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A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates.

Ko SY, Akahata W, Yang ES, Kong WP, Burke CW, Honnold SP, Nichols DK, Huang YS, Schieber GL, Carlton K, DaSilva L, Traina-Dorge V, Vanlandingham DL, Tsybovsky Y, Stephens T, Baxa U, Higgs S, Roy CJ, Glass PJ, Mascola JR, Nabel GJ, Rao SS.

Sci Transl Med. 2019 May 15;11(492). pii: eaav3113. doi: 10.1126/scitranslmed.aav3113.


Adverse event following live attenuated chikungunya vaccine in a cynomolgus macaque with pre-existing chronic hydrocephalus.

Peterson TA, MacLean AG, Russell-Lodrigue KE, Didier PJ, Weaver SC, Roy CJ.

J Med Primatol. 2019 Aug;48(4):257-259. doi: 10.1111/jmp.12414. Epub 2019 Apr 3.


Bioaerosols and Transmission, a Diverse and Growing Community of Practice.

Mubareka S, Groulx N, Savory E, Cutts T, Theriault S, Scott JA, Roy CJ, Turgeon N, Bryce E, Astrakianakis G, Kirychuk S, Girard M, Kobinger G, Zhang C, Duchaine C.

Front Public Health. 2019 Feb 21;7:23. doi: 10.3389/fpubh.2019.00023. eCollection 2019. Review.


Transient Ischemic Attack in a High-Risk Cardiovascular Patient with Renal Dysfunction after Treatment with Rivaroxaban and Clopidogrel: A Case Report.

Kary SJ, Roy CJ, Semchuk WM, Lavoie AJ.

Can J Hosp Pharm. 2019 Jan-Feb;72(1):49-51. Epub 2018 Feb 28. No abstract available.


Wildfire Associated Health Risks Impacting Farmers and Ranchers.

Corrieri ML, Roy NC, Rose-Davison KN, Roy CJ.

J Agromedicine. 2019 Apr;24(2):129-132. doi: 10.1080/1059924X.2019.1581494. Epub 2019 Feb 26.


Effective Treatment of Staphylococcal Enterotoxin B Aerosol Intoxication in Rhesus Macaques by Using Two Parenterally Administered High-Affinity Monoclonal Antibodies.

Verreault D, Ennis J, Whaley K, Killeen SZ, Karauzum H, Aman MJ, Holtsberg R, Doyle-Meyers L, Didier PJ, Zeitlin L, Roy CJ.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02049-18. doi: 10.1128/AAC.02049-18. Print 2019 May.


Rescue of rhesus macaques from the lethality of aerosolized ricin toxin.

Roy CJ, Ehrbar DJ, Bohorova N, Bohorov O, Kim D, Pauly M, Whaley K, Rong Y, Torres-Velez FJ, Vitetta ES, Didier PJ, Doyle-Meyers L, Zeitlin L, Mantis NJ.

JCI Insight. 2019 Jan 10;4(1). pii: 124771. doi: 10.1172/jci.insight.124771. [Epub ahead of print]


Comparative in vitro effectiveness of a novel contact lens multipurpose solution on Acanthamoeba castellanii.

Fears AC, Metzinger RC, Killeen SZ, Reimers RS, Roy CJ.

J Ophthalmic Inflamm Infect. 2018 Oct 24;8(1):19. doi: 10.1186/s12348-018-0161-8.


Synthetic vaccine particles for durable cytolytic T lymphocyte responses and anti-tumor immunotherapy.

Ilyinskii PO, Kovalev GI, O'Neil CP, Roy CJ, Michaud AM, Drefs NM, Pechenkin MA, Fu FN, Johnston LPM, Ovchinnikov DA, Kishimoto TK.

PLoS One. 2018 Jun 1;13(6):e0197694. doi: 10.1371/journal.pone.0197694. eCollection 2018.


Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models.

Langsjoen RM, Haller SL, Roy CJ, Vinet-Oliphant H, Bergren NA, Erasmus JH, Livengood JA, Powell TD, Weaver SC, Rossi SL.

MBio. 2018 Mar 6;9(2). pii: e02449-17. doi: 10.1128/mBio.02449-17.


High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Kuroda MJ, Sugimoto C, Cai Y, Merino KM, Mehra S, Araínga M, Roy CJ, Midkiff CC, Alvarez X, Didier ES, Kaushal D.

J Infect Dis. 2018 May 25;217(12):1865-1874. doi: 10.1093/infdis/jix625.


A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates.

Baker SM, Davitt CJH, Motyka N, Kikendall NL, Russell-Lodrigue K, Roy CJ, Morici LA.

Vaccines (Basel). 2017 Dec 9;5(4). pii: E49. doi: 10.3390/vaccines5040049.


Mucosal bacterial dissemination in a rhesus macaque model of experimental brucellosis.

Russell-Lodrigue KE, Killeen SZ, Ficht TA, Roy CJ.

J Med Primatol. 2018 Feb;47(1):75-77. doi: 10.1111/jmp.12282. Epub 2017 Jun 2.


CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.

Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi: 10.1073/pnas.1611987113. Epub 2016 Sep 6.


Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin.

Respaud R, Marchand D, Pelat T, Tchou-Wong KM, Roy CJ, Parent C, Cabrera M, Guillemain J, Mac Loughlin R, Levacher E, Fontayne A, Douziech-Eyrolles L, Junqua-Moullet A, Guilleminault L, Thullier P, Guillot-Combe E, Vecellio L, Heuzé-Vourc'h N.

J Control Release. 2016 Jul 28;234:21-32. doi: 10.1016/j.jconrel.2016.05.018. Epub 2016 May 9.


Recent advances in the development of vaccines against ricin.

Brey RN 3rd, Mantis NJ, Pincus SH, Vitetta ES, Smith LA, Roy CJ.

Hum Vaccin Immunother. 2016 May 3;12(5):1196-201. doi: 10.1080/21645515.2015.1124202. Epub 2016 Jan 25.


Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.

Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S.

Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.


Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation.

Inglis FM, Lee KM, Chiu KB, Purcell OM, Didier PJ, Russell-Lodrigue K, Weaver SC, Roy CJ, MacLean AG.

J Neurovirol. 2016 Apr;22(2):140-8. doi: 10.1007/s13365-015-0378-3. Epub 2015 Sep 29.


Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.

Sugimoto C, Hasegawa A, Saito Y, Fukuyo Y, Chiu KB, Cai Y, Breed MW, Mori K, Roy CJ, Lackner AA, Kim WK, Didier ES, Kuroda MJ.

J Immunol. 2015 Aug 15;195(4):1774-81. doi: 10.4049/jimmunol.1500522. Epub 2015 Jul 15.


Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin.

Pincus SH, Bhaskaran M, Brey RN 3rd, Didier PJ, Doyle-Meyers LA, Roy CJ.

Toxins (Basel). 2015 Jun 9;7(6):2121-33. doi: 10.3390/toxins7062121.


IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge.

Rossi SL, Russell-Lodrigue KE, Killeen SZ, Wang E, Leal G, Bergren NA, Vinet-Oliphant H, Weaver SC, Roy CJ.

PLoS Negl Trop Dis. 2015 May 28;9(5):e0003797. doi: 10.1371/journal.pntd.0003797. eCollection 2015 May. Erratum in: PLoS Negl Trop Dis. 2015 Jun;9(6):e0003912.


Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

Roy CJ, Brey RN, Mantis NJ, Mapes K, Pop IV, Pop LM, Ruback S, Killeen SZ, Doyle-Meyers L, Vinet-Oliphant HS, Didier PJ, Vitetta ES.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3782-7. doi: 10.1073/pnas.1502585112. Epub 2015 Mar 9.


The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.

Mehra S, Foreman TW, Didier PJ, Ahsan MH, Hudock TA, Kissee R, Golden NA, Gautam US, Johnson AM, Alvarez X, Russell-Lodrigue KE, Doyle LA, Roy CJ, Niu T, Blanchard JL, Khader SA, Lackner AA, Sherman DR, Kaushal D.

Am J Respir Crit Care Med. 2015 May 15;191(10):1185-96. doi: 10.1164/rccm.201408-1502OC.


Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine.

Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ.

Vaccine. 2015 Jan 29;33(5):686-92. doi: 10.1016/j.vaccine.2014.11.057. Epub 2014 Dec 19.


Immunologic characterization of a rhesus macaque H1N1 challenge model for candidate influenza virus vaccine assessment.

Skinner JA, Zurawski SM, Sugimoto C, Vinet-Oliphant H, Vinod P, Xue Y, Russell-Lodrigue K, Albrecht RA, García-Sastre A, Salazar AM, Roy CJ, Kuroda MJ, Oh S, Zurawski G.

Clin Vaccine Immunol. 2014 Dec;21(12):1668-80. doi: 10.1128/CVI.00547-14. Epub 2014 Oct 8.


Evaluation of a Burkholderia pseudomallei Outer Membrane Vesicle Vaccine in Nonhuman Primates.

Petersen H, Nieves W, Russell-Lodrigue K, Roy CJ, Morici LA.

Procedia Vaccinol. 2014 Jan 1;8:38-42.


Design of an environmentally controlled rotating chamber for bioaerosol aging studies.

Verreault D, Duchaine C, Marcoux-Voiselle M, Turgeon N, Roy CJ.

Inhal Toxicol. 2014 Aug;26(9):554-8. doi: 10.3109/08958378.2014.928763.


Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.

Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA.

J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14.


Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana.

Garcia JP, Beingesser J, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Roy CJ, Uzal FA.

Toxicon. 2014 Sep;88:93-8. doi: 10.1016/j.toxicon.2014.06.012. Epub 2014 Jun 17.


A Burkholderia pseudomallei outer membrane vesicle vaccine provides protection against lethal sepsis.

Nieves W, Petersen H, Judy BM, Blumentritt CA, Russell-Lodrigue K, Roy CJ, Torres AG, Morici LA.

Clin Vaccine Immunol. 2014 May;21(5):747-54. doi: 10.1128/CVI.00119-14. Epub 2014 Mar 26.


Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.

Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK.

Vaccine. 2014 May 19;32(24):2882-95. doi: 10.1016/j.vaccine.2014.02.027. Epub 2014 Mar 1.


Chimeric plantibody passively protects mice against aerosolized ricin challenge.

Sully EK, Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ.

Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26.


Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.

Roy CJ, Adams AP, Wang E, Plante K, Gorchakov R, Seymour RL, Vinet-Oliphant H, Weaver SC.

J Infect Dis. 2014 Jun 15;209(12):1891-9. doi: 10.1093/infdis/jiu014. Epub 2014 Jan 7.


Aerosol-induced brucellosis increases TLR-2 expression and increased complexity in the microanatomy of astroglia in rhesus macaques.

Lee KM, Chiu KB, Sansing HA, Didier PJ, Ficht TA, Arenas-Gamboa AM, Roy CJ, Maclean AG.

Front Cell Infect Microbiol. 2013 Dec 2;3:86. doi: 10.3389/fcimb.2013.00086. eCollection 2013.


Pathology of lethal and sublethal doses of aerosolized ricin in rhesus macaques.

Bhaskaran M, Didier PJ, Sivasubramani SK, Doyle LA, Holley J, Roy CJ.

Toxicol Pathol. 2014;42(3):573-81. doi: 10.1177/0192623313492248. Epub 2013 Jun 11.


Post-exposure therapeutic efficacy of COX-2 inhibition against Burkholderia pseudomallei.

Asakrah S, Nieves W, Mahdi Z, Agard M, Zea AH, Roy CJ, Morici LA.

PLoS Negl Trop Dis. 2013 May 9;7(5):e2212. doi: 10.1371/journal.pntd.0002212. Print 2013.


Challenges and Practices in Building and Implementing Biosafety and Biosecurity Programs to Enable Basic and Translational Research with Select Agents.

Jonsson CB, Cole KS, Roy CJ, Perlin DS, Byrne G; members of the RBL-NBL Directors Network.

J Bioterror Biodef. 2013 Apr 29;Suppl 3(15):12634.


A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.

Roy CJ, Adams AP, Wang E, Leal G, Seymour RL, Sivasubramani SK, Mega W, Frolov I, Didier PJ, Weaver SC.

Vaccine. 2013 Mar 1;31(11):1464-70. doi: 10.1016/j.vaccine.2013.01.014. Epub 2013 Jan 16.


Infectious disease aerobiology: miasma incarnate.

Roy CJ, Reed DS.

Front Cell Infect Microbiol. 2012 Dec 19;2:163. doi: 10.3389/fcimb.2012.00163. eCollection 2012. No abstract available.


Susceptibility of monkeypox virus aerosol suspensions in a rotating chamber.

Verreault D, Killeen SZ, Redmann RK, Roy CJ.

J Virol Methods. 2013 Feb;187(2):333-7. doi: 10.1016/j.jviromet.2012.10.009. Epub 2012 Nov 6.


Synthetic human monoclonal antibodies toward staphylococcal enterotoxin B (SEB) protective against toxic shock syndrome.

Karauzum H, Chen G, Abaandou L, Mahmoudieh M, Boroun AR, Shulenin S, Devi VS, Stavale E, Warfield KL, Zeitlin L, Roy CJ, Sidhu SS, Aman MJ.

J Biol Chem. 2012 Jul 20;287(30):25203-15. doi: 10.1074/jbc.M112.364075. Epub 2012 May 29.


The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs.

Mehra S, Golden NA, Stuckey K, Didier PJ, Doyle LA, Russell-Lodrigue KE, Sugimoto C, Hasegawa A, Sivasubramani SK, Roy CJ, Alvarez X, Kuroda MJ, Blanchard JL, Lackner AA, Kaushal D.

J Infect Dis. 2012 Apr 15;205(8):1203-13. doi: 10.1093/infdis/jis102. Epub 2012 Mar 7.


Evaluation of inhaled cidofovir as postexposure prophylactic in an aerosol rabbitpox model.

Verreault D, Sivasubramani SK, Talton JD, Doyle LA, Reddy JD, Killeen SZ, Didier PJ, Marx PA, Roy CJ.

Antiviral Res. 2012 Jan;93(1):204-8. doi: 10.1016/j.antiviral.2011.11.013. Epub 2011 Nov 29.


Aerosolized gentamicin reduces the burden of tuberculosis in a murine model.

Roy CJ, Sivasubramani SK, Dutta NK, Mehra S, Golden NA, Killeen S, Talton JD, Hammoud BE, Didier PJ, Kaushal D.

Antimicrob Agents Chemother. 2012 Feb;56(2):883-6. doi: 10.1128/AAC.05633-11. Epub 2011 Dec 5. Erratum in: Antimicrob Agents Chemother. 2012 Mar;56(3):1672.


Aerosolized adenovirus-vectored vaccine as an alternative vaccine delivery method.

Roy CJ, Ault A, Sivasubramani SK, Gorres JP, Wei CJ, Andersen H, Gall J, Roederer M, Rao SS.

Respir Res. 2011 Nov 21;12:153. doi: 10.1186/1465-9921-12-153.


Animal models of ricin toxicosis.

Roy CJ, Song K, Sivasubramani SK, Gardner DJ, Pincus SH.

Curr Top Microbiol Immunol. 2012;357:243-57. doi: 10.1007/82_2011_173.


A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection.

Nieves W, Asakrah S, Qazi O, Brown KA, Kurtz J, Aucoin DP, McLachlan JB, Roy CJ, Morici LA.

Vaccine. 2011 Oct 26;29(46):8381-9. doi: 10.1016/j.vaccine.2011.08.058. Epub 2011 Aug 24.


Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus.

Mehra S, Golden NA, Dutta NK, Midkiff CC, Alvarez X, Doyle LA, Asher M, Russell-Lodrigue K, Monjure C, Roy CJ, Blanchard JL, Didier PJ, Veazey RS, Lackner AA, Kaushal D.

J Med Primatol. 2011 Aug;40(4):233-43. doi: 10.1111/j.1600-0684.2011.00485.x.


Mucosal vaccines for biodefense.

Mantis NJ, Morici LA, Roy CJ.

Curr Top Microbiol Immunol. 2012;354:181-95. doi: 10.1007/82_2011_122. Review.


Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.

Nieves W, Heang J, Asakrah S, Höner zu Bentrup K, Roy CJ, Morici LA.

PLoS One. 2010 Dec 17;5(12):e14361. doi: 10.1371/journal.pone.0014361.

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