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Items: 49

1.

Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa.

Remy S, Solis D, Silland P, Neyts J, Roussi F, Touboul D, Litaudon M.

Phytochemistry. 2019 Nov;167:112101. doi: 10.1016/j.phytochem.2019.112101. Epub 2019 Aug 29.

PMID:
31473556
2.

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation.

Nothias-Esposito M, Nothias LF, Da Silva RR, Retailleau P, Zhang Z, Leyssen P, Roussi F, Touboul D, Paolini J, Dorrestein PC, Litaudon M.

J Nat Prod. 2019 Jun 28;82(6):1459-1470. doi: 10.1021/acs.jnatprod.8b00916. Epub 2019 Jun 5.

PMID:
31181921
3.

Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research.

Fox Ramos AE, Le Pogam P, Fox Alcover C, Otogo N'Nang E, Cauchie G, Hazni H, Awang K, Bréard D, Echavarren AM, Frédérich M, Gaslonde T, Girardot M, Grougnet R, Kirillova MS, Kritsanida M, Lémus C, Le Ray AM, Lewin G, Litaudon M, Mambu L, Michel S, Miloserdov FM, Muratore ME, Richomme-Peniguel P, Roussi F, Evanno L, Poupon E, Champy P, Beniddir MA.

Sci Data. 2019 Apr 3;6(1):15. doi: 10.1038/s41597-019-0028-3.

4.

Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach.

Olivon F, Remy S, Grelier G, Apel C, Eydoux C, Guillemot JC, Neyts J, Delang L, Touboul D, Roussi F, Litaudon M.

J Nat Prod. 2019 Feb 22;82(2):330-340. doi: 10.1021/acs.jnatprod.8b00800. Epub 2019 Jan 25.

PMID:
30681849
5.

N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë.

Apel C, Bignon J, Garcia-Alvarez MC, Ciccone S, Clerc P, Grondin I, Girard-Valenciennes E, Smadja J, Lopes P, Frédérich M, Roussi F, Meinnel T, Giglione C, Litaudon M.

Fitoterapia. 2018 Nov;131:91-95. doi: 10.1016/j.fitote.2018.10.014. Epub 2018 Oct 17.

PMID:
30342177
6.

MetGem Software for the Generation of Molecular Networks Based on the t-SNE Algorithm.

Olivon F, Elie N, Grelier G, Roussi F, Litaudon M, Touboul D.

Anal Chem. 2018 Dec 4;90(23):13900-13908. doi: 10.1021/acs.analchem.8b03099. Epub 2018 Nov 14.

PMID:
30335965
7.

Natural Inhibitors of the RhoA-p115 Complex from the Bark of Meiogyne baillonii.

Olivon F, Nothias LF, Dumontet V, Retailleau P, Berger S, Ferry G, Cohen W, Pfeiffer B, Boutin JA, Scalbert E, Roussi F, Litaudon M.

J Nat Prod. 2018 Jul 27;81(7):1610-1618. doi: 10.1021/acs.jnatprod.8b00209. Epub 2018 Jul 3.

PMID:
29969260
8.

Structurally Diverse Diterpenoids from Sandwithia guyanensis.

Remy S, Olivon F, Desrat S, Blanchard F, Eparvier V, Leyssen P, Neyts J, Roussi F, Touboul D, Litaudon M.

J Nat Prod. 2018 Apr 27;81(4):901-912. doi: 10.1021/acs.jnatprod.7b01025. Epub 2018 Mar 1.

PMID:
29493237
9.

Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A.

Abou Samra A, Robert A, Gov C, Favre L, Eloy L, Jacquet E, Bignon J, Wiels J, Desrat S, Roussi F.

Eur J Med Chem. 2018 Mar 25;148:26-38. doi: 10.1016/j.ejmech.2018.01.100. Epub 2018 Feb 5.

PMID:
29453135
10.

(+)- and (-)-Ecarlottones, Uncommon Chalconoids from Fissistigma latifolium with Pro-Apoptotic Activity.

Gény C, Abou Samra A, Retailleau P, Iorga BI, Nedev H, Awang K, Roussi F, Litaudon M, Dumontet V.

J Nat Prod. 2017 Dec 22;80(12):3179-3185. doi: 10.1021/acs.jnatprod.7b00494. Epub 2017 Nov 21.

PMID:
29160716
11.

Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius.

Péresse T, Jézéquel G, Allard PM, Pham VC, Huong DTM, Blanchard F, Bignon J, Lévaique H, Wolfender JL, Litaudon M, Roussi F.

J Nat Prod. 2017 Oct 27;80(10):2684-2691. doi: 10.1021/acs.jnatprod.7b00409. Epub 2017 Oct 3.

PMID:
28972755
12.

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

Nothias LF, Boutet-Mercey S, Cachet X, De La Torre E, Laboureur L, Gallard JF, Retailleau P, Brunelle A, Dorrestein PC, Costa J, Bedoya LM, Roussi F, Leyssen P, Alcami J, Paolini J, Litaudon M, Touboul D.

J Nat Prod. 2017 Oct 27;80(10):2620-2629. doi: 10.1021/acs.jnatprod.7b00113. Epub 2017 Sep 19.

PMID:
28925702
13.

Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.

Olivon F, Allard PM, Koval A, Righi D, Genta-Jouve G, Neyts J, Apel C, Pannecouque C, Nothias LF, Cachet X, Marcourt L, Roussi F, Katanaev VL, Touboul D, Wolfender JL, Litaudon M.

ACS Chem Biol. 2017 Oct 20;12(10):2644-2651. doi: 10.1021/acschembio.7b00413. Epub 2017 Sep 15.

PMID:
28829118
14.

Dual Beam Depth Profiling and Imaging with Argon and Bismuth Clusters of Prenylated Stilbenes on Glandular Trichomes of Macaranga vedeliana.

Péresse T, Elie N, Touboul D, Pham VC, Dumontet V, Roussi F, Litaudon M, Brunelle A.

Anal Chem. 2017 Sep 5;89(17):9247-9252. doi: 10.1021/acs.analchem.7b02020. Epub 2017 Aug 22.

PMID:
28780852
15.

Optimized experimental workflow for tandem mass spectrometry molecular networking in metabolomics.

Olivon F, Roussi F, Litaudon M, Touboul D.

Anal Bioanal Chem. 2017 Sep;409(24):5767-5778. doi: 10.1007/s00216-017-0523-3. Epub 2017 Jul 31.

PMID:
28762069
16.

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking.

Esposito M, Nothias LF, Retailleau P, Costa J, Roussi F, Neyts J, Leyssen P, Touboul D, Litaudon M, Paolini J.

J Nat Prod. 2017 Jul 28;80(7):2051-2059. doi: 10.1021/acs.jnatprod.7b00233. Epub 2017 Jul 3.

PMID:
28671832
17.

MZmine 2 Data-Preprocessing To Enhance Molecular Networking Reliability.

Olivon F, Grelier G, Roussi F, Litaudon M, Touboul D.

Anal Chem. 2017 Aug 1;89(15):7836-7840. doi: 10.1021/acs.analchem.7b01563. Epub 2017 Jul 11.

PMID:
28644610
18.

Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels-Alder and ene-reactions.

Brossard D, Retailleau P, Dumontet V, Breton P, Desrat S, Roussi F.

Org Biomol Chem. 2017 Jul 5;15(26):5585-5592. doi: 10.1039/c7ob01236e.

PMID:
28639654
19.

Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters.

Esposito M, Nim S, Nothias LF, Gallard JF, Rawal MK, Costa J, Roussi F, Prasad R, Di Pietro A, Paolini J, Litaudon M.

J Nat Prod. 2017 Feb 24;80(2):479-487. doi: 10.1021/acs.jnatprod.6b00990. Epub 2017 Jan 20.

PMID:
28106996
20.

Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity.

Esposito M, Nothias LF, Nedev H, Gallard JF, Leyssen P, Retailleau P, Costa J, Roussi F, Iorga BI, Paolini J, Litaudon M.

J Nat Prod. 2016 Nov 23;79(11):2873-2882. Epub 2016 Oct 27.

PMID:
27786472
21.

Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors.

Gherbovet O, García Alvarez MC, Bignon J, Roussi F.

J Med Chem. 2016 Dec 8;59(23):10774-10780. Epub 2016 Nov 23.

PMID:
27753480
22.

Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.

Gény C, Rivière G, Bignon J, Birlirakis N, Guittet E, Awang K, Litaudon M, Roussi F, Dumontet V.

J Nat Prod. 2016 Apr 22;79(4):838-44. doi: 10.1021/acs.jnatprod.5b00915. Epub 2016 Mar 23.

PMID:
27008174
23.

Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication.

Allard PM, Péresse T, Bisson J, Gindro K, Marcourt L, Pham VC, Roussi F, Litaudon M, Wolfender JL.

Anal Chem. 2016 Mar 15;88(6):3317-23. doi: 10.1021/acs.analchem.5b04804. Epub 2016 Mar 1.

PMID:
26882108
24.

Kingianins O-Q: Pentacyclic polyketides from Endiandra kingiana as inhibitor of Mcl-1/Bid interaction.

Azmi MN, Péresse T, Remeur C, Chan G, Roussi F, Litaudon M, Awang K.

Fitoterapia. 2016 Mar;109:190-5. doi: 10.1016/j.fitote.2016.01.004. Epub 2016 Jan 11.

PMID:
26779944
25.

Correction to Advanced Structural Determination of Diterpene Esters Using Molecular Modeling and NMR Spectroscopy.

Nothias-Scaglia LF, Gallard JF, Dumontet V, Roussi F, Costa J, Iorga BI, Paolini J, Litaudon M.

J Nat Prod. 2015 Dec 24;78(12):3084. doi: 10.1021/acs.jnatprod.5b01048. Epub 2015 Dec 8. No abstract available.

PMID:
26645695
26.

Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain.

Ngo QA, Nguyen le A, Vo NB, Nguyen TH, Roussi F, Nguyen TH, Nguyen VT.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5597-600. doi: 10.1016/j.bmcl.2015.10.040. Epub 2015 Oct 23.

PMID:
26522953
27.

Insights on profiling of phorbol, deoxyphorbol, ingenol and jatrophane diterpene esters by high performance liquid chromatography coupled to multiple stage mass spectrometry.

Nothias-Scaglia LF, Schmitz-Afonso I, Renucci F, Roussi F, Touboul D, Costa J, Litaudon M, Paolini J.

J Chromatogr A. 2015 Nov 27;1422:128-139. doi: 10.1016/j.chroma.2015.09.092. Epub 2015 Oct 13.

PMID:
26522744
28.

Advanced Structural Determination of Diterpene Esters Using Molecular Modeling and NMR Spectroscopy.

Nothias-Scaglia LF, Gallard JF, Dumontet V, Roussi F, Costa J, Iorga BI, Paolini J, Litaudon M.

J Nat Prod. 2015 Oct 23;78(10):2423-31. doi: 10.1021/acs.jnatprod.5b00511. Epub 2015 Oct 2. Erratum in: J Nat Prod. 2015 Dec 24;78(12):3084.

PMID:
26431312
29.

LC-MS²-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity.

Nothias-Scaglia LF, Dumontet V, Neyts J, Roussi F, Costa J, Leyssen P, Litaudon M, Paolini J.

Fitoterapia. 2015 Sep;105:202-9. doi: 10.1016/j.fitote.2015.06.021. Epub 2015 Jul 4.

PMID:
26151856
30.

Antibacterial Labdane Diterpenoids from Vitex vestita.

Corlay N, Lecsö-Bornet M, Leborgne E, Blanchard F, Cachet X, Bignon J, Roussi F, Butel MJ, Awang K, Litaudon M.

J Nat Prod. 2015 Jun 26;78(6):1348-56. doi: 10.1021/acs.jnatprod.5b00206. Epub 2015 Jun 2.

PMID:
26034885
31.

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication.

Nothias-Scaglia LF, Pannecouque C, Renucci F, Delang L, Neyts J, Roussi F, Costa J, Leyssen P, Litaudon M, Paolini J.

J Nat Prod. 2015 Jun 26;78(6):1277-83. doi: 10.1021/acs.jnatprod.5b00073. Epub 2015 May 13.

PMID:
25970561
32.

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata.

Olivon F, Palenzuela H, Girard-Valenciennes E, Neyts J, Pannecouque C, Roussi F, Grondin I, Leyssen P, Litaudon M.

J Nat Prod. 2015 May 22;78(5):1119-28. doi: 10.1021/acs.jnatprod.5b00116. Epub 2015 May 6.

PMID:
25946116
33.

Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.

Desrat S, Remeur C, Roussi F.

Org Biomol Chem. 2015 May 21;13(19):5520-31. doi: 10.1039/c5ob00354g.

PMID:
25877523
34.

Synthesis and biological evaluation of C-13' substituted 7'-homo-anhydrovinblastine derivatives.

Gherbovet O, La Spisa F, Thoret S, Alvarez MCG, Levaique H, Bignon J, Roussi F.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1771-1773. doi: 10.1016/j.bmcl.2015.02.045. Epub 2015 Mar 7.

PMID:
25804719
35.

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.

Gherbovet O, Sánchez-Murcia PA, García Alvarez MC, Bignon J, Thoret S, Gago F, Roussi F.

Org Biomol Chem. 2015 Mar 14;13(10):3144-54. doi: 10.1039/c4ob02114b.

PMID:
25634805
36.

Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.

Desrat S, Pujals A, Colas C, Dardenne J, Gény C, Favre L, Dumontet V, Iorga BI, Litaudon M, Raphaël M, Wiels J, Roussi F.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5086-8. doi: 10.1016/j.bmcl.2014.09.004. Epub 2014 Sep 6.

PMID:
25266781
37.

From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.

Desrat S, Remeur C, Gény C, Rivière G, Colas C, Dumontet V, Birlirakis N, Iorga BI, Roussi F.

Chem Commun (Camb). 2014 Aug 11;50(62):8593-6. doi: 10.1039/c4cc01830c.

PMID:
24956071
38.

Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.

Nothias-Scaglia LF, Retailleau P, Paolini J, Pannecouque C, Neyts J, Dumontet V, Roussi F, Leyssen P, Costa J, Litaudon M.

J Nat Prod. 2014 Jun 27;77(6):1505-12. doi: 10.1021/np500271u. Epub 2014 Jun 13.

PMID:
24926807
39.

Endiandric acid analogues from Beilschmiedia ferruginea as dual inhibitors of Bcl-xL/Bak and Mcl-1/Bid interactions.

Apel C, Gény C, Dumontet V, Birlirakis N, Roussi F, Pham VC, Doan Thi Mai H, Nguyen VH, Chau VM, Litaudon M.

J Nat Prod. 2014 Jun 27;77(6):1430-7. doi: 10.1021/np500170v. Epub 2014 Jun 5.

PMID:
24901800
40.

One-pot synthesis of vinca alkaloids-phomopsin hybrids.

Gherbovet O, Coderch C, García Alvarez MC, Bignon J, Thoret S, Guéritte F, Gago F, Roussi F.

J Med Chem. 2014 Jun 26;57(12):5470-6. doi: 10.1021/jm500530v. Epub 2014 Jun 10.

PMID:
24871162
41.

Synthesis and biological evaluation of a new series of highly functionalized 7'-homo-anhydrovinblastine derivatives.

Gherbovet O, Coderch C, García Alvarez MC, Bignon J, Thoret S, Martin MT, Guéritte F, Gago F, Roussi F.

J Med Chem. 2013 Aug 8;56(15):6088-100. doi: 10.1021/jm4004347. Epub 2013 Jul 18.

PMID:
23822556
42.

Elaboration of vinblastine hybrids using a reactive in situ generated N-carboxyanhydride.

Rannoux C, Roussi F, Martin MT, Guéritte F.

Org Biomol Chem. 2011 Jul 7;9(13):4873-81. doi: 10.1039/c0ob01065k. Epub 2011 May 24.

PMID:
21607276
43.

Biomimetic total synthesis of meiogynin A, an inhibitor of Bcl-xL and Bak interaction.

Fotsop DF, Roussi F, Leverrier A, Bretéché A, Guéritte F.

J Org Chem. 2010 Nov 5;75(21):7412-5. doi: 10.1021/jo101088h.

PMID:
20929197
44.

Elaboration of simplified vinca alkaloids and phomopsin hybrids.

Ngo QA, Roussi F, Thoret S, Guéritte F.

Chem Biol Drug Des. 2010 Mar;75(3):284-94. doi: 10.1111/j.1747-0285.2009.00922.x. Epub 2010 Jan 19.

PMID:
20659111
45.

Direct and selective functionalization of a tetrahydro-beta-carboline at position 4.

Rannoux C, Roussi F, Retailleau P, Guéritte F.

Org Lett. 2010 Mar 19;12(6):1240-3. doi: 10.1021/ol100094s.

PMID:
20158220
46.

Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids.

Ngo QA, Roussi F, Cormier A, Thoret S, Knossow M, Guénard D, Guéritte F.

J Med Chem. 2009 Jan 8;52(1):134-42. doi: 10.1021/jm801064y.

PMID:
19072542
47.

Structural basis for the regulation of tubulin by vinblastine.

Gigant B, Wang C, Ravelli RB, Roussi F, Steinmetz MO, Curmi PA, Sobel A, Knossow M.

Nature. 2005 May 26;435(7041):519-22.

48.

Synthesis of C2-C3'N-linked macrocyclic taxoids. Novel docetaxel analogues with high tubulin activity.

Querolle O, Dubois J, Thoret S, Roussi F, Guéritte F, Guénard D.

J Med Chem. 2004 Nov 18;47(24):5937-44.

PMID:
15537348
49.

Synthesis of novel macrocyclic docetaxel analogues. Influence of their macrocyclic ring size on tubulin activity.

Querolle O, Dubois J, Thoret S, Roussi F, Montiel-Smith S, Guéritte F, Guénard D.

J Med Chem. 2003 Aug 14;46(17):3623-30.

PMID:
12904066

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