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The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 1000 consecutive cases.

Alijotas-Reig J, Esteve-Valverde E, Ferrer-Oliveras R, Sáez-Comet L, Lefkou E, Mekinian A, Belizna C, Ruffatti A, Tincani A, Marozio L, Espinosa G, Cervera R, Ríos-Garcés R, De Carolis S, Latino O, LLurba E, Chighizola CB, Gerosa M, Pengo V, Lundelin K, Rovere-Querini P, Canti V, Mayer-Pickel K, Reshetnyak T, Hoxha A, Tabacco S, Stojanovich L, Gogou V, Varoudis A, Arnau A, Ruiz-Hidalgo D, Trapé J, Sos L, Stoppani C, Martí-Cañamares A, Farran-Codina I; EUROAPS Study Group.

Autoimmun Rev. 2019 Feb 15. pii: S1568-9972(19)30038-2. doi: 10.1016/j.autrev.2018.12.006. [Epub ahead of print] Review.


To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.

Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M.

Cell Death Differ. 2019 Mar;26(3):395-408. doi: 10.1038/s41418-018-0261-x. Epub 2019 Jan 8. Review.


The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function.

Ramirez GA, Coletto LA, Bozzolo EP, Citterio L, Delli Carpini S, Zagato L, Rovere-Querini P, Lanzani C, Manunta P, Manfredi AA, Sciorati C.

J Neuroimmunol. 2018 Dec 15;325:43-53. doi: 10.1016/j.jneuroim.2018.10.010. Epub 2018 Oct 23.


Eculizumab in a pregnant patient with laboratory onset of catastrophic antiphospholipid syndrome: A case report.

Rovere-Querini P, Canti V, Erra R, Bianchi E, Slaviero G, D'Angelo A, Rosa S, Candiani M, Castiglioni MT.

Medicine (Baltimore). 2018 Oct;97(40):e12584. doi: 10.1097/MD.0000000000012584.


Psoriatic disease, aging, chronic inflammation and acute coronary syndromes. Two and two may not always make four.

Manfredi AA, Rovere-Querini P.

Int J Cardiol. 2018 Dec 15;273:47-48. doi: 10.1016/j.ijcard.2018.09.045. Epub 2018 Sep 15. No abstract available.


Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis.

Maugeri N, Capobianco A, Rovere-Querini P, Ramirez GA, Tombetti E, Valle PD, Monno A, D'Alberti V, Gasparri AM, Franchini S, D'Angelo A, Bianchi ME, Manfredi AA.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaao3089. doi: 10.1126/scitranslmed.aao3089.


Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia.

Canti V, Del Rosso S, Tonello M, Lucianò R, Hoxha A, Coletto LA, Vaglio Tessitore I, Rosa S, Manfredi AA, Castiglioni MT, Ruffatti A, Rovere-Querini P.

J Rheumatol. 2018 Aug;45(9):1263-1272. doi: 10.3899/jrheum.170751. Epub 2018 Jul 15.


Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6.

Ramirez GA, Coletto LA, Sciorati C, Bozzolo EP, Manunta P, Rovere-Querini P, Manfredi AA.

Cells. 2018 Jul 4;7(7). pii: E70. doi: 10.3390/cells7070070. Review.


Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition.

Perrotta C, Cervia D, Di Renzo I, Moscheni C, Bassi MT, Campana L, Martelli C, Catalani E, Giovarelli M, Zecchini S, Coazzoli M, Capobianco A, Ottobrini L, Lucignani G, Rosa P, Rovere-Querini P, De Palma C, Clementi E.

Front Immunol. 2018 May 29;9:1186. doi: 10.3389/fimmu.2018.01186. eCollection 2018.


Exacerbation of Murine Experimental Autoimmune Myositis by Toll-Like Receptor 7/8.

Sciorati C, Monno A, Doglio MG, Rigamonti E, Ascherman DP, Manfredi AA, Rovere-Querini P.

Arthritis Rheumatol. 2018 Aug;70(8):1276-1287. doi: 10.1002/art.40503. Epub 2018 Jun 27.


The Neutrophil's Choice: Phagocytose vs Make Neutrophil Extracellular Traps.

Manfredi AA, Ramirez GA, Rovere-Querini P, Maugeri N.

Front Immunol. 2018 Feb 20;9:288. doi: 10.3389/fimmu.2018.00288. eCollection 2018. Review.


Comparative study between obstetric antiphospholipid syndrome and obstetric morbidity related with antiphospholipid antibodies.

Alijotas-Reig J, Esteve-Valverde E, Ferrer-Oliveras R, LLurba E, Ruffatti A, Tincani A, Lefkou E, Bertero MT, Espinosa G, de Carolis S, Rovere-Querini P, Lundelin K, Picardo E, Mekinian A; EUROAPS Study Group.

Med Clin (Barc). 2018 Sep 21;151(6):215-222. doi: 10.1016/j.medcli.2017.11.017. Epub 2017 Dec 20. English, Spanish.


High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair.

Bianchi ME, Crippa MP, Manfredi AA, Mezzapelle R, Rovere Querini P, Venereau E.

Immunol Rev. 2017 Nov;280(1):74-82. doi: 10.1111/imr.12601. Review.


The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis.

Erreni M, Manfredi AA, Garlanda C, Mantovani A, Rovere-Querini P.

Immunol Rev. 2017 Nov;280(1):112-125. doi: 10.1111/imr.12570. Review.


Biomarkers of vascular inflammation. Cell stress offers new clues.

Tombetti E, Maugeri N, Rovere-Querini P, Manfredi AA.

Int J Cardiol. 2017 Nov 1;246:18-19. doi: 10.1016/j.ijcard.2017.05.115. Epub 2017 Jun 5. No abstract available.


The peritoneum: healing, immunity, and diseases.

Capobianco A, Cottone L, Monno A, Manfredi AA, Rovere-Querini P.

J Pathol. 2017 Oct;243(2):137-147. doi: 10.1002/path.4942. Epub 2017 Sep 5. Review.


Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps.

Manfredi AA, Rovere-Querini P, D'Angelo A, Maugeri N.

Pharmacol Res. 2017 Sep;123:146-156. doi: 10.1016/j.phrs.2016.08.008. Epub 2017 Feb 1.


The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3.

Vezzoli M, Sciorati C, Campana L, Monno A, Doglio MG, Rigamonti E, Corna G, Touvier T, Castiglioni A, Capobianco A, Mantovani A, Manfredi AA, Garlanda C, Rovere-Querini P.

Mol Med. 2017 Jan;22:809-820. doi: 10.2119/molmed.2016.00002. Epub 2016 Nov 23.


Bet on NETs! Or on How to Translate Basic Science into Clinical Practice.

Ramirez GA, Manfredi AA, Rovere-Querini P, Maugeri N.

Front Immunol. 2016 Oct 14;7:417. eCollection 2016. No abstract available.


Chromogranin-A production and fragmentation in patients with Takayasu arteritis.

Tombetti E, Colombo B, Di Chio MC, Sartorelli S, Papa M, Salerno A, Bozzolo EP, Tombolini E, Benedetti G, Godi C, Lanzani C, Rovere-Querini P, Del Maschio A, Ambrosi A, De Cobelli F, Sabbadini MG, Baldissera E, Corti A, Manfredi AA.

Arthritis Res Ther. 2016 Aug 17;18:187. doi: 10.1186/s13075-016-1082-2.


Regulatory T cells and skeletal muscle regeneration.

Schiaffino S, Pereira MG, Ciciliot S, Rovere-Querini P.

FEBS J. 2017 Feb;284(4):517-524. doi: 10.1111/febs.13827. Epub 2016 Aug 18. Review.


Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis.

Cottone L, Capobianco A, Gualteroni C, Monno A, Raccagni I, Valtorta S, Canu T, Di Tomaso T, Lombardo A, Esposito A, Moresco RM, Maschio AD, Naldini L, Rovere-Querini P, Bianchi ME, Manfredi AA.

Oncoimmunology. 2016 Jan 8;5(5):e1122860. doi: 10.1080/2162402X.2015.1122860. eCollection 2016 May.


The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin.

Corna G, Caserta I, Monno A, Apostoli P, Manfredi AA, Camaschella C, Rovere-Querini P.

J Immunol. 2016 Sep 1;197(5):1914-25. doi: 10.4049/jimmunol.1501417. Epub 2016 Jul 27.


Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort.

Alijotas-Reig J, Ferrer-Oliveras R, Esteve-Valverde E, Ruffatti A, Tincani A, Lefkou E, Bertero MT, Espinosa G, Coloma E, de Carolis S, Rovere-Querini P, Canti V, Picardo E, Fredi M, Mekinian A; EUROAPS Study Group.

Am J Reprod Immunol. 2016 Aug;76(2):164-71. doi: 10.1111/aji.12534.


Association of genetic variants in the 3'UTR of HLA-G with Recurrent Pregnancy Loss.

Amodio G, Canti V, Maggio L, Rosa S, Castiglioni MT, Rovere-Querini P, Gregori S.

Hum Immunol. 2016 Oct;77(10):886-891. doi: 10.1016/j.humimm.2016.06.020. Epub 2016 Jun 29.


Clinical trials in rheumatology. Does one size fit all?

Tombetti E, Rovere-Querini P, Manfredi AA.

Rheumatology (Oxford). 2017 May 1;56(5):675-676. doi: 10.1093/rheumatology/kew253. No abstract available.


Disruption of a Regulatory Network Consisting of Neutrophils and Platelets Fosters Persisting Inflammation in Rheumatic Diseases.

Maugeri N, Rovere-Querini P, Manfredi AA.

Front Immunol. 2016 May 19;7:182. doi: 10.3389/fimmu.2016.00182. eCollection 2016. Review.


Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis.

Nicolosi PA, Tombetti E, Maugeri N, Rovere-Querini P, Brunelli S, Manfredi AA.

Stem Cells Int. 2016;2016:4636859. doi: 10.1155/2016/4636859. Epub 2016 Mar 16. Review.


Cell death, clearance and immunity in the skeletal muscle.

Sciorati C, Rigamonti E, Manfredi AA, Rovere-Querini P.

Cell Death Differ. 2016 Jun;23(6):927-37. doi: 10.1038/cdd.2015.171. Epub 2016 Feb 12. Review.


Anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis.

Manfredi AA, Baldini M, Camera M, Baldissera E, Brambilla M, Peretti G, Maseri A, Rovere-Querini P, Tremoli E, Sabbadini MG, Maugeri N.

Ann Rheum Dis. 2016 Aug;75(8):1511-20. doi: 10.1136/annrheumdis-2015-208442. Epub 2016 Jan 27.


Plasma levels of M-CSF are increased in ANCA-associated vasculitides with active nephritis.

Ramirez GA, Blasi M, Sciorati C, Rovere-Querini P, Manfredi AA.

Results Immunol. 2015 Oct 21;5:33-6. doi: 10.1016/j.rinim.2015.10.002. eCollection 2015.


TRPC6 gene variants and neuropsychiatric lupus.

Ramirez GA, Lanzani C, Bozzolo EP, Citterio L, Zagato L, Casamassima N, Canti V, Sabbadini MG, Rovere-Querini P, Manunta P, Manfredi AA.

J Neuroimmunol. 2015 Nov 15;288:21-4. doi: 10.1016/j.jneuroim.2015.08.015. Epub 2015 Aug 28.


MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms.

Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, Kilstrup-Nielsen C, Rovere-Querini P, Brunelli S, Landsberger N.

PLoS One. 2015 Jun 22;10(6):e0130183. doi: 10.1371/journal.pone.0130183. eCollection 2015.


Beta-adducin and sodium-calcium exchanger 1 gene variants are associated with systemic lupus erythematosus and lupus nephritis.

Ramirez GA, Lanzani C, Bozzolo EP, Zagato L, Citterio L, Casamassima N, Canti V, Sabbadini MG, Rovere-Querini P, Manunta P, Manfredi AA.

Rheumatol Int. 2015 Dec;35(12):1975-83. doi: 10.1007/s00296-015-3298-x. Epub 2015 Jun 5.


FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration.

Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, Almada AE, Mondino A, Wagers AJ, Manfredi AA, Rovere-Querini P.

PLoS One. 2015 Jun 3;10(6):e0128094. doi: 10.1371/journal.pone.0128094. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0133101.


Consensus guidelines for the detection of immunogenic cell death.

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, Faggioni A, Formenti SC, Fučíková J, Gabriele L, Gaipl US, Galon J, Garg A, Ghiringhelli F, Giese NA, Guo ZS, Hemminki A, Herrmann M, Hodge JW, Holdenrieder S, Honeychurch J, Hu HM, Huang X, Illidge TM, Kono K, Korbelik M, Krysko DV, Loi S, Lowenstein PR, Lugli E, Ma Y, Madeo F, Manfredi AA, Martins I, Mavilio D, Menger L, Merendino N, Michaud M, Mignot G, Mossman KL, Multhoff G, Oehler R, Palombo F, Panaretakis T, Pol J, Proietti E, Ricci JE, Riganti C, Rovere-Querini P, Rubartelli A, Sistigu A, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Sukkurwala AQ, Tartour E, Thorburn A, Thorne SH, Vandenabeele P, Velotti F, Workenhe ST, Yang H, Zong WX, Zitvogel L, Kroemer G, Galluzzi L.

Oncoimmunology. 2014 Dec 13;3(9):e955691. eCollection 2014 Oct. Review.


Parietal and intravascular innate mechanisms of vascular inflammation.

Ramirez GA, Rovere-Querini P, Sabbadini MG, Manfredi AA.

Arthritis Res Ther. 2015 Jan 28;17:16. doi: 10.1186/s13075-015-0528-2. Review.


Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players.

Sciorati C, Clementi E, Manfredi AA, Rovere-Querini P.

Cell Mol Life Sci. 2015 Jun;72(11):2135-56. doi: 10.1007/s00018-015-1857-7. Epub 2015 Feb 18. Review.


The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases.

Alijotas-Reig J, Ferrer-Oliveras R, Ruffatti A, Tincani A, Lefkou E, Bertero MT, Coloma-Bazan E, de Carolis S, Espinosa G, Rovere-Querini P, Kuzenko A, Valverde EE, Robles A, Cervera R, Canti V, Fredi M, Gil-Aguado A, Lundelin K, Llurba E, Melnychuk T, Nalli C, Picardo E, Silvestro E, del Ross T, Farran-Codina I; (EUROAPS Study Group Collaborators).

Autoimmun Rev. 2015 May;14(5):387-95. doi: 10.1016/j.autrev.2014.12.010. Epub 2014 Dec 31. Review.


Required role of apoptotic myogenic precursors and toll-like receptor stimulation for the establishment of autoimmune myositis in experimental murine models.

Sciorati C, Monno A, Ascherman DP, Seletti E, Manfredi AA, Rovere-Querini P.

Arthritis Rheumatol. 2015 Mar;67(3):809-22. doi: 10.1002/art.38985.


Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis.

Tombetti E, Di Chio MC, Sartorelli S, Papa M, Salerno A, Bottazzi B, Bozzolo EP, Greco M, Rovere-Querini P, Baldissera E, Del Maschio A, Mantovani A, De Cobelli F, Sabbadini MG, Manfredi AA.

Arthritis Res Ther. 2014 Nov 14;16(6):479. doi: 10.1186/s13075-014-0479-z.


Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.

Maugeri N, Campana L, Gavina M, Covino C, De Metrio M, Panciroli C, Maiuri L, Maseri A, D'Angelo A, Bianchi ME, Rovere-Querini P, Manfredi AA.

J Thromb Haemost. 2014 Dec;12(12):2074-88. doi: 10.1111/jth.12710. Epub 2014 Nov 14.


Autophagy as a new therapeutic target in Duchenne muscular dystrophy.

De Palma C, Morisi F, Cheli S, Pambianco S, Cappello V, Vezzoli M, Rovere-Querini P, Moggio M, Ripolone M, Francolini M, Sandri M, Clementi E.

Cell Death Dis. 2014 Aug 7;5:e1363. doi: 10.1038/cddis.2014.312. No abstract available.


5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells.

Cottone L, Capobianco A, Gualteroni C, Perrotta C, Bianchi ME, Rovere-Querini P, Manfredi AA.

Int J Cancer. 2015 Mar 15;136(6):1381-9. doi: 10.1002/ijc.29125. Epub 2014 Aug 18.


7-Tesla magnetic resonance imaging precisely and noninvasively reflects inflammation and remodeling of the skeletal muscle in a mouse model of antisynthetase syndrome.

Sciorati C, Esposito A, Campana L, Canu T, Monno A, Palmisano A, De Cobelli F, Del Maschio A, Ascheman DP, Manfredi AA, Rovere-Querini P.

Biomed Res Int. 2014;2014:879703. doi: 10.1155/2014/879703. Epub 2014 May 5.


Macrophage plasticity in skeletal muscle repair.

Rigamonti E, Zordan P, Sciorati C, Rovere-Querini P, Brunelli S.

Biomed Res Int. 2014;2014:560629. doi: 10.1155/2014/560629. Epub 2014 Apr 17. Review.


Mothers' antiphospholipid antibodies during pregnancy and the relation to offspring outcome.

Mekinian A, Carbillon L, Nicaise-Roland P, Rousseau H, Lachassinne E, Motta M, Vicaut E, Boinot C, Avcin T, De Carolis S, Rovere-Querini P, Lambert M, Derenne S, Pourrat O, Chollet-Martin S, Biasini-Rebaioli R, Rovelli R, Lojacono A, Ambrozic A, Benbara A, Pierre F, Allegri F, Nuzzo M, Hatron PY, Tincani A, Aurousseau MH, Boffa MC, Fain O.

Clin Exp Rheumatol. 2014 May-Jun;32(3):446. Epub 2014 May 21. No abstract available.


Leukocyte HMGB1 is required for vessel remodeling in regenerating muscles.

Campana L, Santarella F, Esposito A, Maugeri N, Rigamonti E, Monno A, Canu T, Del Maschio A, Bianchi ME, Manfredi AA, Rovere-Querini P.

J Immunol. 2014 Jun 1;192(11):5257-64. doi: 10.4049/jimmunol.1300938. Epub 2014 Apr 21.


Vessel-associated myogenic precursors control macrophage activation and clearance of apoptotic cells.

Bosurgi L, Brunelli S, Rigamonti E, Monno A, Manfredi AA, Rovere-Querini P.

Clin Exp Immunol. 2015 Jan;179(1):62-7. doi: 10.1111/cei.12356.


Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation.

Manfredi AA, Covino C, Rovere-Querini P, Maugeri N.

Clin Exp Immunol. 2015 Jan;179(1):24-9. doi: 10.1111/cei.12320.

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