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Items: 1 to 50 of 177

1.

Potential role of iron in repair of inflammatory demyelinating lesions.

Lee NJ, Ha SK, Sati P, Absinta M, Nair G, Luciano NJ, Leibovitch EC, Yen CC, Rouault TA, Silva AC, Jacobson S, Reich DS.

J Clin Invest. 2019 Sep 9. pii: 126809. doi: 10.1172/JCI126809. [Epub ahead of print]

2.

Reply: IREB2-associated neurodegeneration.

Maio N, Ghosh MC, Costain G, Carnevale A, Si Y, Yoon G, Rouault TA.

Brain. 2019 Aug 1;142(8):e41. doi: 10.1093/brain/awz185. No abstract available.

PMID:
31243430
3.

Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.

Aerbajinai W, Ghosh MC, Liu J, Kumkhaek C, Zhu J, Chin K, Rouault TA, Rodgers GP.

Blood Adv. 2019 Apr 23;3(8):1211-1225. doi: 10.1182/bloodadvances.2018026070.

4.

The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways.

Rouault TA.

Biometals. 2019 Jun;32(3):343-353. doi: 10.1007/s10534-019-00191-7. Epub 2019 Mar 28. Review.

5.

Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome.

Costain G, Ghosh MC, Maio N, Carnevale A, Si YC, Rouault TA, Yoon G.

Brain. 2019 May 1;142(5):1195-1202. doi: 10.1093/brain/awz072.

PMID:
30915432
6.

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA.

Haematologica. 2019 Sep;104(9):1756-1767. doi: 10.3324/haematol.2018.214320. Epub 2019 Feb 14.

7.

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.

Rice CM, Davies LC, Subleski JJ, Maio N, Gonzalez-Cotto M, Andrews C, Patel NL, Palmieri EM, Weiss JM, Lee JM, Annunziata CM, Rouault TA, Durum SK, McVicar DW.

Nat Commun. 2018 Nov 30;9(1):5099. doi: 10.1038/s41467-018-07505-2.

8.

Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice.

Kim KS, Zhang DL, Kovtunovych G, Ghosh MC, Ollivierre H, Eckhaus MA, Rouault TA.

Blood Adv. 2018 Oct 23;2(20):2732-2743. doi: 10.1182/bloodadvances.2018019737.

9.

Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention.

Weiss A, Spektor L, A Cohen L, Lifshitz L, Magid Gold I, Zhang DL, Truman-Rosentsvit M, Leichtmann-Bardoogo Y, Nyska A, Addadi S, Rouault TA, Meyron-Holtz EG.

PLoS One. 2018 Oct 15;13(10):e0204471. doi: 10.1371/journal.pone.0204471. eCollection 2018.

10.

Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress.

Zhang DL, Ghosh MC, Ollivierre H, Li Y, Rouault TA.

Blood. 2018 Nov 8;132(19):2078-2087. doi: 10.1182/blood-2018-04-842997. Epub 2018 Sep 13.

PMID:
30213870
11.

Heme, whence come thy carbon building blocks?

Rouault TA.

Blood. 2018 Sep 6;132(10):981-982. doi: 10.1182/blood-2018-07-864215. No abstract available.

12.

TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation.

Tong WH, Maio N, Zhang DL, Palmieri EM, Ollivierre H, Ghosh MC, McVicar DW, Rouault TA.

Blood Adv. 2018 May 22;2(10):1146-1156. doi: 10.1182/bloodadvances.2018015669.

13.

Methods for Studying Iron Regulatory Protein 1: An Important Protein in Human Iron Metabolism.

Holmes-Hampton GP, Ghosh MC, Rouault TA.

Methods Enzymol. 2018;599:139-155. doi: 10.1016/bs.mie.2017.09.006. Epub 2017 Dec 6.

PMID:
29746238
14.

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

Zhang DL, Wu J, Shah BN, Greutélaers KC, Ghosh MC, Ollivierre H, Su XZ, Thuma PE, Bedu-Addo G, Mockenhaupt FP, Gordeuk VR, Rouault TA.

Science. 2018 Mar 30;359(6383):1520-1523. doi: 10.1126/science.aal2022.

PMID:
29599243
15.

Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells.

Crooks DR, Maio N, Lane AN, Jarnik M, Higashi RM, Haller RG, Yang Y, Fan TW, Linehan WM, Rouault TA.

J Biol Chem. 2018 May 25;293(21):8297-8311. doi: 10.1074/jbc.RA118.001885. Epub 2018 Mar 9.

16.

Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia.

Ghosh MC, Zhang DL, Ollivierre H, Eckhaus MA, Rouault TA.

J Clin Invest. 2018 Apr 2;128(4):1317-1325. doi: 10.1172/JCI97684. Epub 2018 Feb 26.

17.

How does hepcidin hinder ferroportin activity?

Zhang DL, Rouault TA.

Blood. 2018 Feb 22;131(8):840-842. doi: 10.1182/blood-2018-01-824151. No abstract available.

18.

Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.

Kim KS, Maio N, Singh A, Rouault TA.

Hum Mol Genet. 2018 Mar 1;27(5):837-852. doi: 10.1093/hmg/ddy004.

19.

Ferritin is secreted via 2 distinct nonclassical vesicular pathways.

Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG.

Blood. 2018 Jan 18;131(3):342-352. doi: 10.1182/blood-2017-02-768580. Epub 2017 Oct 26.

20.

Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways.

Rouault TA, Maio N.

J Biol Chem. 2017 Aug 4;292(31):12744-12753. doi: 10.1074/jbc.R117.789537. Epub 2017 Jun 14. Review.

21.

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

Maio N, Kim KS, Singh A, Rouault TA.

Cell Metab. 2017 Apr 4;25(4):945-953.e6. doi: 10.1016/j.cmet.2017.03.010.

22.

Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines.

Holmes-Hampton GP, Crooks DR, Haller RG, Guo S, Freier SM, Monia BP, Rouault TA.

Hum Mol Genet. 2016 Dec 1;25(23):5178-5187. doi: 10.1093/hmg/ddw338.

23.
24.

Mitochondrial iron overload: causes and consequences.

Rouault TA.

Curr Opin Genet Dev. 2016 Jun;38:31-37. doi: 10.1016/j.gde.2016.02.004. Epub 2016 Mar 25. Review.

25.

Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.

Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM.

Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11.

26.

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.

Maio N, Ghezzi D, Verrigni D, Rizza T, Bertini E, Martinelli D, Zeviani M, Singh A, Carrozzo R, Rouault TA.

Cell Metab. 2016 Feb 9;23(2):292-302. doi: 10.1016/j.cmet.2015.12.005. Epub 2015 Dec 31.

27.

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.

Saxena N, Maio N, Crooks DR, Ricketts CJ, Yang Y, Wei MH, Fan TW, Lane AN, Sourbier C, Singh A, Killian JK, Meltzer PS, Vocke CD, Rouault TA, Linehan WM.

J Natl Cancer Inst. 2016 Jan;108(1). doi: 10.1093/jnci/djv287.

28.

Iron-sulfur proteins hiding in plain sight.

Rouault TA.

Nat Chem Biol. 2015 Jul;11(7):442-5. doi: 10.1038/nchembio.1843. No abstract available.

PMID:
26083061
29.

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.

Ghosh MC, Zhang DL, Rouault TA.

Neurobiol Dis. 2015 Sep;81:66-75. doi: 10.1016/j.nbd.2015.02.026. Epub 2015 Mar 11. Review.

30.

Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM.

Cancer Cell. 2014 Dec 8;26(6):840-850. doi: 10.1016/j.ccell.2014.10.005.

31.

Mammalian iron-sulphur proteins: novel insights into biogenesis and function.

Rouault TA.

Nat Rev Mol Cell Biol. 2015 Jan;16(1):45-55. doi: 10.1038/nrm3909. Epub 2014 Nov 26. Review.

PMID:
25425402
32.

Biochemical and biophysical methods for studying mitochondrial iron metabolism.

Holmes-Hampton GP, Tong WH, Rouault TA.

Methods Enzymol. 2014;547:275-307. doi: 10.1016/B978-0-12-801415-8.00015-1.

PMID:
25416363
33.

Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.

Maio N, Rouault TA.

Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19. Review.

34.

The physiological functions of iron regulatory proteins in iron homeostasis - an update.

Zhang DL, Ghosh MC, Rouault TA.

Front Pharmacol. 2014 Jun 13;5:124. doi: 10.3389/fphar.2014.00124. eCollection 2014. Review.

35.

Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice.

Kovtunovych G, Ghosh MC, Ollivierre W, Weitzel RP, Eckhaus MA, Tisdale JF, Yachie A, Rouault TA.

Blood. 2014 Aug 28;124(9):1522-30. doi: 10.1182/blood-2014-02-554162. Epub 2014 Jun 24.

36.

Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.

Frey AG, Nandal A, Park JH, Smith PM, Yabe T, Ryu MS, Ghosh MC, Lee J, Rouault TA, Park MH, Philpott CC.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8031-6. doi: 10.1073/pnas.1402732111. Epub 2014 May 19.

37.

Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.

Kosmidis S, Missirlis F, Botella JA, Schneuwly S, Rouault TA, Skoulakis EM.

Front Pharmacol. 2014 Apr 4;5:66. doi: 10.3389/fphar.2014.00066. eCollection 2014.

38.

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.

Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH, Rouault TA.

Cell Metab. 2014 Mar 4;19(3):445-57. doi: 10.1016/j.cmet.2014.01.015.

39.

Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.

Yang Y, Lane AN, Ricketts CJ, Sourbier C, Wei MH, Shuch B, Pike L, Wu M, Rouault TA, Boros LG, Fan TW, Linehan WM.

PLoS One. 2013 Aug 15;8(8):e72179. doi: 10.1371/journal.pone.0072179. eCollection 2013.

40.

Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle.

Crooks DR, Natarajan TG, Jeong SY, Chen C, Park SY, Huang H, Ghosh MC, Tong WH, Haller RG, Wu C, Rouault TA.

Hum Mol Genet. 2014 Jan 1;23(1):24-39. doi: 10.1093/hmg/ddt393. Epub 2013 Aug 13.

41.

Iron metabolism in the CNS: implications for neurodegenerative diseases.

Rouault TA.

Nat Rev Neurosci. 2013 Aug;14(8):551-64. doi: 10.1038/nrn3453. Epub 2013 Jul 3. Review.

PMID:
23820773
42.

Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.

Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG.

Hum Mol Genet. 2013 Nov 15;22(22):4460-73. doi: 10.1093/hmg/ddt295. Epub 2013 Jun 28.

43.

Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.

Linehan WM, Rouault TA.

Clin Cancer Res. 2013 Jul 1;19(13):3345-52. doi: 10.1158/1078-0432.CCR-13-0304. Epub 2013 Apr 30. Review.

44.

Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis.

Uhrigshardt H, Rouault TA, Missirlis F.

J Biol Inorg Chem. 2013 Apr;18(4):441-9. doi: 10.1007/s00775-013-0988-2. Epub 2013 Feb 27.

45.

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA.

Cell Metab. 2013 Feb 5;17(2):271-81. doi: 10.1016/j.cmet.2012.12.016.

46.

Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma.

Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM.

Oncotarget. 2012 Nov;3(11):1472-82.

47.

Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia.

Xia H, Cao Y, Dai X, Marelja Z, Zhou D, Mo R, Al-Mahdawi S, Pook MA, Leimkühler S, Rouault TA, Li K.

PLoS One. 2012;7(10):e47847. doi: 10.1371/journal.pone.0047847. Epub 2012 Oct 17.

48.

Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy.

Crooks DR, Jeong SY, Tong WH, Ghosh MC, Olivierre H, Haller RG, Rouault TA.

J Biol Chem. 2012 Nov 23;287(48):40119-30. doi: 10.1074/jbc.M112.418889. Epub 2012 Oct 3.

49.

Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.

Kwan JY, Jeong SY, Van Gelderen P, Deng HX, Quezado MM, Danielian LE, Butman JA, Chen L, Bayat E, Russell J, Siddique T, Duyn JH, Rouault TA, Floeter MK.

PLoS One. 2012;7(4):e35241. doi: 10.1371/journal.pone.0035241. Epub 2012 Apr 17.

50.

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease.

Rouault TA.

Dis Model Mech. 2012 Mar;5(2):155-64. doi: 10.1242/dmm.009019. Review.

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