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Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization.

Rossi A, Roviezzo F, Sorrentino R, Riemma MA, Cerqua I, Bilancia R, Spaziano G, Troisi F, Pace S, Pinto A, D'Agostino B, Werz O, Cirino G.

Pharmacol Res. 2019 Jan;139:182-190. doi: 10.1016/j.phrs.2018.11.024. Epub 2018 Nov 20.


Nociceptin/Orphanin Fq in inflammation and remodeling of the small airways in experimental model of airway hyperresponsiveness.

Tartaglione G, Spaziano G, Sgambato M, Russo TP, Liparulo A, Esposito R, Mirra S, Filosa R, Roviezzo F, Polverino F, D'Agostino B.

Physiol Rep. 2018 Oct;6(20):e13906. doi: 10.14814/phy2.13906.


Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A.

Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5.


Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.

Cheung SY, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S.

Eur J Med Chem. 2018 Aug 5;156:815-830. doi: 10.1016/j.ejmech.2018.07.031. Epub 2018 Jul 25.


Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse.

Roviezzo F, Rossi A, Caiazzo E, Orlando P, Riemma MA, Iacono VM, Guarino A, Ialenti A, Cicala C, Peritore A, Capasso R, Di Marzo V, Izzo AA.

Front Pharmacol. 2017 Dec 12;8:857. doi: 10.3389/fphar.2017.00857. eCollection 2017.


Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma.

Bruno F, Spaziano G, Liparulo A, Roviezzo F, Nabavi SM, Sureda A, Filosa R, D'Agostino B.

Eur J Med Chem. 2018 Jun 10;153:65-72. doi: 10.1016/j.ejmech.2017.10.020. Epub 2017 Oct 10. Review.


Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents.

Corvino A, Rosa R, Incisivo GM, Fiorino F, Frecentese F, Magli E, Perissutti E, Saccone I, Santagada V, Cirino G, Riemma MA, Temussi PA, Ciciola P, Bianco R, Caliendo G, Roviezzo F, Severino B.

Int J Mol Sci. 2017 Nov 5;18(11). pii: E2332. doi: 10.3390/ijms18112332.


Toll-Like Receptor 4 Is Essential for the Expression of Sphingosine-1-Phosphate-Dependent Asthma-Like Disease in Mice.

Roviezzo F, Sorrentino R, Terlizzi M, Riemma MA, Iacono VM, Rossi A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Front Immunol. 2017 Oct 18;8:1336. doi: 10.3389/fimmu.2017.01336. eCollection 2017.


Salvinorin A Inhibits Airway Hyperreactivity Induced by Ovalbumin Sensitization.

Rossi A, Caiazzo E, Bilancia R, Riemma MA, Pagano E, Cicala C, Ialenti A, Zjawiony JK, Izzo AA, Capasso R, Roviezzo F.

Front Pharmacol. 2017 Jan 13;7:525. doi: 10.3389/fphar.2016.00525. eCollection 2016.


Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction.

Esposito G, Cappetta D, Russo R, Rivellino A, Ciuffreda LP, Roviezzo F, Piegari E, Berrino L, Rossi F, De Angelis A, Urbanek K.

Br J Pharmacol. 2017 Nov;174(22):4070-4086. doi: 10.1111/bph.13686. Epub 2017 Mar 21. Erratum in: Br J Pharmacol. 2018 May;175(10 ):1781.


Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.

Peduto A, Scuotto M, Krauth V, Roviezzo F, Rossi A, Temml V, Esposito V, Stuppner H, Schuster D, D'Agostino B, Schiraldi C, de Rosa M, Werz O, Filosa R.

Eur J Med Chem. 2017 Feb 15;127:715-726. doi: 10.1016/j.ejmech.2016.10.046. Epub 2016 Oct 22.


Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate.

Roviezzo F, Sorrentino R, Iacono VM, Brancaleone V, Terlizzi M, Riemma MA, Bertolino A, Rossi A, Matteis M, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2016 Nov;113(Pt A):626-635. doi: 10.1016/j.phrs.2016.09.014. Epub 2016 Oct 3.


Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents.

Zotti AI, Di Gennaro E, Corvino A, Frecentese F, Magli E, Perissutti E, Cirino G, Roviezzo F, Terranova-Barberio M, Iannelli F, Caliendo G, Santagada V, Fiorino F, Budillon A, Severino B.

Anticancer Agents Med Chem. 2017;17(7):973-981. doi: 10.2174/1871520616666160926120904.


Proteinase activated receptor-2 counterbalances the vascular effects of endothelin-1 in fibrotic tight-skin mice.

Roviezzo F, Brancaleone V, Mattera Iacono V, Bertolino A, De Cunto G, Vellecco V, Lungarella G, Lucattelli M, Cirino G.

Br J Pharmacol. 2017 Nov;174(22):4032-4042. doi: 10.1111/bph.13618. Epub 2016 Oct 5.


Nociceptin reduces the inflammatory immune microenvironment in a conventional murine model of airway hyperresponsiveness.

Spaziano G, Sorrentino R, Matteis M, Malgieri G, Sgambato M, Russo TP, Terlizzi M, Roviezzo F, Rossi F, Pinto A, Fattorusso R, D'Agostino B.

Clin Exp Allergy. 2017 Feb;47(2):208-216. doi: 10.1111/cea.12808. Epub 2016 Oct 5.


The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U, Liening S, Weinigel C, Rummler S, Schieferdecker S, Nett M, Peduto A, Collarile S, Scuotto M, Roviezzo F, Spaziano G, de Rosa M, Stuppner H, Schuster D, D'Agostino B, Werz O.

Biochem Pharmacol. 2016 Jul 15;112:60-71. doi: 10.1016/j.bcp.2016.04.019. Epub 2016 May 5.


The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation.

Rossi A, Pace S, Tedesco F, Pagano E, Guerra G, Troisi F, Werner M, Roviezzo F, Zjawiony JK, Werz O, Izzo AA, Capasso R.

Pharmacol Res. 2016 Apr;106:64-71. doi: 10.1016/j.phrs.2016.01.032. Epub 2016 Feb 6.


Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation.

Nigro E, Matteis M, Roviezzo F, Mattera Iacono V, Scudiero O, Spaziano G, Tartaglione G, Urbanek K, Filosa R, Daniele A, D'Agostino B.

Pharmacol Res. 2016 Jan;103:114-22. doi: 10.1016/j.phrs.2015.10.004. Epub 2015 Oct 20.


Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation.

Roviezzo F, Bertolino A, Sorrentino R, Terlizzi M, Matteis M, Calderone V, Mattera V, Martelli A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2015 Oct;100:85-92. doi: 10.1016/j.phrs.2015.07.032. Epub 2015 Aug 1.


Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.

Filosa R, Peduto A, Schaible AM, Krauth V, Weinigel C, Barz D, Petronzi C, Bruno F, Roviezzo F, Spaziano G, D'Agostino B, De Rosa M, Werz O.

Eur J Med Chem. 2015 Apr 13;94:132-9. doi: 10.1016/j.ejmech.2015.02.042. Epub 2015 Feb 24.


Adiponectin in asthma: implications for phenotyping.

Nigro E, Daniele A, Scudiero O, Ludovica Monaco M, Roviezzo F, D'Agostino B, Mazzarella G, Bianco A.

Curr Protein Pept Sci. 2015;16(3):182-7. Review.


S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms.

Roviezzo F, Sorrentino R, Bertolino A, De Gruttola L, Terlizzi M, Pinto A, Napolitano M, Castello G, D'Agostino B, Ianaro A, Sorrentino R, Cirino G.

Br J Pharmacol. 2015 Apr;172(7):1882-93. doi: 10.1111/bph.13033. Epub 2015 Jan 23.


B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice.

Sorrentino R, Bertolino A, Terlizzi M, Iacono VM, Maiolino P, Cirino G, Roviezzo F, Pinto A.

Am J Respir Cell Mol Biol. 2015 May;52(5):571-83. doi: 10.1165/rcmb.2014-0207OC.


Effects of sex hormones on bronchial reactivity during the menstrual cycle.

Matteis M, Polverino F, Spaziano G, Roviezzo F, Santoriello C, Sullo N, Bucci MR, Rossi F, Polverino M, Owen CA, D'Agostino B.

BMC Pulm Med. 2014 Jul 1;14:108. doi: 10.1186/1471-2466-14-108.


Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.

Schaible AM, Filosa R, Temml V, Krauth V, Matteis M, Peduto A, Bruno F, Luderer S, Roviezzo F, Di Mola A, de Rosa M, D'Agostino B, Weinigel C, Barz D, Koeberle A, Pergola C, Schuster D, Werz O.

Br J Pharmacol. 2014 May;171(9):2399-412. doi: 10.1111/bph.12592.


Identification of a pepducin acting as S1P3 receptor antagonist.

Severino B, Incisivo GM, Fiorino F, Bertolino A, Frecentese F, Barbato F, Manganelli S, Maggioni G, Capasso D, Caliendo G, Santagada V, Sorrentino R, Roviezzo F, Perissutti E.

J Pept Sci. 2013 Nov;19(11):717-24. doi: 10.1002/psc.2554. Epub 2013 Sep 20.


Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.

Roviezzo F, De Angelis A, De Gruttola L, Bertolino A, Sullo N, Brancaleone V, Bucci M, De Palma R, Urbanek K, D'Agostino B, Ianaro A, Sorrentino R, Cirino G.

Clin Sci (Lond). 2014 Apr;126(8):545-56. doi: 10.1042/CS20130272.


Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice.

Sullo N, Roviezzo F, Matteis M, Ianaro A, Calò G, Guerrini R, De Gruttola L, Spaziano G, Cirino G, Rossi F, D'Agostino B.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L657-64. doi: 10.1152/ajplung.00358.2012. Epub 2013 Mar 15.


Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction.

Sullo N, Roviezzo F, Matteis M, Spaziano G, Del Gaudio S, Lombardi A, Lucattelli M, Polverino F, Lungarella G, Cirino G, Rossi F, D'Agostino B.

Am J Respir Cell Mol Biol. 2013 Feb;48(2):198-203. doi: 10.1165/rcmb.2012-0167OC. Epub 2012 Nov 9.


Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function.

Bucci M, Vellecco V, Harrington L, Brancaleone V, Roviezzo F, Mattace Raso G, Ianaro A, Lungarella G, De Palma R, Meli R, Cirino G.

Br J Pharmacol. 2013 Jan;168(2):411-20. doi: 10.1111/j.1476-5381.2012.02205.x.


Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.

Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R, Perretti M, Cirino G.

J Pharmacol Exp Ther. 2011 Jun;337(3):830-7. doi: 10.1124/jpet.111.179168. Epub 2011 Mar 18.


Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.

Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1998-2004. doi: 10.1161/ATVBAHA.110.209783. Epub 2010 Jul 15.


Tedanol: a potent anti-inflammatory ent-pimarane diterpene from the Caribbean Sponge Tedania ignis.

Costantino V, Fattorusso E, Mangoni A, Perinu C, Cirino G, De Gruttola L, Roviezzo F.

Bioorg Med Chem. 2009 Nov 1;17(21):7542-7. doi: 10.1016/j.bmc.2009.09.010. Epub 2009 Sep 13.


Urotensin II: a novel target in human corpus cavernosum.

d'Emmanuele di Villa Bianca R, Cirino G, Mitidieri E, Coletta C, Grassia G, Roviezzo F, Grieco P, Novellino E, Imbimbo C, Mirone V, Sorrentino R.

J Sex Med. 2010 May;7(5):1778-86. doi: 10.1111/j.1743-6109.2009.01450.x. Epub 2009 Sep 25.


Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse.

Roviezzo F, D'Agostino B, Brancaleone V, De Gruttola L, Bucci M, De Dominicis G, Orlotti D, D'Aiuto E, De Palma R, Rossi F, Sorrentino R, Cirino G.

Am J Respir Cell Mol Biol. 2010 May;42(5):572-7. doi: 10.1165/rcmb.2009-0108OC. Epub 2009 Jun 25.


Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice.

Brancaleone V, Roviezzo F, Vellecco V, De Gruttola L, Bucci M, Cirino G.

Br J Pharmacol. 2008 Nov;155(5):673-80. doi: 10.1038/bjp.2008.296. Epub 2008 Jul 21.


ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice.

Bucci M, Roviezzo F, Brancaleone V, Di Lorenzo A, Evangelista S, Gori M, Cirino G.

Vascul Pharmacol. 2008 Aug-Sep;49(2-3):84-90. doi: 10.1016/j.vph.2008.06.002. Epub 2008 Jun 13.


Hydrogen sulphide is involved in testosterone vascular effect.

Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Ciro I, Cirino G.

Eur Urol. 2009 Aug;56(2):378-83. doi: 10.1016/j.eururo.2008.05.014. Epub 2008 May 22.


Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds.

Severino B, Fiorino F, Perissutti E, Frecentese F, Cirino G, Roviezzo F, Santagada V, Caliendo G.

Bioorg Med Chem. 2008 Jun 1;16(11):6009-20. doi: 10.1016/j.bmc.2008.04.059. Epub 2008 Apr 26.


Activation of protease-activated receptor-2 reduces airways inflammation in experimental allergic asthma.

D'Agostino B, Roviezzo F, De Palma R, Terracciano S, De Nardo M, Gallelli L, Abbate GF, D'Aiuto E, Russo M, Cirino G, Rossi F.

Clin Exp Allergy. 2007 Oct;37(10):1436-43.


Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock.

Roviezzo F, Cuzzocrea S, Di Lorenzo A, Brancaleone V, Mazzon E, Di Paola R, Bucci M, Cirino G.

Br J Pharmacol. 2007 Jun;151(3):377-83. Epub 2007 Apr 23.


Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness.

Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.

Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62. Epub 2007 Feb 22.


Synthesis of 2-methyl-3-indolylacetic derivatives as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 without gastric damage.

Perissutti E, Fiorino F, Renner C, Severino B, Roviezzo F, Sautebin L, Rossi A, Cirino G, Santagada V, Caliendo G.

J Med Chem. 2006 Dec 28;49(26):7774-80.


Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation.

Roviezzo F, Bucci M, Delisle C, Brancaleone V, Di Lorenzo A, Mayo IP, Fiorucci S, Fontana A, Gratton JP, Cirino G.

FASEB J. 2006 Feb;20(2):340-2. Epub 2005 Dec 1.


A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats.

Morello S, Vellecco V, Roviezzo F, Maffia P, Cuzzocrea S, Cirino G, Cicala C.

Biochem Pharmacol. 2005 Dec 19;71(1-2):223-30. Epub 2005 Nov 21.


Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels.

Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Antonelli E, Roviezzo F, Morelli A, Cirino G, Wallace JL, Fiorucci S.

J Pharmacol Exp Ther. 2006 Jan;316(1):325-35. Epub 2005 Sep 28.


Protease-activated receptor-2 (PAR2) in cardiovascular system.

Bucci M, Roviezzo F, Cirino G.

Vascul Pharmacol. 2005 Oct;43(4):247-53. Epub 2005 Sep 23. Review.


Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes.

Roviezzo F, Bucci M, Brancaleone V, Di Lorenzo A, Geppetti P, Farneti S, Parente L, Lungarella G, Fiorucci S, Cirino G.

Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2349-54. Epub 2005 Sep 1.


Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage.

Roviezzo F, Tsigkos S, Kotanidou A, Bucci M, Brancaleone V, Cirino G, Papapetropoulos A.

J Pharmacol Exp Ther. 2005 Aug;314(2):738-44. Epub 2005 May 3.


Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo.

Bucci M, Roviezzo F, Posadas I, Yu J, Parente L, Sessa WC, Ignarro LJ, Cirino G.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):904-8. Epub 2005 Jan 7.

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