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The impact of a multidisciplinary algorithmic approach to acute lower gastrointestinal bleeding.

Petersile M, Haroon M, Belkin D, Pinheiro A, Weinberg J, Roy HK, Jacobson BC.

Am J Emerg Med. 2019 Sep;37(9):1751-1753. doi: 10.1016/j.ajem.2019.06.034. Epub 2019 Jun 21. No abstract available.


Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer.

Ruderman S, Eshein A, Valuckaite V, Dougherty U, Almoghrabi A, Gomes A, Singh A, Pabla B, Roy HK, Hart J, Bissonnette M, Konda V, Backman V.

BMC Cancer. 2018 Aug 13;18(1):814. doi: 10.1186/s12885-018-4709-7.


Correction: Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study.

Kalman RS, Stawarz A, Nunes D, Zhang D, Dela Cruz MA, Mohanty A, Subramanian H, Backman V, Roy HK.

PLoS One. 2018 Jul 24;13(7):e0201500. doi: 10.1371/journal.pone.0201500. eCollection 2018.


Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study.

Kalman RS, Stawarz A, Nunes D, Zhang D, Dela Cruz MA, Mohanty A, Subramanian H, Backman V, Roy HK.

PLoS One. 2018 May 17;13(5):e0197427. doi: 10.1371/journal.pone.0197427. eCollection 2018. Erratum in: PLoS One. 2018 Jul 24;13(7):e0201500.


Prevention of colonic neoplasia with polyethylene glycol: A short term randomized placebo-controlled double-blinded trial.

Wali RK, Bianchi L, Kupfer S, De La Cruz M, Jovanovic B, Weber C, Goldberg MJ, Rodriguez LM, Bergan R, Rubin D, Tull MB, Richmond E, Parker B, Khan S, Roy HK.

PLoS One. 2018 Apr 4;13(4):e0193544. doi: 10.1371/journal.pone.0193544. eCollection 2018.


Correlating colorectal cancer risk with field carcinogenesis progression using partial wave spectroscopic microscopy.

Gladstein S, Damania D, Almassalha LM, Smith LT, Gupta V, Subramanian H, Rex DK, Roy HK, Backman V.

Cancer Med. 2018 May;7(5):2109-2120. doi: 10.1002/cam4.1357. Epub 2018 Mar 23.


Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities.

Datta S, Sherva RM, De La Cruz M, Long MT, Roy P, Backman V, Chowdhury S, Roy HK.

Neoplasia. 2018 Mar;20(3):289-294. doi: 10.1016/j.neo.2018.01.003. Epub 2018 Feb 19.


Macrogenomic engineering via modulation of the scaling of chromatin packing density.

Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, Backman V.

Nat Biomed Eng. 2017 Nov;1(11):902-913. doi: 10.1038/s41551-017-0153-2. Epub 2017 Nov 6.


Exercise-induced myokines as emerging therapeutic agents in colorectal cancer prevention and treatment.

Roy P, Chowdhury S, Roy HK.

Future Oncol. 2018 Feb;14(4):309-312. doi: 10.2217/fon-2017-0555. Epub 2018 Jan 10. No abstract available.


The transformation of the nuclear nanoarchitecture in human field carcinogenesis.

Bauer GM, Stypula-Cyrus Y, Subramanian H, Cherkezyan L, Viswanathan P, Zhang D, Iyengar R, Bagalkar S, Derbas J, Graff T, Gladstein S, Almassalha LM, Chandler JE, Roy HK, Backman V.

Future Sci OA. 2017 May 5;3(3):FSO206. doi: 10.4155/fsoa-2017-0027. eCollection 2017 Aug. Review.


Metabolism, microbiome and colorectal cancer.

Datta S, Chowdhury S, Roy HK.

Aging (Albany NY). 2017 Apr;9(4):1086-1087. doi: 10.18632/aging.101234. No abstract available.


Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis.

Cruz MD, Ledbetter S, Chowdhury S, Tiwari AK, Momi N, Wali RK, Bliss C, Huang C, Lichtenstein D, Bhattacharya S, Varma-Wilson A, Backman V, Roy HK.

Oncotarget. 2017 Mar 28;8(13):20543-20557. doi: 10.18632/oncotarget.16129.


ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.

Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP 3rd, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT.

Trials. 2017 Feb 1;18(1):50. doi: 10.1186/s13063-016-1744-z.


The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression.

Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, Backman V.

Sci Rep. 2017 Jan 24;7:41061. doi: 10.1038/srep41061.


Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer.

Calderwood AH, Lasser KE, Roy HK.

World J Gastrointest Oncol. 2016 Dec 15;8(12):826-834. doi: 10.4251/wjgo.v8.i12.826.


Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1.

Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM.

Antioxid Redox Signal. 2017 Aug 20;27(6):313-327. doi: 10.1089/ars.2016.6716. Epub 2017 Feb 16.


Using electron microscopy to calculate optical properties of biological samples.

Wu W, Radosevich AJ, Eshein A, Nguyen TQ, Yi J, Cherkezyan L, Roy HK, Szleifer I, Backman V.

Biomed Opt Express. 2016 Oct 27;7(11):4749-4762. eCollection 2016 Nov 1.


Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications.

Wali RK, Momi N, Dela Cruz M, Calderwood AH, Stypula-Cyrus Y, Almassalha L, Chhaparia A, Weber CR, Radosevich A, Tiwari AK, Latif B, Backman V, Roy HK.

Cancer Prev Res (Phila). 2016 Nov;9(11):844-854. Epub 2016 Aug 22.


The genetics and molecular biology of colonic neoplasia: practical implications for the clinician.

Chowdhury S, Roy HK.

Curr Opin Gastroenterol. 2017 Jan;33(1):47-52. doi: 10.1097/MOG.0000000000000323. Review.


Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy.

Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Thusgaard Ruhoff P, Roy HK, Subramanian H, Chandel NS, Szleifer I, Backman V.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6372-E6381. Epub 2016 Oct 4.


Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance.

Krishn SR, Kaur S, Sheinin YM, Smith LM, Gautam SK, Patel A, Jain M, Juvvigunta V, Pai P, Lazenby AJ, Roy HK, Batra SK.

Oncotarget. 2017 Jan 24;8(4):7025-7038. doi: 10.18632/oncotarget.12347.


Procedures for risk-stratification of lung cancer using buccal nanocytology.

Subramanian H, Viswanathan P, Cherkezyan L, Iyengar R, Rozhok S, Verleye M, Derbas J, Czarnecki J, Roy HK, Backman V.

Biomed Opt Express. 2016 Aug 31;7(9):3795-3810. eCollection 2016 Sep 1.


The Greater Genomic Landscape: The Heterogeneous Evolution of Cancer.

Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Szleifer I, Roy HK, Backman V.

Cancer Res. 2016 Oct 1;76(19):5605-5609. Epub 2016 Aug 22.


Fractal Characterization of Chromatin Decompaction in Live Cells.

Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V.

Biophys J. 2015 Dec 1;109(11):2218-26. doi: 10.1016/j.bpj.2015.10.014.


Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin.

Roy HK, Turzhitsky V, Wali R, Radosevich AJ, Jovanovic B, Della'Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez L, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman V.

Gut. 2017 Feb;66(2):285-292. doi: 10.1136/gutjnl-2015-309996. Epub 2015 Oct 26.


Clinical Trial Laboratory Data Nested With in Subject: Components of Variance, Sample Size and Cost.

Jovanovic BD, Subramanian H, Helenowski IB, Roy HK, Backman V.

Biom Biostat Int J. 2015;2(3). pii: 00029. Epub 2015 Apr 15.


Harnessing novel modalities: field carcinogenesis detection for personalizing prostate cancer management.

Momi N, Backman V, Brendler CB, Roy HK.

Future Oncol. 2015;11(20):2737-41. doi: 10.2217/fon.15.182. Epub 2015 Sep 16. No abstract available.


Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.

Das S, Rachagani S, Sheinin Y, Smith LM, Gurumurthy CB, Roy HK, Batra SK.

Oncogene. 2016 May 19;35(20):2645-54. doi: 10.1038/onc.2015.327. Epub 2015 Sep 14.


Lynch syndrome in the 21st century: clinical perspectives.

Tiwari AK, Roy HK, Lynch HT.

QJM. 2016 Mar;109(3):151-8. doi: 10.1093/qjmed/hcv137. Epub 2015 Jul 29. Review.


Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions.

Radosevich AJ, Mutyal NN, Eshein A, Nguyen TQ, Gould B, Rogers JD, Goldberg MJ, Bianchi LK, Yen EF, Konda V, Rex DK, Van Dam J, Backman V, Roy HK.

Clin Cancer Res. 2015 Oct 1;21(19):4347-4355. doi: 10.1158/1078-0432.CCR-15-0136. Epub 2015 May 19.


In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa.

Mutyal NN, Radosevich AJ, Bajaj S, Konda V, Siddiqui UD, Waxman I, Goldberg MJ, Rogers JD, Gould B, Eshein A, Upadhye S, Koons A, Gonzalez-Haba Ruiz M, Roy HK, Backman V.

Pancreas. 2015 Jul;44(5):735-41. doi: 10.1097/MPA.0000000000000340.


Nanocytological field carcinogenesis detection to mitigate overdiagnosis of prostate cancer: a proof of concept study.

Roy HK, Brendler CB, Subramanian H, Zhang D, Maneval C, Chandler J, Bowen L, Kaul KL, Helfand BT, Wang CH, Quinn M, Petkewicz J, Paterakos M, Backman V.

PLoS One. 2015 Feb 23;10(2):e0115999. doi: 10.1371/journal.pone.0115999. eCollection 2015.


Buccal spectral markers for lung cancer risk stratification.

Radosevich AJ, Mutyal NN, Rogers JD, Gould B, Hensing TA, Ray D, Backman V, Roy HK.

PLoS One. 2014 Oct 9;9(10):e110157. doi: 10.1371/journal.pone.0110157. eCollection 2014.


Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.

Cruz MD, Wali RK, Bianchi LK, Radosevich AJ, Crawford SE, Jepeal L, Goldberg MJ, Weinstein J, Momi N, Roy P, Calderwood AH, Backman V, Roy HK.

Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2413-21. doi: 10.1158/1055-9965.EPI-14-0026. Epub 2014 Aug 25.


Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications.

Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Momi N, Backman V, Roy HK.

Int J Oncol. 2014 Sep;45(3):1209-15. doi: 10.3892/ijo.2014.2495. Epub 2014 Jun 11.


Dysplasia and cancer screening in 21st century.

Khunger M, Kumar U, Roy HK, Tiwari AK.

APMIS. 2014 Aug;122(8):674-82. doi: 10.1111/apm.12283. Epub 2014 Jun 7. Review.


Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.

Yi J, Radosevich AJ, Stypula-Cyrus Y, Mutyal NN, Azarin SM, Horcher E, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V.

J Biomed Opt. 2014 Mar;19(3):36013. doi: 10.1117/1.JBO.19.3.036013.


Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study.

Cherkezyan L, Stypula-Cyrus Y, Subramanian H, White C, Dela Cruz M, Wali RK, Goldberg MJ, Bianchi LK, Roy HK, Backman V.

BMC Cancer. 2014 Mar 14;14:189. doi: 10.1186/1471-2407-14-189.


End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis.

Stypula-Cyrus Y, Mutyal NN, Dela Cruz M, Kunte DP, Radosevich AJ, Wali R, Roy HK, Backman V.

FEBS Lett. 2014 Mar 3;588(5):829-35. doi: 10.1016/j.febslet.2014.01.046. Epub 2014 Feb 1.


Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening.

Konda VJ, Cherkezyan L, Subramanian H, Wroblewski K, Damania D, Becker V, Gonzalez MH, Koons A, Goldberg M, Ferguson MK, Waxman I, Roy HK, Backman V.

Endoscopy. 2013 Dec;45(12):983-8. doi: 10.1055/s-0033-1344617. Epub 2013 Sep 9.


Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy.

Radosevich AJ, Mutyal NN, Yi J, Stypula-Cyrus Y, Rogers JD, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V.

J Biomed Opt. 2013 Sep;18(9):097002. doi: 10.1117/1.JBO.18.9.097002.


Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening.

Roy HK, Damania DP, DelaCruz M, Kunte DP, Subramanian H, Crawford SE, Tiwari AK, Wali RK, Backman V.

Cancer Prev Res (Phila). 2013 Oct;6(10):1111-9. doi: 10.1158/1940-6207.CAPR-13-0138. Epub 2013 Aug 27.


HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure.

Stypula-Cyrus Y, Damania D, Kunte DP, Cruz MD, Subramanian H, Roy HK, Backman V.

PLoS One. 2013 May 28;8(5):e64600. doi: 10.1371/journal.pone.0064600. Print 2013.


FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.

Qi W, Fitchev PS, Cornwell ML, Greenberg J, Cabe M, Weber CR, Roy HK, Crawford SE, Savkovic SD.

J Biol Chem. 2013 Jun 7;288(23):16274-81. doi: 10.1074/jbc.M113.470617. Epub 2013 Apr 18.


Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification.

Backman V, Roy HK.

J Cancer. 2013;4(3):251-61. doi: 10.7150/jca.5838. Epub 2013 Mar 15.


Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells.

Damania D, Roy HK, Kunte D, Hurteau JA, Subramanian H, Cherkezyan L, Krosnjar N, Shah M, Backman V.

Int J Cancer. 2013 Sep 1;133(5):1143-52. doi: 10.1002/ijc.28122. Epub 2013 Apr 1.


Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopy.

Mutyal NN, Radosevich A, Tiwari AK, Stypula Y, Wali R, Kunte D, Roy HK, Backman V.

PLoS One. 2013;8(2):e57206. doi: 10.1371/journal.pone.0057206. Epub 2013 Feb 19.


Increasing colorectal cancer screening adherence: comment on "A randomized comparison of print and web communication on colorectal cancer screening".

Calderwood AH, Roy HK.

JAMA Intern Med. 2013 Jan 28;173(2):129-31. doi: 10.1001/jamainternmed.2013.2527. No abstract available.


NIH: Drop re-review for big grant holders.

Roy HK.

Nature. 2012 Oct 11;490(7419):176. doi: 10.1038/490176a. No abstract available.


Spectroscopic applications in gastrointestinal endoscopy.

Roy HK, Backman V.

Clin Gastroenterol Hepatol. 2012 Dec;10(12):1335-41. doi: 10.1016/j.cgh.2012.10.002. Epub 2012 Oct 8. Review.

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