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Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter.

Gillet L, Guichard S, Essers MC, Rougier JS, Abriel H.

Sci Rep. 2019 Dec 19;9(1):19422. doi: 10.1038/s41598-019-55950-w.


Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice.

Casini S, Albesa M, Wang Z, Portero V, Ross-Kaschitza D, Rougier JS, Marchal GA, Chung WK, Bezzina CR, Abriel H, Remme CA.

Int J Mol Sci. 2019 Oct 11;20(20). pii: E5033. doi: 10.3390/ijms20205033.


Functional characterization of a novel SCN5A variant associated with long QT syndrome and sudden cardiac death.

Neubauer J, Wang Z, Rougier JS, Abriel H, Rieubland C, Bartholdi D, Haas C, Medeiros-Domingo A.

Int J Legal Med. 2019 Nov;133(6):1733-1742. doi: 10.1007/s00414-019-02141-x. Epub 2019 Aug 27.


A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes.

Rougier JS, Essers MC, Gillet L, Guichard S, Sonntag S, Shmerling D, Abriel H.

Front Physiol. 2019 Jul 3;10:834. doi: 10.3389/fphys.2019.00834. eCollection 2019.


An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation.

Blancard M, Debbiche A, Kato K, Cardin C, Sabrina G, Gandjbakhch E, Probst V, Haissaguerre M, Extramiana F, Hocini M, Olivier G, Leenhardt A, Guicheney P, Rougier JS.

Sci Rep. 2018 Oct 2;8(1):14619. doi: 10.1038/s41598-018-32867-4.


Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.

Tamò L, Hibaoui Y, Kallol S, Alves MP, Albrecht C, Hostettler KE, Feki A, Rougier JS, Abriel H, Knudsen L, Gazdhar A, Geiser T.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L921-L932. doi: 10.1152/ajplung.00357.2017. Epub 2018 Sep 13.


Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential.

Liu H, He Z, April SL, Trefny MP, Rougier JS, Salemi S, Olariu R, Widmer HR, Simon HU.

Cell Death Differ. 2019 Jun;26(6):1048-1061. doi: 10.1038/s41418-018-0182-8. Epub 2018 Aug 28.


Functional implications of a rare variant in the sodium channel β1B subunit (SCN1B) in a 5-month-old male sudden infant death syndrome case.

Neubauer J, Rougier JS, Abriel H, Haas C.

HeartRhythm Case Rep. 2018 Mar 12;4(5):187-190. doi: 10.1016/j.hrcr.2018.01.010. eCollection 2018 May. No abstract available.


Annotation of functional impact of voltage-gated sodium channel mutations.

Hinard V, Britan A, Schaeffer M, Zahn-Zabal M, Thomet U, Rougier JS, Bairoch A, Abriel H, Gaudet P.

Hum Mutat. 2017 May;38(5):485-493. doi: 10.1002/humu.23191. Epub 2017 Feb 28.


On the use of Bayesian decision theory for issuing natural hazard warnings.

Economou T, Stephenson DB, Rougier JC, Neal RA, Mylne KR.

Proc Math Phys Eng Sci. 2016 Oct;472(2194):20160295.


Calcium/calmodulin-dependent serine protein kinase CASK modulates the L-type calcium current.

Nafzger S, Rougier JS.

Cell Calcium. 2017 Jan;61:10-21. doi: 10.1016/j.ceca.2016.10.001. Epub 2016 Oct 5.


Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes.

Eichel CA, Beuriot A, Chevalier MY, Rougier JS, Louault F, Dilanian G, Amour J, Coulombe A, Abriel H, Hatem SN, Balse E.

Circ Res. 2016 Aug 5;119(4):544-56. doi: 10.1161/CIRCRESAHA.116.309254. Epub 2016 Jun 30.


Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block.

Syam N, Chatel S, Ozhathil LC, Sottas V, Rougier JS, Baruteau A, Baron E, Amarouch MY, Daumy X, Probst V, Schott JJ, Abriel H.

J Am Heart Assoc. 2016 May 20;5(5). pii: e001625. doi: 10.1161/JAHA.114.001625.


ICEPO: the ion channel electrophysiology ontology.

Hinard V, Britan A, Rougier JS, Bairoch A, Abriel H, Gaudet P.

Database (Oxford). 2016 Apr 7;2016. pii: baw017. doi: 10.1093/database/baw017. Print 2016.


Cardiac voltage-gated calcium channel macromolecular complexes.

Rougier JS, Abriel H.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1806-12. doi: 10.1016/j.bbamcr.2015.12.014. Epub 2015 Dec 18. Review.


Uncertainty analysis of a model of wind-blown volcanic plumes.

Woodhouse MJ, Hogg AJ, Phillips JC, Rougier JC.

Bull Volcanol. 2015;77(10):83. Epub 2015 Sep 7.


Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death.

Abriel H, Rougier JS, Jalife J.

Circ Res. 2015 Jun 5;116(12):1971-88. doi: 10.1161/CIRCRESAHA.116.305017. Review.


Multivariate spatio-temporal modelling for assessing Antarctica's present-day contribution to sea-level rise.

Zammit-Mangion A, Rougier J, Schön N, Lindgren F, Bamber J.

Environmetrics. 2015 May;26(3):159-177. Epub 2015 Jan 16.


Outcome of patients with systemic lupus erythematosus on chronic dialysis: an observational study of incident patients of the French National Registry 2002-2012.

Levy B, Couchoud C, Rougier JP, Jourde-Chiche N, Daugas E.

Lupus. 2015 Sep;24(10):1111-21. doi: 10.1177/0961203315578763. Epub 2015 Mar 25.


Resolving the Antarctic contribution to sea-level rise: a hierarchical modelling framework.

Zammit-Mangion A, Rougier J, Bamber J, Schön N.

Environmetrics. 2014 Jun;25(4):245-264. Epub 2013 Dec 26.


Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current.

Gillet L, Rougier JS, Shy D, Sonntag S, Mougenot N, Essers M, Shmerling D, Balse E, Hatem SN, Abriel H.

Heart Rhythm. 2015 Jan;12(1):181-92. doi: 10.1016/j.hrthm.2014.09.057. Epub 2014 Nov 18.


Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels.

Rougier JS, Albesa M, Syam N, Halet G, Abriel H, Viard P.

Pflugers Arch. 2015 Sep;467(9):1919-29. doi: 10.1007/s00424-014-1636-6. Epub 2014 Nov 5.


PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

Shy D, Gillet L, Ogrodnik J, Albesa M, Verkerk AO, Wolswinkel R, Rougier JS, Barc J, Essers MC, Syam N, Marsman RF, van Mil AM, Rotman S, Redon R, Bezzina CR, Remme CA, Abriel H.

Circulation. 2014 Jul 8;130(2):147-60. doi: 10.1161/CIRCULATIONAHA.113.007852. Epub 2014 Jun 3.


Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects.

Syam N, Rougier JS, Abriel H.

Front Cell Neurosci. 2014 Feb 24;8:52. doi: 10.3389/fncel.2014.00052. eCollection 2014.


Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na v1.5 expressed in HEK293 cells.

Reinhard K, Rougier JS, Ogrodnik J, Abriel H.

Version 2. F1000Res. 2013 Feb 13 [revised 2013 Jan 1];2:48. doi: 10.12688/f1000research.2-48.v2. eCollection 2013.


β-blockers in congenital short-QT syndrome as ion channel blockers.

Abriel H, Rougier JS.

J Cardiovasc Electrophysiol. 2013 Oct;24(10):1172-4. doi: 10.1111/jce.12204. Epub 2013 Jul 25. No abstract available.


Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias.

Sottas V, Rougier JS, Jousset F, Kucera JP, Shestak A, Makarov LM, Zaklyazminskaya EV, Abriel H.

J Cardiovasc Electrophysiol. 2013 Sep;24(9):1037-46. doi: 10.1111/jce.12173. Epub 2013 May 20.


'Intractable and unsolved': some thoughts on statistical data assimilation with uncertain static parameters.

Rougier J.

Philos Trans A Math Phys Eng Sci. 2013 Apr 15;371(1991):20120297. doi: 10.1098/rsta.2012.0297. Print 2013 May 28.


Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice.

Rougier JS, Gavillet B, Abriel H.

Front Physiol. 2013 Mar 26;4:51. doi: 10.3389/fphys.2013.00051. eCollection 2013.


LG3 fragment of endorepellin is a possible biomarker of severity in IgA nephropathy.

Surin B, Sachon E, Rougier JP, Steverlynck C, Garreau C, Lelongt B, Ronco P, Piedagnel R.

Proteomics. 2013 Jan;13(1):142-52. doi: 10.1002/pmic.201200267. Epub 2012 Dec 18.


Role of "non-cardiac" voltage-gated sodium channels in cardiac cells.

Rougier JS, Abriel H.

J Mol Cell Cardiol. 2012 Nov;53(5):589-90. doi: 10.1016/j.yjmcc.2012.08.011. Epub 2012 Aug 19. No abstract available.


Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via α-subunit interaction.

Rougier JS, Abriel H.

Cardiovasc Res. 2012 Oct 1;96(1):1-3. doi: 10.1093/cvr/cvs264. Epub 2012 Aug 7. No abstract available.


TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology.

Abriel H, Syam N, Sottas V, Amarouch MY, Rougier JS.

Biochem Pharmacol. 2012 Oct 1;84(7):873-81. doi: 10.1016/j.bcp.2012.06.021. Epub 2012 Jun 27. Review.


[Renal biopsy practice: results of a French study and recommendations].

Bollée G, Moulin B, Martinez F, Meulders Q, Rougier JP, Baumelou A, Glotz D, Subra JF, Ulinski T, Vrigneaud L, Brasseur J, Alhenc-Gelas M, Martin L, Daniel L, Kourilsky O, Deteix P, Sie P, Ronco P, Houillier P; Groupe de travail de la Société de Néphrologie.

Nephrol Ther. 2012 Jun;8(3):168-76. doi: 10.1016/j.nephro.2011.12.005. Epub 2012 Mar 16. French.


Patterns of noncryoglobulinemic glomerulonephritis with monoclonal Ig deposits: correlation with IgG subclass and response to rituximab.

Guiard E, Karras A, Plaisier E, Duong Van Huyen JP, Fakhouri F, Rougier JP, Noel LH, Callard P, Delahousse M, Ronco P.

Clin J Am Soc Nephrol. 2011 Jul;6(7):1609-16. doi: 10.2215/CJN.10611110. Epub 2011 Jun 23.


Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6).

Templin C, Ghadri JR, Rougier JS, Baumer A, Kaplan V, Albesa M, Sticht H, Rauch A, Puleo C, Hu D, Barajas-Martinez H, Antzelevitch C, Lüscher TF, Abriel H, Duru F.

Eur Heart J. 2011 May;32(9):1077-88. doi: 10.1093/eurheartj/ehr076. Epub 2011 Mar 7.


Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels.

Rougier JS, Albesa M, Abriel H, Viard P.

J Biol Chem. 2011 Mar 18;286(11):8829-38. doi: 10.1074/jbc.M110.166520. Epub 2011 Jan 10.


Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice.

Albesa M, Ogrodnik J, Rougier JS, Abriel H.

Cardiovasc Res. 2011 Feb 1;89(2):320-8. doi: 10.1093/cvr/cvq326. Epub 2010 Oct 14.


Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.

Pignier C, Rougier JS, Vié B, Culié C, Verscheure Y, Vacher B, Abriel H, Le Grand B.

Br J Pharmacol. 2010 Sep;161(1):79-91. doi: 10.1111/j.1476-5381.2010.00884.x.


Renal biopsy practice in France: results of a nationwide study.

Bollée G, Martinez F, Moulin B, Meulders Q, Rougier JP, Baumelou A, Glotz D, Subra JF, Ulinski T, Vrigneaud L, Brasseur J, Martin L, Daniel L, Kourilsky O, Deteix P, Sie P, Ronco P, Houillier P.

Nephrol Dial Transplant. 2010 Nov;25(11):3579-85. doi: 10.1093/ndt/gfq254. Epub 2010 May 11.


Ubiquitylation and SUMOylation of cardiac ion channels.

Rougier JS, Albesa M, Abriel H.

J Cardiovasc Pharmacol. 2010 Jul;56(1):22-8. doi: 10.1097/FJC.0b013e3181daaff9. Review.


Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.

Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F.

PLoS One. 2010 Feb 19;5(2):e9298. doi: 10.1371/journal.pone.0009298.


[High cardiovascular complications in systemic lupus erythematosus: physiopathology and risk management].

Boffa JJ, Rougier JP, Noël N, Ronco P.

Nephrol Ther. 2009 Dec;5(7):595-602. doi: 10.1016/j.nephro.2009.06.009. Epub 2009 Sep 4. Review. French.


Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.

Rougier JS, Muller O, Berger S, Centeno G, Schütz G, Firsov D, Abriel H.

Pflugers Arch. 2008 May;456(2):407-12. Epub 2007 Nov 27.


D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease.

Bienaimé F, Clerbaux G, Plaisier E, Mougenot B, Ronco P, Rougier JP.

Am J Kidney Dis. 2007 Nov;50(5):821-5.


ANCA-related crescentic glomerulonephritis in systemic sclerosis: revisiting the "normotensive scleroderma renal crisis".

Arnaud L, Huart A, Plaisier E, Francois H, Mougenot B, Tiev K, Kettaneh A, Ronco P, Rougier JP.

Clin Nephrol. 2007 Sep;68(3):165-70.


Brugada syndrome unmasked by accidental inhalation of gasoline vapors.

Kranjcec D, Bergovec M, Rougier JS, Raguz M, Pavlovic S, Jespersen T, Castella V, Keller DI, Abriel H.

Pacing Clin Electrophysiol. 2007 Oct;30(10):1294-8.


Inference in ensemble experiments.

Rougier J, Sexton DM.

Philos Trans A Math Phys Eng Sci. 2007 Aug 15;365(1857):2133-43.


Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers.

Eap CB, Crettol S, Rougier JS, Schläpfer J, Sintra Grilo L, Déglon JJ, Besson J, Croquette-Krokar M, Carrupt PA, Abriel H.

Clin Pharmacol Ther. 2007 May;81(5):719-28. Epub 2007 Feb 28.


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