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Actin dynamics in cell migration.

Schaks M, Giannone G, Rottner K.

Essays Biochem. 2019 Sep 24. pii: EBC20190015. doi: 10.1042/EBC20190015. [Epub ahead of print] Review.


RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding.

Schaks M, Döring H, Kage F, Steffen A, Klünemann T, Blankenfeldt W, Stradal T, Rottner K.

Small GTPases. 2019 Aug 26:1-11. doi: 10.1080/21541248.2019.1657755. [Epub ahead of print]


Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion.

Mehidi A, Rossier O, Schaks M, Chazeau A, Binamé F, Remorino A, Coppey M, Karatas Z, Sibarita JB, Rottner K, Moreau V, Giannone G.

Curr Biol. 2019 Sep 9;29(17):2852-2866.e5. doi: 10.1016/j.cub.2019.07.035. Epub 2019 Aug 15.


The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices.

Kunschmann T, Puder S, Fischer T, Steffen A, Rottner K, Mierke CT.

Sci Rep. 2019 May 22;9(1):7675. doi: 10.1038/s41598-019-43975-0.


Role of Src and Cortactin in Pemphigus Skin Blistering.

Kugelmann D, Rötzer V, Walter E, Egu DT, Fuchs MT, Vielmuth F, Vargas-Robles H, Schnoor M, Hertl M, Eming R, Rottner K, Schmidt A, Spindler V, Waschke J.

Front Immunol. 2019 Apr 4;10:626. doi: 10.3389/fimmu.2019.00626. eCollection 2019.


Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.

Litschko C, Brühmann S, Csiszár A, Stephan T, Dimchev V, Damiano-Guercio J, Junemann A, Körber S, Winterhoff M, Nordholz B, Ramalingam N, Peckham M, Rottner K, Merkel R, Faix J.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3594-3603. doi: 10.1073/pnas.1821638116. Epub 2019 Feb 11.


High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.

Velázquez-Avila M, Balandrán JC, Ramírez-Ramírez D, Velázquez-Avila M, Sandoval A, Felipe-López A, Nava P, Alvarado-Moreno JA, Dozal D, Prieto-Chávez JL, Schaks M, Rottner K, Dorantes-Acosta E, López-Martínez B, Schnoor M, Pelayo R.

Leukemia. 2019 Jun;33(6):1337-1348. doi: 10.1038/s41375-018-0333-4. Epub 2018 Dec 20.


Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo.

Schaks M, Singh SP, Kage F, Thomason P, Klünemann T, Steffen A, Blankenfeldt W, Stradal TE, Insall RH, Rottner K.

Curr Biol. 2018 Nov 19;28(22):3674-3684.e6. doi: 10.1016/j.cub.2018.10.002. Epub 2018 Nov 1.


Assembling actin filaments for protrusion.

Rottner K, Schaks M.

Curr Opin Cell Biol. 2019 Feb;56:53-63. doi: 10.1016/ Epub 2018 Oct 1. Review.


On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.

Dolati S, Kage F, Mueller J, Müsken M, Kirchner M, Dittmar G, Sixt M, Rottner K, Falcke M.

Mol Biol Cell. 2018 Nov 1;29(22):2674-2686. doi: 10.1091/mbc.E18-02-0082. Epub 2018 Aug 29.


Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate.

Beer LA, Tatge H, Reich N, Tenspolde M, Olling A, Goy S, Rottner K, Alekov AK, Gerhard R.

Cell Microbiol. 2018 Oct;20(10):e12865. doi: 10.1111/cmi.12865. Epub 2018 Jun 28.


RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

Ge J, Burnier L, Adamopoulou M, Kwa MQ, Schaks M, Rottner K, Brakebusch C.

J Biol Chem. 2018 Jun 15;293(24):9358-9369. doi: 10.1074/jbc.RA117.001113. Epub 2018 Apr 26.


Imaging the Molecular Machines That Power Cell Migration.

Steffen A, Kage F, Rottner K.

Methods Mol Biol. 2018;1749:257-277. doi: 10.1007/978-1-4939-7701-7_19.


Actin Networks: Adapting to Load through Geometry.

Rottner K, Kage F.

Curr Biol. 2017 Dec 4;27(23):R1274-R1277. doi: 10.1016/j.cub.2017.10.042.


Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein.

Schnoor M, Stradal TE, Rottner K.

Trends Cell Biol. 2018 Feb;28(2):79-98. doi: 10.1016/j.tcb.2017.10.009. Epub 2017 Nov 20. Review.


Actin assembly mechanisms at a glance.

Rottner K, Faix J, Bogdan S, Linder S, Kerkhoff E.

J Cell Sci. 2017 Oct 15;130(20):3427-3435. doi: 10.1242/jcs.206433. Review.


High-resolution MR imaging for dental impressions: a feasibility study.

Boldt J, Rottner K, Schmitter M, Hopfgartner A, Jakob P, Richter EJ, Tymofiyeva O.

Clin Oral Investig. 2018 Apr;22(3):1209-1213. doi: 10.1007/s00784-017-2204-1. Epub 2017 Sep 19.


Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R.

J Cell Biol. 2017 Nov 6;216(11):3785-3798. doi: 10.1083/jcb.201701176. Epub 2017 Sep 14.


Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes.

Litschko C, Linkner J, Brühmann S, Stradal TEB, Reinl T, Jänsch L, Rottner K, Faix J.

Eur J Cell Biol. 2017 Dec;96(8):715-727. doi: 10.1016/j.ejcb.2017.08.003. Epub 2017 Sep 4.


FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.

Kage F, Steffen A, Ellinger A, Ranftler C, Gehre C, Brakebusch C, Pavelka M, Stradal T, Rottner K.

Sci Rep. 2017 Aug 29;7(1):9791. doi: 10.1038/s41598-017-09952-1.


Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly.

Dimchev G, Steffen A, Kage F, Dimchev V, Pernier J, Carlier MF, Rottner K.

Mol Biol Cell. 2017 May 15;28(10):1311-1325. doi: 10.1091/mbc.E16-05-0334. Epub 2017 Mar 22.


FMNL formins boost lamellipodial force generation.

Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K.

Nat Commun. 2017 Mar 22;8:14832. doi: 10.1038/ncomms14832.


Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis.

Citalán-Madrid AF, Vargas-Robles H, García-Ponce A, Shibayama M, Betanzos A, Nava P, Salinas-Lara C, Rottner K, Mennigen R, Schnoor M.

Mucosal Immunol. 2017 Sep;10(5):1237-1247. doi: 10.1038/mi.2016.136. Epub 2017 Jan 25.


High isotropic resolution magnetic resonance imaging of the mandibular canal at 1.5 T: a comparison of gradient and spin echo sequences.

Kreutner J, Hopfgartner A, Weber D, Boldt J, Rottner K, Richter E, Jakob PM, Haddad D.

Dentomaxillofac Radiol. 2017 Feb;46(2):20160268. doi: 10.1259/dmfr.20160268. Epub 2016 Oct 27.


Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes.

Leithner A, Eichner A, Müller J, Reversat A, Brown M, Schwarz J, Merrin J, de Gorter DJ, Schur F, Bayerl J, de Vries I, Wieser S, Hauschild R, Lai FP, Moser M, Kerjaschki D, Rottner K, Small JV, Stradal TE, Sixt M.

Nat Cell Biol. 2016 Nov;18(11):1253-1259. doi: 10.1038/ncb3426. Epub 2016 Oct 24.


Signalling Pathways Controlling Cellular Actin Organization.

Steffen A, Stradal TE, Rottner K.

Handb Exp Pharmacol. 2017;235:153-178. doi: 10.1007/164_2016_35. Review.


A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.

Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, Rämö P, Rottner K, Kerkhoff E, Wada T, Penninger JM, Beerenwinkel N, Horvath P, Dehio C, Hardt WD.

PLoS One. 2016 Sep 14;11(9):e0161965. doi: 10.1371/journal.pone.0161965. eCollection 2016.


Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility.

García Ponce A, Citalán Madrid AF, Vargas Robles H, Chánez Paredes S, Nava P, Betanzos A, Zarbock A, Rottner K, Vestweber D, Schnoor M.

Sci Rep. 2016 Jun 30;6:29003. doi: 10.1038/srep29003.


CELL BIOLOGY. Formin' filaments at a faster CLIP.

Rottner K.

Science. 2016 May 20;352(6288):894-5. doi: 10.1126/science.aaf9624. No abstract available.


Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S.

Nat Struct Mol Biol. 2016 Apr;23(4):300-308. doi: 10.1038/nsmb.3187. Epub 2016 Mar 7.


How distinct Arp2/3 complex variants regulate actin filament assembly.

Rottner K, Stradal TE.

Nat Cell Biol. 2016 Jan;18(1):1-3. doi: 10.1038/ncb3293.


The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.

Kühn S, Erdmann C, Kage F, Block J, Schwenkmezger L, Steffen A, Rottner K, Geyer M.

Nat Commun. 2015 May 12;6:7088. doi: 10.1038/ncomms8088.


Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.

Chazeau A, Mehidi A, Nair D, Gautier JJ, Leduc C, Chamma I, Kage F, Kechkar A, Thoumine O, Rottner K, Choquet D, Gautreau A, Sibarita JB, Giannone G.

EMBO J. 2014 Dec 1;33(23):2745-64. doi: 10.15252/embj.201488837. Epub 2014 Oct 7.


Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry.

May M, Schelle I, Brakebusch C, Rottner K, Genth H.

Cell Cycle. 2014;13(14):2211-21. doi: 10.4161/cc.29279. Epub 2014 May 19.


Requirements for and consequences of Rac-dependent protrusion.

Steffen A, Koestler SA, Rottner K.

Eur J Cell Biol. 2014 May-Jun;93(5-6):184-93. doi: 10.1016/j.ejcb.2014.01.008. Epub 2014 Feb 11. Review.


Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.

Biosse Duplan M, Zalli D, Stephens S, Zenger S, Neff L, Oelkers JM, Lai FP, Horne W, Rottner K, Baron R.

Mol Cell Biol. 2014 Jan;34(1):16-29. doi: 10.1128/MCB.00578-13. Epub 2013 Oct 21.


Inhibitory signalling to the Arp2/3 complex steers cell migration.

Dang I, Gorelik R, Sousa-Blin C, Derivery E, Guérin C, Linkner J, Nemethova M, Dumortier JG, Giger FA, Chipysheva TA, Ermilova VD, Vacher S, Campanacci V, Herrada I, Planson AG, Fetics S, Henriot V, David V, Oguievetskaia K, Lakisic G, Pierre F, Steffen A, Boyreau A, Peyriéras N, Rottner K, Zinn-Justin S, Cherfils J, Bièche I, Alexandrova AY, David NB, Small JV, Faix J, Blanchoin L, Gautreau A.

Nature. 2013 Nov 14;503(7475):281-4. doi: 10.1038/nature12611. Epub 2013 Oct 16.


Dynamic MRI of the TMJ under physical load.

Hopfgartner AJ, Tymofiyeva O, Ehses P, Rottner K, Boldt J, Richter EJ, Jakob PM.

Dentomaxillofac Radiol. 2013;42(9):20120436. doi: 10.1259/dmfr.20120436. Epub 2013 Aug 23.


ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells.

Junemann A, Winterhoff M, Nordholz B, Rottner K, Eichinger L, Gräf R, Faix J.

Eur J Cell Biol. 2013 Jun-Jul;92(6-7):201-12. doi: 10.1016/j.ejcb.2013.07.001. Epub 2013 Jul 11.


Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.

Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Margit Holleboom J, Schur F, Victor Small J, Schwarz J, Gerhard R, Faix J, Stradal TE, Brakebusch C, Rottner K.

J Cell Sci. 2013 Oct 15;126(Pt 20):4572-88. doi: 10.1242/jcs.118232. Epub 2013 Jul 31.


Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin.

Koestler SA, Steffen A, Nemethova M, Winterhoff M, Luo N, Holleboom JM, Krupp J, Jacob S, Vinzenz M, Schur F, Schlüter K, Gunning PW, Winkler C, Schmeiser C, Faix J, Stradal TE, Small JV, Rottner K.

Mol Biol Cell. 2013 Sep;24(18):2861-75. doi: 10.1091/mbc.E12-12-0857. Epub 2013 Jul 24.


Cytotoxic necrotizing factor-Y boosts Yersinia effector translocation by activating Rac protein.

Wolters M, Boyle EC, Lardong K, Trülzsch K, Steffen A, Rottner K, Ruckdeschel K, Aepfelbacher M.

J Biol Chem. 2013 Aug 9;288(32):23543-53. doi: 10.1074/jbc.M112.448662. Epub 2013 Jun 26.


Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

Huelsenbeck SC, Roggenkamp D, May M, Huelsenbeck J, Brakebusch C, Rottner K, Ladwein M, Just I, Fritz G, Schmidt G, Genth H.

Int J Biochem Cell Biol. 2013 Aug;45(8):1767-75. doi: 10.1016/j.biocel.2013.05.020. Epub 2013 May 31.


Diagnosis of dental abnormalities in children using 3-dimensional magnetic resonance imaging.

Tymofiyeva O, Proff PC, Rottner K, Düring M, Jakob PM, Richter EJ.

J Oral Maxillofac Surg. 2013 Jul;71(7):1159-69. doi: 10.1016/j.joms.2013.02.014. Epub 2013 Apr 21.


Influence of dental materials on dental MRI.

Tymofiyeva O, Vaegler S, Rottner K, Boldt J, Hopfgartner AJ, Proff PC, Richter EJ, Jakob PM.

Dentomaxillofac Radiol. 2013;42(6):20120271. doi: 10.1259/dmfr.20120271. Epub 2013 Apr 22.


Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structures.

Vestweber D, Zeuschner D, Rottner K, Schnoor M.

Tissue Barriers. 2013 Jan 1;1(1):e23862. doi: 10.4161/tisb.23862.


Metavinculin: New insights into functional properties of a muscle adhesion protein.

Thoss F, Dietrich F, Punkt K, Illenberger S, Rottner K, Himmel M, Ziegler WH.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):7-13. doi: 10.1016/j.bbrc.2012.11.013. Epub 2012 Nov 14.


Serine-71 phosphorylation of Rac1 modulates downstream signaling.

Schwarz J, Proff J, Hävemeier A, Ladwein M, Rottner K, Barlag B, Pich A, Tatge H, Just I, Gerhard R.

PLoS One. 2012;7(9):e44358. doi: 10.1371/journal.pone.0044358. Epub 2012 Sep 10.


FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

Block J, Breitsprecher D, Kühn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K.

Curr Biol. 2012 Jun 5;22(11):1005-12. doi: 10.1016/j.cub.2012.03.064. Epub 2012 May 17.

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