016 Aug 18;6:31955. doi: 10.1038/srep31955.

19.

Pharmacogenomic and personalized approaches to tackle nonalcoholic fatty liver disease.

Lorbek G, Urlep Ž, Rozman D.

Pharmacogenomics. 2016 Jul;17(11):1273-1288. Epub 2016 Jul 5. Review.

20.

Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.

Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D.

Sci Rep. 2016 Jun 23;6:28462. doi: 10.1038/srep28462.

21.

Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors.

Rozman D, Acimovic J, Schmeck B.

Methods Mol Biol. 2016;1386:73-86. doi: 10.1007/978-1-4939-3283-2_5. Review.

PMID:
26677180
22.

Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells.

Vidak M, Rozman D, Komel R.

Molecules. 2015 Oct 23;20(10):19406-32. doi: 10.3390/molecules201019406. Review.

23.

Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury.

Lorbek G, Perše M, Jeruc J, Juvan P, Gutierrez-Mariscal FM, Lewinska M, Gebhardt R, Keber R, Horvat S, Björkhem I, Rozman D.

Sci Rep. 2015 Mar 5;5:8777. doi: 10.1038/srep08777.

24.

Identification of natural RORγ ligands that regulate the development of lymphoid cells.

Santori FR, Huang P, van de Pavert SA, Douglass EF Jr, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR.

Cell Metab. 2015 Feb 3;21(2):286-298. doi: 10.1016/j.cmet.2015.01.004.

25.

SteatoNet: the first integrated human metabolic model with multi-layered regulation to investigate liver-associated pathologies.

Naik A, Rozman D, Belič A.

PLoS Comput Biol. 2014 Dec 11;10(12):e1003993. doi: 10.1371/journal.pcbi.1003993. eCollection 2014 Dec.

26.

Structural insight into the unique binding properties of pyridylethanol(phenylethyl)amine inhibitor in human CYP51.

Zelenko U, Hodošček M, Rozman D, Golič Grdadolnik S.

J Chem Inf Model. 2014 Dec 22;54(12):3384-95. doi: 10.1021/ci500556k. Epub 2014 Dec 5.

PMID:
25419870
27.

Hidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesis.

Lewinska M, Juvan P, Perse M, Jeruc J, Kos S, Lorbek G, Urlep Z, Keber R, Horvat S, Rozman D.

PLoS One. 2014 Nov 13;9(11):e112787. doi: 10.1371/journal.pone.0112787. eCollection 2014.

28.

Timing of circadian genes in mammalian tissues.

Korenčič A, Košir R, Bordyugov G, Lehmann R, Rozman D, Herzel H.

Sci Rep. 2014 Jul 22;4:5782. doi: 10.1038/srep05782.

29.

Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression.

Nekvindova J, Contreras JA, Juvan P, Fon Tacer K, Anzenbacher P, Zidek Z, Kopecna Zapletalova M, Rozman D, Anzenbacherova E.

Xenobiotica. 2014 Aug;44(8):708-15. doi: 10.3109/00498254.2014.895880. Epub 2014 Mar 5.

PMID:
24593268
30.

From nonalcoholic Fatty liver disease to hepatocellular carcinoma: a systems understanding.

Rozman D.

Dig Dis Sci. 2014 Feb;59(2):238-41. doi: 10.1007/s10620-013-2998-x. No abstract available.

PMID:
24385011
31.
32.

Polymorphisms of CYP51A1 from cholesterol synthesis: associations with birth weight and maternal lipid levels and impact on CYP51 protein structure.

Lewińska M, Zelenko U, Merzel F, Golic Grdadolnik S, Murray JC, Rozman D.

PLoS One. 2013 Dec 17;8(12):e82554. doi: 10.1371/journal.pone.0082554. eCollection 2013.

33.

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

Wang W, Mutka AL, Zmrzljak UP, Rozman D, Tanila H, Gylling H, Remes AM, Huttunen HJ, Ikonen E.

FASEB J. 2014 Feb;28(2):849-60. doi: 10.1096/fj.13-239301. Epub 2013 Nov 18.

PMID:
24249638
34.

The Interplay between Circadian System, Cholesterol Synthesis, and Steroidogenesis Affects Various Aspects of Female Reproduction.

Urlep Z, Rozman D.

Front Endocrinol (Lausanne). 2013 Sep 2;4:111. doi: 10.3389/fendo.2013.00111. Review.

35.

Sex differences in the hepatic cholesterol sensing mechanisms in mice.

Lorbek G, Perše M, Horvat S, Björkhem I, Rozman D.

Molecules. 2013 Sep 10;18(9):11067-85. doi: 10.3390/molecules180911067.

36.

Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor.

Belic A, Tóth K, Vrzal R, Temesvári M, Porrogi P, Orbán E, Rozman D, Dvorak Z, Monostory K.

Chem Biol Interact. 2013 May 25;203(3):597-603. doi: 10.1016/j.cbi.2013.04.002. Epub 2013 Apr 17.

PMID:
23603339
37.

An algorithm for rapid computational construction of metabolic networks: a cholesterol biosynthesis example.

Belič A, Pompon D, Monostory K, Kelly D, Kelly S, Rozman D.

Comput Biol Med. 2013 Jun;43(5):471-80. doi: 10.1016/j.compbiomed.2013.02.017. Epub 2013 Mar 16.

PMID:
23566393
38.

Steroidal triterpenes of cholesterol synthesis.

Ačimovič J, Rozman D.

Molecules. 2013 Apr 4;18(4):4002-17. doi: 10.3390/molecules18044002. Review.

39.

Circadian events in human diseases and in cytochrome P450-related drug metabolism and therapy.

Košir R, Španinger K, Rozman D.

IUBMB Life. 2013 Jun;65(6):487-96. doi: 10.1002/iub.1160. Epub 2013 Apr 3. Review.

40.

Genomic aspects of NAFLD pathogenesis.

Naik A, Košir R, Rozman D.

Genomics. 2013 Aug;102(2):84-95. doi: 10.1016/j.ygeno.2013.03.007. Epub 2013 Mar 29. Review.

41.

Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51).

Keber R, Acimovic J, Majdic G, Motaln H, Rozman D, Horvat S.

J Lipid Res. 2013 Jun;54(6):1653-61. doi: 10.1194/jlr.M035717. Epub 2013 Mar 18.

42.

Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.

Zmrzljak UP, Korenčič A, Košir R, Goličnik M, Sassone-Corsi P, Rozman D.

J Biol Chem. 2013 Apr 12;288(15):10318-27. doi: 10.1074/jbc.M112.445692. Epub 2013 Feb 25.

43.

Molecular Interactions between NAFLD and Xenobiotic Metabolism.

Naik A, Belič A, Zanger UM, Rozman D.

Front Genet. 2013 Jan 22;4:2. doi: 10.3389/fgene.2013.00002. eCollection 2013.

44.

The interplay of cis-regulatory elements rules circadian rhythms in mouse liver.

Korenčič A, Bordyugov G, Košir R, Rozman D, Goličnik M, Herzel H.

PLoS One. 2012;7(11):e46835. doi: 10.1371/journal.pone.0046835. Epub 2012 Nov 5.

45.

Sterols in spermatogenesis and sperm maturation.

Keber R, Rozman D, Horvat S.

J Lipid Res. 2013 Jan;54(1):20-33. doi: 10.1194/jlr.R032326. Epub 2012 Oct 23. Review.

46.

Cumulus cells gene expression profiling in terms of oocyte maturity in controlled ovarian hyperstimulation using GnRH agonist or GnRH antagonist.

Devjak R, Fon Tacer K, Juvan P, Virant Klun I, Rozman D, Vrtačnik Bokal E.

PLoS One. 2012;7(10):e47106. doi: 10.1371/journal.pone.0047106. Epub 2012 Oct 17.

47.

Cholesterogenic genes expression in brain and liver of ganglioside-deficient mice.

Mlinac K, Fon Tacer K, Heffer M, Rozman D, Bognar SK.

Mol Cell Biochem. 2012 Oct;369(1-2):127-33. doi: 10.1007/s11010-012-1375-y. Epub 2012 Jul 6.

PMID:
22766767
48.

Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis.

Kosir R, Juvan P, Perse M, Budefeld T, Majdic G, Fink M, Sassone-Corsi P, Rozman D.

PLoS One. 2012;7(2):e31798. doi: 10.1371/journal.pone.0031798. Epub 2012 Feb 22.

49.

Circadian regulation of the hepatic endobiotic and xenobitoic detoxification pathways: the time matters.

Zmrzljak UP, Rozman D.

Chem Res Toxicol. 2012 Apr 16;25(4):811-24. doi: 10.1021/tx200538r. Epub 2012 Feb 24. Review.

PMID:
22303888
50.

Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.

Lorbek G, Lewinska M, Rozman D.

FEBS J. 2012 May;279(9):1516-33. doi: 10.1111/j.1742-4658.2011.08432.x. Epub 2011 Dec 22. Review.

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