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Items: 1 to 50 of 99

1.

Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors.

Hynds RE, Ben Aissa A, Gowers KHC, Watkins TBK, Bosshard-Carter L, Rowan AJ, Veeriah S, Wilson GA, Quezada SA, Swanton C; TRACERx Consortium, Janes SM.

Int J Cancer. 2018 Jul 1;143(1):160-166. doi: 10.1002/ijc.31383. Epub 2018 Apr 6.

2.

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.

McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, Wilson GA, Birkbak NJ, Veeriah S, Van Loo P, Herrero J, Swanton C; TRACERx Consortium.

Cell. 2017 Nov 30;171(6):1259-1271.e11. doi: 10.1016/j.cell.2017.10.001. Epub 2017 Oct 26.

3.

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

López-García C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak NJ, Horswell S, Grönroos E, Favero F, Rowan AJ, Matthews N, Begum S, Phillimore B, Burrell R, Oukrif D, Spencer-Dene B, Kovac M, Stamp G, Stewart A, Danielsen H, Novelli M, Tomlinson I, Swanton C.

Cancer Cell. 2017 Jan 9;31(1):79-93. doi: 10.1016/j.ccell.2016.11.001.

4.

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.

Kanu N, Grönroos E, Martinez P, Burrell RA, Yi Goh X, Bartkova J, Maya-Mendoza A, Mistrík M, Rowan AJ, Patel H, Rabinowitz A, East P, Wilson G, Santos CR, McGranahan N, Gulati S, Gerlinger M, Birkbak NJ, Joshi T, Alexandrov LB, Stratton MR, Powles T, Matthews N, Bates PA, Stewart A, Szallasi Z, Larkin J, Bartek J, Swanton C.

Oncogene. 2015 Nov 12;34(46):5699-708. doi: 10.1038/onc.2015.24. Epub 2015 Mar 2.

5.

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.

de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, Yates L, Jamal-Hanjani M, Shafi S, Murugaesu N, Rowan AJ, Grönroos E, Muhammad MA, Horswell S, Gerlinger M, Varela I, Jones D, Marshall J, Voet T, Van Loo P, Rassl DM, Rintoul RC, Janes SM, Lee SM, Forster M, Ahmad T, Lawrence D, Falzon M, Capitanio A, Harkins TT, Lee CC, Tom W, Teefe E, Chen SC, Begum S, Rabinowitz A, Phillimore B, Spencer-Dene B, Stamp G, Szallasi Z, Matthews N, Stewart A, Campbell P, Swanton C.

Science. 2014 Oct 10;346(6206):251-6. doi: 10.1126/science.1253462.

6.

Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers.

Gulati S, Martinez P, Joshi T, Birkbak NJ, Santos CR, Rowan AJ, Pickering L, Gore M, Larkin J, Szallasi Z, Bates PA, Swanton C, Gerlinger M.

Eur Urol. 2014 Nov;66(5):936-48. doi: 10.1016/j.eururo.2014.06.053. Epub 2014 Jul 19.

7.

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.

Gerlinger M, Horswell S, Larkin J, Rowan AJ, Salm MP, Varela I, Fisher R, McGranahan N, Matthews N, Santos CR, Martinez P, Phillimore B, Begum S, Rabinowitz A, Spencer-Dene B, Gulati S, Bates PA, Stamp G, Pickering L, Gore M, Nicol DL, Hazell S, Futreal PA, Stewart A, Swanton C.

Nat Genet. 2014 Mar;46(3):225-233. doi: 10.1038/ng.2891. Epub 2014 Feb 2.

8.

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

Dewhurst SM, McGranahan N, Burrell RA, Rowan AJ, Grönroos E, Endesfelder D, Joshi T, Mouradov D, Gibbs P, Ward RL, Hawkins NJ, Szallasi Z, Sieber OM, Swanton C.

Cancer Discov. 2014 Feb;4(2):175-185. doi: 10.1158/2159-8290.CD-13-0285. Epub 2014 Jan 19.

9.

Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas.

Gerlinger M, Quezada SA, Peggs KS, Furness AJ, Fisher R, Marafioti T, Shende VH, McGranahan N, Rowan AJ, Hazell S, Hamm D, Robins HS, Pickering L, Gore M, Nicol DL, Larkin J, Swanton C.

J Pathol. 2013 Dec;231(4):424-32. doi: 10.1002/path.4284.

10.

Parallel evolution of tumour subclones mimics diversity between tumours.

Martinez P, Birkbak NJ, Gerlinger M, McGranahan N, Burrell RA, Rowan AJ, Joshi T, Fisher R, Larkin J, Szallasi Z, Swanton C.

J Pathol. 2013 Aug;230(4):356-64. doi: 10.1002/path.4214.

PMID:
23716380
11.

Replication stress links structural and numerical cancer chromosomal instability.

Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C.

Nature. 2013 Feb 28;494(7438):492-496. doi: 10.1038/nature11935. Erratum in: Nature. 2013 Aug 22;500(7463):490.

12.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Gerlinger M, Rowan AJ, Horswell S, Math M, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C.

N Engl J Med. 2012 Mar 8;366(10):883-892. doi: 10.1056/NEJMoa1113205. Erratum in: N Engl J Med. 2012 Sep 6;367(10):976.

13.

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.

Lee AJ, Roylance R, Sander J, Gorman P, Endesfelder D, Kschischo M, Jones NP, East P, Nicke B, Spassieva S, Obeid LM, Birkbak NJ, Szallasi Z, McKnight NC, Rowan AJ, Speirs V, Hanby AM, Downward J, Tooze SA, Swanton C.

J Pathol. 2012 Feb;226(3):482-94. doi: 10.1002/path.2998. Epub 2011 Oct 19.

PMID:
21953249
14.

Chromosomal instability confers intrinsic multidrug resistance.

Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, Kschischo M, Swanton C.

Cancer Res. 2011 Mar 1;71(5):1858-70. doi: 10.1158/0008-5472.CAN-10-3604.

15.

APC and the three-hit hypothesis.

Segditsas S, Rowan AJ, Howarth K, Jones A, Leedham S, Wright NA, Gorman P, Chambers W, Domingo E, Roylance RR, Sawyer EJ, Sieber OM, Tomlinson IP.

Oncogene. 2009 Jan 8;28(1):146-55. doi: 10.1038/onc.2008.361. Epub 2008 Oct 6.

PMID:
18836487
16.

Topiramate in older patients with partial-onset seizures: a pilot double-blind, dose-comparison study.

Ramsay RE, Uthman B, Pryor FM, Rowan AJ, Bainbridge J, Spitz M, Sirven JI, Frederick TE.

Epilepsia. 2008 Jul;49(7):1180-5. doi: 10.1111/j.1528-1167.2008.01584.x.

17.

Population pharmacokinetics of lamotrigine in elderly patients.

Punyawudho B, Ramsay RE, Macias FM, Rowan AJ, Collins JF, Brundage RC, Birnbaum AK.

J Clin Pharmacol. 2008 Apr;48(4):455-63. doi: 10.1177/0091270007313391. Epub 2008 Feb 22.

PMID:
18296554
18.

Palinacousis - auditory perseveration: two cases and a review of the literature.

Di Dio AS, Fields MC, Rowan AJ.

Epilepsia. 2007 Sep;48(9):1801-1806. doi: 10.1111/j.1528-1167.2007.01179.x. Epub 2007 Jul 18. Review.

19.

Recruitment and retention in clinical trials of the elderly.

Macias FM, Ramsay RE, Rowan AJ.

Int Rev Neurobiol. 2007;81:265-72.

PMID:
17433930
20.

Diagnosing epilepsy in the elderly.

Ramsay RE, Macias FM, Rowan AJ.

Int Rev Neurobiol. 2007;81:129-51. Review.

PMID:
17433921
21.

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.

Gaasenbeek M, Howarth K, Rowan AJ, Gorman PA, Jones A, Chaplin T, Liu Y, Bicknell D, Davison EJ, Fiegler H, Carter NP, Roylance RR, Tomlinson IP.

Cancer Res. 2006 Apr 1;66(7):3471-9.

22.

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

Sieber OM, Segditsas S, Knudsen AL, Zhang J, Luz J, Rowan AJ, Spain SL, Thirlwell C, Howarth KM, Jaeger EE, Robinson J, Volikos E, Silver A, Kelly G, Aretz S, Frayling I, Hutter P, Dunlop M, Guenther T, Neale K, Phillips R, Heinimann K, Tomlinson IP.

Gut. 2006 Oct;55(10):1440-8. Epub 2006 Feb 4.

23.

Outcomes research: clinical trials in the elderly.

Leppik IE, Brodie MJ, Saetre ER, Rowan AJ, Ramsay RE, Macias F, Jacobs MP.

Epilepsy Res. 2006 Jan;68 Suppl 1:S71-6. Epub 2006 Jan 18. Review. Erratum in: Epilepsy Res. 2007 Apr;74(1):79. Macias, Flavia [added].

PMID:
16413171
24.

Epilepsy in older adults. Common morbidities influence development, treatment strategies, and expected outcomes.

Rowan AJ; Epilepsy Foundation of America.

Geriatrics. 2005 Dec;60(12):30-2, 34.

PMID:
16343034
25.

Social factors associated with treating epilepsy in the elderly.

Rowan AJ.

Geriatrics. 2005 May;Suppl:16-9. No abstract available.

PMID:
16025884
26.

New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine.

Rowan AJ, Ramsay RE, Collins JF, Pryor F, Boardman KD, Uthman BM, Spitz M, Frederick T, Towne A, Carter GS, Marks W, Felicetta J, Tomyanovich ML; VA Cooperative Study 428 Group.

Neurology. 2005 Jun 14;64(11):1868-73.

PMID:
15955935
27.

Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome.

Alam NA, Barclay E, Rowan AJ, Tyrer JP, Calonje E, Manek S, Kelsell D, Leigh I, Olpin S, Tomlinson IP.

Arch Dermatol. 2005 Feb;141(2):199-206.

PMID:
15724016
28.

Advances in antiepileptic drug treatments. A rational basis for selecting drugs for older patients with epilepsy.

Leppik IE, Bergey GK, Ramsay RE, Rowan AJ, Gidal BE, Birnbaum AK, Elliott MB.

Geriatrics. 2004 Dec;59(12):14-8, 22-4. Review.

PMID:
15667018
29.

Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.

El-Bahrawy M, Poulsom R, Rowan AJ, Tomlinson IT, Alison MR.

Int J Exp Pathol. 2004 Apr;85(2):65-74. Erratum in: Int J Exp Pathol. 2004 Jun;85(3):175. Poulsom, S Richard [corrected to Poulsom, Richard]; Tomlinson, Ian T [corrected to Tomlinson, Ian T M].

30.

Special considerations in treating the elderly patient with epilepsy.

Ramsay RE, Rowan AJ, Pryor FM.

Neurology. 2004 Mar 9;62(5 Suppl 2):S24-9. Review.

PMID:
15007161
31.

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency.

Alam NA, Rowan AJ, Wortham NC, Pollard PJ, Mitchell M, Tyrer JP, Barclay E, Calonje E, Manek S, Adams SJ, Bowers PW, Burrows NP, Charles-Holmes R, Cook LJ, Daly BM, Ford GP, Fuller LC, Hadfield-Jones SE, Hardwick N, Highet AS, Keefe M, MacDonald-Hull SP, Potts ED, Crone M, Wilkinson S, Camacho-Martinez F, Jablonska S, Ratnavel R, MacDonald A, Mann RJ, Grice K, Guillet G, Lewis-Jones MS, McGrath H, Seukeran DC, Morrison PJ, Fleming S, Rahman S, Kelsell D, Leigh I, Olpin S, Tomlinson IP.

Hum Mol Genet. 2003 Jun 1;12(11):1241-52.

PMID:
12761039
32.

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

Halford SE, Rowan AJ, Lipton L, Sieber OM, Pack K, Thomas HJ, Hodgson SV, Bodmer WF, Tomlinson IP.

Am J Pathol. 2003 May;162(5):1545-8.

33.

An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.

Jaeger EE, Woodford-Richens KL, Lockett M, Rowan AJ, Sawyer EJ, Heinimann K, Rozen P, Murday VA, Whitelaw SC, Ginsberg A, Atkin WS, Lynch HT, Southey MC, Debinski H, Eng C, Bodmer WF, Talbot IC, Hodgson SV, Thomas HJ, Tomlinson IP.

Am J Hum Genet. 2003 May;72(5):1261-7. Epub 2003 Apr 14.

34.

What We Owe Our Seniors with Epilepsy-Thoughts on Quality of Life.

Rowan AJ.

Epilepsy Behav. 2000 Aug;1(4):215-216. No abstract available.

PMID:
12609436
35.

Epilepsy and the elderly.

Rowan AJ.

Epilepsy Behav. 2000 Feb;1(1):S12-4. doi: 10.1006/ebeh.2000.0039. No abstract available.

PMID:
12609132
36.

Seizure. Fundamentals of drug management of epilepsy in the older patient.

Rowan AJ.

Geriatrics. 2002 Sep;57(9):33-7; quiz 38. Review.

PMID:
12271827
37.

The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.

Sawyer EJ, Hanby AM, Rowan AJ, Gillett CE, Thomas RE, Poulsom R, Lakhani SR, Ellis IO, Ellis P, Tomlinson IP.

J Pathol. 2002 Apr;196(4):437-44.

PMID:
11920740
38.

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.

Sieber OM, Lamlum H, Crabtree MD, Rowan AJ, Barclay E, Lipton L, Hodgson S, Thomas HJ, Neale K, Phillips RK, Farrington SM, Dunlop MG, Mueller HJ, Bisgaard ML, Bulow S, Fidalgo P, Albuquerque C, Scarano MI, Bodmer W, Tomlinson IP, Heinimann K.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2954-8. Epub 2002 Feb 26.

39.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomäki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen LA; Multiple Leiomyoma Consortium.

Nat Genet. 2002 Apr;30(4):406-10. Epub 2002 Feb 25.

PMID:
11865300
40.

Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers.

Woodford-Richens KL, Rowan AJ, Poulsom R, Bevan S, Salovaara R, Aaltonen LA, Houlston RS, Wright NA, Tomlinson IP.

Am J Pathol. 2001 Oct;159(4):1293-300.

41.

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.

Woodford-Richens KL, Rowan AJ, Gorman P, Halford S, Bicknell DC, Wasan HS, Roylance RR, Bodmer WF, Tomlinson IP.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9719-23. Epub 2001 Jul 31.

42.

Status epilepticus arising de novo in hospitalized patients: an analysis of 41 patients.

Delanty N, French JA, Labar DR, Pedley TA, Rowan AJ.

Seizure. 2001 Mar;10(2):116-9.

43.

Management of seizures in the elderly.

Rowan AJ.

Pharmacotherapy. 2000 Aug;20(8 Pt 2):178S-184S. Review.

PMID:
10937817
44.

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".

Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A, Bicknell D, Bodmer WF, Tomlinson IP.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3352-7.

45.

CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy.

Gluck MR, Jayatilleke E, Shaw S, Rowan AJ, Haroutunian V.

Epilepsy Res. 2000 Mar;39(1):63-71.

PMID:
10690755
46.

Treatment of refractory complex-partial status epilepticus with propofol: case report.

Begemann M, Rowan AJ, Tuhrim S.

Epilepsia. 2000 Jan;41(1):105-9.

47.

Mutations in Bcl10 are very rare in colorectal cancer.

Stone JG, Rowan AJ, Tomlinson IP, Houlston RS.

Br J Cancer. 1999 Jul;80(10):1569-70.

48.

Distribution of carcinoembryonic antigen and biologic behavior in colorectal carcinoma.

Kim JC, Han MS, Lee HK, Kim WS, Park SK, Park KC, Bodmer WF, Rowan AJ, Kim OJ.

Dis Colon Rectum. 1999 May;42(5):640-8. Erratum in: Dis Colon Rectum 1999 Aug;42(8):993.

PMID:
10344687
49.

Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line.

Mao X, Jones TA, Tomlinson I, Rowan AJ, Fedorova LI, Zelenin AV, Mao JI, Gutowski NJ, Noble M, Sheer D.

Br J Cancer. 1999 Feb;79(5-6):724-31.

50.

Reflections on the treatment of seizures in the elderly population.

Rowan AJ.

Neurology. 1998 Nov;51(5 Suppl 4):S28-33. Review.

PMID:
9818921

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