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Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb.

Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD.

Am J Physiol Regul Integr Comp Physiol. 2019 Sep 4. doi: 10.1152/ajpregu.00115.2019. [Epub ahead of print]


Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal β-Cell Development in C57BL/6 Mice.

Qiao L, Wattez JS, Lim L, Rozance PJ, Hay WW Jr, Shao J.

Diabetes. 2019 Aug;68(8):1604-1613. doi: 10.2337/db18-1308. Epub 2019 May 24.


Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.

Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW Jr, Limesand SW, Wesolowski SR.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E1-E10. doi: 10.1152/ajpendo.00069.2019. Epub 2019 Apr 9.


Hypoglycemia in the Newborn.

Rozance PJ, Wolfsdorf JI.

Pediatr Clin North Am. 2019 Apr;66(2):333-342. doi: 10.1016/j.pcl.2018.12.004. Epub 2019 Feb 1. Review.


Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. doi: 10.1152/ajpregu.00359.2018. Epub 2019 Feb 13.


Alert Newborn Infants Are Ready to Feed and Raise Their Glucose Concentration.

Hay WW Jr, Rozance PJ.

Neonatology. 2019;115(3):239-241. doi: 10.1159/000495730. Epub 2019 Jan 22. No abstract available.


Continuous glucose monitoring in the neonatal intensive care unit: not quite ready for 'plug and play'.

Hernandez TL, Hay WW Jr, Rozance PJ.

Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F344-F345. doi: 10.1136/archdischild-2018-315899. Epub 2018 Nov 13. No abstract available.


Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates.

Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1143-E1153. doi: 10.1152/ajpendo.00128.2018. Epub 2018 Sep 11.


A 1 week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep.

White A, Louey S, Chang EI, Boehmer BH, Goldstrohm D, Jonker SS, Rozance PJ.

Physiol Rep. 2018 Sep;6(17):e13840. doi: 10.14814/phy2.13840.


Pulsatile hyperglycemia increases insulin secretion but not pancreatic β-cell mass in intrauterine growth-restricted fetal sheep.

Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ.

J Dev Orig Health Dis. 2018 Oct;9(5):492-499. doi: 10.1017/S2040174418000417. Epub 2018 Jul 5.


Reply to the Letter to the Editor "The Postnatal Glucose Concentration Nadir Is Not Abnormal and Does Not Need to Be Treated".

Kaiser JR, Bai S, Rozance PJ.

Neonatology. 2018;114(2):164. doi: 10.1159/000489553. Epub 2018 Jun 12. No abstract available.


Neonatal Hyperglycemia-Causes, Treatments, and Cautions.

Hay WW Jr, Rozance PJ.

J Pediatr. 2018 Sep;200:6-8. doi: 10.1016/j.jpeds.2018.04.046. Epub 2018 May 9. No abstract available.


Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep.

Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L348-L359. doi: 10.1152/ajplung.00052.2018. Epub 2018 May 3.


Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group.

Kaiser JR, Bai S, Rozance PJ.

Neonatology. 2018;113(4):353-359. doi: 10.1159/000487222. Epub 2018 Mar 6. Erratum in: Neonatology. 2018;114(2):165. Erratum in: Neonatology. 2018;114(2):166.


Consensus Based Definition of Growth Restriction in the Newborn.

Beune IM, Bloomfield FH, Ganzevoort W, Embleton ND, Rozance PJ, van Wassenaer-Leemhuis AG, Wynia K, Gordijn SJ.

J Pediatr. 2018 May;196:71-76.e1. doi: 10.1016/j.jpeds.2017.12.059. Epub 2018 Feb 28.


Searching for the Best Oral Treatment for Hypoglycemic Newborns.

Rozance PJ, Bai S, Kaiser JR.

J Pediatr. 2017 Nov;190:10-12. doi: 10.1016/j.jpeds.2017.08.025. No abstract available.


50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy.

Bourque SL, Rozance PJ, Hay WW.

J Pediatr. 2017 Oct;189:53. doi: 10.1016/j.jpeds.2017.03.059. No abstract available.


Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.

Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD.

J Physiol. 2018 Jan 1;596(1):67-82. doi: 10.1113/JP275230. Epub 2017 Oct 26.


Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage.

Rozance PJ, Wright CJ.

J Physiol. 2017 Nov 1;595(21):6595-6596. doi: 10.1113/JP275015. Epub 2017 Oct 4. No abstract available.


The impact of IUGR on pancreatic islet development and β-cell function.

Boehmer BH, Limesand SW, Rozance PJ.

J Endocrinol. 2017 Nov;235(2):R63-R76. doi: 10.1530/JOE-17-0076. Epub 2017 Aug 14. Review.


Does dextrose gel prevent treatment failure in infants with neonatal hypoglycaemia?

Bourque SL, Rozance PJ.

Acta Paediatr. 2017 Jul;106(7):1201. doi: 10.1111/apa.13756. Epub 2017 Feb 20. No abstract available.


Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency.

Limesand SW, Rozance PJ.

J Physiol. 2017 Aug 1;595(15):5103-5113. doi: 10.1113/JP273324. Epub 2017 May 26. Review.


Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep.

Brown LD, Kohn JR, Rozance PJ, Hay WW Jr, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R654-R663. doi: 10.1152/ajpregu.00502.2016. Epub 2017 Feb 8.


Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.

Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW Jr, Rozance PJ.

Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R492-R500. doi: 10.1152/ajpregu.00484.2016. Epub 2017 Jan 18.


Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.

Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD.

J Endocrinol. 2017 Mar;232(3):475-491. doi: 10.1530/JOE-16-0123. Epub 2017 Jan 4.


Modern Management of Preterm Infants Prevents Adverse Developmental Outcomes From Hypoglycemia.

Rozance PJ, Hay WW Jr.

Pediatrics. 2016 Dec;138(6). pii: e20162881. Epub 2016 Nov 4. No abstract available.


Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep.

Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW Jr, Limesand SW, Rozance PJ.

Endocrinology. 2016 Oct;157(10):3788-3799. Epub 2016 Aug 8.


Antenatal corticosteroids beyond 34 weeks gestation: What do we do now?

Kamath-Rayne BD, Rozance PJ, Goldenberg RL, Jobe AH.

Am J Obstet Gynecol. 2016 Oct;215(4):423-30. doi: 10.1016/j.ajog.2016.06.023. Epub 2016 Jun 21. Review.


Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.

Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW Jr, Rozance PJ.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R200-8. doi: 10.1152/ajpregu.00037.2016. Epub 2016 May 11.


New approaches to management of neonatal hypoglycemia.

Rozance PJ, Hay WW Jr.

Matern Health Neonatol Perinatol. 2016 May 10;2:3. doi: 10.1186/s40748-016-0031-z. eCollection 2016. Review.


Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle.

Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW Jr, Rozance PJ.

Endocrinology. 2016 Jun;157(6):2447-60. doi: 10.1210/en.2015-1744. Epub 2016 Apr 6.


Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.

Hay WW Jr, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW.

Acta Paediatr. 2016 Aug;105(8):881-9. doi: 10.1111/apa.13413. Epub 2016 May 10. Review.


50 Years Ago in The Journal of Pediatrics: Perinatal Stress and the Premature Neonate. II. Effect of Fluid and Calorie Deprivation on Blood Glucose.

Rozance PJ.

J Pediatr. 2016 Mar;170:89. doi: 10.1016/j.jpeds.2015.10.055. No abstract available.


Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.

Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW Jr.

Exp Biol Med (Maywood). 2016 Apr;241(8):839-47. doi: 10.1177/1535370216632621. Epub 2016 Feb 11.


Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses.

Rozance PJ, Hay WW Jr.

Mol Cell Endocrinol. 2016 Nov 5;435:78-84. doi: 10.1016/j.mce.2016.01.025. Epub 2016 Jan 26. Review.


A Sweet Addition for the Treatment of Neonatal Hypoglycemia.

Brown LD, Rozance PJ.

J Pediatr. 2016 Mar;170:10-2. doi: 10.1016/j.jpeds.2015.12.036. Epub 2015 Dec 31. No abstract available.


Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction.

Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. doi: 10.1152/ajpregu.00197.2015. Epub 2015 Jul 29.


Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children.

Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Rozance PJ, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI; Pediatric Endocrine Society.

J Pediatr. 2015 Aug;167(2):238-45. doi: 10.1016/j.jpeds.2015.03.057. Epub 2015 May 6. No abstract available.


Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management.

Stanley CA, Rozance PJ, Thornton PS, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI.

J Pediatr. 2015 Jun;166(6):1520-5.e1. doi: 10.1016/j.jpeds.2015.02.045. Epub 2015 Mar 25. Review. No abstract available.


Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.

Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR.

Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14. doi: 10.1152/ajpendo.00396.2014. Epub 2014 Dec 16.


Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus.

Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ.

Endocrinology. 2015 Jan;156(1):367-76. doi: 10.1210/en.2014-1393.


Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep.

Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW.

Diabetes. 2015 Feb;64(2):555-64. doi: 10.2337/db14-0462. Epub 2014 Sep 23.


A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia.

Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ.

Physiol Rep. 2014 Jun 18;2(6). pii: e12045. doi: 10.14814/phy2.12045.


Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep.

Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ.

J Anim Sci Biotechnol. 2014 May 22;5(1):28. doi: 10.1186/2049-1891-5-28. eCollection 2014.


50 years ago in the Journal of pediatrics: The incidence of neonatal hypoglycemia in a nursery for premature infants.

Houin S, Rozance PJ.

J Pediatr. 2014 Jun;164(6):1485. doi: 10.1016/j.jpeds.2014.01.015. No abstract available.


Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted fetal sheep.

Dodson RB, Rozance PJ, Petrash CC, Hunter KS, Ferguson VL.

Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H429-37. doi: 10.1152/ajpheart.00472.2013. Epub 2013 Dec 6.


Update on neonatal hypoglycemia.

Rozance PJ.

Curr Opin Endocrinol Diabetes Obes. 2014 Feb;21(1):45-50. doi: 10.1097/MED.0000000000000027. Review.


Hyperelastic remodeling in the intrauterine growth restricted (IUGR) carotid artery in the near-term fetus.

Dodson RB, Rozance PJ, Reina-Romo E, Ferguson VL, Hunter KS.

J Biomech. 2013 Mar 15;46(5):956-63. doi: 10.1016/j.jbiomech.2012.12.013. Epub 2013 Jan 16.


Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency.

Limesand SW, Rozance PJ, Macko AR, Anderson MJ, Kelly AC, Hay WW Jr.

Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E516-23. doi: 10.1152/ajpendo.00435.2012. Epub 2012 Dec 31.


Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep.

Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E352-62. doi: 10.1152/ajpendo.00377.2012. Epub 2012 Dec 4.

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