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Items: 1 to 50 of 265

1.

Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.

Leclerc D, Christensen KE, Cauvi O, Yang E, Fournelle F, Bahous RH, Malysheva OV, Deng L, Wu Q, Zhou Z, Gao ZH, Chaurand P, Caudill MA, Rozen R.

Mol Nutr Food Res. 2019 Feb;63(3):e1801001. doi: 10.1002/mnfr.201801001. Epub 2018 Nov 23.

PMID:
30408316
2.

Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.

Bahous RH, Cosín-Tomás M, Deng L, Leclerc D, Malysheva O, Ho MK, Pallàs M, Kaliman P, Bedell BJ, Caudill MA, Rozen R.

Mol Neurobiol. 2019 Jun;56(6):4175-4191. doi: 10.1007/s12035-018-1375-3. Epub 2018 Oct 4.

PMID:
30288696
3.

Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.

Christensen KE, Bahous RH, Hou W, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R.

J Nutr. 2018 Apr 1;148(4):501-509. doi: 10.1093/jn/nxy013.

PMID:
29659962
4.

Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.

Aarabi M, Christensen KE, Chan D, Leclerc D, Landry M, Ly L, Rozen R, Trasler J.

Hum Mol Genet. 2018 Apr 1;27(7):1123-1135. doi: 10.1093/hmg/ddy021.

5.

Oncogenic role of PDK4 in human colon cancer cells.

Leclerc D, Pham DN, Lévesque N, Truongcao M, Foulkes WD, Sapienza C, Rozen R.

Br J Cancer. 2017 Mar 28;116(7):930-936. doi: 10.1038/bjc.2017.38. Epub 2017 Feb 16.

6.

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

Bahous RH, Jadavji NM, Deng L, Cosín-Tomás M, Lu J, Malysheva O, Leung KY, Ho MK, Pallàs M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R.

Hum Mol Genet. 2017 Mar 1;26(5):888-900. doi: 10.1093/hmg/ddx004.

7.

Liver Transplantation for a Patient with Hepatocellular Carcinoma with Vascular Invasion and Exceeding Milan Criteria-Happy End Despite it all.

Rozen R, Menachem Y, Carr BI, Shibolet O.

J Gastrointest Cancer. 2018 Jun;49(2):214-217. doi: 10.1007/s12029-016-9890-9. No abstract available.

PMID:
27834046
8.

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.

Christensen KE, Hou W, Bahous RH, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R.

Am J Clin Nutr. 2016 Nov;104(5):1459-1469. Epub 2016 Oct 5.

PMID:
27707701
9.

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.

Lévesque N, Christensen KE, Van Der Kraak L, Best AF, Deng L, Caldwell D, MacFarlane AJ, Beauchemin N, Rozen R.

Mol Carcinog. 2017 Mar;56(3):1030-1040. doi: 10.1002/mc.22568. Epub 2016 Nov 1.

PMID:
27597531
10.

Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus.

Parente MK, Rozen R, Seeholzer SH, Wolfe JH.

Mol Genet Metab. 2016 May;118(1):41-54. doi: 10.1016/j.ymgme.2016.03.003. Epub 2016 Mar 7.

11.

Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation.

Lévesque N, Leclerc D, Gayden T, Lazaris A, De Jay N, Petrillo S, Metrakos P, Jabado N, Rozen R.

Mamm Genome. 2016 Apr;27(3-4):122-34. doi: 10.1007/s00335-016-9624-0. Epub 2016 Mar 7.

PMID:
26951114
12.

Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.

Markand S, Saul A, Tawfik A, Cui X, Rozen R, Smith SB.

Exp Eye Res. 2016 Apr;145:164-172. doi: 10.1016/j.exer.2015.11.013. Epub 2015 Dec 2.

13.

High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection.

Meadows DN, Bahous RH, Best AF, Rozen R.

PLoS One. 2015 Nov 24;10(11):e0143738. doi: 10.1371/journal.pone.0143738. eCollection 2015.

14.

MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.

Christensen KE, Deng L, Bahous RH, Jerome-Majewska LA, Rozen R.

Birth Defects Res A Clin Mol Teratol. 2015 Dec;103(12):1031-8. doi: 10.1002/bdra.23451. Epub 2015 Sep 26.

PMID:
26408344
15.

Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice.

Orozco LD, Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis AJ, Pellegrini M.

Cell Metab. 2015 Jun 2;21(6):905-17. doi: 10.1016/j.cmet.2015.04.025.

16.

MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.

Jadavji NM, Deng L, Malysheva O, Caudill MA, Rozen R.

Neuroscience. 2015 Aug 6;300:1-9. doi: 10.1016/j.neuroscience.2015.04.067. Epub 2015 May 6.

PMID:
25956258
17.

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.

Markand S, Saul A, Roon P, Prasad P, Martin P, Rozen R, Ganapathy V, Smith SB.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2684-95. doi: 10.1167/iovs.14-16190.

18.

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

Christensen KE, Mikael LG, Leung KY, Lévesque N, Deng L, Wu Q, Malysheva OV, Best A, Caudill MA, Greene ND, Rozen R.

Am J Clin Nutr. 2015 Mar;101(3):646-58. doi: 10.3945/ajcn.114.086603. Epub 2015 Jan 7.

19.

Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency.

Leclerc D, Dejgaard K, Mazur A, Deng L, Wu Q, Nilsson T, Rozen R.

Proteomics. 2014 Nov;14(21-22):2558-65. doi: 10.1002/pmic.201400280. Epub 2014 Sep 5.

PMID:
25081070
20.

Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.

Jadavji NM, Bahous RH, Deng L, Malysheva O, Grand'maison M, Bedell BJ, Caudill MA, Rozen R.

Biochem J. 2014 Jul 15;461(2):205-12. doi: 10.1042/BJ20131568.

PMID:
24800750
21.

Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia.

Lossos A, Teltsh O, Milman T, Meiner V, Rozen R, Leclerc D, Schwahn BC, Karp N, Rosenblatt DS, Watkins D, Shaag A, Korman SH, Heyman SN, Gal A, Newman JP, Steiner-Birmanns B, Abramsky O, Kohn Y.

JAMA Neurol. 2014 Jul 1;71(7):901-4. doi: 10.1001/jamaneurol.2014.116.

PMID:
24797679
22.

Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant.

Meadows DN, Pyzik M, Wu Q, Torre S, Gros P, Vidal SM, Rozen R.

Hum Mutat. 2014 May;35(5):594-600. doi: 10.1002/humu.22533. Epub 2014 Mar 31.

PMID:
24616178
23.

The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort.

Christensen KE, Dahhou M, Kramer MS, Rozen R.

Mol Genet Metab. 2014 Mar;111(3):390-392. doi: 10.1016/j.ymgme.2013.12.004. Epub 2013 Dec 11.

PMID:
24368157
24.

Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients.

Leclerc D, Lévesque N, Cao Y, Deng L, Wu Q, Powell J, Sapienza C, Rozen R.

Cancer Prev Res (Phila). 2013 Nov;6(11):1171-81. doi: 10.1158/1940-6207.CAPR-13-0198. Epub 2013 Oct 29.

25.

β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells.

Pham DN, Leclerc D, Lévesque N, Deng L, Rozen R.

Am J Clin Nutr. 2013 Aug;98(2):413-22. doi: 10.3945/ajcn.113.060996. Epub 2013 Jun 26.

PMID:
23803888
26.

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.

Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R.

Hum Mol Genet. 2013 Sep 15;22(18):3705-19. doi: 10.1093/hmg/ddt223. Epub 2013 May 23.

PMID:
23704330
27.

Moderately high intake of folic acid has a negative impact on mouse embryonic development.

Mikael LG, Deng L, Paul L, Selhub J, Rozen R.

Birth Defects Res A Clin Mol Teratol. 2013 Jan;97(1):47-52. doi: 10.1002/bdra.23092. Epub 2012 Nov 2.

PMID:
23125102
28.

Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.

Mikael LG, Pancer J, Jiang X, Wu Q, Caudill M, Rozen R.

Mol Nutr Food Res. 2013 Apr;57(4):661-70. doi: 10.1002/mnfr.201200152. Epub 2012 Oct 30.

PMID:
23112124
29.

Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.

Leclerc D, Cao Y, Deng L, Mikael LG, Wu Q, Rozen R.

Mol Nutr Food Res. 2013 Apr;57(4):686-97. doi: 10.1002/mnfr.201200212. Epub 2012 Sep 24.

PMID:
23001810
30.

DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.

Saferali A, Moussette S, Chan D, Trasler J, Chen T, Rozen R, Naumova AK.

Genome. 2012 Sep;55(9):673-82. doi: 10.1139/g2012-056. Epub 2012 Sep 11.

PMID:
22967183
31.

Radiologic predictors of hyponatremia in children hospitalized with community-acquired pneumonia.

Glatstein M, Rozen R, Scolnik D, Rimon A, Grisaru-Soen G, Freedman S, Reif S.

Pediatr Emerg Care. 2012 Aug;28(8):764-6.

PMID:
22858749
32.

Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.

Jadavji NM, Deng L, Leclerc D, Malysheva O, Bedell BJ, Caudill MA, Rozen R.

Mol Genet Metab. 2012 Jun;106(2):149-59. doi: 10.1016/j.ymgme.2012.03.020. Epub 2012 Apr 4.

PMID:
22521626
33.

Risk of congenital heart defects is influenced by genetic variation in folate metabolism.

Christensen KE, Zada YF, Rohlicek CV, Andelfinger GU, Michaud JL, Bigras JL, Richter A, Dubé MP, Rozen R.

Cardiol Young. 2013 Feb;23(1):89-98. doi: 10.1017/S1047951112000431. Epub 2012 Apr 5.

PMID:
22475273
34.

Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology.

Parente MK, Rozen R, Cearley CN, Wolfe JH.

PLoS One. 2012;7(3):e32419. doi: 10.1371/journal.pone.0032419. Epub 2012 Mar 5.

35.
36.

Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.

Pickell L, Wu Q, Wang XL, Leclerc D, Friedman H, Peterson AC, Rozen R.

Mamm Genome. 2011 Dec;22(11-12):635-47. doi: 10.1007/s00335-011-9351-5. Epub 2011 Jul 19.

PMID:
21769670
37.

Design and rationale of a genetic cohort study on congenital cardiac disease: experiences from a multi-institutional platform in Quebec.

Dubé MP, Bigras JL, Thibeault M, Bureau N, Chetaille P, Richter A, Mercier J, Bellavance M, Rohlicek C, Rozen R, Nemer M, Khairy P, Gendron R, Andelfinger G.

Cardiol Young. 2011 Dec;21(6):654-64. doi: 10.1017/S1047951111000813. Epub 2011 Jul 4.

PMID:
21729494
38.

High intake of folic acid disrupts embryonic development in mice.

Pickell L, Brown K, Li D, Wang XL, Deng L, Wu Q, Selhub J, Luo L, Jerome-Majewska L, Rozen R.

Birth Defects Res A Clin Mol Teratol. 2011 Jan;91(1):8-19. doi: 10.1002/bdra.20754. Epub 2010 Dec 22.

PMID:
21254354
39.

Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.

Knock E, Deng L, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R.

J Nutr Biochem. 2011 Nov;22(11):1022-9. doi: 10.1016/j.jnutbio.2010.07.015. Epub 2010 Dec 28.

PMID:
21193302
40.

Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.

Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA.

Nutr Res. 2010 Jul;30(7):492-500. doi: 10.1016/j.nutres.2010.06.017.

41.

Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.

Christensen KE, Wu Q, Wang X, Deng L, Caudill MA, Rozen R.

J Nutr. 2010 Oct;140(10):1736-41. doi: 10.3945/jn.110.124917. Epub 2010 Aug 19.

PMID:
20724492
42.

A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J, Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP, Elleder M, Rozen R, Patterson D, Kraus JP.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):153-62. doi: 10.1016/j.ymgme.2010.06.010. Epub 2010 Jun 23.

43.

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.

De Castro SC, Leung KY, Savery D, Burren K, Rozen R, Copp AJ, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):612-8. doi: 10.1002/bdra.20690.

44.

Body fluid retention and body weight change in anorexia nervosa patients during refeeding.

Rigaud D, Boulier A, Tallonneau I, Brindisi MC, Rozen R.

Clin Nutr. 2010 Dec;29(6):749-55. doi: 10.1016/j.clnu.2010.05.007. Epub 2010 Jul 2.

PMID:
20584564
45.

Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.

Lawrance AK, Racine J, Deng L, Wang X, Lachapelle P, Rozen R.

J Inherit Metab Dis. 2011 Feb;34(1):147-57. doi: 10.1007/s10545-010-9127-1. Epub 2010 Jun 8.

PMID:
20532821
46.

Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice.

Chan D, Cushnie DW, Neaga OR, Lawrance AK, Rozen R, Trasler JM.

Endocrinology. 2010 Jul;151(7):3363-73. doi: 10.1210/en.2009-1340. Epub 2010 May 5.

PMID:
20444942
47.

Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.

Chan J, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R.

Am J Clin Nutr. 2010 Apr;91(4):1035-43. doi: 10.3945/ajcn.2009.28754. Epub 2010 Feb 17.

PMID:
20164309
48.

Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection.

Fodil-Cornu N, Kozij N, Wu Q, Rozen R, Vidal SM.

Genes Immun. 2009 Oct;10(7):662-6. doi: 10.1038/gene.2009.50. Epub 2009 Jul 16.

PMID:
19609317
49.

Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase.

Celtikci B, Lawrance AK, Wu Q, Rozen R.

Anticancer Drugs. 2009 Oct;20(9):787-93. doi: 10.1097/CAD.0b013e32832f4aa8.

PMID:
19593106
50.

Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm birth.

Kramer MS, Kahn SR, Platt RW, Genest J, Rozen R, Chen MF, Goulet L, Séguin L, Dassa C, Lydon J, McNamara H, Dahhou M, Lamoureux J, Evans RW.

Epidemiology. 2009 Sep;20(5):707-13. doi: 10.1097/EDE.0b013e3181a818c5.

PMID:
19568173

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