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Items: 1 to 50 of 205


Short link N acts as a disease modifying osteoarthritis drug.

Antoniou J, Epure LM, Grant MP, Richard H, Sampalis J, Roughley PJ, Laverty S, Mwale F.

Eur Cell Mater. 2019 May 2;37:347-359. doi: 10.22203/eCM.v037a21.


Short Link N promotes disc repair in a rabbit model of disc degeneration.

Mwale F, Masuda K, Grant MP, Epure LM, Kato K, Miyazaki S, Cheng K, Yamada J, Bae WC, Muehleman C, Roughley PJ, Antoniou J.

Arthritis Res Ther. 2018 Aug 29;20(1):201. doi: 10.1186/s13075-018-1625-9.


Absence of the dermatan sulfate chain of decorin does not affect mouse development.

Moffatt P, Geng Y, Lamplugh L, Nanci A, Roughley PJ.

J Negat Results Biomed. 2017 Apr 17;16(1):7. doi: 10.1186/s12952-017-0074-3.


Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis.

Mort JS, Geng Y, Fisher WD, Roughley PJ.

BMC Musculoskelet Disord. 2016 Feb 18;17:89. doi: 10.1186/s12891-016-0944-8.


Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor.

Rosenzweig DH, Gawri R, Moir J, Beckman L, Eglin D, Steffen T, Roughley PJ, Ouellet JA, Haglund L.

Eur Cell Mater. 2016 Jan 5;31:26-39.


TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs.

Walter BA, Likhitpanichkul M, Illien-Junger S, Roughley PJ, Hecht AC, Iatridis JC.

PLoS One. 2015 Mar 3;10(3):e0118358. doi: 10.1371/journal.pone.0118358. eCollection 2015.


Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability.

Purmessur D, Cornejo MC, Cho SK, Roughley PJ, Linhardt RJ, Hecht AC, Iatridis JC.

Spine J. 2015 May 1;15(5):1060-9. doi: 10.1016/j.spinee.2015.02.003. Epub 2015 Feb 7.


The role of aggrecan in normal and osteoarthritic cartilage.

Roughley PJ, Mort JS.

J Exp Orthop. 2014 Dec;1(1):8. doi: 10.1186/s40634-014-0008-7. Epub 2014 Jul 16.


The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism.

Roughley PJ, Geng Y, Mort JS.

Eur Cell Mater. 2014 Sep 12;28:129-36; discussion 136.


Acute mechanical injury of the human intervertebral disc: link to degeneration and pain.

Alkhatib B, Rosenzweig DH, Krock E, Roughley PJ, Beckman L, Steffen T, Weber MH, Ouellet JA, Haglund L.

Eur Cell Mater. 2014 Sep 12;28:98-110; discussion 110-1.


Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1.

Ho YY, Baron M, Recklies AD, Roughley PJ, Mort JS.

BBA Clin. 2014 Jan 8;1:2-11. doi: 10.1016/j.bbacli.2013.12.001. eCollection 2014 Jun.


Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.

Illien-Jünger S, Lu Y, Purmessur D, Mayer JE, Walter BA, Roughley PJ, Qureshi SA, Hecht AC, Iatridis JC.

Spine J. 2014 Nov 1;14(11):2724-32. doi: 10.1016/j.spinee.2014.04.017. Epub 2014 Apr 24.


Metabolic Effects of Angulation, Compression, and Reduced Mobility on Annulus Fibrosis in a Model of Altered Mechanical Environment in Scoliosis.

Stokes IA, McBride CA, Aronsson DD, Roughley PJ.

Spine Deform. 2013 May;1(3):161-170. doi: 10.1016/j.jspd.2013.02.001. Epub 2013 Jun 6.


A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift.

Purmessur D, Walter BA, Roughley PJ, Laudier DM, Hecht AC, Iatridis J.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):151-6. doi: 10.1016/j.bbrc.2013.02.034. Epub 2013 Feb 22.


Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.

Lee HY, Han L, Roughley PJ, Grodzinsky AJ, Ortiz C.

J Struct Biol. 2013 Mar;181(3):264-73. doi: 10.1016/j.jsb.2012.12.008. Epub 2012 Dec 25.


The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells.

Antoniou J, Wang HT, Alaseem AM, Haglund L, Roughley PJ, Mwale F.

Arthritis Res Ther. 2012 Dec 10;14(6):R267. doi: 10.1186/ar4113.


The effects of chlorhexidine graft decontamination on tendon graft collagen and cell viability.

Alomar AZ, Gawri R, Roughley PJ, Haglund L, Burman M.

Am J Sports Med. 2012 Jul;40(7):1646-53. doi: 10.1177/0363546512443808. Epub 2012 Apr 20.


Extracellular matrix composition in COPD.

Annoni R, Lanças T, Yukimatsu Tanigawa R, de Medeiros Matsushita M, de Morais Fernezlian S, Bruno A, Fernando Ferraz da Silva L, Roughley PJ, Battaglia S, Dolhnikoff M, Hiemstra PS, Sterk PJ, Rabe KF, Mauad T.

Eur Respir J. 2012 Dec;40(6):1362-73. doi: 10.1183/09031936.00192611. Epub 2012 Apr 10.


Analysis of aggrecan catabolism by immunoblotting and immunohistochemistry.

Roughley PJ, Mort JS.

Methods Mol Biol. 2012;836:219-37. doi: 10.1007/978-1-61779-498-8_15.


The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration.

Mwale F, Masuda K, Pichika R, Epure LM, Yoshikawa T, Hemmad A, Roughley PJ, Antoniou J.

Arthritis Res Ther. 2011 Jul 25;13(4):R120. doi: 10.1186/ar3423.


Intervertebral disc changes with angulation, compression and reduced mobility simulating altered mechanical environment in scoliosis.

Stokes IA, McBride C, Aronsson DD, Roughley PJ.

Eur Spine J. 2011 Oct;20(10):1735-44. doi: 10.1007/s00586-011-1868-5. Epub 2011 Jun 26.


Calcification in human intervertebral disc degeneration and scoliosis.

Hristova GI, Jarzem P, Ouellet JA, Roughley PJ, Epure LM, Antoniou J, Mwale F.

J Orthop Res. 2011 Dec;29(12):1888-95. doi: 10.1002/jor.21456. Epub 2011 May 16.


Complex loading affects intervertebral disc mechanics and biology.

Walter BA, Korecki CL, Purmessur D, Roughley PJ, Michalek AJ, Iatridis JC.

Osteoarthritis Cartilage. 2011 Aug;19(8):1011-8. doi: 10.1016/j.joca.2011.04.005. Epub 2011 Apr 22.


Development of an organ culture system for long-term survival of the intact human intervertebral disc.

Gawri R, Mwale F, Ouellet J, Roughley PJ, Steffen T, Antoniou J, Haglund L.

Spine (Phila Pa 1976). 2011 Oct 15;36(22):1835-42. doi: 10.1097/BRS.0b013e3181f81314.


Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development.

Moffatt P, Lee ER, St-Jacques B, Matsumoto K, Yamaguchi Y, Roughley PJ.

Dev Dyn. 2011 Feb;240(2):404-12. doi: 10.1002/dvdy.22529. Epub 2011 Jan 3.


Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.

Durigova M, Troeberg L, Nagase H, Roughley PJ, Mort JS.

Eur Cell Mater. 2011 Jan 12;21:31-45.


The role of hyaluronan produced by Has2 gene expression in development of the spine.

Roughley PJ, Lamplugh L, Lee ER, Matsumoto K, Yamaguchi Y.

Spine (Phila Pa 1976). 2011 Jun 15;36(14):E914-20. doi: 10.1097/BRS.0b013e3181f1e84f.


MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.

Durigova M, Nagase H, Mort JS, Roughley PJ.

Matrix Biol. 2011 Mar;30(2):145-53. doi: 10.1016/j.matbio.2010.10.007. Epub 2010 Nov 3.


Region-dependent aggrecan degradation patterns in the rat intervertebral disc are affected by mechanical loading in vivo.

latridis JC, Godburn K, Wuertz K, Alini M, Roughley PJ.

Spine (Phila Pa 1976). 2011 Feb 1;36(3):203-9. doi: 10.1097/BRS.0b013e3181cec247.


A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.

Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2054-9. doi: 10.1073/pnas.0910875107. Epub 2009 Dec 22.


Improved bioengineered cartilage tissue formation following cyclic compression is dependent on upregulation of MT1-MMP.

De Croos JN, Roughley PJ, Kandel RA.

J Orthop Res. 2010 Jul;28(7):921-7. doi: 10.1002/jor.21064.


In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression.

Wuertz K, Godburn K, MacLean JJ, Barbir A, Donnelly JS, Roughley PJ, Alini M, Iatridis JC.

J Orthop Res. 2009 Sep;27(9):1235-42. doi: 10.1002/jor.20867.


Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues.

Melrose J, Fuller ES, Roughley PJ, Smith MM, Kerr B, Hughes CE, Caterson B, Little CB.

Arthritis Res Ther. 2008;10(4):R79. doi: 10.1186/ar2453. Epub 2008 Jul 14.


Lumican inhibits collagen deposition in tissue engineered cartilage.

Kafienah W, Cheung FL, Sims T, Martin I, Miot S, Von Ruhland C, Roughley PJ, Hollander AP.

Matrix Biol. 2008 Jul;27(6):526-34. doi: 10.1016/j.matbio.2008.04.002. Epub 2008 Apr 24.


Cartilage in normal and osteoarthritis conditions.

Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ.

Best Pract Res Clin Rheumatol. 2008 Apr;22(2):351-84. doi: 10.1016/j.berh.2008.02.001. Review.


Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.

Durigova M, Soucy P, Fushimi K, Nagase H, Mort JS, Roughley PJ.

Osteoarthritis Cartilage. 2008 Oct;16(10):1245-52. doi: 10.1016/j.joca.2008.02.013. Epub 2008 Mar 26.


In vivo intervertebral disc remodeling: kinetics of mRNA expression in response to a single loading event.

MacLean JJ, Roughley PJ, Monsey RD, Alini M, Iatridis JC.

J Orthop Res. 2008 May;26(5):579-88. doi: 10.1002/jor.20560.


Identification of beta1 integrin as mediator of melanoma cell adhesion to lumican.

D'Onofrio MF, Brézillon S, Baranek T, Perreau C, Roughley PJ, Maquart FX, Wegrowski Y.

Biochem Biophys Res Commun. 2008 Jan 11;365(2):266-72. Epub 2007 Nov 5.


Measurement of glycosaminoglycan release from cartilage explants.

Mort JS, Roughley PJ.

Methods Mol Med. 2007;135:201-9.


Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs.

Melrose J, Smith SM, Fuller ES, Young AA, Roughley PJ, Dart A, Little CB.

Eur Spine J. 2007 Dec;16(12):2193-205. Epub 2007 Sep 25.


WITHDRAWN: PUBLISHED IN ERROR BY PUBLISHER: Lumican core protein increases melanoma cell adhesion through a beta 1-type integrin receptor.

D'Onofrio MF, Brézillon S, Baranek T, Perreau C, Radwanska A, Brassart B, Roughley PJ, Malicka-Blaszkiewicz M, Ricard-Blum S, Maquart FX, Wegrowski Y.

J Biol Chem. 2007 Dec 12. [Epub ahead of print]


Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M.

Durigova M, Roughley PJ, Mort JS.

Osteoarthritis Cartilage. 2008 Jan;16(1):98-104. Epub 2007 Jun 18.


The structure and function of cartilage proteoglycans.

Roughley PJ.

Eur Cell Mater. 2006 Nov 30;12:92-101. Review.


The consequence of PRELP overexpression on skin.

Grover J, Lee ER, Mounkes LC, Stewart CL, Roughley PJ.

Matrix Biol. 2007 Mar;26(2):140-3. Epub 2006 Oct 20.


Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans.

Marini JC, Forlino A, Cabral WA, Barnes AM, San Antonio JD, Milgrom S, Hyland JC, Körkkö J, Prockop DJ, De Paepe A, Coucke P, Symoens S, Glorieux FH, Roughley PJ, Lund AM, Kuurila-Svahn K, Hartikka H, Cohn DH, Krakow D, Mottes M, Schwarze U, Chen D, Yang K, Kuslich C, Troendle J, Dalgleish R, Byers PH.

Hum Mutat. 2007 Mar;28(3):209-21. Review.


SLRP interaction can protect collagen fibrils from cleavage by collagenases.

Geng Y, McQuillan D, Roughley PJ.

Matrix Biol. 2006 Oct;25(8):484-91. Epub 2006 Aug 15.


Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration.

Séguin CA, Bojarski M, Pilliar RM, Roughley PJ, Kandel RA.

Matrix Biol. 2006 Sep;25(7):409-18. Epub 2006 Aug 23.


Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.

Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR.

Matrix Biol. 2006 Sep;25(7):419-29. Epub 2006 Jun 30.


What is intervertebral disc degeneration, and what causes it?

Adams MA, Roughley PJ.

Spine (Phila Pa 1976). 2006 Aug 15;31(18):2151-61. Review.


The cleavage of biglycan by aggrecanases.

Melching LI, Fisher WD, Lee ER, Mort JS, Roughley PJ.

Osteoarthritis Cartilage. 2006 Nov;14(11):1147-54. Epub 2006 Jun 30.

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