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Items: 1 to 50 of 65

1.

A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer.

Roseweir AK, Kong CY, Park JH, Bennett L, Powell AGMT, Quinn J, van Wyk HC, Horgan PG, McMillan DC, Edwards J, Roxburgh CS.

Int J Cancer. 2018 Jul 11. doi: 10.1002/ijc.31739. [Epub ahead of print]

PMID:
29992570
2.

The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer.

McSorley ST, Roxburgh CSD, Horgan PG, McMillan DC.

Perioper Med (Lond). 2018 Jun 15;7:11. doi: 10.1186/s13741-018-0093-8. eCollection 2018.

3.

Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer.

Roxburgh CS, Shia J, Vakiani E, Daniel T, Weiser MR.

Oncoimmunology. 2018 Feb 22;7(6):e1435227. doi: 10.1080/2162402X.2018.1435227. eCollection 2018.

PMID:
29872576
4.

Selective use of radiation for locally advanced rectal cancer: one size does not fit all.

Roxburgh CS, Weiser MR.

Minerva Chir. 2018 May 25. doi: 10.23736/S0026-4733.18.07791-X. [Epub ahead of print]

PMID:
29806758
5.

The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores.

Dolan RD, McSorley ST, Park JH, Watt DG, Roxburgh CS, Horgan PG, McMillan DC.

Br J Cancer. 2018 Jul;119(1):40-51. doi: 10.1038/s41416-018-0095-9. Epub 2018 May 23.

PMID:
29789606
6.

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR.

JAMA Oncol. 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. Epub 2018 Jun 14.

PMID:
29566109
7.

The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer.

Patel M, McSorley ST, Park JH, Roxburgh CSD, Edwards J, Horgan PG, McMillan DC.

Br J Cancer. 2018 Mar 6;118(5):705-712. doi: 10.1038/bjc.2017.441. Epub 2018 Jan 16.

PMID:
29337962
8.

Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer.

Park JH, Ishizuka M, McSorley ST, Kubota K, Roxburgh CSD, Nagata H, Takagi K, Iwasaki Y, Aoki T, Horgan PG, McMillan DC.

Am J Surg. 2018 Sep;216(3):458-464. doi: 10.1016/j.amjsurg.2017.08.044. Epub 2017 Sep 20.

PMID:
28967380
9.

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer.

Park JH, van Wyk H, Roxburgh CSD, Horgan PG, Edwards J, McMillan DC.

Br J Cancer. 2017 May 23;116(11):1444-1450. doi: 10.1038/bjc.2017.108. Epub 2017 Apr 20.

10.

The Impact of Preoperative Dexamethasone on the Magnitude of the Postoperative Systemic Inflammatory Response and Complications Following Surgery for Colorectal Cancer.

McSorley ST, Roxburgh CSD, Horgan PG, McMillan DC.

Ann Surg Oncol. 2017 Aug;24(8):2104-2112. doi: 10.1245/s10434-017-5817-3. Epub 2017 Mar 1.

11.

In reply to 'Hynes et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study'.

Park JH, Roxburgh CSD, Edwards J, Horgan PG, McMillan DC.

Histopathology. 2017 Aug;71(2):326-327. doi: 10.1111/his.13195. Epub 2017 Apr 12. No abstract available.

PMID:
28226191
12.

Distance to the anal verge is associated with pathologic complete response to neoadjuvant therapy in locally advanced rectal cancer.

Patel SV, Roxburgh CS, Vakiani E, Shia J, Smith JJ, Temple LK, Paty P, Garcia-Aguilar J, Nash G, Guillem J, Wu A, Reyngold M, Weiser MR.

J Surg Oncol. 2016 Oct;114(5):637-641. doi: 10.1002/jso.24358. Epub 2016 Sep 19.

13.

Outcomes of Open vs Laparoscopic Rectal Cancer Resection.

Roxburgh CS, Guillem JG.

JAMA Oncol. 2017 Jan 1;3(1):115-116. doi: 10.1001/jamaoncol.2016.3205. No abstract available.

PMID:
27684053
14.

Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host.

Park JH, van Wyk H, McMillan DC, Quinn J, Clark J, Roxburgh CS, Horgan PG, Edwards J.

Clin Cancer Res. 2017 Apr 1;23(7):1698-1709. doi: 10.1158/1078-0432.CCR-16-1416. Epub 2016 Sep 27.

15.

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer.

Park JH, McMillan DC, Edwards J, Horgan PG, Roxburgh CS.

Oncoimmunology. 2016 Mar 21;5(3):e1098801. eCollection 2016 Mar.

16.

Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment.

Park JH, Powell AG, Roxburgh CS, Horgan PG, McMillan DC, Edwards J.

Br J Cancer. 2016 Mar 1;114(5):562-70. doi: 10.1038/bjc.2016.17. Epub 2016 Feb 9.

17.

Comparison of Methods to Identify Lymphatic and Blood Vessel Invasion and their Prognostic Value in Patients with Primary Operable Colorectal Cancer.

Van Wyk HC, Foulis AK, Roxburgh CS, Orange C, Horgan PG, McMillan DC.

Anticancer Res. 2015 Dec;35(12):6457-63.

PMID:
26637856
18.

A Survey of Attitudes towards the Clinical Application of Systemic Inflammation Based Prognostic Scores in Cancer.

Watt DG, Roxburgh CS, White M, Chan JZ, Horgan PG, McMillan DC.

Mediators Inflamm. 2015;2015:842070. doi: 10.1155/2015/842070. Epub 2015 Oct 4.

19.

Therapeutics targeting innate immune/inflammatory responses through the interleukin-6/JAK/STAT signal transduction pathway in patients with cancer.

Roxburgh CS, McMillan DC.

Transl Res. 2016 Jan;167(1):61-6. doi: 10.1016/j.trsl.2015.08.013. Epub 2015 Sep 16. Review.

PMID:
26432924
20.

The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer.

Little CH, Combet E, McMillan DC, Horgan PG, Roxburgh CS.

Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2310-2320. doi: 10.1080/10408398.2014.997866. Review.

PMID:
26066365
21.

Colorectal Cancer, Systemic Inflammation, and Outcome: Staging the Tumor and Staging the Host.

Park JH, Watt DG, Roxburgh CS, Horgan PG, McMillan DC.

Ann Surg. 2016 Feb;263(2):326-36. doi: 10.1097/SLA.0000000000001122.

PMID:
25575264
22.

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer.

Park JH, McMillan DC, Powell AG, Richards CH, Horgan PG, Edwards J, Roxburgh CS.

Clin Cancer Res. 2015 Feb 15;21(4):882-8. doi: 10.1158/1078-0432.CCR-14-1686. Epub 2014 Dec 3.

23.

Comment on 'Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis'.

Park JH, Roxburgh CS, McMillan DC.

Br J Cancer. 2014 Dec 9;111(12):2372. doi: 10.1038/bjc.2014.296. Epub 2014 Oct 28. No abstract available.

24.

Surgical outcome in patients undergoing reversal of Hartmann's procedures: a multicentre study.

Richards CH, Roxburgh CS; Scottish Surgical Research Group (SSRG).

Colorectal Dis. 2015 Mar;17(3):242-9. doi: 10.1111/codi.12807.

PMID:
25331720
25.

Is there a role for surgical resections of hepatic breast cancer metastases?

Elsberger B, Roxburgh CS, Horgan PG.

Hepatogastroenterology. 2014 Jan-Feb;61(129):181-6. Review.

PMID:
24895817
26.

Cancer and systemic inflammation: treat the tumour and treat the host.

Roxburgh CS, McMillan DC.

Br J Cancer. 2014 Mar 18;110(6):1409-12. doi: 10.1038/bjc.2014.90. Epub 2014 Feb 18. Review.

27.

The perioperative immune/inflammatory insult in cancer surgery: Time for intervention?

Roxburgh CS, Horgan PG, McMillan DC.

Oncoimmunology. 2013 Dec 1;2(12):e27324. Epub 2013 Dec 9.

28.

The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer.

Park JH, Richards CH, McMillan DC, Horgan PG, Roxburgh CS.

Ann Oncol. 2014 Mar;25(3):644-51. doi: 10.1093/annonc/mdt593. Epub 2014 Jan 23.

29.

A national survey of attitudes to research in Scottish General Surgery Trainees.

Roxburgh CS, Richards CH, O'Neill S, Ramsay G, Velineni R, Robson AJ, Watt DG, Mittapalli D, Milburn JA, Robertson AG, Jamieson NB; Scottish Surgical Research Group.

Scott Med J. 2014 Feb;59(1):9-15. doi: 10.1177/0036933013518142. Epub 2014 Jan 16.

PMID:
24434857
30.

Comparison of visual and automated assessment of tumour inflammatory infiltrates in patients with colorectal cancer.

Forrest R, Guthrie GJ, Orange C, Horgan PG, McMillan DC, Roxburgh CS.

Eur J Cancer. 2014 Feb;50(3):544-52. doi: 10.1016/j.ejca.2013.11.003. Epub 2013 Dec 11.

PMID:
24332571
31.

The detection and role of lymphatic and blood vessel invasion in predicting survival in patients with node negative operable primary colorectal cancer.

van Wyk HC, Roxburgh CS, Horgan PG, Foulis AF, McMillan DC.

Crit Rev Oncol Hematol. 2014 Apr;90(1):77-90. doi: 10.1016/j.critrevonc.2013.11.004. Epub 2013 Nov 21. Review.

PMID:
24332522
32.

The role of S100 staining in the pathological assessment of perineural invasion in rectal cancer.

White M, Foulis AK, Smith G, Horgan PG, Roxburgh CS.

Colorectal Dis. 2014 Jan;16(1):71-2. doi: 10.1111/codi.12471. No abstract available.

PMID:
24164952
33.

The clinical utility of the local inflammatory response in colorectal cancer.

Richards CH, Roxburgh CS, Powell AG, Foulis AK, Horgan PG, McMillan DC.

Eur J Cancer. 2014 Jan;50(2):309-19. doi: 10.1016/j.ejca.2013.09.008. Epub 2013 Oct 5.

PMID:
24103145
34.

The clinical utility of the combination of T stage and venous invasion to predict survival in patients undergoing surgery for colorectal cancer.

Roxburgh CS, McMillan DC, Richards CH, Atwan M, Anderson JH, Harvey T, Horgan PG, Foulis AK.

Ann Surg. 2014 Jun;259(6):1156-65. doi: 10.1097/SLA.0000000000000229.

PMID:
24100338
35.

The in situ local immune response, tumour senescence and proliferation in colorectal cancer.

Roxburgh CS, Richards CH, Macdonald AI, Powell AG, McGlynn LM, McMillan DC, Horgan PG, Edwards J, Shiels PG.

Br J Cancer. 2013 Oct 15;109(8):2207-16. doi: 10.1038/bjc.2013.556. Epub 2013 Sep 10.

36.

Flexible sigmoidoscopy following a positive faecal occult blood test within a bowel screening programme may reduce the detection of neoplasia.

Mansouri D, McMillan DC, Roxburgh CS, Moug SJ, Crighton EM, Horgan PG.

Colorectal Dis. 2013 Nov;15(11):1375-81. doi: 10.1111/codi.12377.

PMID:
23927751
37.

Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer.

Guthrie GJ, Roxburgh CS, Farhan-Alanie OM, Horgan PG, McMillan DC.

Br J Cancer. 2013 Jul 9;109(1):24-8. doi: 10.1038/bjc.2013.330. Epub 2013 Jun 25.

38.

The impact of aspirin, statins and ACE-inhibitors on the presentation of colorectal neoplasia in a colorectal cancer screening programme.

Mansouri D, McMillan DC, Roxburgh CS, Crighton EM, Horgan PG.

Br J Cancer. 2013 Jul 9;109(1):249-56. doi: 10.1038/bjc.2013.292. Epub 2013 Jun 18.

39.

The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer.

Park JH, McMillan DC, Horgan PG, Roxburgh CS.

Cancer Treat Rev. 2014 Feb;40(1):68-77. doi: 10.1016/j.ctrv.2013.05.006. Epub 2013 Jun 14. Review.

PMID:
23773805
40.

Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer.

Guthrie GJ, Roxburgh CS, Richards CH, Horgan PG, McMillan DC.

Br J Cancer. 2013 Jul 9;109(1):131-7. doi: 10.1038/bjc.2013.291. Epub 2013 Jun 11.

41.

The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer.

Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ.

Crit Rev Oncol Hematol. 2013 Oct;88(1):218-30. doi: 10.1016/j.critrevonc.2013.03.010. Epub 2013 Apr 17. Review.

PMID:
23602134
42.

Is perioperative systemic inflammation the result of insufficient cortisol production in patients with colorectal cancer?

Ramanathan ML, Roxburgh CS, Guthrie GJ, Orange C, Talwar D, Horgan PG, McMillan DC.

Ann Surg Oncol. 2013 Jul;20(7):2172-9. doi: 10.1245/s10434-013-2943-4. Epub 2013 Mar 16.

PMID:
23504123
43.

The relationships between body composition and the systemic inflammatory response in patients with primary operable colorectal cancer.

Richards CH, Roxburgh CS, MacMillan MT, Isswiasi S, Robertson EG, Guthrie GK, Horgan PG, McMillan DC.

PLoS One. 2012;7(8):e41883. doi: 10.1371/journal.pone.0041883. Epub 2012 Aug 3.

44.

Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer?

Guthrie GJ, Roxburgh CS, Horgan PG, McMillan DC.

Cancer Treat Rev. 2013 Feb;39(1):89-96. doi: 10.1016/j.ctrv.2012.07.003. Epub 2012 Aug 2. Review.

PMID:
22858249
45.

Impact of the bowel-screening programme on the diagnosis of colorectal cancer in Ayrshire and Arran.

Roxburgh CS, McTaggart F, Balsitis M, Diament RH.

Colorectal Dis. 2013 Jan;15(1):34-41. doi: 10.1111/j.1463-1318.2012.03100.x.

PMID:
22632378
46.

The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer.

Richards CH, Flegg KM, Roxburgh CS, Going JJ, Mohammed Z, Horgan PG, McMillan DC.

Br J Cancer. 2012 Jun 5;106(12):2010-5. doi: 10.1038/bjc.2012.211. Epub 2012 May 17.

47.

The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer.

Leung EY, Roxburgh CS, Talwar D, O'Reilly DS, McKee RF, Horgan PG, McMillan DC.

Nutr Cancer. 2012;64(4):515-20. doi: 10.1080/01635581.2012.661512. Epub 2012 Mar 22.

PMID:
22439733
48.

A case of acute pancreatitis: could this be caused by dermal filler injections?

Lucas-Herald A, Jamieson N, Roxburgh C.

J Surg Case Rep. 2012 Aug 1;2012(8):5. doi: 10.1093/jscr/2012.8.5.

49.

Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer.

Richards CH, Roxburgh CS, Anderson JH, McKee RF, Foulis AK, Horgan PG, McMillan DC.

Br J Surg. 2012 Feb;99(2):287-94. doi: 10.1002/bjs.7755. Epub 2011 Nov 16.

PMID:
22086662
50.

Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases.

Roxburgh CS, Richards CH, Moug SJ, Foulis AK, McMillan DC, Horgan PG.

Int J Colorectal Dis. 2012 Mar;27(3):363-9. doi: 10.1007/s00384-011-1339-9. Epub 2011 Nov 17.

PMID:
22086199

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