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Items: 15


Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.

Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO, Risbud MV.

JCI Insight. 2020 Jan 21. pii: 131382. doi: 10.1172/jci.insight.131382. [Epub ahead of print]


Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.

Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L.

J Immunol. 2019 Feb 15;202(4):1265-1286. doi: 10.4049/jimmunol.1800002. Epub 2019 Jan 18.


Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.

Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W.

Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973.


Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice.

Zhao L, Cozzo AJ, Johnson AR, Christensen T, Freemerman AJ, Bear JE, Rotty JD, Bennett BJ, Makowski L.

Atherosclerosis. 2017 Nov;266:182-189. doi: 10.1016/j.atherosclerosis.2017.10.009. Epub 2017 Oct 7.


Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility.

Rotty JD, Brighton HE, Craig SL, Asokan SB, Cheng N, Ting JP, Bear JE.

Dev Cell. 2017 Sep 11;42(5):498-513.e6. doi: 10.1016/j.devcel.2017.08.003. Epub 2017 Aug 31.


Lamellipodia are crucial for haptotactic sensing and response.

King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG Jr, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, Bear JE.

J Cell Sci. 2016 Jun 15;129(12):2329-42. doi: 10.1242/jcs.184507. Epub 2016 May 12.


Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton.

Rotty JD, Bear JE.

Bioarchitecture. 2014;5(1-2):27-34. doi: 10.1080/19490992.2015.1090670. Epub 2015 Oct 2.


F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling.

Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM.

J Cell Biol. 2015 Feb 16;208(4):443-55. doi: 10.1083/jcb.201406102. Epub 2015 Feb 9.


Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE.

Dev Cell. 2015 Jan 12;32(1):54-67. doi: 10.1016/j.devcel.2014.10.026. Epub 2014 Dec 24.


Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway.

Asokan SB, Johnson HE, Rahman A, King SJ, Rotty JD, Lebedeva IP, Haugh JM, Bear JE.

Dev Cell. 2014 Dec 22;31(6):747-60. doi: 10.1016/j.devcel.2014.10.024. Epub 2014 Dec 4.


Keratin 16 regulates innate immunity in response to epidermal barrier breach.

Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42. doi: 10.1073/pnas.1309576110. Epub 2013 Nov 11.


Networking galore: intermediate filaments and cell migration.

Chung BM, Rotty JD, Coulombe PA.

Curr Opin Cell Biol. 2013 Oct;25(5):600-12. doi: 10.1016/ Epub 2013 Jul 22. Review.


New insights into the regulation and cellular functions of the ARP2/3 complex.

Rotty JD, Wu C, Bear JE.

Nat Rev Mol Cell Biol. 2013 Jan;14(1):7-12. doi: 10.1038/nrm3492. Epub 2012 Dec 5. Review.


A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair.

Rotty JD, Coulombe PA.

J Cell Biol. 2012 Apr 30;197(3):381-9. doi: 10.1083/jcb.201107078. Epub 2012 Apr 23.


Stressing the role of O-GlcNAc: linking cell survival to keratin modification.

Rotty JD, Hart GW, Coulombe PA.

Nat Cell Biol. 2010 Sep;12(9):847-9. doi: 10.1038/ncb0910-847.


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