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Items: 4


The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.

Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA.

Sci Signal. 2020 Jan 7;13(613). pii: eaax4569. doi: 10.1126/scisignal.aax4569.


MRAP2 regulates ghrelin receptor signaling and hunger sensing.

Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA.

Nat Commun. 2017 Sep 28;8(1):713. doi: 10.1038/s41467-017-00747-6.


Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.

Rouault AAJ, Lee AA, Sebag JA.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2322-2329. doi: 10.1016/j.bbamcr.2017.09.008. Epub 2017 Sep 20.


Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.

Rouault AAJ, Srinivasan DK, Yin TC, Lee AA, Sebag JA.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2462-2467. doi: 10.1016/j.bbadis.2017.05.008. Epub 2017 May 9. Review.

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