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Items: 22


Paving New Roads for CARs.

Hyrenius-Wittsten A, Roybal KT.

Trends Cancer. 2019 Oct;5(10):583-592. doi: 10.1016/j.trecan.2019.09.005. Epub 2019 Oct 19. Review.


NextGen cell-based immunotherapies in cancer and other immune disorders.

Azimi CS, Tang Q, Roybal KT, Bluestone JA.

Curr Opin Immunol. 2019 Aug;59:79-87. doi: 10.1016/j.coi.2019.03.007. Epub 2019 May 6. Review.


Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L.

Immunity. 2019 Feb 19;50(2):477-492.e8. doi: 10.1016/j.immuni.2019.01.006. Epub 2019 Feb 5.


Refining cell therapy.

Roybal KT.

Science. 2018 Mar 9;359(6380):1112-1113. doi: 10.1126/science.aat0962. Epub 2018 Mar 8. No abstract available.


Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.

Roybal KT, Lim WA.

Annu Rev Immunol. 2017 Apr 26;35:229-253. doi: 10.1146/annurev-immunol-051116-052302. Review.


CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.

Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A.

Sci Rep. 2017 Apr 7;7(1):737. doi: 10.1038/s41598-017-00462-8.


Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.

Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA.

Cell. 2016 Oct 6;167(2):419-432.e16. doi: 10.1016/j.cell.2016.09.011. Epub 2016 Sep 29.


Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics.

Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF.

Sci Signal. 2016 Apr 19;9(424):rs3. doi: 10.1126/scisignal.aad4149.


Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.

Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA.

Cell. 2016 Feb 11;164(4):770-9. doi: 10.1016/j.cell.2016.01.011. Epub 2016 Jan 28.


Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.

Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA.

Cell. 2016 Feb 11;164(4):780-91. doi: 10.1016/j.cell.2016.01.012. Epub 2016 Jan 28.


Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.

Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA.

Science. 2015 Oct 16;350(6258):aab4077. doi: 10.1126/science.aab4077. Epub 2015 Sep 24.


Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling.

Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C.

PLoS One. 2015 Aug 3;10(8):e0133231. doi: 10.1371/journal.pone.0133231. eCollection 2015.


Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network.

Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C.

PLoS One. 2015 Aug 3;10(8):e0133299. doi: 10.1371/journal.pone.0133299. eCollection 2015.


Synthetic biology approaches to engineer T cells.

Wu CY, Rupp LJ, Roybal KT, Lim WA.

Curr Opin Immunol. 2015 Aug;35:123-30. doi: 10.1016/j.coi.2015.06.015. Epub 2015 Jul 25. Review.


IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells.

Huber JP, Gonzales-van Horn SR, Roybal KT, Gill MA, Farrar JD.

J Immunol. 2014 Jun 15;192(12):5687-94. doi: 10.4049/jimmunol.1301908. Epub 2014 May 9.


The actin-driven spatiotemporal organization of T-cell signaling at the system scale.

Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C.

Immunol Rev. 2013 Nov;256(1):133-47. doi: 10.1111/imr.12103. Review.


New TACTICS for finding Numb.

Roybal KT, Wülfing C.

Immunol Cell Biol. 2013 Jan;91(1):1-2. doi: 10.1038/icb.2012.63. Epub 2012 Nov 27. Review. No abstract available.


Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages.

Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS.

Appl Environ Microbiol. 2012 Oct;78(19):6829-37. doi: 10.1128/AEM.01674-12. Epub 2012 Jul 20.


The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.

DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS.

J Immunol. 2011 Jun 15;186(12):6839-47. doi: 10.4049/jimmunol.1002721. Epub 2011 May 4.


Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy.

Sinai P, Roybal KT, Wülfing C.

Commun Integr Biol. 2010 Nov;3(6):545-8. doi: 10.4161/cib.3.6.12843. Epub 2010 Nov 1.


Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function.

Roybal KT, Wülfing C.

Sci Signal. 2010 Jul 27;3(132):pe24. doi: 10.1126/scisignal.3132pe24.


Spatiotemporal patterning during T cell activation is highly diverse.

Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C.

Sci Signal. 2009 Apr 7;2(65):ra15. doi: 10.1126/scisignal.2000199.

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