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Reply: Reuse of the Masseteric Nerve for Dynamic Reanimation in Facial Palsy Patients with Previously Failed One-Stage Dynamic Smile Reanimation.

Rozen SM.

Plast Reconstr Surg. 2019 Dec;144(6):1124e-1125e. doi: 10.1097/PRS.0000000000006236. No abstract available.


Discussion: Neurotized Platysma Graft: A New Technique for Functional Reanimation of the Eye Sphincter in Longstanding Facial Paralysis.

Rozen SM.

Plast Reconstr Surg. 2019 Dec;144(6):1071e-1072e. doi: 10.1097/PRS.0000000000006297. No abstract available.


DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial.

Sundar R, Ng A, Zouridis H, Padmanabhan N, Sheng T, Zhang S, Lee MH, Ooi WF, Qamra A, Inam I, Hewitt LC, So JB, Koh V, Nankivell MG, Langley RE, Allum WH, Cunningham D, Rozen SG, Yong WP, Grabsch HI, Tan P.

Eur J Cancer. 2019 Dec;123:48-57. doi: 10.1016/j.ejca.2019.09.016. Epub 2019 Oct 23.


Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.

Teo JX, Davila S, Yang C, Hii AA, Pua CJ, Yap J, Tan SY, Sahlén A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P, Lim WK.

Commun Biol. 2019 Oct 4;2:361. doi: 10.1038/s42003-019-0605-1. eCollection 2019.


Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma.

Ooi WF, Nargund AM, Lim KJ, Zhang S, Xing M, Mandoli A, Lim JQ, Ho SWT, Guo Y, Yao X, Lin SJ, Nandi T, Xu C, Ong X, Lee M, Tan AL, Lam YN, Teo JX, Kaneda A, White KP, Lim WK, Rozen SG, Teh BT, Li S, Skanderup AJ, Tan P.

Gut. 2019 Sep 21. pii: gutjnl-2018-317612. doi: 10.1136/gutjnl-2018-317612. [Epub ahead of print]


Experimental Delineation of Mutational Signatures Is an Essential Tool in Cancer Epidemiology and Prevention.

Zavadil J, Rozen SG.

Chem Res Toxicol. 2019 Nov 18;32(11):2153-2155. doi: 10.1021/acs.chemrestox.9b00339. Epub 2019 Sep 11.


SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events.

Bergstrom EN, Huang MN, Mahto U, Barnes M, Stratton MR, Rozen SG, Alexandrov LB.

BMC Genomics. 2019 Aug 30;20(1):685. doi: 10.1186/s12864-019-6041-2.


Detection of high-risk human papillomavirus in the tonsils of galilee region adults and young adults undergoing tonsillectomy.

Mordechai RA, Steinberg S, Apel-Sarid L, Shaoul E, Rozen SZ, Khoury L, Ronen O.

Eur Arch Otorhinolaryngol. 2019 Oct;276(10):2865-2871. doi: 10.1007/s00405-019-05543-0. Epub 2019 Jul 12.


Implementation of genomics in medical practice to deliver precision medicine for an Asian population.

Bylstra Y, Davila S, Lim WK, Wu R, Teo JX, Kam S, Lysaght T, Rozen S, Teh BT, Yeo KK, Cook SA, Tan P, Jamuar SS.

NPJ Genom Med. 2019 Jun 7;4:12. doi: 10.1038/s41525-019-0085-8. eCollection 2019. Review.


Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Xue R, Chen L, Zhang C, Fujita M, Li R, Yan SM, Ong CK, Liao X, Gao Q, Sasagawa S, Li Y, Wang J, Guo H, Huang QT, Zhong Q, Tan J, Qi L, Gong W, Hong Z, Li M, Zhao J, Peng T, Lu Y, Lim KHT, Boot A, Ono A, Chayama K, Zhang Z, Rozen SG, Teh BT, Wang XW, Nakagawa H, Zeng MS, Bai F, Zhang N.

Cancer Cell. 2019 Jun 10;35(6):932-947.e8. doi: 10.1016/j.ccell.2019.04.007. Epub 2019 May 23.


Early Masseter to Facial Nerve Transfer May Improve Smile Excursion in Facial Paralysis.

Zhang S, Hembd A, Ching CW, Tolley P, Rozen SM.

Plast Reconstr Surg Glob Open. 2018 Nov 15;6(11):e2023. doi: 10.1097/GOX.0000000000002023. eCollection 2018 Nov.


Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.

Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, Villar S, Cahais V, Robitaille A, Bouaoun L, Heguy A, Guyton KZ, Stampfer MR, McKay J, Hollstein M, Olivier M, Rozen SG, Beland FA, Korenjak M, Zavadil J.

Genome Res. 2019 Apr;29(4):521-531. doi: 10.1101/gr.242453.118. Epub 2019 Mar 7.


Facial Nerve Trauma: Clinical Evaluation and Management Strategies.

Brown S, Isaacson B, Kutz W, Barnett S, Rozen SM.

Plast Reconstr Surg. 2019 May;143(5):1498-1512. doi: 10.1097/PRS.0000000000005572.


Reuse of the Masseteric Nerve for Dynamic Reanimation in Facial Palsy Patients with Previously Failed One-Stage Dynamic Smile Reanimation.

Mohanty AJ, Hembd A, Thrikutam N, Rozen SM.

Plast Reconstr Surg. 2019 Feb;143(2):567-571. doi: 10.1097/PRS.0000000000005253.


Role of MR Neurography in Groin and Genital Pain: Ilioinguinal, Iliohypogastric, and Genitofemoral Neuralgia.

Poh F, Xi Y, Rozen SM, Scott KM, Hlis R, Chhabra A.

AJR Am J Roentgenol. 2019 Mar;212(3):632-643. doi: 10.2214/AJR.18.20316. Epub 2019 Jan 8.


Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism.

Comby A, Bloch E, Bond CMM, Descamps D, Miles J, Petit S, Rozen S, Greenwood JB, Blanchet V, Mairesse Y.

Nat Commun. 2018 Dec 6;9(1):5212. doi: 10.1038/s41467-018-07609-9.


[All]-S,S-dioxide Oligo-Thienylenevinylenes: Synthesis and Structural/Electronic Shapes from Their Molecular Force Fields.

Aharon C, Guijarro FG, Medina Rivero S, Ramírez FJ, Caballero R, Casado J, Langa F, Rozen S.

Chemistry. 2019 Jan 7;25(2):464-468. doi: 10.1002/chem.201805245. Epub 2018 Dec 11.


Lower Facial Rejuvenation.

Rozen SM, Ishii LE.

Clin Plast Surg. 2018 Oct;45(4):ix-x. doi: 10.1016/j.cps.2018.07.001. No abstract available.


Correction: Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS.

Genet Med. 2018 Dec;20(12):1692. doi: 10.1038/s41436-018-0142-1.


Attosecond time-resolved photoelectron holography.

Porat G, Alon G, Rozen S, Pedatzur O, Krüger M, Azoury D, Natan A, Orenstein G, Bruner BD, Vrakking MJJ, Dudovich N.

Nat Commun. 2018 Jul 18;9(1):2805. doi: 10.1038/s41467-018-05185-6.


Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders.

Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS.

Genet Med. 2019 Jan;21(1):207-212. doi: 10.1038/s41436-018-0008-6. Epub 2018 Jul 2. Erratum in: Genet Med. 2018 Dec;20(12):1692.


Discussion: Incomplete Facial Paralysis: The Use of the Ipsilateral Residual Facial Nerve as a Donor Nerve for Facial Reanimation.

Rozen SM.

Plast Reconstr Surg. 2018 Jul;142(1):215-216. doi: 10.1097/PRS.0000000000004527. No abstract available.


Relational Anatomy of the Mimetic Muscles and Its Implications on Free Functional Muscle Inset in Facial Reanimation.

Zabojova J, Thrikutam N, Tolley P, Perez J, Rozen SM, Rodriguez-Lorenzo A.

Ann Plast Surg. 2018 Aug;81(2):203-207. doi: 10.1097/SAP.0000000000001507.


Facial Reanimation in the Seventh and Eighth Decades of Life.

Hembd A, Harrison B, Rocha CSM, Rocha FS, Chamseddin K, Labbé D, Cárdenas-Mejía A, Rozen SM.

Plast Reconstr Surg. 2018 May;141(5):1239-1251. doi: 10.1097/PRS.0000000000004329. Review.


Qualitative and Quantitative Analysis of Smile Excursion in Facial Reanimation: A Systematic Review and Meta-analysis of 1- versus 2-stage Procedures.

Natghian H, Fransén J, Rozen SM, Rodriguez-Lorenzo A.

Plast Reconstr Surg Glob Open. 2017 Dec 28;5(12):e1621. doi: 10.1097/GOX.0000000000001621. eCollection 2017 Dec.


In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors.

Boot A, Huang MN, Ng AWT, Ho SC, Lim JQ, Kawakami Y, Chayama K, Teh BT, Nakagawa H, Rozen SG.

Genome Res. 2018 May;28(5):654-665. doi: 10.1101/gr.230219.117. Epub 2018 Apr 9.


Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.

Tang YC, Ho SC, Tan E, Ng AWT, McPherson JR, Goh GYL, Teh BT, Bard F, Rozen SG.

Breast Cancer Res. 2018 Mar 22;20(1):22. doi: 10.1186/s13058-018-0949-3.


Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming.

Thekkeparambil Chandrabose S, Sriram S, Subramanian S, Cheng S, Ong WK, Rozen S, Kasim NHA, Sugii S.

Stem Cell Res Ther. 2018 Mar 20;9(1):68. doi: 10.1186/s13287-018-0796-2.


Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research.

Lim WK, Davila S, Teo JX, Yang C, Pua CJ, Blöcker C, Lim JQ, Ching J, Yap JJL, Tan SY, Sahlén A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P.

PLoS Biol. 2018 Feb 27;16(2):e2004285. doi: 10.1371/journal.pbio.2004285. eCollection 2018 Feb.


HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.

Yan T, Ooi WF, Qamra A, Cheung A, Ma D, Sundaram GM, Xu C, Xing M, Poon L, Wang J, Loh YP, Ho JHJ, Ng JJQ, Ramlee MK, Aswad L, Rozen SG, Ghosh S, Bard FA, Sampath P, Tergaonkar V, Davies JOJ, Hughes JR, Goh E, Bi X, Fullwood MJ, Tan P, Li S.

Nat Commun. 2018 Jan 8;9(1):100. doi: 10.1038/s41467-017-02601-1.


Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, Fatehullah A, Alkaff SMF, Lim TKH, Lee J, Ho KY, Rozen SG, Teh BT, Barker N, Chia CK, Khor C, Ooi CJ, Fock KM, So J, Lim WC, Ling KL, Ang TL, Wong A, Rao J, Rajnakova A, Lim LG, Yap WM, Teh M, Yeoh KG, Tan P.

Cancer Cell. 2018 Jan 8;33(1):137-150.e5. doi: 10.1016/j.ccell.2017.11.018. Epub 2017 Dec 28.


Sensation of the autologous reconstructed breast improves quality of life: a pilot study.

Cornelissen AJM, Beugels J, van Kuijk SMJ, Heuts EM, Rozen SM, Spiegel AJ, van der Hulst RRWJ, Tuinder SMH.

Breast Cancer Res Treat. 2018 Feb;167(3):687-695. doi: 10.1007/s10549-017-4547-3. Epub 2017 Oct 25.


Comparing the sensation of common donor site regions for autologous breast reconstruction to that of a healthy breast.

Cornelissen AJM, Beugels J, Lataster A, Heuts EM, Rozen SM, Spiegel AJ, van der Hulst RRWJ, Tuinder SMH.

J Plast Reconstr Aesthet Surg. 2018 Mar;71(3):327-335. doi: 10.1016/j.bjps.2017.09.011. Epub 2017 Sep 25.


Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia.

Ng AWT, Poon SL, Huang MN, Lim JQ, Boot A, Yu W, Suzuki Y, Thangaraju S, Ng CCY, Tan P, Pang ST, Huang HY, Yu MC, Lee PH, Hsieh SY, Chang AY, Teh BT, Rozen SG.

Sci Transl Med. 2017 Oct 18;9(412). pii: eaan6446. doi: 10.1126/scitranslmed.aan6446.


The draft genome of tropical fruit durian (Durio zibethinus).

Teh BT, Lim K, Yong CH, Ng CCY, Rao SR, Rajasegaran V, Lim WK, Ong CK, Chan K, Cheng VKY, Soh PS, Swarup S, Rozen SG, Nagarajan N, Tan P.

Nat Genet. 2017 Nov;49(11):1633-1641. doi: 10.1038/ng.3972. Epub 2017 Oct 9.


Discussion: Symmetry Restoration at Rest after Masseter-to-Facial Nerve Transfer: Is It as Efficient as Smile Reanimation?

Rozen SM.

Plast Reconstr Surg. 2017 Oct;140(4):802-804. doi: 10.1097/PRS.0000000000003736. No abstract available.


VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P.

Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11.


Synthesis of N,N-Dioxopyridazines.

Rozen S, Shaffer A.

Org Lett. 2017 Sep 15;19(18):4707-4709. doi: 10.1021/acs.orglett.7b02310. Epub 2017 Aug 24.


Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.

Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, Othman R, Poon SL, Heguy A, Olivier M, Hollstein M, Tan P, Teh BT, Sabapathy K, Zavadil J, Rozen SG.

Genome Res. 2017 Sep;27(9):1475-1486. doi: 10.1101/gr.220038.116. Epub 2017 Jul 24.


Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Jusakul A, Cutcutache I, Yong CH, Lim JQ, Huang MN, Padmanabhan N, Nellore V, Kongpetch S, Ng AWT, Ng LM, Choo SP, Myint SS, Thanan R, Nagarajan S, Lim WK, Ng CCY, Boot A, Liu M, Ong CK, Rajasegaran V, Lie S, Lim AST, Lim TH, Tan J, Loh JL, McPherson JR, Khuntikeo N, Bhudhisawasdi V, Yongvanit P, Wongkham S, Totoki Y, Nakamura H, Arai Y, Yamasaki S, Chow PK, Chung AYF, Ooi LLPJ, Lim KH, Dima S, Duda DG, Popescu I, Broet P, Hsieh SY, Yu MC, Scarpa A, Lai J, Luo DX, Carvalho AL, Vettore AL, Rhee H, Park YN, Alexandrov LB, Gordân R, Rozen SG, Shibata T, Pairojkul C, Teh BT, Tan P.

Cancer Discov. 2017 Oct;7(10):1116-1135. doi: 10.1158/2159-8290.CD-17-0368. Epub 2017 Jun 30.


A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.

Low YS, Blöcker C, McPherson JR, Tang SA, Cheng YY, Wong JYS, Chua C, Lim TKH, Tang CL, Chew MH, Tan P, Tan IB, Rozen SG, Cheah PY.

Cancer Lett. 2017 Sep 10;403:13-20. doi: 10.1016/j.canlet.2017.05.031. Epub 2017 Jun 15.


Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.

Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z.

Mol Cell. 2017 Jun 1;66(5):684-697.e9. doi: 10.1016/j.molcel.2017.04.026. Epub 2017 May 25.


Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma.

Qamra A, Xing M, Padmanabhan N, Kwok JJT, Zhang S, Xu C, Leong YS, Lee Lim AP, Tang Q, Ooi WF, Suling Lin J, Nandi T, Yao X, Ong X, Lee M, Tay ST, Keng ATL, Gondo Santoso E, Ng CCY, Ng A, Jusakul A, Smoot D, Ashktorab H, Rha SY, Yeoh KG, Peng Yong W, Chow PKH, Chan WH, Ong HS, Soo KC, Kim KM, Wong WK, Rozen SG, Teh BT, Kappei D, Lee J, Connolly J, Tan P.

Cancer Discov. 2017 Jun;7(6):630-651. doi: 10.1158/2159-8290.CD-16-1022. Epub 2017 Mar 20.


Wnt proteins synergize to activate β-catenin signaling.

Alok A, Lei Z, Jagannathan NS, Kaur S, Harmston N, Rozen SG, Tucker-Kellogg L, Virshup DM.

J Cell Sci. 2017 May 1;130(9):1532-1544. doi: 10.1242/jcs.198093. Epub 2017 Mar 13.


Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.

Ler LD, Ghosh S, Chai X, Thike AA, Heng HL, Siew EY, Dey S, Koh LK, Lim JQ, Lim WK, Myint SS, Loh JL, Ong P, Sam XX, Huang D, Lim T, Tan PH, Nagarajan S, Cheng CW, Ho H, Ng LG, Yuen J, Lin PH, Chuang CK, Chang YH, Weng WH, Rozen SG, Tan P, Creasy CL, Pang ST, McCabe MT, Poon SL, Teh BT.

Sci Transl Med. 2017 Feb 22;9(378). pii: eaai8312. doi: 10.1126/scitranslmed.aai8312.


Correlation between Facial Nerve Axonal Load and Age and Its Relevance to Facial Reanimation.

Hembd A, Nagarkar P, Perez J, Gassman A, Tolley P, Reisch J, White CL 3rd, Rozen SM.

Plast Reconstr Surg. 2017 Jun;139(6):1459-1464. doi: 10.1097/PRS.0000000000003376.


Poly(3-hexylthiophene) Nanoparticles Containing Thiophene-S,S-dioxide: Tuning of Dimensions, Optical and Redox Properties, and Charge Separation under Illumination.

Di Maria F, Zanelli A, Liscio A, Kovtun A, Salatelli E, Mazzaro R, Morandi V, Bergamini G, Shaffer A, Rozen S.

ACS Nano. 2017 Feb 28;11(2):1991-1999. doi: 10.1021/acsnano.6b08176. Epub 2017 Feb 9.


Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.

Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y, Lezhava A, Lai JH, Koh D, Lim KH, Tan P, Rozen SG, Tan IB.

Mol Oncol. 2017 Feb;11(2):124-139. doi: 10.1002/1878-0261.12012. Epub 2016 Oct 20.

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