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Items: 1 to 50 of 61

1.

Anti-Helicobacter pylori activity of ethoxzolamide.

Modak JK, Tikhomirova A, Gorrell RJ, Rahman MM, Kotsanas D, Korman TM, Garcia-Bustos J, Kwok T, Ferrero RL, Supuran CT, Roujeinikova A.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1660-1667. doi: 10.1080/14756366.2019.1663416.

2.

Molecular Basis of Unexpected Specificity of ABC Transporter-Associated Substrate-Binding Protein DppA from Helicobacter pylori.

Rahman MM, Machuca MA, Khan MF, Barlow CK, Schittenhelm RB, Roujeinikova A.

J Bacteriol. 2019 Sep 20;201(20). pii: e00400-19. doi: 10.1128/JB.00400-19. Print 2019 Oct 15.

PMID:
31358613
3.

Preliminary X-ray crystallographic studies on the Helicobacter pylori ABC transporter glutamine-binding protein GlnH.

Rahman MM, Machuca MA, Roujeinikova A.

Drug Discov Ther. 2019;13(1):52-58. doi: 10.5582/ddt.2019.01008.

4.

Purification, crystallization and preliminary X-ray crystallographic studies on the C-terminal domain of the flagellar protein FliL from Helicobacter pylori.

Chan KL, Machuca MA, Rahman MM, Khan MF, Andrews D, Roujeinikova A.

Biosci Trends. 2018;12(6):630-635. doi: 10.5582/bst.2018.01218.

5.

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain.

Machuca MA, Roujeinikova A.

J Vis Exp. 2017 Dec 12;(130). doi: 10.3791/57092.

PMID:
29286481
6.

Flagellin glycosylation with pseudaminic acid in Campylobacter and Helicobacter: prospects for development of novel therapeutics.

Salah Ud-Din AIM, Roujeinikova A.

Cell Mol Life Sci. 2018 Apr;75(7):1163-1178. doi: 10.1007/s00018-017-2696-5. Epub 2017 Oct 27. Review.

PMID:
29080090
7.

Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate.

Machuca MA, Johnson KS, Liu YC, Steer DL, Ottemann KM, Roujeinikova A.

Sci Rep. 2017 Oct 26;7(1):14089. doi: 10.1038/s41598-017-14372-2.

8.

Structural analysis of variant of Helicobacter pylori MotB in its activated form, engineered as chimera of MotB and leucine zipper.

Andrews DA, Nesmelov YE, Wilce MC, Roujeinikova A.

Sci Rep. 2017 Oct 18;7(1):13435. doi: 10.1038/s41598-017-13421-0.

9.

The Middle Fragment of Helicobacter pylori CagA Induces Actin Rearrangement and Triggers Its Own Uptake into Gastric Epithelial Cells.

Tohidpour A, Gorrell RJ, Roujeinikova A, Kwok T.

Toxins (Basel). 2017 Jul 28;9(8). pii: E237. doi: 10.3390/toxins9080237.

10.

Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea.

Salah Ud-Din AIM, Roujeinikova A.

Cell Mol Life Sci. 2017 Sep;74(18):3293-3303. doi: 10.1007/s00018-017-2514-0. Epub 2017 Apr 13. Review.

PMID:
28409190
11.
12.

Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori α-Carbonic Anhydrase.

Modak JK, Liu YC, Supuran CT, Roujeinikova A.

J Med Chem. 2016 Dec 22;59(24):11098-11109. doi: 10.1021/acs.jmedchem.6b01333. Epub 2016 Dec 8.

PMID:
28002963
13.

Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT).

Salah Ud-Din AI, Tikhomirova A, Roujeinikova A.

Int J Mol Sci. 2016 Jun 28;17(7). pii: E1018. doi: 10.3390/ijms17071018. Review.

14.
15.

The periplasmic sensing domain of Vibrio fischeri chemoreceptor protein A (VfcA): cloning, purification and crystallographic analysis.

Salah Ud-Din AI, Roujeinikova A.

Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):382-5. doi: 10.1107/S2053230X16005902. Epub 2016 Apr 22.

16.

The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition.

Machuca MA, Liu YC, Beckham SA, Gunzburg MJ, Roujeinikova A.

J Struct Biol. 2016 May;194(2):205-13. doi: 10.1016/j.jsb.2016.02.019. Epub 2016 Feb 24.

PMID:
26923153
17.

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase.

Modak JK, Rut W, Wijeyewickrema LC, Pike RN, Drag M, Roujeinikova A.

Biochimie. 2016 Feb;121:60-71. doi: 10.1016/j.biochi.2015.11.021. Epub 2015 Dec 1.

PMID:
26616008
18.

Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains.

Liu YC, Machuca MA, Beckham SA, Gunzburg MJ, Roujeinikova A.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2127-36. doi: 10.1107/S139900471501384X. Epub 2015 Sep 30.

PMID:
26457436
19.

Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides.

Modak JK, Liu YC, Machuca MA, Supuran CT, Roujeinikova A.

PLoS One. 2015 May 26;10(5):e0127149. doi: 10.1371/journal.pone.0127149. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0132763. Modakh, Joyanta K [corrected to Modak, Joyanta K].

20.

Crystal structure of Helicobacter pylori pseudaminic acid biosynthesis N-acetyltransferase PseH: implications for substrate specificity and catalysis.

Ud-Din AI, Liu YC, Roujeinikova A.

PLoS One. 2015 Mar 17;10(3):e0115634. doi: 10.1371/journal.pone.0115634. eCollection 2015.

21.

Cloning, refolding, purification and preliminary crystallographic analysis of the sensory domain of the Campylobacter chemoreceptor for multiple ligands (CcmL).

Machuca MA, Liu YC, Beckham SA, Roujeinikova A.

Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):211-6. doi: 10.1107/S2053230X1500045X. Epub 2015 Jan 28.

22.

Cloning, expression, refolding, purification and preliminary crystallographic analysis of the sensory domain of the Campylobacter chemoreceptor for aspartate A (CcaA).

Machuca MA, Liu YC, Roujeinikova A.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):110-3. doi: 10.1107/S2053230X14027381. Epub 2015 Jan 1.

23.

Expression, refolding, purification and crystallization of the sensory domain of the TlpC chemoreceptor from Helicobacter pylori for structural studies.

Liu YC, Roujeinikova A.

Protein Expr Purif. 2015 Mar;107:29-34. doi: 10.1016/j.pep.2014.11.003. Epub 2014 Nov 21.

PMID:
25462804
24.

Cloning, purification and preliminary crystallographic analysis of the Helicobacter pylori pseudaminic acid biosynthesis N-acetyltransferase PseH.

Liu YC, Ud-Din AI, Roujeinikova A.

Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1276-9. doi: 10.1107/S2053230X14015398. Epub 2014 Aug 27.

25.

Purification and biochemical characterization of DnaK and its transcriptional activator RpoH from Neisseria gonorrhoeae.

Narayanan S, Beckham SA, Davies JK, Roujeinikova A.

Mol Biol Rep. 2014 Dec;41(12):7945-53. doi: 10.1007/s11033-014-3689-1. Epub 2014 Aug 26.

PMID:
25156536
26.
27.

Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB.

Alonso H, Kleifeld O, Yeheskel A, Ong PC, Liu YC, Stok JE, De Voss JJ, Roujeinikova A.

Biochem J. 2014 Jun 1;460(2):283-93. doi: 10.1042/BJ20131648.

PMID:
24646189
28.

Mechanism of Escherichia coli resistance to Pyrrhocoricin.

Narayanan S, Modak JK, Ryan CS, Garcia-Bustos J, Davies JK, Roujeinikova A.

Antimicrob Agents Chemother. 2014 May;58(5):2754-62. doi: 10.1128/AAC.02565-13. Epub 2014 Mar 3.

29.

Conformational analysis of isolated domains of Helicobacter pylori CagA.

Woon AP, Tohidpour A, Alonso H, Saijo-Hamano Y, Kwok T, Roujeinikova A.

PLoS One. 2013 Nov 1;8(11):e79367. doi: 10.1371/journal.pone.0079367. eCollection 2013.

30.

Cloning, purification and preliminary crystallographic analysis of the complex of Helicobacter pylori α-carbonic anhydrase with acetazolamide.

Modak JK, Revitt-Mills SA, Roujeinikova A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1252-5. doi: 10.1107/S1744309113026146. Epub 2013 Oct 30.

31.

Cloning, purification and preliminary crystallographic analysis of the Helicobacter pylori leucyl aminopeptidase-bestatin complex.

Modak JK, Roujeinikova A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):1011-4. doi: 10.1107/S174430911302054X. Epub 2013 Aug 19.

32.

Design, purification and characterization of a soluble variant of the integral membrane protein MotB for structural studies.

Andrews DA, Xie M, Hughes V, Wilce MC, Roujeinikova A.

J R Soc Interface. 2013 Feb;10(79):20120717. doi: 10.1098/rsif.2012.0717.

33.

Characterization and two-dimensional crystallization of membrane component AlkB of the medium-chain alkane hydroxylase system from Pseudomonas putida GPo1.

Alonso H, Roujeinikova A.

Appl Environ Microbiol. 2012 Nov;78(22):7946-53. doi: 10.1128/AEM.02053-12. Epub 2012 Aug 31.

34.

Role of the MotB linker in the assembly and activation of the bacterial flagellar motor.

O'Neill J, Xie M, Hijnen M, Roujeinikova A.

Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1009-16. doi: 10.1107/S0907444911041102. Epub 2011 Nov 5.

PMID:
22120737
35.

Structural analysis of the essential resuscitation promoting factor YeaZ suggests a mechanism of nucleotide regulation through dimer reorganization.

Aydin I, Saijo-Hamano Y, Namba K, Thomas C, Roujeinikova A.

PLoS One. 2011;6(8):e23245. doi: 10.1371/journal.pone.0023245. Epub 2011 Aug 17.

36.

An improved procedure for the purification of catalytically active alkane hydroxylase from Pseudomonas putida GPo1.

Xie M, Alonso H, Roujeinikova A.

Appl Biochem Biotechnol. 2011 Oct;165(3-4):823-31. doi: 10.1007/s12010-011-9300-5. Epub 2011 Jun 7.

PMID:
21647685
37.

Purification, crystallization and preliminary X-ray crystallographic analysis of the putative Vibrio parahaemolyticus resuscitation-promoting factor YeaZ.

Aydin I, Dimitropoulos A, Chen SH, Thomas C, Roujeinikova A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):604-7. doi: 10.1107/S1744309111010219. Epub 2011 Apr 28.

38.

Crystallographic and molecular dynamics analysis of loop motions unmasking the peptidoglycan-binding site in stator protein MotB of flagellar motor.

Reboul CF, Andrews DA, Nahar MF, Buckle AM, Roujeinikova A.

PLoS One. 2011 Apr 20;6(4):e18981. doi: 10.1371/journal.pone.0018981.

39.

Allosteric coupling between the lid and interdomain linker in DnaK revealed by inhibitor binding studies.

Liebscher M, Roujeinikova A.

J Bacteriol. 2009 Mar;191(5):1456-62. doi: 10.1128/JB.01131-08. Epub 2008 Dec 19.

40.

Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex.

Hothi P, Hay S, Roujeinikova A, Sutcliffe MJ, Lee M, Leys D, Cullis PM, Scrutton NS.

Chembiochem. 2008 Nov 24;9(17):2839-45. doi: 10.1002/cbic.200800408.

PMID:
19012287
41.

Structure-Based Insight into the Asymmetric Bioreduction of the C=C Double Bond of alpha,beta-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase.

Toogood HS, Fryszkowska A, Hare V, Fisher K, Roujeinikova A, Leys D, Gardiner JM, Stephens GM, Scrutton NS.

Adv Synth Catal. 2008 Nov 17;350(17):2789-2803.

42.

Crystal structure of the cell wall anchor domain of MotB, a stator component of the bacterial flagellar motor: implications for peptidoglycan recognition.

Roujeinikova A.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10348-53. doi: 10.1073/pnas.0803039105. Epub 2008 Jul 22.

43.

Cloning, purification and crystallization of MotB, a stator component of the proton-driven bacterial flagellar motor.

O'Neill J, Roujeinikova A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):561-3. doi: 10.1107/S1744309108012219. Epub 2008 May 30.

44.

Cloning, purification and preliminary X-ray analysis of the C-terminal domain of Helicobacter pylori MotB.

Roujeinikova A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt 4):277-80. doi: 10.1107/S1744309108005277. Epub 2008 Mar 21.

45.

Isotope effects reveal that para-substituted benzylamines are poor reactivity probes of the quinoprotein mechanism for aromatic amine dehydrogenase.

Hothi P, Roujeinikova A, Khadra KA, Lee M, Cullis P, Leys D, Scrutton NS.

Biochemistry. 2007 Aug 14;46(32):9250-9. Epub 2007 Jul 18.

PMID:
17636875
46.

New insights into the reductive half-reaction mechanism of aromatic amine dehydrogenase revealed by reaction with carbinolamine substrates.

Roujeinikova A, Hothi P, Masgrau L, Sutcliffe MJ, Scrutton NS, Leys D.

J Biol Chem. 2007 Aug 17;282(33):23766-77. Epub 2007 May 1.

47.

Structural studies of fatty acyl-(acyl carrier protein) thioesters reveal a hydrophobic binding cavity that can expand to fit longer substrates.

Roujeinikova A, Simon WJ, Gilroy J, Rice DW, Rafferty JB, Slabas AR.

J Mol Biol. 2007 Jan 5;365(1):135-45. Epub 2006 Sep 23.

PMID:
17059829
48.

Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.

Seward HE, Roujeinikova A, McLean KJ, Munro AW, Leys D.

J Biol Chem. 2006 Dec 22;281(51):39437-43. Epub 2006 Oct 6.

49.

Atomic level insight into the oxidative half-reaction of aromatic amine dehydrogenase.

Roujeinikova A, Scrutton NS, Leys D.

J Biol Chem. 2006 Dec 29;281(52):40264-72. Epub 2006 Sep 27.

50.

Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.

Sutcliffe MJ, Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Leys D, Scrutton NS.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1375-86. Review.

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