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Self-administration of benzodiazepine and cocaine combinations by male and female rhesus monkeys in a choice procedure: role of α1 subunit-containing GABAA receptors.

Huskinson SL, Freeman KB, Rowlett JK.

Psychopharmacology (Berl). 2019 Jun 10. doi: 10.1007/s00213-019-05286-0. [Epub ahead of print]


GABAA Receptor Subtypes and the Abuse-Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators.

Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM.

Alcohol Clin Exp Res. 2019 May;43(5):791-802. doi: 10.1111/acer.14000. Epub 2019 Apr 8.


The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats.

Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, Yang L, Guo W, Golani LK, Anderson WH, Catlow JT, Jones TM, Porreca F, Smith JL, Knopp KL, Cook JM.

Pharmacol Biochem Behav. 2019 May;180:22-31. doi: 10.1016/j.pbb.2019.02.013. Epub 2019 Feb 27.


Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys.

Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK.

J Pharmacol Exp Ther. 2018 Jul;366(1):145-157. doi: 10.1124/jpet.118.249250. Epub 2018 May 2.


Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques.

Chandler CM, Follett ME, Porter NJ, Liang KY, Vallender EJ, Miller GM, Rowlett JK, Platt DM.

Alcohol. 2017 Sep;63:19-26. doi: 10.1016/j.alcohol.2017.03.002. Epub 2017 Jun 23.


Choice between variable and fixed cocaine injections in male rhesus monkeys.

Huskinson SL, Freeman KB, Petry NM, Rowlett JK.

Psychopharmacology (Berl). 2017 Aug;234(15):2353-2364. doi: 10.1007/s00213-017-4659-9. Epub 2017 Jun 10.


Reinforcing effectiveness of midazolam, ethanol, and sucrose: behavioral economic comparison of a mixture relative to its component solutions.

Townsend EA, Platt DM, Rowlett JK, Roma PG, Freeman KB.

Behav Pharmacol. 2017 Aug;28(5):386-393. doi: 10.1097/FBP.0000000000000308.


Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration.

Vallender EJ, Goswami DB, Shinday NM, Westmoreland SV, Yao WD, Rowlett JK.

Drug Alcohol Depend. 2017 Jun 1;175:9-23. doi: 10.1016/j.drugalcdep.2017.01.030. Epub 2017 Mar 18.


Shallow discounting of delayed cocaine by male rhesus monkeys when immediate food is the choice alternative.

Huskinson SL, Myerson J, Green L, Rowlett JK, Woolverton WL, Freeman KB.

Exp Clin Psychopharmacol. 2016 Dec;24(6):456-463.


Self-administration and behavioral economics of second-generation synthetic cathinones in male rats.

Huskinson SL, Naylor JE, Townsend EA, Rowlett JK, Blough BE, Freeman KB.

Psychopharmacology (Berl). 2017 Feb;234(4):589-598. doi: 10.1007/s00213-016-4492-6. Epub 2016 Nov 28.


Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects.

Gunter BW, Jones SA, Paul IA, Platt DM, Rowlett JK.

Psychopharmacology (Berl). 2016 Sep;233(17):3237-47. doi: 10.1007/s00213-016-4369-8. Epub 2016 Jun 29.


Self-administration of progesterone and synthetic neuroactive steroids by male rhesus monkeys.

Meng Z, Rowlett JK.

Drug Alcohol Depend. 2016 Aug 1;165:265-9. doi: 10.1016/j.drugalcdep.2016.05.029. Epub 2016 Jun 8.


A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model.

Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM.

Int J Med Chem. 2015;2015:430248. doi: 10.1155/2015/430248. Epub 2015 Nov 10. Review.


Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis.

Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK.

Drug Alcohol Depend. 2016 Jan 1;158:22-9. doi: 10.1016/j.drugalcdep.2015.10.026. Epub 2015 Oct 30.


Differential interactions engendered by benzodiazepine and neuroactive steroid combinations on schedule-controlled responding in rats.

Gunter BW, Platt DM, Rowlett JK.

Pharmacol Biochem Behav. 2015 Oct;137:53-9. doi: 10.1016/j.pbb.2015.08.003. Epub 2015 Aug 6.


Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque.

Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK, Gevers D, Huttenhower C, Morgan XC.

Cell Host Microbe. 2015 Mar 11;17(3):385-391. doi: 10.1016/j.chom.2015.01.015. Epub 2015 Feb 26.


Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95.

Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD.

J Neurogenet. 2014 Mar-Jun;28(1-2):98-111. doi: 10.3109/01677063.2014.892486. Epub 2014 Apr 22.


Predicting abuse potential of stimulants and other dopaminergic drugs: overview and recommendations.

Huskinson SL, Naylor JE, Rowlett JK, Freeman KB.

Neuropharmacology. 2014 Dec;87:66-80. doi: 10.1016/j.neuropharm.2014.03.009. Epub 2014 Mar 22. Review.


Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment.

Licata SC, Shinday NM, Huizenga MN, Darnell SB, Sangrey GR, Rudolph U, Rowlett JK, Sadri-Vakili G.

PLoS One. 2013 Dec 19;8(12):e84806. doi: 10.1371/journal.pone.0084806. eCollection 2013.


Trace amine associated receptor 1 modulates behavioral effects of ethanol.

Lynch LJ, Sullivan KA, Vallender EJ, Rowlett JK, Platt DM, Miller GM.

Subst Abuse. 2013 Jun 4;7:117-26. doi: 10.4137/SART.S12110. Print 2013.


Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation.

Fischer BD, Teixeira LP, van Linn ML, Namjoshi OA, Cook JM, Rowlett JK.

Psychopharmacology (Berl). 2013 May;227(2):347-54. doi: 10.1007/s00213-013-2975-2. Epub 2013 Jan 26.


Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys.

Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK.

Neuropsychopharmacology. 2013 May;38(6):1006-14. doi: 10.1038/npp.2012.265. Epub 2012 Dec 27.


Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.

Makaron L, Moran CA, Namjoshi O, Rallapalli S, Cook JM, Rowlett JK.

Pharmacol Biochem Behav. 2013 Mar;104:62-8. doi: 10.1016/j.pbb.2012.12.018. Epub 2013 Jan 2.


Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes.

Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM Jr, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM.

Bioorg Med Chem. 2013 Jan 1;21(1):93-101. doi: 10.1016/j.bmc.2012.10.057. Epub 2012 Nov 15.


Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys.

Rüedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM.

Alcohol Clin Exp Res. 2013 Apr;37(4):624-34. doi: 10.1111/acer.12018. Epub 2012 Nov 5.


Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys.

Fischer BD, Rowlett JK.

J Pharmacol Exp Ther. 2011 Jun;337(3):805-11. doi: 10.1124/jpet.111.180422. Epub 2011 Mar 16.


Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.

Birkett MA, Shinday NM, Kessler EJ, Meyer JS, Ritchie S, Rowlett JK.

Pharmacol Biochem Behav. 2011 Jun;98(4):544-51. doi: 10.1016/j.pbb.2011.03.006. Epub 2011 Mar 21.


Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.

Fischer BD, Atack JR, Platt DM, Reynolds DS, Dawson GR, Rowlett JK.

Psychopharmacology (Berl). 2011 May;215(2):311-9. doi: 10.1007/s00213-010-2142-y. Epub 2010 Dec 30.


Emergence of anti-conflict effects of zolpidem in rhesus monkeys following extended post-injection intervals.

Rowlett JK, Kehne JH, Sprenger KJ, Maynard GD.

Psychopharmacology (Berl). 2011 Apr;214(4):855-62. doi: 10.1007/s00213-010-2093-3. Epub 2010 Nov 20.


Self-administration of bretazenil under progressive-ratio schedules: behavioral economic analysis of the role intrinsic efficacy plays in the reinforcing effects of benzodiazepines.

Licata SC, Rowlett JK.

Drug Alcohol Depend. 2011 Jan 15;113(2-3):157-64. doi: 10.1016/j.drugalcdep.2010.07.019. Epub 2010 Aug 30.


Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM Jr, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, Rowlett JK.

Neuropharmacology. 2010 Dec;59(7-8):612-8. doi: 10.1016/j.neuropharm.2010.08.011. Epub 2010 Aug 18.


Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle.

Platt DM, Rowlett JK, Spealman RD.

J Pharmacol Exp Ther. 2010 Mar;332(3):985-95. doi: 10.1124/jpet.109.162941. Epub 2009 Dec 4.


Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.

Rüedi-Bettschen D, Rowlett JK, Spealman RD, Platt DM.

Psychopharmacology (Berl). 2010 Jun;210(2):169-77. doi: 10.1007/s00213-009-1705-2. Epub 2009 Oct 27.


Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.

Licata SC, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK.

Neuropharmacology. 2010 Feb;58(2):357-64. doi: 10.1016/j.neuropharm.2009.10.004. Epub 2009 Oct 22.


Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine.

Achat-Mendes C, Valdez GR, Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2009 Jun;204(3):489-98. doi: 10.1007/s00213-009-1480-0. Epub 2009 Feb 19.


Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys.

Licata SC, Platt DM, Cook JM, Van Linn ML, Rowlett JK.

Psychopharmacology (Berl). 2009 Apr;203(3):539-46. doi: 10.1007/s00213-008-1401-7. Epub 2008 Nov 25.


A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.

Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM.

Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2.


Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine.

Platt DM, Rowlett JK, Spealman RD.

Psychopharmacology (Berl). 2008 Oct;200(2):167-76. doi: 10.1007/s00213-008-1191-y. Epub 2008 May 29.


Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond.

Licata SC, Rowlett JK.

Pharmacol Biochem Behav. 2008 Jul;90(1):74-89. doi: 10.1016/j.pbb.2008.01.001. Epub 2008 Jan 12. Review.


Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms.

Valdez GR, Platt DM, Rowlett JK, Rüedi-Bettschen D, Spealman RD.

J Pharmacol Exp Ther. 2007 Nov;323(2):525-33. Epub 2007 Aug 16.


Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Platt DM, Rowlett JK, Spealman RD.

J Pharmacol Exp Ther. 2007 Aug;322(2):894-902. Epub 2007 May 15.


Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys.

Rowlett JK, Platt DM, Yao WD, Spealman RD.

J Pharmacol Exp Ther. 2007 Jun;321(3):1135-43. Epub 2007 Mar 9.


Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes.

Duke AN, Platt DM, Cook JM, Huang S, Yin W, Mattingly BA, Rowlett JK.

Psychopharmacology (Berl). 2006 Aug;187(3):321-30. Epub 2006 Jun 17.


Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors.

Rowlett JK, Lelas S, Tornatzky W, Licata SC.

Psychopharmacology (Berl). 2006 Jan;184(2):201-11. Epub 2005 Dec 24.


Getting back to basics: commentary on McSweeney, Murphy, and Kowal (2005).

Rowlett JK.

Exp Clin Psychopharmacol. 2005 Aug;13(3):187-9; discussion 194-9.


The efficacy of diazepam treatment for the management of acute wounding episodes in captive rhesus macaques.

Tiefenbacher S, Fahey MA, Rowlett JK, Meyer JS, Pouliot AL, Jones BM, Novak MA.

Comp Med. 2005 Aug;55(4):387-92.


Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys.

Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK.

J Pharmacol Exp Ther. 2005 May;313(2):658-67. Epub 2005 Jan 13.


Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.

Rowlett JK, Platt DM, Lelas S, Atack JR, Dawson GR.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):915-20. Epub 2005 Jan 11.

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