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Items: 1 to 50 of 71

1.

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF.

Cell Rep. 2018 May 1;23(5):1476-1490. doi: 10.1016/j.celrep.2018.04.019.

2.

Signaling Pathways Involved in the Regulation of mRNA Translation.

Roux PP, Topisirovic I.

Mol Cell Biol. 2018 May 29;38(12). pii: e00070-18. doi: 10.1128/MCB.00070-18. Print 2018 Jun 15. Review.

3.

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Ben Djoudi Ouadda A, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N.

Oncotarget. 2018 Jan 10;9(14):11646-11664. doi: 10.18632/oncotarget.24126. eCollection 2018 Feb 20.

4.

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP.

Cancer Res. 2018 May 1;78(9):2191-2204. doi: 10.1158/0008-5472.CAN-17-2215. Epub 2018 Feb 12.

PMID:
29440170
5.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J.

Mol Cell. 2017 Aug 3;67(3):512-527.e4. doi: 10.1016/j.molcel.2017.06.033. Epub 2017 Jul 27.

6.

Actin cortex architecture regulates cell surface tension.

Chugh P, Clark AG, Smith MB, Cassani DAD, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch EK.

Nat Cell Biol. 2017 Jun;19(6):689-697. doi: 10.1038/ncb3525. Epub 2017 May 22.

7.

Defining the role of the RSK isoforms in cancer.

Houles T, Roux PP.

Semin Cancer Biol. 2018 Feb;48:53-61. doi: 10.1016/j.semcancer.2017.04.016. Epub 2017 May 2. Review.

PMID:
28476656
8.

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M.

Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.

9.

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G.

Blood. 2017 Jun 22;129(25):3344-3351. doi: 10.1182/blood-2016-11-750729. Epub 2017 Apr 13.

10.

Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.

Zhang X, Lavoie G, Méant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00357-16. doi: 10.1128/MCB.00357-16. Print 2017 Apr 1.

11.

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.

Laflamme C, Galan JA, Ben El Kadhi K, Méant A, Zeledon C, Carréno S, Roux PP, Emery G.

Mol Cell Biol. 2017 Jan 19;37(3). pii: e00278-16. doi: 10.1128/MCB.00278-16. Print 2017 Feb 1.

12.

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.

J Clin Invest. 2016 Dec 1;126(12):4569-4584. doi: 10.1172/JCI86489. Epub 2016 Oct 31.

13.

Regulation of global and specific mRNA translation by the mTOR signaling pathway.

Nandagopal N, Roux PP.

Translation (Austin). 2015 Feb 2;3(1):e983402. doi: 10.4161/21690731.2014.983402. eCollection 2015 Jan-Jun. Review.

14.

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5160-8. doi: 10.1073/pnas.1508836112. Epub 2015 Aug 31.

15.

Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice.

Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R.

PLoS One. 2015 Mar 24;10(3):e0119387. doi: 10.1371/journal.pone.0119387. eCollection 2015.

16.

The expanding role of mTOR in cancer cell growth and proliferation.

Cargnello M, Tcherkezian J, Roux PP.

Mutagenesis. 2015 Mar;30(2):169-76. doi: 10.1093/mutage/geu045. Review.

17.

Translational control by oncogenic signaling pathways.

Gao B, Roux PP.

Biochim Biophys Acta. 2015 Jul;1849(7):753-65. doi: 10.1016/j.bbagrm.2014.11.006. Epub 2014 Dec 2. Review.

PMID:
25477072
18.

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.

Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG.

Nat Commun. 2014 Jul 16;5:4431. doi: 10.1038/ncomms5431.

PMID:
25028204
19.

Cellular control of cortical actin nucleation.

Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, Charras G.

Curr Biol. 2014 Jul 21;24(14):1628-1635. doi: 10.1016/j.cub.2014.05.069. Epub 2014 Jul 10.

20.

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27. doi: 10.1073/pnas.1405601111. Epub 2014 Jul 7.

21.

Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness.

Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Décarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gérard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozet JM, Michaud JL.

Am J Hum Genet. 2014 Jun 5;94(6):891-7. doi: 10.1016/j.ajhg.2014.04.012. Epub 2014 May 8.

22.

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.

Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R.

Mol Reprod Dev. 2014 Jul;81(7):655-65. doi: 10.1002/mrd.22333. Epub 2014 Jun 24.

PMID:
24753052
23.

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation.

Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP.

Genes Dev. 2014 Feb 15;28(4):357-71. doi: 10.1101/gad.231407.113.

24.

Casein kinase 1ε promotes cell proliferation by regulating mRNA translation.

Shin S, Wolgamott L, Roux PP, Yoon SO.

Cancer Res. 2014 Jan 1;74(1):201-11. doi: 10.1158/0008-5472.CAN-13-1175. Epub 2013 Nov 18.

25.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EK.

Cytoskeleton (Hoboken). 2013 Nov;70(11):741-54. doi: 10.1002/cm.21142. Epub 2013 Oct 17.

PMID:
24136886
26.

Rapamycin resistance: mTORC1 substrates hold some of the answers.

Yoon SO, Roux PP.

Curr Biol. 2013 Oct 7;23(19):R880-3. doi: 10.1016/j.cub.2013.08.030.

27.

The coming of age of phosphoproteomics--from large data sets to inference of protein functions.

Roux PP, Thibault P.

Mol Cell Proteomics. 2013 Dec;12(12):3453-64. doi: 10.1074/mcp.R113.032862. Epub 2013 Sep 13. Review.

28.

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette A.

J Biol Chem. 2013 Oct 25;288(43):31165-76. doi: 10.1074/jbc.M113.474148. Epub 2013 Sep 13.

29.

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.

Wang P, Galan JA, Normandin K, Bonneil É, Hickson GR, Roux PP, Thibault P, Archambault V.

J Cell Biol. 2013 Jul 22;202(2):277-93. doi: 10.1083/jcb.201211141. Epub 2013 Jul 15.

30.

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly.

Capo-Chichi JM, Tcherkezian J, Hamdan FF, Décarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha BE, Major P, Shevell M, Bencheikh BO, Joober R, Samuels ME, Rouleau GA, Roux PP, Michaud JL.

J Med Genet. 2013 Nov;50(11):740-4. doi: 10.1136/jmedgenet-2013-101680. Epub 2013 May 17.

PMID:
23687350
31.

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO.

Oncogene. 2014 Mar 27;33(13):1690-9. doi: 10.1038/onc.2013.113. Epub 2013 Apr 15.

PMID:
23584478
32.

Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.

Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP.

Mol Cell Biol. 2013 Apr;33(8):1657-70. doi: 10.1128/MCB.01353-12. Epub 2013 Feb 11.

33.

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance.

Ray-David H, Romeo Y, Lavoie G, Déléris P, Tcherkezian J, Galan JA, Roux PP.

Oncogene. 2013 Sep 19;32(38):4480-9. doi: 10.1038/onc.2012.472. Epub 2012 Oct 29.

PMID:
23108403
34.

Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.

Cargnello M, Tcherkezian J, Dorn JF, Huttlin EL, Maddox PS, Gygi SP, Roux PP.

Mol Cell Biol. 2012 Nov;32(22):4572-84. doi: 10.1128/MCB.00544-12. Epub 2012 Sep 10.

35.

Regulation of mRNA translation by signaling pathways.

Roux PP, Topisirovic I.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a012252. doi: 10.1101/cshperspect.a012252. Review.

36.

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.

Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, Roux PP, Ballif BA.

Biochem J. 2012 Oct 1;447(1):159-66. doi: 10.1042/BJ20120938.

37.

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.

Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP.

Oncogene. 2013 Jun 13;32(24):2917-2926. doi: 10.1038/onc.2012.312. Epub 2012 Jul 16.

38.

F-box proteins elongate translation during stress recovery.

Meloche S, Roux PP.

Sci Signal. 2012 Jun 5;5(227):pe25. doi: 10.1126/scisignal.2003163.

PMID:
22669843
39.

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.

Fielhaber JA, Tan J, Joung KB, Attias O, Huegel S, Bader M, Roux PP, Kristof AS.

J Biol Chem. 2012 Apr 27;287(18):14325-35. doi: 10.1074/jbc.M111.246785. Epub 2012 Mar 6.

40.

Regulation and function of the RSK family of protein kinases.

Romeo Y, Zhang X, Roux PP.

Biochem J. 2012 Jan 15;441(2):553-69. doi: 10.1042/BJ20110289. Review.

PMID:
22187936
41.

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.

Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault C.

Mol Syst Biol. 2011 Sep 27;7:533. doi: 10.1038/msb.2011.68.

42.

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.

Cargnello M, Roux PP.

Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83. doi: 10.1128/MMBR.00031-10. Review. Erratum in: Microbiol Mol Biol Rev. 2012 Jun;76(2):496.

43.

[mTOR, the mammalian target of rapamycin].

Julien LA, Roux PP.

Med Sci (Paris). 2010 Dec;26(12):1056-60. doi: 10.1051/medsci/201026121056. Review. French.

44.

A comprehensive map of the mTOR signaling network.

Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H.

Mol Syst Biol. 2010 Dec 21;6:453. doi: 10.1038/msb.2010.108. Review.

45.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP.

J Biol Chem. 2011 Jan 7;286(1):567-77. doi: 10.1074/jbc.M110.159046. Epub 2010 Nov 11.

46.

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.

Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E.

EMBO J. 2010 Dec 1;29(23):3939-51. doi: 10.1038/emboj.2010.271. Epub 2010 Nov 2.

47.

Paving the way for targeting RSK in cancer.

Romeo Y, Roux PP.

Expert Opin Ther Targets. 2011 Jan;15(1):5-9. doi: 10.1517/14728222.2010.531014. Epub 2010 Oct 19.

PMID:
20958120
48.

Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.

Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG.

Cell. 2010 May 14;141(4):632-44. doi: 10.1016/j.cell.2010.04.008. Epub 2010 Apr 29.

49.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

50.

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC.

J Biol Chem. 2010 Jan 1;285(1):80-94. doi: 10.1074/jbc.M109.029637. Epub 2009 Oct 28.

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