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Items: 50


Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation.

Teijeira A, Labiano S, Garasa S, Etxeberria I, Santamaría E, Rouzaut A, Enamorado M, Azpilikueta A, Inoges S, Bolaños E, Aznar MA, Sánchez-Paulete AR, Sancho D, Melero I.

Cancer Immunol Res. 2018 Jul;6(7):798-811. doi: 10.1158/2326-6066.CIR-17-0767. Epub 2018 Apr 20.


The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element.

Marín-Béjar O, Mas AM, González J, Martinez D, Athie A, Morales X, Galduroz M, Raimondi I, Grossi E, Guo S, Rouzaut A, Ulitsky I, Huarte M.

Genome Biol. 2017 Oct 27;18(1):202. doi: 10.1186/s13059-017-1331-y.


β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells.

Peláez R, Morales X, Salvo E, Garasa S, Ortiz de Solórzano C, Martínez A, Larrayoz IM, Rouzaut A.

PLoS One. 2017 Aug 2;12(8):e0181579. doi: 10.1371/journal.pone.0181579. eCollection 2017.


Characterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis.

Anguiano M, Castilla C, Maška M, Ederra C, Peláez R, Morales X, Muñoz-Arrieta G, Mujika M, Kozubek M, Muñoz-Barrutia A, Rouzaut A, Arana S, Garcia-Aznar JM, Ortiz-de-Solorzano C.

PLoS One. 2017 Feb 6;12(2):e0171417. doi: 10.1371/journal.pone.0171417. eCollection 2017.


T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions.

Teijeira A, Hunter MC, Russo E, Proulx ST, Frei T, Debes GF, Coles M, Melero I, Detmar M, Rouzaut A, Halin C.

Cell Rep. 2017 Jan 24;18(4):857-865. doi: 10.1016/j.celrep.2016.12.078.


Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule Are Induced by Ionizing Radiation on Lymphatic Endothelium.

Rodriguez-Ruiz ME, Garasa S, Rodriguez I, Solorzano JL, Barbes B, Yanguas A, Teijeira A, Etxeberria I, Aristu JJ, Halin C, Melero I, Rouzaut A.

Int J Radiat Oncol Biol Phys. 2017 Feb 1;97(2):389-400. doi: 10.1016/j.ijrobp.2016.10.043. Epub 2016 Nov 7.


A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.

de Miguel FJ, Pajares MJ, Martínez-Terroba E, Ajona D, Morales X, Sharma RD, Pardo FJ, Rouzaut A, Rubio A, Montuenga LM, Pio R.

Mol Oncol. 2016 Nov;10(9):1437-1449. doi: 10.1016/j.molonc.2016.08.001. Epub 2016 Aug 9.


Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming.

Rodriguez-Ruiz ME, Rodriguez I, Garasa S, Barbes B, Solorzano JL, Perez-Gracia JL, Labiano S, Sanmamed MF, Azpilikueta A, Bolaños E, Sanchez-Paulete AR, Aznar MA, Rouzaut A, Schalper KA, Jure-Kunkel M, Melero I.

Cancer Res. 2016 Oct 15;76(20):5994-6005. Epub 2016 Aug 22.


Characterization of the role of collagen network structure and composition in cancer cell migration.

Anguiano M, Castilla C, Maska M, Ederra C, Fernandez-Marques J, Pelaez R, Rouzaut A, Munoz-Barrutia A, Kozubek M, Ortiz-de-Solorzano C.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:8139-42. doi: 10.1109/EMBC.2015.7320283.


Functional expression of CD137 (4-1BB) on T helper follicular cells.

Alfaro C, Echeveste JI, Rodriguez-Ruiz ME, Solorzano JL, Perez-Gracia JL, Idoate MA, Lopez-Picazo JM, Sanchez-Paulete AR, Labiano S, Rouzaut A, Oñate C, Aznar A, Lozano MD, Melero I.

Oncoimmunology. 2015 May 29;4(12):e1054597. eCollection 2015 Dec.


Combined targeting of TGF-β1 and integrin β3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer.

Salvo E, Garasa S, Dotor J, Morales X, Peláez R, Altevogt P, Rouzaut A.

Mol Cancer. 2014 May 19;13:112. doi: 10.1186/1476-4598-13-112.


T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.

Melero I, Rouzaut A, Motz GT, Coukos G.

Cancer Discov. 2014 May;4(5):522-6. doi: 10.1158/2159-8290.CD-13-0985.


TGFBI expression is an independent predictor of survival in adjuvant-treated lung squamous cell carcinoma patients.

Pajares MJ, Agorreta J, Salvo E, Behrens C, Wistuba II, Montuenga LM, Pio R, Rouzaut A.

Br J Cancer. 2014 Mar 18;110(6):1545-51. doi: 10.1038/bjc.2014.33. Epub 2014 Jan 30.


Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes.

Teijeira A, Rouzaut A, Melero I.

Front Immunol. 2013 Dec 9;4:433. doi: 10.3389/fimmu.2013.00433. Review.


Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.

Morales-Kastresana A, Sanmamed MF, Rodriguez I, Palazon A, Martinez-Forero I, Labiano S, Hervas-Stubbs S, Sangro B, Ochoa C, Rouzaut A, Azpilikueta A, Bolaños E, Jure-Kunkel M, Gütgemann I, Melero I.

Clin Cancer Res. 2013 Nov 15;19(22):6151-62. doi: 10.1158/1078-0432.CCR-13-1189. Epub 2013 Sep 12.


Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels.

Teijeira A, Garasa S, Peláez R, Azpilikueta A, Ochoa C, Marré D, Rodrigues M, Alfaro C, Aubá C, Valitutti S, Melero I, Rouzaut A.

J Invest Dermatol. 2013 Sep;133(9):2276-85. doi: 10.1038/jid.2013.152. Epub 2013 Mar 25.


Segmentation and shape tracking of whole fluorescent cells based on the Chan-Vese model.

Maška M, Daněk O, Garasa S, Rouzaut A, Muñoz-Barrutia A, Ortiz-de-Solorzano C.

IEEE Trans Med Imaging. 2013 Jun;32(6):995-1006. doi: 10.1109/TMI.2013.2243463. Epub 2013 Jan 29.


Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression.

Corrales L, Ajona D, Rafail S, Lasarte JJ, Riezu-Boj JI, Lambris JD, Rouzaut A, Pajares MJ, Montuenga LM, Pio R.

J Immunol. 2012 Nov 1;189(9):4674-83. doi: 10.4049/jimmunol.1201654. Epub 2012 Oct 1.


Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC.

Oliemuller E, Peláez R, Garasa S, Pajares MJ, Agorreta J, Pío R, Montuenga LM, Teijeira A, Llanos S, Rouzaut A.

Int J Cancer. 2013 May 1;132(9):1986-95. doi: 10.1002/ijc.27881. Epub 2012 Oct 20.


The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy.

Palazón A, Martínez-Forero I, Teijeira A, Morales-Kastresana A, Alfaro C, Sanmamed MF, Perez-Gracia JL, Peñuelas I, Hervás-Stubbs S, Rouzaut A, de Landázuri MO, Jure-Kunkel M, Aragonés J, Melero I.

Cancer Discov. 2012 Jul;2(7):608-23. doi: 10.1158/2159-8290.CD-11-0314. Epub 2012 Jun 19.


CD137 on inflamed lymphatic endothelial cells enhances CCL21-guided migration of dendritic cells.

Teijeira Á, Palazón A, Garasa S, Marré D, Aubá C, Rogel A, Murillo O, Martínez-Forero I, Lang F, Melero I, Rouzaut A.

FASEB J. 2012 Aug;26(8):3380-92. doi: 10.1096/fj.11-201061. Epub 2012 May 16.


Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.

Alfaro C, Suárez N, Martínez-Forero I, Palazón A, Rouzaut A, Solano S, Feijoo E, Gúrpide A, Bolaños E, Erro L, Dubrot J, Hervás-Stubbs S, Gonzalez A, Perez-Gracia JL, Melero I.

PLoS One. 2011 Mar 14;6(3):e17922. doi: 10.1371/journal.pone.0017922.


Direct effects of type I interferons on cells of the immune system.

Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I.

Clin Cancer Res. 2011 May 1;17(9):2619-27. doi: 10.1158/1078-0432.CCR-10-1114. Epub 2011 Mar 3. Review.


Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

Palazón A, Teijeira A, Martínez-Forero I, Hervás-Stubbs S, Roncal C, Peñuelas I, Dubrot J, Morales-Kastresana A, Pérez-Gracia JL, Ochoa MC, Ochoa-Callejero L, Martínez A, Luque A, Dinchuk J, Rouzaut A, Jure-Kunkel M, Melero I.

Cancer Res. 2011 Feb 1;71(3):801-11. doi: 10.1158/0008-5472.CAN-10-1733. Epub 2011 Jan 25.


Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α.

Rouzaut A, Garasa S, Teijeira A, González I, Martinez-Forero I, Suarez N, Larrea E, Alfaro C, Palazón A, Dubrot J, Hervás-Stubbs S, Melero I.

Eur J Immunol. 2010 Nov;40(11):3054-63. doi: 10.1002/eji.201040523. Epub 2010 Oct 27.


Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells.

Dubrot J, Portero A, Orive G, Hernández RM, Palazón A, Rouzaut A, Perez-Gracia JL, Hervás-Stubbs S, Pedraz JL, Melero I.

Cancer Immunol Immunother. 2010 Nov;59(11):1621-31. doi: 10.1007/s00262-010-0888-z. Epub 2010 Jul 6.


TGFBI expression is associated with a better response to chemotherapy in NSCLC.

Irigoyen M, Pajares MJ, Agorreta J, Ponz-Sarvisé M, Salvo E, Lozano MD, Pío R, Gil-Bazo I, Rouzaut A.

Mol Cancer. 2010 May 28;9:130. doi: 10.1186/1476-4598-9-130.


Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment.

Martínez-García E, Irigoyen M, González-Moreno O, Corrales L, Teijeira A, Salvo E, Rouzaut A.

Toxicol Sci. 2010 Aug;116(2):467-76. doi: 10.1093/toxsci/kfq138. Epub 2010 May 10.


Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.

Dubrot J, Palazón A, Alfaro C, Azpilikueta A, Ochoa MC, Rouzaut A, Martinez-Forero I, Teijeira A, Berraondo P, Le Bon A, Hervás-Stubbs S, Melero I.

Int J Cancer. 2011 Jan 1;128(1):105-18. doi: 10.1002/ijc.25333.


Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

Ansó E, Zuazo A, Irigoyen M, Urdaci MC, Rouzaut A, Martínez-Irujo JJ.

Biochem Pharmacol. 2010 Jun 1;79(11):1600-9. doi: 10.1016/j.bcp.2010.02.004. Epub 2010 Feb 11.


Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation.

Martinez-Forero I, Rouzaut A, Palazon A, Dubrot J, Melero I.

Clin Cancer Res. 2009 Nov 15;15(22):6751-7. doi: 10.1158/1078-0432.CCR-09-1225. Epub 2009 Nov 3. Review.


TGFbeta-induced protein mediates lymphatic endothelial cell adhesion to the extracellular matrix under low oxygen conditions.

Irigoyen M, Ansó E, Salvo E, Dotor de las Herrerías J, Martínez-Irujo JJ, Rouzaut A.

Cell Mol Life Sci. 2008 Jul;65(14):2244-55. doi: 10.1007/s00018-008-8071-9.


Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation.

Martínez-García E, Irigoyen M, Ansó E, Martínez-Irujo JJ, Rouzaut A.

Toxicol Appl Pharmacol. 2008 May 1;228(3):334-42. doi: 10.1016/j.taap.2007.12.016. Epub 2007 Dec 23.


Lymphangiogenesis and lung cancer.

Rouzaut A, Irigoyen M, Montuenga LM.

J Thorac Oncol. 2007 May;2(5):384-6. Review. No abstract available.


Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study.

Irigoyen M, Ansó E, Martínez E, Garayoa M, Martínez-Irujo JJ, Rouzaut A.

Biochim Biophys Acta. 2007 Jun;1773(6):880-90. Epub 2007 Mar 12.


A new strategy to inhibit the excision reaction catalysed by HIV-1 reverse transcriptase: compounds that compete with the template-primer.

Cruchaga C, Anso E, Font M, Martino VS, Rouzaut A, Martinez-Irujo JJ.

Biochem J. 2007 Jul 1;405(1):165-71.


All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation.

Fontán-Gabás L, Oliemuller E, Martínez-Irujo JJ, de Miguel C, Rouzaut A.

FEBS J. 2007 Jan;274(2):498-511.


Selective excision of chain-terminating nucleotides by HIV-1 reverse transcriptase with phosphonoformate as substrate.

Cruchaga C, Ansó E, Rouzaut A, Martínez-Irujo JJ.

J Biol Chem. 2006 Sep 22;281(38):27744-52. Epub 2006 Jul 6.


Targeting hypoxia and angiogenesis through HIF-1alpha inhibition.

Diaz-Gonzalez JA, Russell J, Rouzaut A, Gil-Bazo I, Montuenga L.

Cancer Biol Ther. 2005 Oct;4(10):1055-62. Epub 2005 Oct 21. Review.


Differential regulation of the response to DNA damage in Ewing's sarcoma cells by ETS1 and EWS/FLI-1.

Soldatenkov VA, Trofimova IN, Rouzaut A, McDermott F, Dritschilo A, Notario V.

Oncogene. 2002 Apr 25;21(18):2890-5.


Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene.

Solanas M, Escrich E, Rouzaut A, Costa I, Martínez A, Notario V.

Mol Carcinog. 2002 Apr;33(4):219-27.


Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene.

Páez JG, Recio JA, Rouzaut A, Notario V.

Int J Oncol. 2001 Dec;19(6):1249-54.


Expression of the protein product of the PCPH proto-oncogene in human tumor cell lines.

Rouzaut A, Recio JA, Notario V.

Radiat Res. 2001 Jan;155(1 Pt 2):181-187.


The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.

Recio JA, Zambrano N, Peña Ld, Reig JA, Rhoads A, Rouzaut A, Notario V V.

Mol Carcinog. 2000 May;28(1):62. No abstract available.


The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.

Recio JA, Zambrano N, Peña Ld, Reig JA, Rhoads A, Rouzaut A, Notario V.

Mol Carcinog. 2000 Mar;27(3):229-36. Erratum in: Mol Carcinog 2000 May;28(1):62.


Differential gene expression in the activation and maturation of human monocytes.

Rouzaut A, López-Moratalla N, de Miguel C.

Arch Biochem Biophys. 2000 Feb 15;374(2):153-60.


Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.

Rouzaut A, Subirá ML, de Miguel C, Domingo-de-Miguel E, González A, Santiago E, López-Moratalla N.

Biochim Biophys Acta. 1999 Sep 21;1451(2-3):319-33.


Nitric oxide activates granule-associated DNase in human monocytes.

Pío R, López-Zabalza MJ, Rouzaut A, Santiago E, López-Moratalla N.

Nitric Oxide. 1998;2(3):165-73.


Selection of down-regulated sequences along the monocytic differentiation of leukemic HL60 cells.

Herblot S, Vekris A, Rouzaut A, Najeme F, de Miguel C, Bezian JH, Bonnet J.

FEBS Lett. 1997 Sep 1;414(1):146-52.

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