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Items: 46


T cell-mediated regulation of the microbiota protects against obesity.

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL.

Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351.


The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling.

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL.

Elife. 2019 Jul 16;8. pii: e47117. doi: 10.7554/eLife.47117.


Does MHC heterozygosity influence microbiota form and function?

Khan MAW, Stephens WZ, Mohammed AD, Round JL, Kubinak JL.

PLoS One. 2019 May 16;14(5):e0215946. doi: 10.1371/journal.pone.0215946. eCollection 2019.


Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM.

PLoS Genet. 2019 Feb 15;15(2):e1007970. doi: 10.1371/journal.pgen.1007970. eCollection 2019 Feb.


Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL.

Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8. doi: 10.1016/j.chom.2019.01.008.


MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers.

Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, O'Connell RM.

JCI Insight. 2019 Mar 21;4(6). pii: 126543. doi: 10.1172/jci.insight.126543. eCollection 2019 Mar 21.


Fiber Puts Lactobacillus to SLEep.

Chiaro TR, Round JL.

Cell Host Microbe. 2019 Jan 9;25(1):3-5. doi: 10.1016/j.chom.2018.12.012.


Gut microbiota: a new way to take your vitamins.

Gomes-Neto JC, Round JL.

Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):521-522. doi: 10.1038/s41575-018-0044-3. No abstract available.


Communication Between the Microbiota and Mammalian Immunity.

Ost KS, Round JL.

Annu Rev Microbiol. 2018 Sep 8;72:399-422. doi: 10.1146/annurev-micro-090817-062307. Epub 2018 Jun 21. Review.


Commensal regulation of T cell survival through Erdr1.

Weis AM, Soto R, Round JL.

Gut Microbes. 2018;9(5):458-464. doi: 10.1080/19490976.2018.1441662. Epub 2018 Apr 11. Review.


Causal effects of the microbiota on immune-mediated diseases.

Round JL, Palm NW.

Sci Immunol. 2018 Feb 9;3(20). pii: eaao1603. doi: 10.1126/sciimmunol.aao1603. Review.


Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model.

Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami RS.

Benef Microbes. 2018 Apr 25;9(3):495-513. doi: 10.3920/BM2017.0116. Epub 2018 Jan 30.


IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis.

Whiteside SK, Snook JP, Ma Y, Sonderegger FL, Fisher C, Petersen C, Zachary JF, Round JL, Williams MA, Weis JJ.

J Immunol. 2018 Feb 15;200(4):1457-1470. doi: 10.4049/jimmunol.1701248. Epub 2018 Jan 12.


Friends in Low Places: Intestinal Commensals Limit Colitis through Molecular Mimicry.

Brown DG, Round JL.

Cell. 2017 Oct 19;171(3):503-505. doi: 10.1016/j.cell.2017.09.053.


Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.

Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

J Immunol. 2017 Nov 15;199(10):3559-3570. doi: 10.4049/jimmunol.1700904. Epub 2017 Oct 4.


Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.

Huffaker TB, Lee SH, Tang WW, Wallace JA, Alexander M, Runtsch MC, Larsen DK, Thompson J, Ramstead AG, Voth WP, Hu R, Round JL, Williams MA, O'Connell RM.

J Biol Chem. 2017 Nov 10;292(45):18530-18541. doi: 10.1074/jbc.M117.808121. Epub 2017 Sep 14.


A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella.

Ost KS, Round JL.

Immunity. 2017 Jun 20;46(6):977-979. doi: 10.1016/j.immuni.2017.06.010.


Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.

Soto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE, Fujinami RS, Bosque A, O'Connell RM, Round JL.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5497-5502. doi: 10.1073/pnas.1619336114. Epub 2017 May 9.


miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response.

Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander M, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth WP, Rao DS, Miles RR, Round JL, Deininger MW, O'Connell RM.

Blood. 2017 Jun 8;129(23):3074-3086. doi: 10.1182/blood-2016-09-740209. Epub 2017 Apr 21.


A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice.

Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round JL.

Sci Transl Med. 2017 Mar 8;9(380). pii: eaaf9044. doi: 10.1126/scitranslmed.aaf9044. Erratum in: Sci Transl Med. 2017 May 3;9(388):.


Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity.

Biswas S, McCullough BS, Ma ES, LaJoie D, Russell CW, Garrett Brown D, Round JL, Ullman KS, Mulvey MA, Barrios AM.

Chem Commun (Camb). 2017 Feb 14;53(14):2233-2236. doi: 10.1039/c6cc09204g.


Do antibodies select a healthy microbiota?

Kubinak JL, Round JL.

Nat Rev Immunol. 2016 Dec;16(12):767-774. doi: 10.1038/nri.2016.114. Epub 2016 Nov 7. Review.


The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability.

Libbey JE, Doty DJ, Sim JT, Cusick MF, Round JL, Fujinami RS.

Nutrition. 2016 Jul-Aug;32(7-8):877-83. doi: 10.1016/j.nut.2016.01.009. Epub 2016 Jan 21.


Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth.

Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM.

PLoS One. 2016 Apr 15;11(4):e0153689. doi: 10.1371/journal.pone.0153689. eCollection 2016.


MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection.

Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL.

Nat Commun. 2015 Oct 23;6:8642. doi: 10.1038/ncomms9642.


MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis.

Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell RM.

Oncotarget. 2015 Oct 6;6(30):28556-72.


Innate-like lymphocytes in intestinal infections.

Bennett MS, Round JL, Leung DT.

Curr Opin Infect Dis. 2015 Oct;28(5):457-63. doi: 10.1097/QCO.0000000000000189. Review.


Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.

Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

Nat Commun. 2015 Jun 18;6:7321. doi: 10.1038/ncomms8321.


MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health.

Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O'Connell RM, Round JL.

Cell Host Microbe. 2015 Feb 11;17(2):153-63. doi: 10.1016/j.chom.2014.12.009. Epub 2015 Jan 22.


miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM.

Immunity. 2014 Oct 16;41(4):605-19. doi: 10.1016/j.immuni.2014.09.015.


MicroRNAs and the regulation of intestinal homeostasis.

Runtsch MC, Round JL, O'Connell RM.

Front Genet. 2014 Oct 1;5:347. doi: 10.3389/fgene.2014.00347. eCollection 2014. Review.


IgA targets the troublemakers.

Stephens WZ, Round JL.

Cell Host Microbe. 2014 Sep 10;16(3):265-7. doi: 10.1016/j.chom.2014.08.012.


Defining dysbiosis and its influence on host immunity and disease.

Petersen C, Round JL.

Cell Microbiol. 2014 Jul;16(7):1024-33. doi: 10.1111/cmi.12308. Epub 2014 Jun 2. Review.


Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation.

Novis CL, Archin NM, Buzon MJ, Verdin E, Round JL, Lichterfeld M, Margolis DM, Planelles V, Bosque A.

Retrovirology. 2013 Oct 24;10:119. doi: 10.1186/1742-4690-10-119.


MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression.

Hu R, Huffaker TB, Kagele DA, Runtsch MC, Bake E, Chaudhuri AA, Round JL, O'Connell RM.

J Immunol. 2013 Jun 15;190(12):5972-80. doi: 10.4049/jimmunol.1300351. Epub 2013 May 17.


Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity.

Huffaker TB, Hu R, Runtsch MC, Bake E, Chen X, Zhao J, Round JL, Baltimore D, O'Connell RM.

Cell Rep. 2012 Dec 27;2(6):1697-709. doi: 10.1016/j.celrep.2012.10.025. Epub 2012 Nov 29.


Characterization of in vivo Dlg1 deletion on T cell development and function.

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.

PLoS One. 2012;7(9):e45276. doi: 10.1371/journal.pone.0045276. Epub 2012 Sep 18.


Toll-like receptors promote mutually beneficial commensal-host interactions.

Kubinak JL, Round JL.

PLoS Pathog. 2012;8(7):e1002785. doi: 10.1371/journal.ppat.1002785. Epub 2012 Jul 26. Review. No abstract available.


The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota.

Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK.

Science. 2011 May 20;332(6032):974-7. doi: 10.1126/science.1206095. Epub 2011 Apr 21.


MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.

O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D.

Immunity. 2010 Oct 29;33(4):607-19. doi: 10.1016/j.immuni.2010.09.009. Epub 2010 Sep 30.


Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.

Round JL, Mazmanian SK.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9. doi: 10.1073/pnas.0909122107. Epub 2010 Jun 21.


Coordination of tolerogenic immune responses by the commensal microbiota.

Round JL, O'Connell RM, Mazmanian SK.

J Autoimmun. 2010 May;34(3):J220-5. doi: 10.1016/j.jaut.2009.11.007. Epub 2009 Dec 6. Review.


The gut microbiota shapes intestinal immune responses during health and disease.

Round JL, Mazmanian SK.

Nat Rev Immunol. 2009 May;9(5):313-23. doi: 10.1038/nri2515. Review. Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600.


A microbial symbiosis factor prevents intestinal inflammatory disease.

Mazmanian SK, Round JL, Kasper DL.

Nature. 2008 May 29;453(7195):620-5. doi: 10.1038/nature07008.


Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.

Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC.

Nat Immunol. 2007 Feb;8(2):154-61. Epub 2006 Dec 24.


Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.

Round JL, Tomassian T, Zhang M, Patel V, Schoenberger SP, Miceli MC.

J Exp Med. 2005 Feb 7;201(3):419-30.

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