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Items: 1 to 50 of 214


Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective.

Ainslie GR, Davis M, Ewart L, Lieberman LA, Rowlands DJ, Thorley AJ, Yoder G, Ryan AM.

Lab Chip. 2019 Sep 27;19(19):3152-3161. doi: 10.1039/c9lc00492k.


Career thoughts and recollections: 50 years of publishing in the Journal of General Virology.

Rowlands DJ.

J Gen Virol. 2019 Oct;100(10):1390-1392. doi: 10.1099/jgv.0.001311. Epub 2019 Aug 27. No abstract available.


Involvement of a Nonstructural Protein in Poliovirus Capsid Assembly.

Adeyemi OO, Sherry L, Ward JC, Pierce DM, Herod MR, Rowlands DJ, Stonehouse NJ.

J Virol. 2019 Feb 19;93(5). pii: e01447-18. doi: 10.1128/JVI.01447-18. Print 2019 Mar 1.


Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Zhou D, Zhao Y, Kotecha A, Fry EE, Kelly JT, Wang X, Rao Z, Rowlands DJ, Ren J, Stuart DI.

Nat Microbiol. 2019 Mar;4(3):414-419. doi: 10.1038/s41564-018-0319-z. Epub 2018 Dec 10.


Recombinant Expression of Tandem-HBc Virus-Like Particles (VLPs).

Stephen SL, Beales L, Peyret H, Roe A, Stonehouse NJ, Rowlands DJ.

Methods Mol Biol. 2018;1776:97-123. doi: 10.1007/978-1-4939-7808-3_7.


Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates.

Kazaks A, Lu IN, Farinelle S, Ramirez A, Crescente V, Blaha B, Ogonah O, Mukhopadhyay T, de Obanos MP, Krimer A, Akopjana I, Bogans J, Ose V, Kirsteina A, Kazaka T, Stonehouse NJ, Rowlands DJ, Muller CP, Tars K, Rosenberg WM.

BMC Biotechnol. 2017 Nov 10;17(1):79. doi: 10.1186/s12896-017-0396-8.


Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.

Herod MR, Gold S, Lasecka-Dykes L, Wright C, Ward JC, McLean TC, Forrest S, Jackson T, Tuthill TJ, Rowlands DJ, Stonehouse NJ.

PLoS Pathog. 2017 Oct 2;13(10):e1006666. doi: 10.1371/journal.ppat.1006666. eCollection 2017 Oct.


Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.

Marsian J, Fox H, Bahar MW, Kotecha A, Fry EE, Stuart DI, Macadam AJ, Rowlands DJ, Lomonossoff GP.

Nat Commun. 2017 Aug 15;8(1):245. doi: 10.1038/s41467-017-00090-w.


High-speed fixed-target serial virus crystallography.

Roedig P, Ginn HM, Pakendorf T, Sutton G, Harlos K, Walter TS, Meyer J, Fischer P, Duman R, Vartiainen I, Reime B, Warmer M, Brewster AS, Young ID, Michels-Clark T, Sauter NK, Kotecha A, Kelly J, Rowlands DJ, Sikorsky M, Nelson S, Damiani DS, Alonso-Mori R, Ren J, Fry EE, David C, Stuart DI, Wagner A, Meents A.

Nat Methods. 2017 Aug;14(8):805-810. doi: 10.1038/nmeth.4335. Epub 2017 Jun 19.


Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes.

Groppelli E, Levy HC, Sun E, Strauss M, Nicol C, Gold S, Zhuang X, Tuthill TJ, Hogle JM, Rowlands DJ.

PLoS Pathog. 2017 Feb 6;13(2):e1006197. doi: 10.1371/journal.ppat.1006197. eCollection 2017 Feb.


Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.

Adeyemi OO, Nicol C, Stonehouse NJ, Rowlands DJ.

J Virol. 2017 Jan 31;91(4). pii: e01586-16. doi: 10.1128/JVI.01586-16. Print 2017 Feb 15.


miRNA-140-5p: new avenue for pulmonary arterial hypertension drug development?

Rothman AM, Rowlands DJ, Lawrie A.

Epigenomics. 2016 Oct;8(10):1311-1313. Epub 2016 Sep 7. No abstract available.


Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander?

Rowlands DJ.

Pharmacol Ther. 2016 Oct;166:96-105. doi: 10.1016/j.pharmthera.2016.06.019. Epub 2016 Jul 1. Review.


MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.

Rothman AM, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen RM, Guth-Gundel S, Southwood M, Morrell NW, Thomas M, Francis SE, Rowlands DJ, Lawrie A.

J Clin Invest. 2016 Jul 1;126(7):2495-508. doi: 10.1172/JCI83361. Epub 2016 May 23.


Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.

Herod MR, Ferrer-Orta C, Loundras EA, Ward JC, Verdaguer N, Rowlands DJ, Stonehouse NJ.

J Virol. 2016 Jul 11;90(15):6864-6883. doi: 10.1128/JVI.00469-16. Print 2016 Aug 1.


Human hepatitis A virus is united with a host of relations.

Rowlands DJ.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15010-1. doi: 10.1073/pnas.1520121112. Epub 2015 Nov 18. No abstract available.


Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.

Kelly JT, De Colibus L, Elliott L, Fry EE, Stuart DI, Rowlands DJ, Stonehouse NJ.

Antiviral Res. 2015 Dec;124:77-82. doi: 10.1016/j.antiviral.2015.10.006. Epub 2015 Oct 30.


Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication.

Herod MR, Loundras EA, Ward JC, Tulloch F, Rowlands DJ, Stonehouse NJ.

J Gen Virol. 2015 Dec;96(12):3507-18.


Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers.

Holmes K, Shepherd DA, Ashcroft AE, Whelan M, Rowlands DJ, Stonehouse NJ.

J Biol Chem. 2015 Jun 26;290(26):16238-45. doi: 10.1074/jbc.M114.622035. Epub 2015 May 7.


Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins.

Peyret H, Gehin A, Thuenemann EC, Blond D, El Turabi A, Beales L, Clarke D, Gilbert RJ, Fry EE, Stuart DI, Holmes K, Stonehouse NJ, Whelan M, Rosenberg W, Lomonossoff GP, Rowlands DJ.

PLoS One. 2015 Apr 1;10(4):e0120751. doi: 10.1371/journal.pone.0120751. eCollection 2015.


Revealing the density of encoded functions in a viral RNA.

Patel N, Dykeman EC, Coutts RH, Lomonossoff GP, Rowlands DJ, Phillips SE, Ranson N, Twarock R, Tuma R, Stockley PG.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2227-32. doi: 10.1073/pnas.1420812112. Epub 2015 Feb 2.


Hepatitis A virus and the origins of picornaviruses.

Wang X, Ren J, Gao Q, Hu Z, Sun Y, Li X, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE.

Nature. 2015 Jan 1;517(7532):85-88. doi: 10.1038/nature13806. Epub 2014 Oct 19.


FMDV replicons encoding green fluorescent protein are replication competent.

Tulloch F, Pathania U, Luke GA, Nicholson J, Stonehouse NJ, Rowlands DJ, Jackson T, Tuthill T, Haas J, Lamond AI, Ryan MD.

J Virol Methods. 2014 Dec;209:35-40. doi: 10.1016/j.jviromet.2014.08.020. Epub 2014 Sep 4.


Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore.

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ.

PLoS Pathog. 2014 Aug 7;10(8):e1004294. doi: 10.1371/journal.ppat.1004294. eCollection 2014 Aug.


Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.

Forrest S, Lear Z, Herod MR, Ryan M, Rowlands DJ, Stonehouse NJ.

J Gen Virol. 2014 Dec;95(Pt 12):2649-57. doi: 10.1099/vir.0.067751-0. Epub 2014 Aug 5.


NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.

Bentham MJ, Marraiki N, McCormick CJ, Rowlands DJ, Griffin S.

J Gen Virol. 2014 Nov;95(Pt 11):2427-41. doi: 10.1099/vir.0.068932-0. Epub 2014 Jul 14.


Sex-dependent influence of endogenous estrogen in pulmonary hypertension.

Mair KM, Wright AF, Duggan N, Rowlands DJ, Hussey MJ, Roberts S, Fullerton J, Nilsen M, Loughlin L, Thomas M, MacLean MR.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):456-67. doi: 10.1164/rccm.201403-0483OC.


Limits of structural plasticity in a picornavirus capsid revealed by a massively expanded equine rhinitis A virus particle.

Bakker SE, Groppelli E, Pearson AR, Stockley PG, Rowlands DJ, Ranson NA.

J Virol. 2014 Jun;88(11):6093-9. doi: 10.1128/JVI.01979-13. Epub 2014 Mar 19.


Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.

Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands DJ, Homans SW, Harris M, Foster R, Griffin S.

Hepatology. 2014 Feb;59(2):408-22. doi: 10.1002/hep.26685. Epub 2013 Dec 24.


Using ion mobility spectrometry-mass spectrometry to decipher the conformational and assembly characteristics of the hepatitis B capsid protein.

Shepherd DA, Holmes K, Rowlands DJ, Stonehouse NJ, Ashcroft AE.

Biophys J. 2013 Sep 3;105(5):1258-67. doi: 10.1016/j.bpj.2013.07.028.


Picornavirus uncoating intermediate captured in atomic detail.

Ren J, Wang X, Hu Z, Gao Q, Sun Y, Li X, Porta C, Walter TS, Gilbert RJ, Zhao Y, Axford D, Williams M, McAuley K, Rowlands DJ, Yin W, Wang J, Stuart DI, Rao Z, Fry EE.

Nat Commun. 2013;4:1929. doi: 10.1038/ncomms2889.


Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

Ciuclan L, Hussey MJ, Burton V, Good R, Duggan N, Beach S, Jones P, Fox R, Clay I, Bonneau O, Konstantinova I, Pearce A, Rowlands DJ, Jarai G, Westwick J, MacLean MR, Thomas M.

Am J Respir Crit Care Med. 2013 Jan 1;187(1):78-89. doi: 10.1164/rccm.201206-1028OC. Epub 2012 Oct 18.


A plate-based high-throughput assay for virus stability and vaccine formulation.

Walter TS, Ren J, Tuthill TJ, Rowlands DJ, Stuart DI, Fry EE.

J Virol Methods. 2012 Oct;185(1):166-70. doi: 10.1016/j.jviromet.2012.06.014. Epub 2012 Jun 26.


Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.

Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, Rowlands DJ, Quadri SK, Bhattacharya S, Bhattacharya J.

Nat Med. 2012 Apr 15;18(5):759-65. doi: 10.1038/nm.2736.


A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.

Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, Li X, Yin W, Shen X, Porta C, Walter TS, Evans G, Axford D, Owen R, Rowlands DJ, Wang J, Stuart DI, Fry EE, Rao Z.

Nat Struct Mol Biol. 2012 Mar 4;19(4):424-9. doi: 10.1038/nsmb.2255.


Graphical representation of QT rate correction formulae: an aid facilitating the use of a given formula and providing a visual comparison of the impact of different formulae.

Rowlands DJ.

J Electrocardiol. 2012 May-Jun;45(3):288-93. doi: 10.1016/j.jelectrocard.2012.01.003. Epub 2012 Feb 21.


Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity.

Bentham M, Holmes K, Forrest S, Rowlands DJ, Stonehouse NJ.

J Virol. 2012 Feb;86(4):2371-4. doi: 10.1128/JVI.05696-11. Epub 2011 Dec 7.


Inadvertent interchange of electrocardiogram limb lead connections: analysis of predicted consequences part II: double interconnection errors.

Rowlands DJ.

J Electrocardiol. 2012 Jan-Feb;45(1):1-6. doi: 10.1016/j.jelectrocard.2011.07.005. Epub 2011 Aug 24.


Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels.

Rowlands DJ, Islam MN, Das SR, Huertas A, Quadri SK, Horiuchi K, Inamdar N, Emin MT, Lindert J, Ten VS, Bhattacharya S, Bhattacharya J.

J Clin Invest. 2011 May;121(5):1986-99. doi: 10.1172/JCI43839. Epub 2011 Apr 25.


Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30.

Rowlands DJ, Chapple S, Siow RC, Mann GE.

Hypertension. 2011 Apr;57(4):833-40. doi: 10.1161/HYPERTENSIONAHA.110.162198. Epub 2011 Feb 7.


Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.

Fry EE, Tuthill TJ, Harlos K, Walter TS, Rowlands DJ, Stuart DI.

J Gen Virol. 2010 Aug;91(Pt 8):1971-7. doi: 10.1099/vir.0.020420-0. Epub 2010 Apr 28.



Tuthill TJ, Groppelli E, Hogle JM, Rowlands DJ.

Curr Top Microbiol Immunol. 2010;343:43-89. doi: 10.1007/82_2010_37.


Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification.

Groppelli E, Tuthill TJ, Rowlands DJ.

J Virol. 2010 Jun;84(12):6235-40. doi: 10.1128/JVI.02375-09. Epub 2010 Apr 7.


Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

Tuthill TJ, Harlos K, Walter TS, Knowles NJ, Groppelli E, Rowlands DJ, Stuart DI, Fry EE.

PLoS Pathog. 2009 Oct;5(10):e1000620. doi: 10.1371/journal.ppat.1000620. Epub 2009 Oct 9.


Foot-and-mouth disease virus assembly: processing of recombinant capsid precursor by exogenous protease induces self-assembly of pentamers in vitro in a myristoylation-dependent manner.

Goodwin S, Tuthill TJ, Arias A, Killington RA, Rowlands DJ.

J Virol. 2009 Nov;83(21):11275-82. doi: 10.1128/JVI.01263-09. Epub 2009 Aug 26.


Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA.

Adair R, Patel AH, Corless L, Griffin S, Rowlands DJ, McCormick CJ.

J Gen Virol. 2009 Apr;90(Pt 4):833-42. doi: 10.1099/vir.2008.006049-0. Epub 2009 Feb 17.


Fred Brown: 31 January 1925 - 20 February 2004.

Rowlands DJ, Skehel JJ.

Biogr Mem Fellows R Soc. 2007;53:93-108.


Inadvertent interchange of electrocardiogram limb lead connections. Analysis of predicted consequences.

Rowlands DJ.

J Electrocardiol. 2008 Mar-Apr;41(2):84-90. doi: 10.1016/j.jelectrocard.2007.08.060. No abstract available. Erratum in: J Electrocardiol. 2008 Sep-Oct;41(5):403.


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