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Items: 1 to 50 of 58

1.

Formation of Ligand Clusters on Multimodal Chromatographic Surfaces.

Bilodeau CL, Lau EY, Roush D, Garde S, Cramer SM.

Langmuir. 2019 Oct 11. doi: 10.1021/acs.langmuir.9b01925. [Epub ahead of print]

PMID:
31603330
2.

Retrospective Evaluation of Cycled Resin in Viral Clearance Studies-A Multiple Company Collaboration.

Mattila J, Curtis S, Webb-Vargas Y, Wilson E, Galperina O, Roush D, Tobler S, Stanley B, Clark M, Weaver J, Pike J, Yu D, Li X, Flicker A, Kindermann J, Schuelke N, Whitcombe R, Bennett L.

PDA J Pharm Sci Technol. 2019 Sep-Oct;73(5):470-486. doi: 10.5731/pdajpst.2018.009605. Epub 2019 May 17.

PMID:
31101706
3.

Data-driven multi-objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications.

Konstantinidis S, Welsh JP, Titchener-Hooker NJ, Roush DJ, Velayudhan A.

Biotechnol Prog. 2018 Nov;34(6):1393-1406. doi: 10.1002/btpr.2673. Epub 2018 Oct 9.

4.

Proceedings of the 2017 Viral Clearance Symposium, Session 2.1: DSP Unit Operations-Virus Filtration/Inactivation.

Kreil TR, Roush D.

PDA J Pharm Sci Technol. 2018 Sep-Oct;72(5):470-478. doi: 10.5731/pdajpst.2018.009118. Epub 2018 Jul 20.

PMID:
30030356
5.

Proceedings of the 2017 Viral Clearance Symposium, Session 2.2: DSP Unit Operations-Purification Unit Operations.

Roush D, Kreil TR.

PDA J Pharm Sci Technol. 2018 Sep-Oct;72(5):479-487. doi: 10.5731/pdajpst.2018.009126. Epub 2018 Jul 20.

PMID:
30030354
6.

Proceedings of the 2017 Viral Clearance Symposium, Session 6: Ensuring Viral Safety in Continuous Processing.

Johnson SA, Roush D.

PDA J Pharm Sci Technol. 2018 Sep-Oct;72(5):516-524. doi: 10.5731/pdajpst.2018.009183. Epub 2018 Jul 20.

PMID:
30030352
7.

Developmental plasticity in reptiles: Critical evaluation of the evidence for genetic and maternal effects on temperature-dependent sex determination.

Roush D, Rhen T.

J Exp Zool A Ecol Integr Physiol. 2018 Jul;329(6-7):287-297. doi: 10.1002/jez.2194. Epub 2018 Jun 25. Review.

PMID:
29938927
8.

Domain contributions to antibody retention in multimodal chromatography systems.

Robinson J, Roush D, Cramer S.

J Chromatogr A. 2018 Aug 17;1563:89-98. doi: 10.1016/j.chroma.2018.05.058. Epub 2018 May 28.

PMID:
29880216
9.

Defining the mechanistic binding of viral particles to a multi-modal anion exchange resin.

Brown MR, Burnham MS, Lute SC, Johnson SA, Walsh AA, Brorson KA, Roush DJ.

Biotechnol Prog. 2018 Jul;34(4):1019-1026. doi: 10.1002/btpr.2648. Epub 2018 Jul 5.

PMID:
29708638
10.

Erratum for John Mattila, Mike Clark, Shengjiang Liu, et al.: "Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration".

Mattila J, Clark M, Liu S, Pieracci J, Gervais TR, Wilson E, Galperina O, Li X, Roush D, Zoeller K, Brough H, Simpson-Platre C.

PDA J Pharm Sci Technol. 2018 Jul-Aug;72(4):451. doi: 10.5731/pdajpst.2017.007963. Epub 2018 Mar 15. No abstract available.

PMID:
29545323
11.

Integrated viral clearance strategies-reflecting on the present, projecting to the future.

Roush DJ.

Curr Opin Biotechnol. 2018 Oct;53:137-143. doi: 10.1016/j.copbio.2018.01.003. Epub 2018 Jan 23. Review.

PMID:
29367164
12.

Evaluating the effect of in-process material on the binding mechanisms of surrogate viral particles to a multi-modal anion exchange resin.

Brown MR, Burnham MS, Johnson SA, Lute SC, Brorson KA, Roush DJ.

J Biotechnol. 2018 Feb 10;267:29-35. doi: 10.1016/j.jbiotec.2017.12.018. Epub 2017 Dec 24.

PMID:
29278725
13.

A New Niche for Anoxygenic Phototrophs as Endoliths.

Roush D, Couradeau E, Guida B, Neuer S, Garcia-Pichel F.

Appl Environ Microbiol. 2018 Jan 31;84(4). pii: e02055-17. doi: 10.1128/AEM.02055-17. Print 2018 Feb 15.

14.

Exposure to predicted precipitation patterns decreases population size and alters community structure of cyanobacteria in biological soil crusts from the Chihuahuan Desert.

Fernandes VMC, Machado de Lima NM, Roush D, Rudgers J, Collins SL, Garcia-Pichel F.

Environ Microbiol. 2018 Jan;20(1):259-269. doi: 10.1111/1462-2920.13983. Epub 2017 Dec 4.

PMID:
29124873
15.

Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities.

Chmielowski RA, Mathiasson L, Blom H, Go D, Ehring H, Khan H, Li H, Cutler C, Lacki K, Tugcu N, Roush D.

J Chromatogr A. 2017 Dec 1;1526:58-69. doi: 10.1016/j.chroma.2017.10.030. Epub 2017 Oct 13.

PMID:
29078985
16.

13C metabolic flux analysis identifies limitations to increasing specific productivity in fed-batch and perfusion.

Templeton N, Xu S, Roush DJ, Chen H.

Metab Eng. 2017 Nov;44:126-133. doi: 10.1016/j.ymben.2017.09.010. Epub 2017 Sep 22.

PMID:
28951188
17.

The step-wise framework to design a chromatography-based hydrophobicity assay for viral particles.

Johnson SA, Walsh A, Brown MR, Lute SC, Roush DJ, Burnham MS, Brorson KA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:430-437. doi: 10.1016/j.jchromb.2017.08.002. Epub 2017 Aug 9.

PMID:
28818800
18.

A step-wise approach to define binding mechanisms of surrogate viral particles to multi-modal anion exchange resin in a single solute system.

Brown MR, Johnson SA, Brorson KA, Lute SC, Roush DJ.

Biotechnol Bioeng. 2017 Jul;114(7):1487-1494. doi: 10.1002/bit.26251. Epub 2017 Mar 6.

PMID:
28109126
19.

Viral Clearance Using Traditional, Well-Understood Unit Operations Session 1.2: Virus-Retentive Filtration.

Roush D, Ma J.

PDA J Pharm Sci Technol. 2016 Sep 10;70(5):417-427. Epub 2016 Aug 11. No abstract available.

PMID:
27516492
20.

Session 1.1: Viral Clearance Using Traditional, Well-Understood Unit Operations: Low pH and Detergent Viral Inactivation.

Ma J, Roush D.

PDA J Pharm Sci Technol. 2016 Sep 10;70(5):410-416. Epub 2016 Aug 11. No abstract available.

PMID:
27516488
21.

Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration.

Mattila J, Clark M, Liu S, Pieracci J, Gervais TR, Wilson E, Galperina O, Li X, Roush D, Zoeller K, Brough H, Simpson-Platre C.

PDA J Pharm Sci Technol. 2016 May-Jun;70(3):293-9. doi: 10.5731/pdajpst.2016.006478. Epub 2016 Mar 28. Erratum in: PDA J Pharm Sci Technol. 2018 Jul-Aug;72(4):451.

PMID:
27020645
22.

Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing.

Konstantinidis S, Welsh JP, Roush DJ, Velayudhan A.

Biotechnol Prog. 2016 Mar;32(2):404-19. doi: 10.1002/btpr.2234. Epub 2016 Feb 29.

PMID:
26821762
23.

High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody.

Petroff MG, Bao H, Welsh JP, van Beuningen-de Vaan M, Pollard JM, Roush DJ, Kandula S, Machielsen P, Tugcu N, Linden TO.

Biotechnol Bioeng. 2016 Jun;113(6):1273-83. doi: 10.1002/bit.25901. Epub 2015 Dec 31.

PMID:
26639315
24.

Prediction of viral filtration performance of monoclonal antibodies based on biophysical properties of feed.

Rayfield WJ, Roush DJ, Chmielowski RA, Tugcu N, Barakat S, Cheung JK.

Biotechnol Prog. 2015 May-Jun;31(3):765-74. doi: 10.1002/btpr.2094. Epub 2015 May 19.

PMID:
25919945
25.

2013 viral clearance symposia - session 5. Conference summary: key discussion and outcomes, pending questions, and proposed experiments.

Blümel J, Roush D.

PDA J Pharm Sci Technol. 2015 Jan-Feb;69(1):206-10. doi: 10.5731/pdajpst.2015.01044. Review. No abstract available.

PMID:
25691728
26.

Viral clearance using traditional, well-understood unit operations: session 1.2. Anion exchange chromatography; and session 1.3. Protein a chromatography.

Roush D.

PDA J Pharm Sci Technol. 2015 Jan-Feb;69(1):154-62. doi: 10.5731/pdajpst.2015.01039. Review. No abstract available.

PMID:
25691723
27.

Proceedings of the 2013 Viral Clearance Symposium (Princeton, NJ).

Roush D, Brorson K, Levy R.

PDA J Pharm Sci Technol. 2015 Jan-Feb;69(1):140-1. doi: 10.5731/pdajpst.2015.01053. No abstract available.

PMID:
25691721
28.

Targeted purification development enabled by computational biophysical modeling.

Insaidoo FK, Rauscher MA, Smithline SJ, Kaarsholm NC, Feuston BP, Ortigosa AD, Linden TO, Roush DJ.

Biotechnol Prog. 2015 Jan-Feb;31(1):154-64. doi: 10.1002/btpr.2023. Epub 2014 Dec 19.

PMID:
25482184
29.

Limits in virus filtration capability? Impact of virus quality and spike level on virus removal with xenotropic murine leukemia virus.

Roush DJ, Myrold A, Burnham MS, And JV, Hughes JV.

Biotechnol Prog. 2015 Jan-Feb;31(1):135-44. doi: 10.1002/btpr.2020. Epub 2014 Nov 29.

PMID:
25395156
30.

Resolution of heterogeneous charged antibody aggregates via multimodal chromatography: a comparison to conventional approaches.

Chmielowski RA, Meissner S, Roush D, Linden TO, Glowacki E, Konietzko J, Nti-Gyabaah J.

Biotechnol Prog. 2014 May-Jun;30(3):636-45. doi: 10.1002/btpr.1908. Epub 2014 Apr 19.

PMID:
24692271
31.

A practical strategy for using miniature chromatography columns in a standardized high-throughput workflow for purification development of monoclonal antibodies.

Welsh JP, Petroff MG, Rowicki P, Bao H, Linden T, Roush DJ, Pollard JM.

Biotechnol Prog. 2014 May-Jun;30(3):626-35. doi: 10.1002/btpr.1905. Epub 2014 Mar 20.

PMID:
24616450
32.

Emerging Unit Operations (Session III): Hydroxyapatite, Mixed-Mode, and Adsorptive Membrane Chromatography; UV-C Inactivation; Chemical Precipitation.

Hubbard B, Roush D.

PDA J Pharm Sci Technol. 2014 Jan-Feb;68(1):51-65. doi: 10.5731/pdajpst.2014.00966. No abstract available.

PMID:
24504236
33.

Viral Clearance Using Traditional, Well-Understood Unit Operations (Session I): Anion Exchange Chromatography (AEX).

Roush D.

PDA J Pharm Sci Technol. 2014 Jan-Feb;68(1):23-9. doi: 10.5731/pdajpst.2014.00963. No abstract available.

PMID:
24504233
34.

Proceedings of the 2009 Viral Clearance Symposium.

Miesegaes G, Bailey M, Willkommen H, Chen Q, Roush D, Blümel J, Brorson K.

Dev Biol (Basel). 2010;133:3-101.

PMID:
21516942
35.

Virus filtration of high-concentration monoclonal antibody solutions.

Marques BF, Roush DJ, Göklen KE.

Biotechnol Prog. 2009 Mar-Apr;25(2):483-91. doi: 10.1002/btpr.177.

PMID:
19353736
36.

Advances in primary recovery: centrifugation and membrane technology.

Roush DJ, Lu Y.

Biotechnol Prog. 2008 May-Jun;24(3):488-95. doi: 10.1021/bp070414x. Epub 2008 Apr 15. Review.

PMID:
18410157
37.

Maximizing productivity of chromatography steps for purification of monoclonal antibodies.

Tugcu N, Roush DJ, Göklen KE.

Biotechnol Bioeng. 2008 Feb 15;99(3):599-613.

PMID:
17680666
38.

Influence of mobile phase composition and thermodynamics on the normal phase chromatography of echinocandins.

Roush DJ, Hwang LY, Antia FD.

J Chromatogr A. 2005 Dec 9;1098(1-2):55-65. Epub 2005 Aug 31.

PMID:
16314161
39.
40.

Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity.

Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6494-9.

42.

Future Land Use and Concerns About the Idaho National Engineering and Environmental Laboratory: A Survey of Urban Dwellers.

Burger J, Roush D, Wartenberg D, Gochfeld M.

Environ Manage. 1999 Nov;24(4):532-542.

PMID:
10501866
43.

Sorting of P-type ATPases in polarized epithelial cells.

Dunbar LA, Courtois-Coutry N, Roush DL, Muth TR, Gottardi CJ, Rajendran V, Geibel J, Kashgarian M, Caplan MJ.

Acta Physiol Scand Suppl. 1998 Aug;643:289-95. Review.

PMID:
9789572
44.
45.

A basolateral sorting signal is encoded in the alpha-subunit of Na-K-ATPase.

Muth TR, Gottardi CJ, Roush DL, Caplan MJ.

Am J Physiol. 1998 Mar;274(3):C688-96. doi: 10.1152/ajpcell.1998.274.3.C688.

PMID:
9530100
46.

Sorting of ion pumps in polarized epithelial cells.

Dunbar LA, Roush DL, Courtois-Coutry N, Muth TR, Gottardi CJ, Rajendran V, Geibel J, Kashgarian M, Caplan MJ.

Ann N Y Acad Sci. 1997 Nov 3;834:514-23. No abstract available.

PMID:
9405853
47.

Sorting and trafficking of ion transport proteins in polarized epithelial cells.

Muth TR, Dunbar LA, Cortois-Coutry N, Roush DL, Caplan MJ.

Curr Opin Nephrol Hypertens. 1997 Sep;6(5):455-9. Review.

PMID:
9327204
48.

Efficacy of clean v sterile surgical prep kits.

Pearce BA, Miller LH, Martin MA, Roush DL.

AORN J. 1997 Sep;66(3):464-70.

PMID:
9293327
49.

A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion.

Courtois-Coutry N, Roush D, Rajendran V, McCarthy JB, Geibel J, Kashgarian M, Caplan MJ.

Cell. 1997 Aug 8;90(3):501-10.

50.

Survey: how's your ethics education?

Roush DL, Dowell DK.

Am J Nurs. 1997 Feb;97(2):16T, 16V. No abstract available.

PMID:
11644895

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