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Items: 1 to 50 of 57

1.

The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules.

Kamal M, Moshiri H, Magomedova L, Han D, Nguyen KCQ, Yeo M, Knox J, Bagg R, Won AM, Szlapa K, Yip CM, Cummins CL, Hall DH, Roy PJ.

Nat Commun. 2019 Sep 2;10(1):3938. doi: 10.1038/s41467-019-11908-0.

2.

Offering Emergency Buprenorphine Without a Prescription.

Roy PJ, Stein MD.

JAMA. 2019 Jul 8. doi: 10.1001/jama.2019.8309. [Epub ahead of print] No abstract available.

PMID:
31282953
3.

Treating the "Wake-up Call" of Alcohol Use: A Teachable Moment.

Roy PJ, Worsham C.

JAMA Intern Med. 2017 Dec 1;177(12):1849-1850. doi: 10.1001/jamainternmed.2017.5502. No abstract available.

PMID:
29059276
4.

The novel nematicide wact-86 interacts with aldicarb to kill nematodes.

Burns AR, Bagg R, Yeo M, Luciani GM, Schertzberg M, Fraser AG, Roy PJ.

PLoS Negl Trop Dis. 2017 Apr 5;11(4):e0005502. doi: 10.1371/journal.pntd.0005502. eCollection 2017 Apr.

5.

The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans.

D'Souza SA, Rajendran L, Bagg R, Barbier L, van Pel DM, Moshiri H, Roy PJ.

PLoS Genet. 2016 Apr 28;12(4):e1006010. doi: 10.1371/journal.pgen.1006010. eCollection 2016 Apr.

6.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.

7.

EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.

Chan KK, Seetharaman A, Bagg R, Selman G, Zhang Y, Kim J, Roy PJ.

PLoS Genet. 2014 Aug 14;10(8):e1004521. doi: 10.1371/journal.pgen.1004521. eCollection 2014 Aug.

8.

Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.

Tharmalingam S, Burns AR, Roy PJ, Hampson DR.

Neuropharmacology. 2012 Sep;63(4):667-74. doi: 10.1016/j.neuropharm.2012.05.029. Epub 2012 May 28.

PMID:
22652059
9.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ.

Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318.

PMID:
22057127
10.

Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G.

Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018.

11.

MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.

Seetharaman A, Selman G, Puckrin R, Barbier L, Wong E, D'Souza SA, Roy PJ.

Dev Cell. 2011 Oct 18;21(4):669-80. doi: 10.1016/j.devcel.2011.07.020.

12.

MADD-2, a homolog of the Opitz syndrome protein MID1, regulates guidance to the midline through UNC-40 in Caenorhabditis elegans.

Alexander M, Selman G, Seetharaman A, Chan KK, D'Souza SA, Byrne AB, Roy PJ.

Dev Cell. 2010 Jun 15;18(6):961-72. doi: 10.1016/j.devcel.2010.05.016.

13.

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Burns AR, Wallace IM, Wildenhain J, Tyers M, Giaever G, Bader GD, Nislow C, Cutler SR, Roy PJ.

Nat Chem Biol. 2010 Jul;6(7):549-57. doi: 10.1038/nchembio.380. Epub 2010 May 30.

PMID:
20512140
14.

Seeing through the smokescreen.

Roy PJ.

Med Econ. 2010 Mar 5;87(5):55. No abstract available.

PMID:
20377080
15.

An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis elegans.

Alexander M, Chan KK, Byrne AB, Selman G, Lee T, Ono J, Wong E, Puckrin R, Dixon SJ, Roy PJ.

Development. 2009 Mar;136(6):911-22. doi: 10.1242/dev.030759. Epub 2009 Feb 11.

16.

Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs.

Hui K, Kwok TC, Kostelecki W, Leen J, Roy PJ, Feng ZP.

Eur J Pharmacol. 2009 Jan 14;602(2-3):255-61. doi: 10.1016/j.ejphar.2008.11.051. Epub 2008 Dec 3.

PMID:
19068212
17.

A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels.

Kwok TC, Hui K, Kostelecki W, Ricker N, Selman G, Feng ZP, Roy PJ.

PLoS Genet. 2008 May 9;4(5):e1000067. doi: 10.1371/journal.pgen.1000067. Erratum in: PLoS Genet. 2009 Feb;5(2). doi: 10.1371/annotation/c38f7645-c9d8-4371-b363-5a9099c75e83.

18.

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Lory S, Stagljar I.

PLoS Genet. 2008 Feb 29;4(2):e1000005. doi: 10.1371/journal.pgen.1000005. Erratum in: PLoS Genet. 2008 Apr;4(4). doi: 10.1371/annotation/76d35829-07a2-479f-bbc1-cce6755b6d8c. Merrill, Rod A [corrected to Merrill, A Rod].

19.

Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.

Dixon SJ, Alexander M, Chan KK, Roy PJ.

Dev Biol. 2008 Jun 1;318(1):153-61. doi: 10.1016/j.ydbio.2008.03.019. Epub 2008 Mar 20.

20.

Worming our way to the fountain of youth.

Roy PJ.

Nat Chem Biol. 2008 Feb;4(2):88-9. doi: 10.1038/nchembio0208-88. No abstract available.

PMID:
18202675
21.

Health plan ignorance can cost you.

Roy PJ.

Med Econ. 2007 Nov 2;84(21):48-9. No abstract available.

PMID:
18074932
22.

A global analysis of genetic interactions in Caenorhabditis elegans.

Byrne AB, Weirauch MT, Wong V, Koeva M, Dixon SJ, Stuart JM, Roy PJ.

J Biol. 2007;6(3):8. Epub 2007 Sep 26.

23.

Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system.

Von Stetina SE, Watson JD, Fox RM, Olszewski KL, Spencer WC, Roy PJ, Miller DM 3rd.

Genome Biol. 2007;8(7):R135.

24.

High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans.

Burns AR, Kwok TC, Howard A, Houston E, Johanson K, Chan A, Cutler SR, McCourt P, Roy PJ.

Nat Protoc. 2006;1(4):1906-14.

PMID:
17487175
25.

When I follow up, I don't give up.

Roy PJ.

Med Econ. 2006 Aug 4;83(15):68-9. No abstract available.

PMID:
16964732
26.

A small-molecule screen in C. elegans yields a new calcium channel antagonist.

Kwok TC, Ricker N, Fraser R, Chan AW, Burns A, Stanley EF, McCourt P, Cutler SR, Roy PJ.

Nature. 2006 May 4;441(7089):91-5.

PMID:
16672971
27.

FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.

Dixon SJ, Alexander M, Fernandes R, Ricker N, Roy PJ.

Development. 2006 Apr;133(7):1263-75. Epub 2006 Feb 22.

28.

Don't bother donating expired drugs.

Roy PJ.

Med Econ. 2005 Oct 7;82(19):71. No abstract available.

PMID:
16355903
29.
30.

Muscle arm development in Caenorhabditis elegans.

Dixon SJ, Roy PJ.

Development. 2005 Jul;132(13):3079-92. Epub 2005 Jun 1.

31.

Overseas transcription: I say no!

Roy PJ.

Med Econ. 2005 Jan 21;82(2):100. No abstract available.

PMID:
15727346
32.

My malpractice carrier broke my heart.

Roy PJ.

Med Econ. 2004 Feb 20;81(4):42, 45. No abstract available.

PMID:
15015412
33.

Two shifts work great for this office.

Roy PJ.

Med Econ. 2004 Feb 6;81(3):85-6. No abstract available.

PMID:
14983642
34.

Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans.

Roy PJ, Stuart JM, Lund J, Kim SK.

Nature. 2002 Aug 29;418(6901):975-9. Erratum in: Nature. 2007 Nov 1;450(7166):128.

PMID:
12214599
35.
36.

The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells.

Warren CE, Krizus A, Roy PJ, Culotti JG, Dennis JW.

J Biol Chem. 2002 Jun 21;277(25):22829-38. Epub 2002 Apr 5.

37.
38.
39.
40.

How evidence-based medicine will change the way you practice. Panel discussion.

Roy PJ, Nash DB, Davant C 3rd, Brook RH, Solomon GL.

Med Econ. 1999 Mar 8;76(5):120-2, 127-8, 133. No abstract available.

PMID:
10346053
41.

Why I pay all the bills for our practice.

Roy PJ.

Med Econ. 1999 Jan 25;76(2):55-6, 59. No abstract available.

PMID:
10345664
42.

A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.

Suzuki Y, Yandell MD, Roy PJ, Krishna S, Savage-Dunn C, Ross RM, Padgett RW, Wood WB.

Development. 1999 Jan;126(2):241-50.

43.
44.

Never count on a managed-care bonus--even though you've earned one.

Roy PJ.

Med Econ. 1998 Jul 27;75(14):93-4, 97, 101. No abstract available.

PMID:
10181856
45.

Lack of insurance killed these patients.

Roy PJ.

Med Econ. 1998 Jan 26;75(2):168-70m 173. No abstract available.

PMID:
10175887
46.

Do insurers really stand behind preventive care?

Roy PJ.

Med Econ. 1997 Sep 8;74(18):169, 173. No abstract available.

PMID:
10173561
47.

Urgent-care centers don't worry me anymore.

Roy PJ.

Med Econ. 1997 Jul 14;74(14):107-8, 113. No abstract available.

PMID:
10168774
48.

Four myths about teaching medical students.

Roy PJ.

Fam Med. 1996 Oct;28(9):613. No abstract available.

PMID:
8909960
49.

Now I know why some patients sue.

Roy PJ.

Med Econ. 1996 Feb 12;73(3):129-31, 135-6. No abstract available.

PMID:
10154679
50.

Doonesbury's right: we can stay on schedule.

Roy PJ.

Med Econ. 1995 Nov 27;72(22):76, 81-2. No abstract available.

PMID:
10152672

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