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The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability.

Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH.

Cancer Cell. 2018 Nov 12;34(5):823-839.e7. doi: 10.1016/j.ccell.2018.10.002.


Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus.

Spencer JL, Lahon A, Tran LL, Arya RP, Kneubehl AR, Vogt MB, Xavier D, Rowley DR, Kimata JT, Rico-Hesse RR.

J Infect Dis. 2018 Jan 30;217(4):538-547. doi: 10.1093/infdis/jix436.


Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.

San Martin R, Pathak R, Jain A, Jung SY, Hilsenbeck SG, Piña-Barba MC, Sikora AG, Pienta KJ, Rowley DR.

Cancer Res. 2017 Nov 1;77(21):5977-5988. doi: 10.1158/0008-5472.CAN-17-0064. Epub 2017 Sep 15.


Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.

Roberts JM, Martin RS, Piyarathna DB, MacKrell JG, Rocha GV, Dodge JA, Coarfa C, Krishnan V, Rowley DR, Weigel NL.

Oncotarget. 2017 Jul 4;8(27):44447-44464. doi: 10.18632/oncotarget.17968.


A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.

Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F.

Neoplasia. 2017 May;19(5):421-428. doi: 10.1016/j.neo.2017.03.003. Epub 2017 Apr 20.


Reactive stroma in the prostate during late life: The role of microvasculature and antiangiogenic therapy influences.

Montico F, Kido LA, San Martin R, Rowley DR, Cagnon VH.

Prostate. 2015 Oct;75(14):1643-61. doi: 10.1002/pros.23045. Epub 2015 Jul 17.


TGF-β induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways.

Strand DW, Liang YY, Yang F, Barron DA, Ressler SJ, Schauer IG, Feng XH, Rowley DR.

Am J Clin Exp Urol. 2014 Oct 2;2(3):239-48. eCollection 2014.


Stromal TGF-β signaling induces AR activation in prostate cancer.

Yang F, Chen Y, Shen T, Guo D, Dakhova O, Ittmann MM, Creighton CJ, Zhang Y, Dang TD, Rowley DR.

Oncotarget. 2014 Nov 15;5(21):10854-69.


Reprogramming the tumor stroma: a new paradigm.

Rowley DR.

Cancer Cell. 2014 Oct 13;26(4):451-2. doi: 10.1016/j.ccell.2014.09.016.


RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation.

Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16389-94. doi: 10.1073/pnas.1407097111. Epub 2014 Oct 13.


WFDC1 is a key modulator of inflammatory and wound repair responses.

Ressler SJ, Dang TD, Wu SM, Tse DY, Gilbert BE, Vyakarnam A, Yang F, Schauer IG, Barron DA, Rowley DR.

Am J Pathol. 2014 Nov;184(11):2951-64. doi: 10.1016/j.ajpath.2014.07.013. Epub 2014 Sep 16.


Responding to moderate breaches in professionalism: an intervention for medical students.

Gill AC, Nelson EA, Mian AI, Raphael JL, Rowley DR, Mcguire AL.

Med Teach. 2015 Feb;37(2):136-9. doi: 10.3109/0142159X.2014.911270. Epub 2014 May 12.


Recruitment of CD34(+) fibroblasts in tumor-associated reactive stroma: the reactive microvasculature hypothesis.

San Martin R, Barron DA, Tuxhorn JA, Ressler SJ, Hayward SW, Shen X, Laucirica R, Wheeler TM, Gutierrez C, Ayala GE, Ittmann M, Rowley DR.

Am J Pathol. 2014 Jun;184(6):1860-70. doi: 10.1016/j.ajpath.2014.02.021. Epub 2014 Apr 5.


FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma.

Carstens JL, Shahi P, Van Tsang S, Smith B, Creighton CJ, Zhang Y, Seamans A, Seethammagari M, Vedula I, Levitt JM, Ittmann MM, Rowley DR, Spencer DM.

Cancer Res. 2014 Jan 15;74(2):609-20. doi: 10.1158/0008-5472.CAN-13-1093. Epub 2013 Dec 4.


Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma.

Kakarla S, Chow KK, Mata M, Shaffer DR, Song XT, Wu MF, Liu H, Wang LL, Rowley DR, Pfizenmaier K, Gottschalk S.

Mol Ther. 2013 Aug;21(8):1611-20. doi: 10.1038/mt.2013.110. Epub 2013 Jun 4.


FGFR1 is essential for prostate cancer progression and metastasis.

Yang F, Zhang Y, Ressler SJ, Ittmann MM, Ayala GE, Dang TD, Wang F, Rowley DR.

Cancer Res. 2013 Jun 15;73(12):3716-24. doi: 10.1158/0008-5472.CAN-12-3274. Epub 2013 Apr 10.


WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection.

Rogers E, Wang BX, Cui Z, Rowley DR, Ressler SJ, Vyakarnam A, Fish EN.

Antiviral Res. 2012 Nov;96(2):158-68. doi: 10.1016/j.antiviral.2012.08.012. Epub 2012 Sep 6.


The reactive stroma microenvironment and prostate cancer progression.

Barron DA, Rowley DR.

Endocr Relat Cancer. 2012 Oct 30;19(6):R187-204. doi: 10.1530/ERC-12-0085. Print 2012 Dec. Review.


The WFDC1 gene: role in wound response and tissue homoeostasis.

Ressler SJ, Rowley DR.

Biochem Soc Trans. 2011 Oct;39(5):1455-9. doi: 10.1042/BST0391455. Review.


The functional role of reactive stroma in benign prostatic hyperplasia.

Schauer IG, Rowley DR.

Differentiation. 2011 Nov-Dec;82(4-5):200-10. doi: 10.1016/j.diff.2011.05.007. Epub 2011 Jun 12. Review.


Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens.

Ayala GE, Muezzinoglu B, Hammerich KH, Frolov A, Liu H, Scardino PT, Li R, Sayeeduddin M, Ittmann MM, Kadmon D, Miles BJ, Wheeler TM, Rowley DR.

Am J Pathol. 2011 Jan;178(1):79-87. doi: 10.1016/j.ajpath.2010.09.042. Epub 2010 Dec 23.


TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.

Barron DA, Strand DW, Ressler SJ, Dang TD, Hayward SW, Yang F, Ayala GE, Ittmann M, Rowley DR.

PLoS One. 2010 Oct 29;5(10):e13751. doi: 10.1371/journal.pone.0013751.


Keratinocyte-derived chemokine induces prostate epithelial hyperplasia and reactive stroma in a novel transgenic mouse model.

Schauer IG, Ressler SJ, Rowley DR.

Prostate. 2009 Mar 1;69(4):373-84. doi: 10.1002/pros.20886.


Elevated epithelial expression of interleukin-8 correlates with myofibroblast reactive stroma in benign prostatic hyperplasia.

Schauer IG, Ressler SJ, Tuxhorn JA, Dang TD, Rowley DR.

Urology. 2008 Jul;72(1):205-13. doi: 10.1016/j.urology.2007.11.083. Epub 2008 Mar 7.


Eleventh Prouts Neck Meeting on Prostate Cancer: emerging strategies in prostate cancer therapy.

Keller ET, Rowley DR, Tomlins SA, Drake CG, Kantoff PW, Pienta KJ, Montie JE, Carter HB, Hruszkewicz AM, Gomez J, Mohla S, Getzenberg RH.

Cancer Res. 2007 Oct 15;67(20):9613-5. Epub 2007 Oct 10. No abstract available.


Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma.

Yang F, Strand DW, Rowley DR.

Oncogene. 2008 Jan 17;27(4):450-9. Epub 2007 Jul 16.


Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis.

Yang F, Tuxhorn JA, Ressler SJ, McAlhany SJ, Dang TD, Rowley DR.

Cancer Res. 2005 Oct 1;65(19):8887-95.


Transforming growth factor-beta1 induced myofibroblasts regulate LNCaP cell death.

Singh H, Dang TD, Ayala GE, Rowley DR.

J Urol. 2004 Dec;172(6 Pt 1):2421-5.


Decreased stromal expression and increased epithelial expression of WFDC1/ps20 in prostate cancer is associated with reduced recurrence-free survival.

McAlhany SJ, Ayala GE, Frolov A, Ressler SJ, Wheeler TM, Watson JE, Collins C, Rowley DR.

Prostate. 2004 Oct 1;61(2):182-91.


Regulation of rat prostate stromal cell myodifferentiation by androgen and TGF-beta1.

Gerdes MJ, Larsen M, Dang TD, Ressler SJ, Tuxhorn JA, Rowley DR.

Prostate. 2004 Feb 15;58(3):299-307.


Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.

Ayala G, Tuxhorn JA, Wheeler TM, Frolov A, Scardino PT, Ohori M, Wheeler M, Spitler J, Rowley DR.

Clin Cancer Res. 2003 Oct 15;9(13):4792-801.


Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.

McAlhany SJ, Ressler SJ, Larsen M, Tuxhorn JA, Yang F, Dang TD, Rowley DR.

Cancer Res. 2003 Sep 15;63(18):5859-65.


Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer.

Li M, Ittmann MM, Rowley DR, Knowlton AA, Vaid AK, Epner DE.

Prostate. 2003 Jul 1;56(2):98-105.


Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR.

Clin Cancer Res. 2002 Sep;8(9):2912-23.


Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model.

Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR.

Cancer Res. 2002 Jun 1;62(11):3298-307.


Reactive stroma in prostate cancer progression.

Tuxhorn JA, Ayala GE, Rowley DR.

J Urol. 2001 Dec;166(6):2472-83. Review.


Adenovirus-mediated suicide gene therapy for bladder cancer: comparison of the cytomegalovirus- and Rous sarcoma virus-promoter.

Freund CT, Tong XW, Block A, Contant CF, Kieback DG, Rowley DR, Lerner SP.

Anticancer Res. 2000 Sep-Oct;20(5A):2811-6.


In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.

Sutton MA, Freund CT, Berkman SA, Dang TD, Kattan MW, Wheeler TM, Rowley DR, Lerner SP.

Mol Ther. 2000 Sep;2(3):211-7.


The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers.

Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR.

Mamm Genome. 2000 Sep;11(9):767-73.


What might a stromal response mean to prostate cancer progression?

Rowley DR.

Cancer Metastasis Rev. 1998-1999;17(4):411-9. Review.


Localization of transforming growth factor-beta1 and type II receptor in developing normal human prostate and carcinoma tissues.

Gerdes MJ, Larsen M, McBride L, Dang TD, Lu B, Rowley DR.

J Histochem Cytochem. 1998 Mar;46(3):379-88.


Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle.

Larsen M, Ressler SJ, Lu B, Gerdes MJ, McBride L, Dang TD, Rowley DR.

J Biol Chem. 1998 Feb 20;273(8):4574-84.


Adenovirus-mediated suicide gene therapy for experimental bladder cancer.

Sutton MA, Berkman SA, Chen SH, Block A, Dang TD, Kattan MW, Wheeler TM, Rowley DR, Woo SL, Lerner SP.

Urology. 1997 Feb;49(2):173-80.


Androgen-regulated proliferation and gene transcription in a prostate smooth muscle cell line (PS-1).

Gerdes MJ, Dang TD, Lu B, Larsen M, McBride L, Rowley DR.

Endocrinology. 1996 Mar;137(3):864-72.


Purification of a novel protein (ps20) from urogenital sinus mesenchymal cells with growth inhibitory properties in vitro.

Rowley DR, Dang TD, Larsen M, Gerdes MJ, McBride L, Lu B.

J Biol Chem. 1995 Sep 15;270(37):22058-65.


Beta-2 microglobulin is mitogenic to PC-3 prostatic carcinoma cells and antagonistic to transforming growth factor beta 1 action.

Rowley DR, Dang TD, McBride L, Gerdes MJ, Lu B, Larsen M.

Cancer Res. 1995 Feb 15;55(4):781-6.


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