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Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.

Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G.

Lancet Haematol. 2019 Nov 5. pii: S2352-3026(19)30202-9. doi: 10.1016/S2352-3026(19)30202-9. [Epub ahead of print]


Cellular therapy approaches harnessing the power of the immune system for personalized cancer treatment.

Bastien JP, Minguy A, Dave V, Roy DC.

Semin Immunol. 2019 Apr;42:101306. doi: 10.1016/j.smim.2019.101306. Review.


Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT.

Dholaria B, Savani BN, Labopin M, Luznik L, Ruggeri A, Mielke S, Al Malki MM, Kongtim P, Fuchs E, Huang XJ, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Ben Soussan P, Arnault Y, Handgretinger R, Roy DC, O'Donnell P, Bashey A, Solomon S, Romee R, Lewalle P, Gayoso J, Maschan M, Lazarus HM, Ballen K, Giebel S, Baron F, Ciceri F, Esteve J, Gorin NC, Spyridonidis A, Schmid C, Ciurea SO, Nagler A, Mohty M.

Haematologica. 2020 Jan;105(1):47-58. doi: 10.3324/haematol.2019.219790. Epub 2019 Sep 19.


Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Patients with Lymphoma.

Lemieux C, Ahmad I, Bambace NM, Bernard L, Cohen S, Delisle JS, Fleury I, Kiss T, Mollica L, Roy DC, Sauvageau G, Roy J, Lachance S.

Biol Blood Marrow Transplant. 2020 Jan;26(1):157-161. doi: 10.1016/j.bbmt.2019.09.007. Epub 2019 Sep 12.


Biomolecular Analysis of Beta Dose-Dependent Cutaneous Radiation Injury in a Porcine Model.

Burnett LR, Gabard AR, Robinson M, Bourland JD, Dorand JE, Dozier S, Xiao R, Roy DC, Tytell M.

Radiat Res. 2019 Aug;192(2):145-158. doi: 10.1667/RR14283.1. Epub 2019 Jun 5.


Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis.

Roy DC, Lachance S, Cohen S, Delisle JS, Kiss T, Sauvageau G, Busque L, Ahmad I, Bernard L, Bambace N, Boumédine RS, Guertin MC, Rezvani K, Mielke S, Perreault C, Roy J.

Br J Haematol. 2019 Sep;186(5):754-766. doi: 10.1111/bjh.15970. Epub 2019 May 28.


Critical Role for TCR Signal Strength and MHC Specificity in ThPOK-Induced CD4 Helper Lineage Choice.

Zeidan N, Damen H, Roy DC, Dave VP.

J Immunol. 2019 Jun 1;202(11):3211-3225. doi: 10.4049/jimmunol.1801464. Epub 2019 Apr 29.


The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation.

Ciurea SO, Al Malki MM, Kongtim P, Fuchs EJ, Luznik L, Huang XJ, Ciceri F, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Ben Soussan P, Arnault Y, Handgretinger R, Roy DC, O'Donnell PV, Bashey A, Solomon S, Romee R, Gayoso J, Lazarus HM, Ballen K, Savani BN, Mohty M, Nagler A.

Bone Marrow Transplant. 2020 Jan;55(1):12-24. doi: 10.1038/s41409-019-0499-z. Epub 2019 Mar 4. Review.


Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease.

Lemieux C, Ahmad I, Bambace NM, Bernard L, Cohen S, Delisle JS, Fleury I, Kiss T, Mollica L, Roy DC, Sauvageau G, Roy J, Lachance S.

Leuk Res. 2019 Apr;79:75-80. doi: 10.1016/j.leukres.2019.01.002. Epub 2019 Jan 6.


Double-Negative T Cell Levels Correlate with Chronic Graft-versus-Host Disease Severity.

Hillhouse EE, Thiant S, Moutuou MM, Lombard-Vadnais F, Parat R, Delisle JS, Ahmad I, Roy DC, Guimond M, Roy J, Lesage S.

Biol Blood Marrow Transplant. 2019 Jan;25(1):19-25. doi: 10.1016/j.bbmt.2018.09.008. Epub 2018 Sep 19.


Correction: The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation.

Ciurea SO, Cao K, Fernandez-Vina M, Kongtim P, Malki MA, Fuchs E, Luznik L, Huang XJ, Ciceri F, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Handgretinger R, Roy DC, O'Donnell P, Bashey A, Lazarus HM, Ballen K, Savani BN, Mohty M, Nagler A.

Bone Marrow Transplant. 2019 May;54(5):784. doi: 10.1038/s41409-018-0332-0.


Biodegradation of Crystal Violet dye by bacteria isolated from textile industry effluents.

Roy DC, Biswas SK, Saha AK, Sikdar B, Rahman M, Roy AK, Prodhan ZH, Tang SS.

PeerJ. 2018 Jun 21;6:e5015. doi: 10.7717/peerj.5015. eCollection 2018.


Tobacco control policies to promote awareness and smoke-free environments in residence and workplace to reduce passive tobacco smoking in Bangladesh and its correlates.

Sultana P, Rahman MT, Roy DC, Akter S, Jung J, Rahman MM, Akter J.

PLoS One. 2018 Jun 19;13(6):e0198942. doi: 10.1371/journal.pone.0198942. eCollection 2018.


Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells.

Del'Guidice T, Lepetit-Stoffaes JP, Bordeleau LJ, Roberge J, Théberge V, Lauvaux C, Barbeau X, Trottier J, Dave V, Roy DC, Gaillet B, Garnier A, Guay D.

PLoS One. 2018 Apr 4;13(4):e0195558. doi: 10.1371/journal.pone.0195558. eCollection 2018.


Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016.

Al Malki MM, Jones R, Ma Q, Lee D, Reisner Y, Miller JS, Lang P, Hongeng S, Hari P, Strober S, Yu J, Maziarz R, Mavilio D, Roy DC, Bonini C, Champlin RE, Fuchs EJ, Ciurea SO.

Biol Blood Marrow Transplant. 2018 May;24(5):895-908. doi: 10.1016/j.bbmt.2018.01.008. Epub 2018 Jan 12. Review.


The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation.

Ciurea SO, Cao K, Fernandez-Vina M, Kongtim P, Malki MA, Fuchs E, Luznik L, Huang XJ, Ciceri F, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Handgretinger R, Roy DC, O'Donnell P, Bashey A, Lazarus HM, Ballen K, Savani BN, Mohty M, Nagler A.

Bone Marrow Transplant. 2018 May;53(5):521-534. doi: 10.1038/s41409-017-0062-8. Epub 2018 Jan 15. Review. Erratum in: Bone Marrow Transplant. 2018 Sep 19;:.


In Situ Delivery of Fibrin-Based Hydrogels Prevents Contraction and Reduces Inflammation.

Burmeister DM, Roy DC, Becerra SC, Natesan S, Christy RJ.

J Burn Care Res. 2018 Jan 1;39(1):40-53. doi: 10.1097/BCR.0000000000000576.


Major vs minor histocompatibility antigens.

Roy DC, Perreault C.

Blood. 2017 Feb 9;129(6):664-666. doi: 10.1182/blood-2016-12-754515. No abstract available.


The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy.

Noiseux N, Mansour S, Weisel R, Stevens LM, Der Sarkissian S, Tsang K, Crean AM, Larose E, Li SH, Wintersperger B, Vu MQ, Prieto I, Li RK, Roy DC, Yau TM.

J Thorac Cardiovasc Surg. 2016 Dec;152(6):1582-1588.e2. doi: 10.1016/j.jtcvs.2016.07.067. Epub 2016 Aug 13.


Ciprofloxacin-loaded keratin hydrogels reduce infection and support healing in a porcine partial-thickness thermal burn.

Roy DC, Tomblyn S, Isaac KM, Kowalczewski CJ, Burmeister DM, Burnett LR, Christy RJ.

Wound Repair Regen. 2016 Jul;24(4):657-68. doi: 10.1111/wrr.12449. Epub 2016 Jun 23.


An optimized staining technique for the detection of Gram positive and Gram negative bacteria within tissue.

Becerra SC, Roy DC, Sanchez CJ, Christy RJ, Burmeister DM.

BMC Res Notes. 2016 Apr 12;9:216. doi: 10.1186/s13104-016-1902-0.


Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.

Granados DP, Rodenbrock A, Laverdure JP, Côté C, Caron-Lizotte O, Carli C, Pearson H, Janelle V, Durette C, Bonneil E, Roy DC, Delisle JS, Lemieux S, Thibault P, Perreault C.

Leukemia. 2016 Jun;30(6):1344-54. doi: 10.1038/leu.2016.22. Epub 2016 Feb 9.


Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014.

Al Malki MM, Horowitz M, Handgretinger R, Leung W, Roy DC, Huang XJ, Fuchs E, Locatelli F, Blaise D, Mineishi S, Martelli M, Miller J, June C, Ai HS, Luznik L, Mavilio D, Lugli E, van den Brink MRM, Champlin RE, Ciurea SO.

Biol Blood Marrow Transplant. 2016 Apr;22(4):594-604. doi: 10.1016/j.bbmt.2016.01.001. Epub 2016 Jan 13.


Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation.

Ahmad I, LeBlanc R, Cohen S, Lachance S, Kiss T, Sauvageau G, Roy DC, Busque L, Delisle JS, Bambace N, Bernard L, Sabry W, Roy J.

Bone Marrow Transplant. 2016 Apr;51(4):529-35. doi: 10.1038/bmt.2015.319. Epub 2015 Dec 21.


Impact of intracoronary injection of CD133+ bone marrow stem cells on coronary atherosclerotic progression in patients with STEMI: a COMPARE-AMI IVUS substudy.

Qiu F, Maehara A, El Khoury R, Généreux P, LaSalle L, Mintz GS, Noiseux N, Roy DC, Gobeil F, Stevens LM, Reeves F, Leclerc G, Rivard A, Mansour S.

Coron Artery Dis. 2016 Jan;27(1):5-12. doi: 10.1097/MCA.0000000000000302.


Ciprofloxacin-Loaded Keratin Hydrogels Prevent Pseudomonas aeruginosa Infection and Support Healing in a Porcine Full-Thickness Excisional Wound.

Roy DC, Tomblyn S, Burmeister DM, Wrice NL, Becerra SC, Burnett LR, Saul JM, Christy RJ.

Adv Wound Care (New Rochelle). 2015 Aug 1;4(8):457-468.


Early exposure to interleukin-21 limits rapidly generated anti-Epstein-Barr virus T-cell line differentiation.

Orio J, Carli C, Janelle V, Giroux M, Taillefer J, Goupil M, Richaud M, Roy DC, Delisle JS.

Cytotherapy. 2015 Apr;17(4):496-508. doi: 10.1016/j.jcyt.2014.12.009. Epub 2015 Feb 3.


CellCAN: a unique enabler of regenerative medicine and cell therapy in Canada.

Roy DC, Alarco AM, Isasi R.

Stem Cells Dev. 2014 Dec;23 Suppl 1:24-8. doi: 10.1089/scd.2014.0354.


Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.


Harnessing the power of alloreactivity without triggering graft-versus-host disease: how non-engrafting alloreactive cellular therapy might change the landscape of acute myeloid leukemia treatment.

Krakow EF, Bergeron J, Lachance S, Roy DC, Delisle JS.

Blood Rev. 2014 Nov;28(6):249-61. doi: 10.1016/j.blre.2014.08.002. Epub 2014 Sep 6. Review.


Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors.

Dumont N, Boyer L, Émond H, Celebi-Saltik B, Pasha R, Bazin R, Mantovani D, Roy DC, Pineault N.

Exp Hematol. 2014 Sep;42(9):741-52.e1. doi: 10.1016/j.exphem.2014.04.009. Epub 2014 May 2.


Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function.

Gildner CD, Roy DC, Farrar CS, Hocking DC.

Matrix Biol. 2014 Feb;34:33-45. doi: 10.1016/j.matbio.2014.01.017. Epub 2014 Feb 6.


Inability of HOXB4 to enhance self-renewal of malignant B cells: favorable profile for the expansion of autologous hematopoietic stem cells.

Fournier M, Savoie-Rondeau I, Larochelle F, Hassawi M, Shestakova EA, Roy DC, Bijl JJ.

Exp Hematol. 2014 Jul;42(7):526-35.e4. doi: 10.1016/j.exphem.2014.01.011. Epub 2014 Feb 3.


Policy recommendations for addressing privacy challenges associated with cell-based research and interventions.

Ogbogu U, Burningham S, Ollenberger A, Calder K, Du L, El Emam K, Hyde-Lay R, Isasi R, Joly Y, Kerr I, Malin B, McDonald M, Penney S, Piat G, Roy DC, Sugarman J, Vercauteren S, Verhenneman G, West L, Caulfield T.

BMC Med Ethics. 2014 Feb 3;15:7. doi: 10.1186/1472-6939-15-7.


PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.

Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D.

J Clin Invest. 2013 Oct;123(10):4144-57. doi: 10.1172/JCI68951. Epub 2013 Sep 3.


Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.

Walker CJ, Oaks JJ, Santhanam R, Neviani P, Harb JG, Ferenchak G, Ellis JJ, Landesman Y, Eisfeld AK, Gabrail NY, Smith CL, Caligiuri MA, Hokland P, Roy DC, Reid A, Milojkovic D, Goldman JM, Apperley J, Garzon R, Marcucci G, Shacham S, Kauffman MG, Perrotti D.

Blood. 2013 Oct 24;122(17):3034-44. doi: 10.1182/blood-2013-04-495374. Epub 2013 Aug 22.


Fibronectin matrix mimetics promote full-thickness wound repair in diabetic mice.

Roy DC, Mooney NA, Raeman CH, Dalecki D, Hocking DC.

Tissue Eng Part A. 2013 Nov;19(21-22):2517-26. doi: 10.1089/ten.TEA.2013.0024. Epub 2013 Aug 12.


Reply to letter from Kopjar et al.-the IMPACT-CABG Pilot Trial.

Noiseux N, Stevens LM, Prieto I, Salem R, Roy DC, Larose E, Mansour S.

Can J Cardiol. 2013 Nov;29(11):1533.e3. doi: 10.1016/j.cjca.2013.03.016. Epub 2013 May 29. No abstract available.


Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target.

Harb JG, Neviani P, Chyla BJ, Ellis JJ, Ferenchak GJ, Oaks JJ, Walker CJ, Hokland P, Roy DC, Caligiuri MA, Marcucci G, Huettner CS, Perrotti D.

Leukemia. 2013 Oct;27(10):1996-2005. doi: 10.1038/leu.2013.151. Epub 2013 May 14.


Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment.

Manuguerra-Gagné R, Boulos PR, Ammar A, Leblond FA, Krosl G, Pichette V, Lesk MR, Roy DC.

Stem Cells. 2013 Jun;31(6):1136-48. doi: 10.1002/stem.1364.


Implantation of CD133+ stem cells in patients undergoing coronary bypass surgery: IMPACT-CABG pilot trial.

Forcillo J, Stevens LM, Mansour S, Prieto I, Salem R, Baron C, Roy DC, Larose E, Masckauchan D, Noiseux N.

Can J Cardiol. 2013 Apr;29(4):441-7. doi: 10.1016/j.cjca.2012.08.009. Epub 2012 Dec 21.


Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma.

Holbro A, Ahmad I, Cohen S, Roy J, Lachance S, Chagnon M, LeBlanc R, Bernard L, Busque L, Roy DC, Sauvageau G, Kiss TL.

Biol Blood Marrow Transplant. 2013 Apr;19(4):547-51. doi: 10.1016/j.bbmt.2012.12.006. Epub 2012 Dec 16.


Selective T-cell depletion for haplotype-mismatched allogeneic stem cell transplantation.

Bastien JP, Roy J, Roy DC.

Semin Oncol. 2012 Dec;39(6):674-82. doi: 10.1053/j.seminoncol.2012.09.004. Review.


Preconditioning of stem cells by oxytocin to improve their therapeutic potential.

Noiseux N, Borie M, Desnoyers A, Menaouar A, Stevens LM, Mansour S, Danalache BA, Roy DC, Jankowski M, Gutkowska J.

Endocrinology. 2012 Nov;153(11):5361-72. doi: 10.1210/en.2012-1402. Epub 2012 Sep 28.


Recombinant fibronectin matrix mimetics specify integrin adhesion and extracellular matrix assembly.

Roy DC, Hocking DC.

Tissue Eng Part A. 2013 Feb;19(3-4):558-70. doi: 10.1089/ten.TEA.2012.0257. Epub 2012 Nov 1.


Cotransplantation of ex vivo expanded progenitors with nonexpanded cord blood cells improves platelet recovery.

Émond H, Boyer L, Roy DC, Pineault N.

Stem Cells Dev. 2012 Nov 20;21(17):3209-19. doi: 10.1089/scd.2012.0142. Epub 2012 Aug 20.


Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation.

Cheung AM, Leung D, Rostamirad S, Dhillon K, Miller PH, Droumeva R, Brinkman RR, Hogge D, Roy DC, Eaves CJ.

Blood. 2012 Apr 12;119(15):3431-9. doi: 10.1182/blood-2011-12-398024. Epub 2012 Feb 28.


Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity.

Cohen S, Kiss T, Lachance S, Roy DC, Sauvageau G, Busque L, Ahmad I, Roy J.

Biol Blood Marrow Transplant. 2012 Jun;18(6):951-7. doi: 10.1016/j.bbmt.2011.11.028. Epub 2011 Dec 7.


One-Year Safety Analysis of the COMPARE-AMI Trial: Comparison of Intracoronary Injection of CD133 Bone Marrow Stem Cells to Placebo in Patients after Acute Myocardial Infarction and Left Ventricular Dysfunction.

Mansour S, Roy DC, Bouchard V, Stevens LM, Gobeil F, Rivard A, Leclerc G, Reeves F, Noiseux N.

Bone Marrow Res. 2011;2011:385124. doi: 10.1155/2011/385124. Epub 2011 Feb 27.


Next-generation leukemia immunotherapy.

Vincent K, Roy DC, Perreault C.

Blood. 2011 Sep 15;118(11):2951-9. doi: 10.1182/blood-2011-04-350868. Epub 2011 Jul 6. Review.


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