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Legionella remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers.

Arasaki K, Kimura H, Tagaya M, Roy CR.

J Cell Biol. 2018 Nov 5;217(11):3863-3872. doi: 10.1083/jcb.201801208. Epub 2018 Oct 1.


A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel.

Chetrit D, Hu B, Christie PJ, Roy CR, Liu J.

Nat Microbiol. 2018 Jun;3(6):678-686. doi: 10.1038/s41564-018-0165-z. Epub 2018 May 21.


Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system.

Meir A, Chetrit D, Liu L, Roy CR, Waksman G.

Nat Commun. 2018 Feb 6;9(1):507. doi: 10.1038/s41467-017-02578-x.


Dot/Icm-Translocated Proteins Important for Biogenesis of the Coxiella burnetii-Containing Vacuole Identified by Screening of an Effector Mutant Sublibrary.

Crabill E, Schofield WB, Newton HJ, Goodman AL, Roy CR.

Infect Immun. 2018 Mar 22;86(4). pii: e00758-17. doi: 10.1128/IAI.00758-17. Print 2018 Apr.


Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries.

Shames SR, Liu L, Havey JC, Schofield WB, Goodman AL, Roy CR.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10446-E10454. doi: 10.1073/pnas.1708553114. Epub 2017 Nov 13.


DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens.

Guzmán-Herrador DL, Steiner S, Alperi A, González-Prieto C, Roy CR, Llosa M.

Front Microbiol. 2017 Aug 22;8:1503. doi: 10.3389/fmicb.2017.01503. eCollection 2017.


A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection.

Fielden LF, Moffatt JH, Kang Y, Baker MJ, Khoo CA, Roy CR, Stojanovski D, Newton HJ.

Infect Immun. 2017 Apr 21;85(5). pii: e01046-16. doi: 10.1128/IAI.01046-16. Print 2017 May.


Acyl Histidines: New N-Acyl Amides from Legionella pneumophila.

Tørring T, Shames SR, Cho W, Roy CR, Crawford JM.

Chembiochem. 2017 Apr 4;18(7):638-646. doi: 10.1002/cbic.201600618. Epub 2017 Mar 6.


Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System.

Hilbi H, Nagai H, Kubori T, Roy CR.

Curr Top Microbiol Immunol. 2017;413:221-242. doi: 10.1007/978-3-319-75241-9_9.


Autophagic targeting and avoidance in intracellular bacterial infections.

Kohler LJ, Roy CR.

Curr Opin Microbiol. 2017 Feb;35:36-41. doi: 10.1016/j.mib.2016.11.004. Epub 2016 Dec 13. Review.


MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis.

Abshire CF, Dragoi AM, Roy CR, Ivanov SS.

PLoS Pathog. 2016 Dec 12;12(12):e1006088. doi: 10.1371/journal.ppat.1006088. eCollection 2016 Dec.


Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of Legionella Intracellular Infection.

Sherwood RK, Roy CR.

Annu Rev Microbiol. 2016 Sep 8;70:413-33. doi: 10.1146/annurev-micro-102215-095557. Review.


Erratum for Kohler et al., Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole.

Kohler LJ, Reed SC, Sarraf SA, Arteaga DD, Newton HJ, Roy CR.

MBio. 2016 Sep 6;7(5). pii: e01327-16. doi: 10.1128/mBio.01327-16. No abstract available.


Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling.

Campodonico EM, Roy CR, Ninio S.

PLoS One. 2016 Jul 26;11(7):e0159698. doi: 10.1371/journal.pone.0159698. eCollection 2016.


Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia.

Marion CR, Wang J, Sharma L, Losier A, Lui W, Andrews N, Elias JA, Kazmierczak BI, Roy CR, Dela Cruz CS.

Infect Immun. 2016 Jun 23;84(7):2094-2104. doi: 10.1128/IAI.00055-16. Print 2016 Jul.


Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages.

Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S.

Infect Immun. 2016 Mar 24;84(4):998-1015. doi: 10.1128/IAI.01536-15. Print 2016 Apr.


Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA.

Cunha LD, Ribeiro JM, Fernandes TD, Massis LM, Khoo CA, Moffatt JH, Newton HJ, Roy CR, Zamboni DS.

Nat Commun. 2015 Dec 21;6:10205. doi: 10.1038/ncomms10205.


The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs.

Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia TJ, Reinisch KM.

Dev Cell. 2015 Sep 14;34(5):569-76. doi: 10.1016/j.devcel.2015.08.010. Epub 2015 Sep 3.


Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii.

Kohler LJ, Roy CR.

Microbes Infect. 2015 Nov-Dec;17(11-12):766-71. doi: 10.1016/j.micinf.2015.08.006. Epub 2015 Aug 29. Review.


Structure and function of Fic proteins.

Roy CR, Cherfils J.

Nat Rev Microbiol. 2015 Oct;13(10):631-40. doi: 10.1038/nrmicro3520. Epub 2015 Aug 24. Review.


Toxicity and SidJ-Mediated Suppression of Toxicity Require Distinct Regions in the SidE Family of Legionella pneumophila Effectors.

Havey JC, Roy CR.

Infect Immun. 2015 Sep;83(9):3506-14. doi: 10.1128/IAI.00497-15. Epub 2015 Jun 22.


On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF.

Folly-Klan M, Sancerne B, Alix E, Roy CR, Cherfils J, Campanacci V.

J Struct Biol. 2015 Feb;189(2):98-104. doi: 10.1016/j.jsb.2014.12.001. Epub 2014 Dec 9.


Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion.

Copenhaver AM, Casson CN, Nguyen HT, Fung TC, Duda MM, Roy CR, Shin S.

Infect Immun. 2014 Oct;82(10):4325-36. doi: 10.1128/IAI.01891-14. Epub 2014 Aug 4.


A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.

Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR.

PLoS Pathog. 2014 Jul 31;10(7):e1004286. doi: 10.1371/journal.ppat.1004286. eCollection 2014 Jul.


The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins.

Hubber A, Arasaki K, Nakatsu F, Hardiman C, Lambright D, De Camilli P, Nagai H, Roy CR.

PLoS Pathog. 2014 Jul 3;10(7):e1004222. doi: 10.1371/journal.ppat.1004222. eCollection 2014 Jul.


Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.

Del Campo CM, Mishra AK, Wang YH, Roy CR, Janmey PA, Lambright DG.

Structure. 2014 Mar 4;22(3):397-408. doi: 10.1016/j.str.2013.12.018. Epub 2014 Feb 13.


AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.

Hardiman CA, Roy CR.

MBio. 2014 Feb 11;5(1):e01035-13. doi: 10.1128/mBio.01035-13.


Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.

Horenkamp FA, Mukherjee S, Alix E, Schauder CM, Hubber AM, Roy CR, Reinisch KM.

Traffic. 2014 May;15(5):488-99. doi: 10.1111/tra.12158. Epub 2014 Mar 12.


Meeting report - Arf and Rab family G proteins.

Casanova JE, Hsu VW, Jackson CL, Kahn RA, Roy CR, Stow JL, Wandinger-Ness A, Sztul E.

J Cell Sci. 2013 Dec 1;126(Pt 23):5313-6. doi: 10.1242/jcs.143610.


A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF.

Folly-Klan M, Alix E, Stalder D, Ray P, Duarte LV, Delprato A, Zeghouf M, Antonny B, Campanacci V, Roy CR, Cherfils J.

PLoS Pathog. 2013;9(11):e1003747. doi: 10.1371/journal.ppat.1003747. Epub 2013 Nov 14.


Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.

Ivanov SS, Roy CR.

Nat Immunol. 2013 Dec;14(12):1219-28. doi: 10.1038/ni.2740. Epub 2013 Oct 13.


A Rab-centric perspective of bacterial pathogen-occupied vacuoles.

Sherwood RK, Roy CR.

Cell Host Microbe. 2013 Sep 11;14(3):256-68. doi: 10.1016/j.chom.2013.08.010. Review.


Autophagy and bacterial infection: an evolving arms race.

Choy A, Roy CR.

Trends Microbiol. 2013 Sep;21(9):451-6. doi: 10.1016/j.tim.2013.06.009. Epub 2013 Jul 20.


Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes.

Hori JI, Pereira MS, Roy CR, Nagai H, Zamboni DS.

Cell Microbiol. 2013 Dec;15(12):2006-19. doi: 10.1111/cmi.12168. Epub 2013 Aug 2.


The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.

Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG.

J Biol Chem. 2013 Aug 16;288(33):24000-11. doi: 10.1074/jbc.M113.470625. Epub 2013 Jul 2.


Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain.

Campanacci V, Mukherjee S, Roy CR, Cherfils J.

EMBO J. 2013 May 15;32(10):1469-77. doi: 10.1038/emboj.2013.82. Epub 2013 Apr 9.


Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.

McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR.

MBio. 2013 Jan 29;4(1):e00606-12. doi: 10.1128/mBio.00606-12.


Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection.

Jamilloux Y, Pierini R, Querenet M, Juruj C, Fauchais AL, Jauberteau MO, Jarraud S, Lina G, Etienne J, Roy CR, Henry T, Davoust N, Ader F.

Glia. 2013 Apr;61(4):539-49. doi: 10.1002/glia.22454. Epub 2013 Jan 28.


Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole.

Newton HJ, McDonough JA, Roy CR.

PLoS One. 2013;8(1):e54566. doi: 10.1371/journal.pone.0054566. Epub 2013 Jan 17.


Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1851-6. doi: 10.1073/pnas.1211521110. Epub 2013 Jan 10.


The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii.

Hardiman CA, McDonough JA, Newton HJ, Roy CR.

Biochem Soc Trans. 2012 Dec 1;40(6):1353-9. doi: 10.1042/BST20120167. Review.


The capping domain in RalF regulates effector functions.

Alix E, Chesnel L, Bowzard BJ, Tucker AM, Delprato A, Cherfils J, Wood DO, Kahn RA, Roy CR.

PLoS Pathog. 2012;8(11):e1003012. doi: 10.1371/journal.ppat.1003012. Epub 2012 Nov 15.


Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages.

Case CL, Roy CR.

Methods Mol Biol. 2013;954:479-91. doi: 10.1007/978-1-62703-161-5_29.


The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.

Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia TJ, Roy CR.

Science. 2012 Nov 23;338(6110):1072-6. doi: 10.1126/science.1227026. Epub 2012 Oct 25.


Coxiella burnetii secretion systems.

McDonough JA, Newton HJ, Roy CR.

Adv Exp Med Biol. 2012;984:171-97. doi: 10.1007/978-94-007-4315-1_9. Review.


Vacuolar pathogens value membrane integrity.

Roy CR.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3197-8. doi: 10.1073/pnas.1200326109. Epub 2012 Feb 16. No abstract available.


The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.

Arasaki K, Toomre DK, Roy CR.

Cell Host Microbe. 2012 Jan 19;11(1):46-57. doi: 10.1016/j.chom.2011.11.009.


Subversion of membrane transport pathways by vacuolar pathogens.

Alix E, Mukherjee S, Roy CR.

J Cell Biol. 2011 Dec 12;195(6):943-52. doi: 10.1083/jcb.201105019. Epub 2011 Nov 28. Review.


The Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation.

Newton HJ, Roy CR.

MBio. 2011 Oct 18;2(5). pii: e00226-11. doi: 10.1128/mBio.00226-11. Print 2011.

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