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Microbiol Mol Biol Rev. 2019 Jan 9;83(1). pii: e00044-18. doi: 10.1128/MMBR.00044-18. Print 2019 Mar.

Cross-Domain and Viral Interactions in the Microbiome.

Author information

1
Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
2
Infectious Diseases Division, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA.
3
Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA peter_belenky@brown.edu.

Abstract

The importance of the microbiome to human health is increasingly recognized and has become a major focus of recent research. However, much of the work has focused on a few aspects, particularly the bacterial component of the microbiome, most frequently in the gastrointestinal tract. Yet humans and other animals can be colonized by a wide array of organisms spanning all domains of life, including bacteria and archaea, unicellular eukaryotes such as fungi, multicellular eukaryotes such as helminths, and viruses. As they share the same host niches, they can compete with, synergize with, and antagonize each other, with potential impacts on their host. Here, we discuss these major groups making up the human microbiome, with a focus on how they interact with each other and their multicellular host.

KEYWORDS:

archaea; bacteria; bacteriophage; cross-domain; fungi; helminths; microbiome; protozoa; virus

PMID:
30626617
PMCID:
PMC6383444
[Available on 2020-01-09]
DOI:
10.1128/MMBR.00044-18
[Indexed for MEDLINE]

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