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Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E, Helin K, Waisman A, Vinkel C, Thomsen SF, Avgustinova A, Benitah SA, Lovato P, Norsgaard H, Mortensen MS, Veng L, Rozell B, Brakebusch C.

Nat Commun. 2018 Apr 12;9(1):1420. doi: 10.1038/s41467-018-03704-z.


Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice.

Cramer EP, Dahl SL, Rozell B, Knudsen KJ, Thomsen K, Moser C, Cowland JB, Borregaard N.

Blood. 2017 May 18;129(20):2813-2817. doi: 10.1182/blood-2016-11-753434. Epub 2017 Apr 10. No abstract available.


Carotid Catheterization and Automated Blood Sampling Induce Systemic IL-6 Secretion and Local Tissue Damage and Inflammation in the Heart, Kidneys, Liver and Salivary Glands in NMRI Mice.

Teilmann AC, Rozell B, Kalliokoski O, Hau J, Abelson KS.

PLoS One. 2016 Nov 10;11(11):e0166353. doi: 10.1371/journal.pone.0166353. eCollection 2016.


SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.

Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S.

Nat Cell Biol. 2016 Dec;18(12):1357-1366. doi: 10.1038/ncb3436. Epub 2016 Nov 7.


A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis.

Fransén-Pettersson N, Duarte N, Nilsson J, Lundholm M, Mayans S, Larefalk Å, Hannibal TD, Hansen L, Schmidt-Christensen A, Ivars F, Cardell S, Palmqvist R, Rozell B, Holmberg D.

PLoS One. 2016 Jul 21;11(7):e0159850. doi: 10.1371/journal.pone.0159850. eCollection 2016.


Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.

Hoelzl MA, Heby-Henricson K, Bilousova G, Rozell B, Kuiper RV, Kasper M, Toftgård R, Teglund S.

Stem Cells Dev. 2015 Nov 1;24(21):2547-60. doi: 10.1089/scd.2015.0050. Epub 2015 Aug 18.


Cutaneous malignant melanoma in the Swedish organ transplantation cohort: A study of clinicopathological characteristics and mortality.

Krynitz B, Rozell BL, Lyth J, Smedby KE, Lindelöf B.

J Am Acad Dermatol. 2015 Jul;73(1):106-113.e2. doi: 10.1016/j.jaad.2015.03.045. Epub 2015 Apr 28.


Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects.

Strandgren C, Nasser HA, McKenna T, Koskela A, Tuukkanen J, Ohlsson C, Rozell B, Eriksson M.

FASEB J. 2015 Aug;29(8):3193-205. doi: 10.1096/fj.14-269217. Epub 2015 Apr 15.


Physiological and pathological impact of blood sampling by retro-bulbar sinus puncture and facial vein phlebotomy in laboratory mice.

Teilmann AC, Nygaard Madsen A, Holst B, Hau J, Rozell B, Abelson KS.

PLoS One. 2014 Nov 26;9(11):e113225. doi: 10.1371/journal.pone.0113225. eCollection 2014.


Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.

Baek JH, Schmidt E, Viceconte N, Strandgren C, Pernold K, Richard TJ, Van Leeuwen FW, Dantuma NP, Damberg P, Hultenby K, Ulfhake B, Mugnaini E, Rozell B, Eriksson M.

Hum Mol Genet. 2015 Mar 1;24(5):1305-21. doi: 10.1093/hmg/ddu541. Epub 2014 Oct 24.


Laminin α4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain.

Vaicik MK, Thyboll Kortesmaa J, Movérare-Skrtic S, Kortesmaa J, Soininen R, Bergström G, Ohlsson C, Chong LY, Rozell B, Emont M, Cohen RN, Brey EM, Tryggvason K.

PLoS One. 2014 Oct 13;9(10):e109854. doi: 10.1371/journal.pone.0109854. eCollection 2014.


Global and 3D spatial assessment of neuroinflammation in rodent models of Multiple Sclerosis.

Gupta S, Utoft R, Hasseldam H, Schmidt-Christensen A, Hannibal TD, Hansen L, Fransén-Pettersson N, Agarwal-Gupta N, Rozell B, Andersson A, Holmberg D.

PLoS One. 2013 Oct 4;8(10):e76330. doi: 10.1371/journal.pone.0076330. eCollection 2013.


Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular mineralization, and poor biomechanical properties.

Schmidt E, Nilsson O, Koskela A, Tuukkanen J, Ohlsson C, Rozell B, Eriksson M.

J Biol Chem. 2012 Sep 28;287(40):33512-22. Epub 2012 Aug 14.


The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.

Camnasio S, Delli Carri A, Lombardo A, Grad I, Mariotti C, Castucci A, Rozell B, Lo Riso P, Castiglioni V, Zuccato C, Rochon C, Takashima Y, Diaferia G, Biunno I, Gellera C, Jaconi M, Smith A, Hovatta O, Naldini L, Di Donato S, Feki A, Cattaneo E.

Neurobiol Dis. 2012 Apr;46(1):41-51. doi: 10.1016/j.nbd.2011.12.042.


Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia.

Högstrand K, Hejll E, Sander B, Rozell B, Larsson LG, Grandien A.

PLoS One. 2012;7(2):e31366. doi: 10.1371/journal.pone.0031366. Epub 2012 Feb 29.


Targeted expression of GLI1 in the salivary glands results in an altered differentiation program and hyperplasia.

Fiaschi M, Kolterud A, Nilsson M, Toftgård R, Rozell B.

Am J Pathol. 2011 Nov;179(5):2569-79. doi: 10.1016/j.ajpath.2011.07.033. Epub 2011 Sep 18.


Dynamics of early histopathological changes in GVHD after busulphan/cyclophosphamide conditioning regimen.

Al-Hashmi S, Hassan Z, Sadeghi B, Rozell B, Hassan M.

Int J Clin Exp Pathol. 2011 Aug 15;4(6):596-605. Epub 2011 Jul 31.


Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice.

Heby-Henricson K, Bergström A, Rozell B, Toftgård R, Teglund S.

Mol Carcinog. 2012 Sep;51(9):754-60. doi: 10.1002/mc.20852. Epub 2011 Aug 31.


Association between hair-induced oronasal inflammation and ulcerative dermatitis in C57BL/6 mice.

Sundberg JP, Rozell B, Everts H.

Comp Med. 2011 Jun;61(3):204-5; author reply 205. No abstract available.


Glutathione is essential for early embryogenesis--analysis of a glutathione synthetase knockout mouse.

Winkler A, Njålsson R, Carlsson K, Elgadi A, Rozell B, Abraham L, Ercal N, Shi ZZ, Lieberman MW, Larsson A, Norgren S.

Biochem Biophys Res Commun. 2011 Aug 19;412(1):121-6. doi: 10.1016/j.bbrc.2011.07.056. Epub 2011 Jul 23.


Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.

Pazirandeh A, Sultana T, Mirza M, Rozell B, Hultenby K, Wallis K, Vennström B, Davis B, Arner A, Heuchel R, Löhr M, Philipson L, Sollerbrant K.

PLoS One. 2011;6(6):e20203. doi: 10.1371/journal.pone.0020203. Epub 2011 Jun 3.


Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.

Shafaati M, Olin M, Båvner A, Pettersson H, Rozell B, Meaney S, Parini P, Björkhem I.

J Intern Med. 2011 Oct;270(4):377-87. doi: 10.1111/j.1365-2796.2011.02389.x. Epub 2011 May 9.


Expansion and activation kinetics of immune cells during early phase of GVHD in mouse model based on chemotherapy conditioning.

Sadeghi B, Al-Hashmi S, Hassan Z, Rozell B, Concha H, Lundmark C, Grönvik KO, Abedi-Valugerdi M, Hassan M.

Clin Dev Immunol. 2010;2010:142943. doi: 10.1155/2010/142943. Epub 2010 Dec 21.


Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.

Pils MC, Bleich A, Prinz I, Fasnacht N, Bollati-Fogolin M, Schippers A, Rozell B, Müller W.

Inflamm Bowel Dis. 2011 Oct;17(10):2038-46. doi: 10.1002/ibd.21587. Epub 2010 Dec 22.


Scandinavian Fellowship for Oral Pathology and Oral Medicine: statement on oral pathology and oral medicine in the European Dental Curriculum.

Kragelund C, Reibel J, Hadler-Olsen ES, Hietanen J, Johannessen AC, Kenrad B, Nylander K, Puranen M, Rozell B, Salo T, Syrjänen S, Søland TM, van der Waal I, van der Wal JE, Warfvinge G.

J Oral Pathol Med. 2010 Nov;39(10):800-e1. doi: 10.1111/j.1600-0714.2010.00939.x. Epub 2010 Sep 1.


Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome.

Zhou X, Johansson M, Solaroli N, Rozell B, Grandien A, Karlsson A.

J Inherit Metab Dis. 2010 Jun;33(3):231-6. doi: 10.1007/s10545-010-9102-x. Epub 2010 May 4.


A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.

Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkelä E, Aalto-Setälä K, Otonkoski T, Suuronen R, Hovatta O, Skottman H.

PLoS One. 2010 Apr 19;5(4):e10246. doi: 10.1371/journal.pone.0010246.


An effective serum- and xeno-free chemically defined freezing procedure for human embryonic and induced pluripotent stem cells.

Holm F, Ström S, Inzunza J, Baker D, Strömberg AM, Rozell B, Feki A, Bergström R, Hovatta O.

Hum Reprod. 2010 May;25(5):1271-9. doi: 10.1093/humrep/deq040. Epub 2010 Mar 5.


Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model.

Pils MC, Pisano F, Fasnacht N, Heinrich JM, Groebe L, Schippers A, Rozell B, Jack RS, Müller W.

Eur J Immunol. 2010 Feb;40(2):443-8. doi: 10.1002/eji.200939592.


Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.

Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M.

J Exp Med. 2009 Aug 3;206(8):1661-71. doi: 10.1084/jem.20090585. Epub 2009 Jul 27.


Development of mammary tumors by conditional expression of GLI1.

Fiaschi M, Rozell B, Bergström A, Toftgård R.

Cancer Res. 2009 Jun 1;69(11):4810-7. doi: 10.1158/0008-5472.CAN-08-3938. Epub 2009 May 19.


PRIME importance of pathology expertise.

Schofield PN, Brown SD, Sundberg JP, Arends M, Warren MV, Dubus P, Ellender M, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Song JY, van der Valk M, McKerlie C.

Nat Biotechnol. 2009 Jan;27(1):24-5. doi: 10.1038/nbt0109-24. No abstract available.


Differential expression of A-type and B-type lamins during hair cycling.

Hanif M, Rosengardten Y, Sagelius H, Rozell B, Eriksson M.

PLoS One. 2009;4(1):e4114. doi: 10.1371/journal.pone.0004114. Epub 2009 Jan 5.


An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function.

Johansson JU, Ericsson J, Janson J, Beraki S, Stanić D, Mandic SA, Wikström MA, Hökfelt T, Ogren SO, Rozell B, Berggren PO, Bark C.

PLoS Genet. 2008 Nov;4(11):e1000278. doi: 10.1371/journal.pgen.1000278. Epub 2008 Nov 28.


Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome.

Xue Y, Religa P, Cao R, Hansen AJ, Lucchini F, Jones B, Wu Y, Zhu Z, Pytowski B, Liang Y, Zhong W, Vezzoni P, Rozell B, Cao Y.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18513-8. doi: 10.1073/pnas.0807967105. Epub 2008 Nov 18.


An impending crisis in the provision of histopathology expertise for mouse functional genomics.

Warren MV, Studley ML, Dubus P, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Breuer M, Song JY, Gates H, Brown SD, Schofield PN.

J Pathol. 2009 Jan;217(1):4-13. doi: 10.1002/path.2460.


Progress in updating the European Radiobiology Archives.

Tapio S, Schofield PN, Adelmann C, Atkinson MJ, Bard JL, Bijwaard H, Birschwilks M, Dubus P, Fiette L, Gerber G, Gruenberger M, Quintanilla-Martinez L, Rozell B, Saigusa S, Warren M, Watson CR, Grosche B.

Int J Radiat Biol. 2008 Nov;84(11):930-6. doi: 10.1080/09553000802460214.


GVHD after chemotherapy conditioning in allogeneic transplanted mice.

Sadeghi B, Aghdami N, Hassan Z, Forouzanfar M, Rozell B, Abedi-Valugerdi M, Hassan M.

Bone Marrow Transplant. 2008 Dec;42(12):807-18. doi: 10.1038/bmt.2008.261. Epub 2008 Sep 29.


Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome.

Salomonsson S, Rozell BL, Heimburger M, Wahren-Herlenius M.

J Oral Pathol Med. 2009 Mar;38(3):282-8. doi: 10.1111/j.1600-0714.2008.00697.x. Epub 2008 Sep 12.


Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice.

Svärd J, Rozell B, Toftgård R, Teglund S.

Mol Carcinog. 2009 May;48(5):408-19. doi: 10.1002/mc.20479.


Reversible phenotype in a mouse model of Hutchinson-Gilford progeria syndrome.

Sagelius H, Rosengardten Y, Schmidt E, Sonnabend C, Rozell B, Eriksson M.

J Med Genet. 2008 Dec;45(12):794-801. doi: 10.1136/jmg.2008.060772. Epub 2008 Aug 15.


Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice.

Zhou X, Solaroli N, Bjerke M, Stewart JB, Rozell B, Johansson M, Karlsson A.

Hum Mol Genet. 2008 Aug 1;17(15):2329-35. doi: 10.1093/hmg/ddn133. Epub 2008 Apr 22.


Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease.

Sagelius H, Rosengardten Y, Hanif M, Erdos MR, Rozell B, Collins FS, Eriksson M.

J Cell Sci. 2008 Apr 1;121(Pt 7):969-78. doi: 10.1242/jcs.022913. Epub 2008 Mar 11.


The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice.

Tiala I, Wakkinen J, Suomela S, Puolakkainen P, Tammi R, Forsberg S, Rollman O, Kainu K, Rozell B, Kere J, Saarialho-Kere U, Elomaa O.

Hum Mol Genet. 2008 Apr 1;17(7):1043-51. doi: 10.1093/hmg/ddm377. Epub 2008 Jan 3.


Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1.

Sjögren M, Alkemade A, Mittag J, Nordström K, Katz A, Rozell B, Westerblad H, Arner A, Vennström B.

EMBO J. 2007 Oct 31;26(21):4535-45. Epub 2007 Oct 11.


Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure.

Fiaschi M, Rozell B, Bergström A, Toftgård R, Kleman MI.

J Biol Chem. 2007 Dec 7;282(49):36090-101. Epub 2007 Oct 10.


Severe defect in thymic development in an insertional mutant mouse model.

Assarsson E, Chambers BJ, Högstrand K, Berntman E, Lundmark C, Fedorova L, Imreh S, Grandien A, Cardell S, Rozell B, Ljunggren HG.

J Immunol. 2007 Apr 15;178(8):5018-27.


Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse.

Wang J, Olin M, Rozell B, Björkhem I, Einarsson C, Eggertsen G, Gåfvels M.

Histochem Cell Biol. 2007 Mar;127(3):253-61. Epub 2007 Jan 20.


Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.

Sur I, Rozell B, Jaks V, Bergström A, Toftgård R.

J Cell Sci. 2006 Sep 1;119(Pt 17):3593-601. Epub 2006 Aug 15.


Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma.

Hässler S, Ramsey C, Karlsson MC, Larsson D, Herrmann B, Rozell B, Backheden M, Peltonen L, Kämpe O, Winqvist O.

Blood. 2006 Sep 15;108(6):1941-8. Epub 2006 May 18.


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