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Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity.

Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka W, Rozengurt E, Jacobs JP, Eibl G.

Am J Physiol Gastrointest Liver Physiol. 2019 Sep 23. doi: 10.1152/ajpgi.00170.2019. [Epub ahead of print]


Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice.

Hao F, Xu Q, Wang J, Yu S, Chang HH, Sinnett-Smith J, Eibl G, Rozengurt E.

PLoS One. 2019 May 17;14(5):e0216603. doi: 10.1371/journal.pone.0216603. eCollection 2019.


Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells.

Amable G, Martínez-León E, Picco ME, Di Siervi N, Davio C, Rozengurt E, Rey O.

Int J Biochem Cell Biol. 2019 Jul;112:88-94. doi: 10.1016/j.biocel.2019.05.004. Epub 2019 May 10.


Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development.

Rozengurt E, Eibl G.

World J Gastroenterol. 2019 Apr 21;25(15):1797-1816. doi: 10.3748/wjg.v25.i15.1797. Review.


Protein kinase D1 inhibition interferes with mitosis progression.

Martínez-León E, Amable G, Jácamo R, Picco ME, Anaya L, Rozengurt E, Rey O.

J Cell Physiol. 2019 Nov;234(11):20510-20519. doi: 10.1002/jcp.28651. Epub 2019 Apr 17.


Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice.

Xu M, Chang HH, Jung X, Moro A, Chou CEN, King J, Hines OJ, Sinnett-Smith J, Rozengurt E, Eibl G.

BMC Cancer. 2018 Aug 7;18(1):797. doi: 10.1186/s12885-018-4713-y.


Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival.

Rozengurt E, Sinnett-Smith J, Eibl G.

Signal Transduct Target Ther. 2018 Apr 20;3:11. doi: 10.1038/s41392-017-0005-2. eCollection 2018.


Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model.

Chang HH, Moro A, Chou CEN, Dawson DW, French S, Schmidt AI, Sinnett-Smith J, Hao F, Hines OJ, Eibl G, Rozengurt E.

Sci Rep. 2018 Apr 12;8(1):5899. doi: 10.1038/s41598-018-24337-8.


HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection.

Jin YP, Valenzuela NM, Zhang X, Rozengurt E, Reed EF.

J Immunol. 2018 Apr 1;200(7):2372-2390. doi: 10.4049/jimmunol.1701259. Epub 2018 Feb 23.


KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops.

Eibl G, Rozengurt E.

Semin Cancer Biol. 2019 Feb;54:50-62. doi: 10.1016/j.semcancer.2017.10.007. Epub 2017 Oct 24. Review.


Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection.

Salehi S, Sosa RA, Jin YP, Kageyama S, Fishbein MC, Rozengurt E, Kupiec-Weglinski JW, Reed EF.

Am J Transplant. 2018 May;18(5):1096-1109. doi: 10.1111/ajt.14544. Epub 2017 Nov 23.


Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.

Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G.

PLoS One. 2017 Sep 8;12(9):e0184455. doi: 10.1371/journal.pone.0184455. eCollection 2017.


Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.

Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

J Biol Chem. 2017 Jun 9;292(23):9523-9539. doi: 10.1074/jbc.M116.771394. Epub 2017 Apr 13.


Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells.

Hao F, Xu Q, Zhao Y, Stevens JV, Young SH, Sinnett-Smith J, Rozengurt E.

Mol Cancer Res. 2017 Jul;15(7):929-941. doi: 10.1158/1541-7786.MCR-17-0023. Epub 2017 Mar 30.


Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism.

Schmidt A, Sinnett-Smith J, Young S, Chang HH, Hines OJ, Dawson DW, Rozengurt E, Eibl G.

Surgery. 2017 Jun;161(6):1570-1578. doi: 10.1016/j.surg.2016.12.037. Epub 2017 Feb 20.


PDX1 associated therapy in translational medicine.

Yu J, Liu SH, Sanchez R, Nemunaitis J, Rozengurt E, Brunicardi FC.

Ann Transl Med. 2016 Jun;4(11):214. doi: 10.21037/atm.2016.03.51. Review.


Pancreatic cancer actionable genes in precision medicine and personalized surgery.

Yu J, Liu SH, Sanchez R, Nemunaitis J, Rozengurt E, Brunicardi FC.

Surgeon. 2017 Feb;15(1):24-29. doi: 10.1016/j.surge.2016.05.002. Epub 2016 Jun 28. Review.


Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).

Wang J, Sinnett-Smith J, Stevens JV, Young SH, Rozengurt E.

J Biol Chem. 2016 Aug 19;291(34):17988-8005. doi: 10.1074/jbc.M115.711275. Epub 2016 Jul 1.


Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552.

Wang J, Han L, Sinnett-Smith J, Han LL, Stevens JV, Rozengurt N, Young SH, Rozengurt E.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C542-57. doi: 10.1152/ajpcell.00302.2015. Epub 2016 Jan 6.


Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.

Zhou G, Yu J, Wang A, Liu SH, Sinnett-Smith J, Wu J, Sanchez R, Nemunaitis J, Ricordi C, Rozengurt E, Brunicardi FC.

Curr Mol Med. 2016;16(1):83-90.


Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1.

Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G.

Am J Physiol Cell Physiol. 2015 Nov 15;309(10):C639-49. doi: 10.1152/ajpcell.00417.2014. Epub 2015 Aug 26.


Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.

Soares HP, Ming M, Mellon M, Young SH, Han L, Sinnet-Smith J, Rozengurt E.

Mol Cancer Ther. 2015 Apr;14(4):1014-23. doi: 10.1158/1535-7163.MCT-14-0669. Epub 2015 Feb 11.


Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.

Ming M, Sinnett-Smith J, Wang J, Soares HP, Young SH, Eibl G, Rozengurt E.

PLoS One. 2014 Dec 10;9(12):e114573. doi: 10.1371/journal.pone.0114573. eCollection 2014.


Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.

Rozengurt E, Soares HP, Sinnet-Smith J.

Mol Cancer Ther. 2014 Nov;13(11):2477-88. doi: 10.1158/1535-7163.MCT-14-0330. Epub 2014 Oct 16. Review.


Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract.

Vegezzi G, Anselmi L, Huynh J, Barocelli E, Rozengurt E, Raybould H, Sternini C.

PLoS One. 2014 Sep 19;9(9):e107732. doi: 10.1371/journal.pone.0107732. eCollection 2014.


Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.

Zhou G, Sinnett-Smith J, Liu SH, Yu J, Wu J, Sanchez R, Pandol SJ, Abrol R, Nemunaitis J, Rozengurt E, Brunicardi FC.

Front Physiol. 2014 Jun 25;5:226. doi: 10.3389/fphys.2014.00226. eCollection 2014. Review.


Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling.

Sinnett-Smith J, Ni Y, Wang J, Ming M, Young SH, Rozengurt E.

Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. doi: 10.1152/ajpcell.00048.2014. Epub 2014 Mar 19.


Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus.

Jin YP, Valenzuela NM, Ziegler ME, Rozengurt E, Reed EF.

Am J Transplant. 2014 Apr;14(4):806-19. doi: 10.1111/ajt.12669. Epub 2014 Mar 1.


Intracellular Ca2+ oscillations generated via the Ca2+-sensing receptor are mediated by negative feedback by PKCα at Thr888.

Young SH, Rey O, Sinnett-Smith J, Rozengurt E.

Am J Physiol Cell Physiol. 2014 Feb 1;306(3):C298-306. doi: 10.1152/ajpcell.00194.2013. Epub 2013 Dec 11.


PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.

Ni Y, Sinnett-Smith J, Young SH, Rozengurt E.

PLoS One. 2013 Sep 9;8(9):e73149. doi: 10.1371/journal.pone.0073149. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/70d3c7b0-9718-4bb1-abed-d0defc3b7fc4.


High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.

Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G.

Cancer Prev Res (Phila). 2013 Oct;6(10):1064-73. doi: 10.1158/1940-6207.CAPR-13-0065. Epub 2013 Aug 13.


TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.

Yoo J, Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E.

BMC Gastroenterol. 2013 May 20;13:90. doi: 10.1186/1471-230X-13-90.


Metformin inhibits the growth of human pancreatic cancer xenografts.

Kisfalvi K, Moro A, Sinnett-Smith J, Eibl G, Rozengurt E.

Pancreas. 2013 Jul;42(5):781-5. doi: 10.1097/MPA.0b013e31827aec40.


Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.

Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J, Rozengurt E.

PLoS One. 2013;8(2):e57289. doi: 10.1371/journal.pone.0057289. Epub 2013 Feb 21.


Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.

Valenzuela NM, Hong L, Shen XD, Gao F, Young SH, Rozengurt E, Kupiec-Weglinski JW, Fishbein MC, Reed EF.

Am J Transplant. 2013 Feb;13(2):299-311. doi: 10.1111/ajt.12016. Epub 2012 Dec 27.


Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction.

Giovinazzo F, Malpeli G, Zanini S, Parenti M, Piemonti L, Colombatti M, Valenti MT, Dalle Carbonare L, Scarpa A, Sinnett-Smith J, Rozengurt E, Bassi C, Innamorati G.

Cell Signal. 2013 Mar;25(3):651-9. doi: 10.1016/j.cellsig.2012.11.018. Epub 2012 Nov 29.


Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.

Sinnett-Smith J, Kisfalvi K, Kui R, Rozengurt E.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):352-7. doi: 10.1016/j.bbrc.2012.11.010. Epub 2012 Nov 15.


HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells.

Ziegler ME, Jin YP, Young SH, Rozengurt E, Reed EF.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C872-82. doi: 10.1152/ajpcell.00199.2012. Epub 2012 Aug 22.


Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells.

Young SH, Rozengurt N, Sinnett-Smith J, Rozengurt E.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. doi: 10.1152/ajpgi.00025.2012. Epub 2012 May 17.


TNF-α induces upregulation of EGFR expression and signaling in human colonic myofibroblasts.

Yoo J, Rodriguez Perez CE, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E.

Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G805-14. doi: 10.1152/ajpgi.00522.2011. Epub 2012 Feb 2.


Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.

Waldron RT, Innamorati G, Torres-Marquez ME, Sinnett-Smith J, Rozengurt E.

Cell Signal. 2012 Apr;24(4):914-21. doi: 10.1016/j.cellsig.2011.12.014. Epub 2011 Dec 29.


Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.

Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E.

J Biol Chem. 2012 Jan 6;287(2):1158-67. doi: 10.1074/jbc.M111.274589. Epub 2011 Nov 17.


Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts.

Yoo J, Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E.

Biochem Biophys Res Commun. 2011 Sep 16;413(1):30-5. doi: 10.1016/j.bbrc.2011.08.029. Epub 2011 Aug 16.


Neurokinin 1 receptor desensitization and resensitization: is it all happening at the membrane? Focus on "Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor".

Rozengurt E.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C772-4. doi: 10.1152/ajpcell.00274.2011. Epub 2011 Aug 10. No abstract available.


Protein kinase D signaling: multiple biological functions in health and disease.

Rozengurt E.

Physiology (Bethesda). 2011 Feb;26(1):23-33. doi: 10.1152/physiol.00037.2010. Review.


TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts.

Rodriguez Perez CE, Nie W, Sinnett-Smith J, Rozengurt E, Yoo J.

Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G637-46. doi: 10.1152/ajpgi.00381.2010. Epub 2011 Feb 3.


HLA class I molecules partner with integrin β4 to stimulate endothelial cell proliferation and migration.

Zhang X, Rozengurt E, Reed EF.

Sci Signal. 2010 Nov 23;3(149):ra85. doi: 10.1126/scisignal.2001158.


Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts.

Sinnett-Smith J, Rozengurt N, Kui R, Huang C, Rozengurt E.

J Biol Chem. 2011 Jan 7;286(1):511-20. doi: 10.1074/jbc.M110.167528. Epub 2010 Nov 4.

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