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Items: 1 to 50 of 53

1.

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.

Killion EA, Wang J, Yie J, Shi SD, Bates D, Min X, Komorowski R, Hager T, Deng L, Atangan L, Lu SC, Kurzeja RJM, Sivits G, Lin J, Chen Q, Wang Z, Thibault SA, Abbott CM, Meng T, Clavette B, Murawsky CM, Foltz IN, Rottman JB, Hale C, Véniant MM, Lloyd DJ.

Sci Transl Med. 2018 Dec 19;10(472). pii: eaat3392. doi: 10.1126/scitranslmed.aat3392.

PMID:
30567927
2.

A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors.

Kebenko M, Goebeler ME, Wolf M, Hasenburg A, Seggewiss-Bernhardt R, Ritter B, Rautenberg B, Atanackovic D, Kratzer A, Rottman JB, Friedrich M, Vieser E, Elm S, Patzak I, Wessiepe D, Stienen S, Fiedler W.

Oncoimmunology. 2018 Apr 18;7(8):e1450710. doi: 10.1080/2162402X.2018.1450710. eCollection 2018.

3.

Novel protein therapeutic joint retention strategy based on collagen-binding Avimers.

Hulme JT, D'Souza WN, McBride HJ, Yoon BP, Willee AM, Duguay A, Thomas M, Fan B, Dayao MR, Rottman JB, Merriam K, Xie J, Smith R, Alba BM, Case RB, Dang K, Montalvan A, Grinberg N, Sun H, Black RA, Gabel CA, Sims JE, Moore K, Bakker A, Li P.

J Orthop Res. 2018 Apr;36(4):1238-1247. doi: 10.1002/jor.23756. Epub 2017 Nov 22.

4.

Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses.

D'Souza WN, Douangpanya J, Mu S, Jaeckel P, Zhang M, Maxwell JR, Rottman JB, Labitzke K, Willee A, Beckmann H, Wang Y, Li Y, Schwandner R, Johnston JA, Towne JE, Hsu H.

PLoS One. 2017 Jul 20;12(7):e0180190. doi: 10.1371/journal.pone.0180190. eCollection 2017.

5.

Local Delivery of OncoVEXmGM-CSF Generates Systemic Antitumor Immune Responses Enhanced by Cytotoxic T-Lymphocyte-Associated Protein Blockade.

Moesta AK, Cooke K, Piasecki J, Mitchell P, Rottman JB, Fitzgerald K, Zhan J, Yang B, Le T, Belmontes B, Ikotun OF, Merriam K, Glaus C, Ganley K, Cordover DH, Boden AM, Ponce R, Beers C, Beltran PJ.

Clin Cancer Res. 2017 Oct 15;23(20):6190-6202. doi: 10.1158/1078-0432.CCR-17-0681. Epub 2017 Jul 13.

6.

In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.

Rulifson IC, Collins P, Miao L, Nojima D, Lee KJ, Hardy M, Gupte J, Hensley K, Samayoa K, Cam C, Rottman JB, Ollmann M, Richards WG, Li Y.

J Biol Chem. 2017 Feb 3;292(5):1951-1969. doi: 10.1074/jbc.M116.751404. Epub 2016 Dec 23.

7.

Large-scale gene expression profiling reveals distinct type 2 inflammatory patterns in chronic rhinosinusitis subtypes.

Tyler MA, Russell CB, Smith DE, Rottman JB, Padro Dietz CJ, Hu X, Citardi MJ, Fakhri S, Assassi S, Luong A.

J Allergy Clin Immunol. 2017 Mar;139(3):1061-1064.e4. doi: 10.1016/j.jaci.2016.09.048. Epub 2016 Nov 18. No abstract available.

8.

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.

Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, Budelsky AL, Symons A, Towne JE.

Immunity. 2015 Oct 20;43(4):739-50. doi: 10.1016/j.immuni.2015.08.019. Epub 2015 Sep 29.

9.

IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma.

Willis CR, Siegel L, Leith A, Mohn D, Escobar S, Wannberg S, Misura K, Rickel E, Rottman JB, Comeau MR, Sullivan JK, Metz DP, Tocker J, Budelsky AL.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):810-21. doi: 10.1165/rcmb.2015-0038OC.

PMID:
25919006
10.

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Gingras J, Smith S, Matson DJ, Johnson D, Nye K, Couture L, Feric E, Yin R, Moyer BD, Peterson ML, Rottman JB, Beiler RJ, Malmberg AB, McDonough SI.

PLoS One. 2014 Sep 4;9(9):e105895. doi: 10.1371/journal.pone.0105895. eCollection 2014.

11.

Immunogenicity/hypersensitivity of biologics.

Leach MW, Rottman JB, Hock MB, Finco D, Rojko JL, Beyer JC.

Toxicol Pathol. 2014 Jan;42(1):293-300. doi: 10.1177/0192623313510987. Epub 2013 Nov 14.

PMID:
24240973
12.

AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models.

Bush TL, Payton M, Heller S, Chung G, Hanestad K, Rottman JB, Loberg R, Friberg G, Kendall RL, Saffran D, Radinsky R.

Mol Cancer Ther. 2013 Nov;12(11):2356-66. doi: 10.1158/1535-7163.MCT-12-1178. Epub 2013 Aug 29.

13.

IL-22 regulates iron availability in vivo through the induction of hepcidin.

Smith CL, Arvedson TL, Cooke KS, Dickmann LJ, Forte C, Li H, Merriam KL, Perry VK, Tran L, Rottman JB, Maxwell JR.

J Immunol. 2013 Aug 15;191(4):1845-55. doi: 10.4049/jimmunol.1202716. Epub 2013 Jul 8.

14.

Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells.

Swanson RM, Gavin MA, Escobar SS, Rottman JB, Lipsky BP, Dube S, Li L, Bigler J, Wolfson M, Arnett HA, Viney JL.

J Immunol. 2013 Mar 1;190(5):2027-35. doi: 10.4049/jimmunol.1201760. Epub 2013 Jan 28.

15.

IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung.

Beamer CA, Girtsman TA, Seaver BP, Finsaas KJ, Migliaccio CT, Perry VK, Rottman JB, Smith DE, Holian A.

Nanotoxicology. 2013 Sep;7(6):1070-81. doi: 10.3109/17435390.2012.702230. Epub 2012 Jun 29.

16.

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT.

J Allergy Clin Immunol. 2012 Jan;129(1):216-27.e1-6. doi: 10.1016/j.jaci.2011.10.036. Epub 2011 Nov 25.

17.

Mouse models of systemic lupus erythematosus reveal a complex pathogenesis.

Rottman JB, Willis CR.

Vet Pathol. 2010 Jul;47(4):664-76. doi: 10.1177/0300985810370005. Epub 2010 May 6. Review.

PMID:
20448279
18.

Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors.

Coxon A, Bush T, Saffran D, Kaufman S, Belmontes B, Rex K, Hughes P, Caenepeel S, Rottman JB, Tasker A, Patel V, Kendall R, Radinsky R, Polverino A.

Clin Cancer Res. 2009 Jan 1;15(1):110-8. doi: 10.1158/1078-0432.CCR-08-1155.

19.

Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities.

Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL.

J Immunol. 2008 Sep 15;181(6):4299-310.

20.

ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis.

Ruth JH, Rottman JB, Kingsbury GA, Coyle AJ, Haines GK 3rd, Pope RM, Koch AE.

Cytometry A. 2007 May;71(5):317-26.

21.

Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals.

Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB.

Mol Microbiol. 2004 Oct;54(2):407-19.

22.
23.

Protective efficacy of antigenic fractions in mouse models of cryptococcosis.

Mansour MK, Yauch LE, Rottman JB, Levitz SM.

Infect Immun. 2004 Mar;72(3):1746-54.

25.

Programmed death-1 targeting can promote allograft survival.

Ozkaynak E, Wang L, Goodearl A, McDonald K, Qin S, O'Keefe T, Duong T, Smith T, Gutierrez-Ramos JC, Rottman JB, Coyle AJ, Hancock WW.

J Immunol. 2002 Dec 1;169(11):6546-53.

26.

The ribonuclease protection assay: a powerful tool for the veterinary pathologist.

Rottman JB.

Vet Pathol. 2002 Jan;39(1):2-9. Review.

PMID:
12102215
27.

Selective lymphocyte chemokine receptor expression in the rheumatoid joint.

Ruth JH, Rottman JB, Katschke KJ Jr, Qin S, Wu L, LaRosa G, Ponath P, Pope RM, Koch AE.

Arthritis Rheum. 2001 Dec;44(12):2750-60.

28.

Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection.

Haskell CA, Hancock WW, Salant DJ, Gao W, Csizmadia V, Peters W, Faia K, Fituri O, Rottman JB, Charo IF.

J Clin Invest. 2001 Sep;108(5):679-88.

29.

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.

Rottman JB, Smith T, Tonra JR, Ganley K, Bloom T, Silva R, Pierce B, Gutierrez-Ramos JC, Ozkaynak E, Coyle AJ.

Nat Immunol. 2001 Jul;2(7):605-11.

PMID:
11429544
30.

ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses.

Gonzalo JA, Tian J, Delaney T, Corcoran J, Rottman JB, Lora J, Al-garawi A, Kroczek R, Gutierrez-Ramos JC, Coyle AJ.

Nat Immunol. 2001 Jul;2(7):597-604.

PMID:
11429543
31.

Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.

Ozkaynak E, Gao W, Shemmeri N, Wang C, Gutierrez-Ramos JC, Amaral J, Qin S, Rottman JB, Coyle AJ, Hancock WW.

Nat Immunol. 2001 Jul;2(7):591-6.

PMID:
11429542
32.

Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis.

Katschke KJ Jr, Rottman JB, Ruth JH, Qin S, Wu L, LaRosa G, Ponath P, Park CC, Pope RM, Koch AE.

Arthritis Rheum. 2001 May;44(5):1022-32.

33.

Differential NF-kappaB and IkappaB gene expression during development of cardiac allograft rejection versus CD154 monoclonal antibody-induced tolerance.

Csizmadia V, Gao W, Hancock SA, Rottman JB, Wu Z, Turka LA, Siebenlist U, Hancock WW.

Transplantation. 2001 Apr 15;71(7):835-40.

PMID:
11349713
34.

Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris.

Rottman JB, Smith TL, Ganley KG, Kikuchi T, Krueger JG.

Lab Invest. 2001 Mar;81(3):335-47.

35.

Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent.

Rottman JB, Slavin AJ, Silva R, Weiner HL, Gerard CG, Hancock WW.

Eur J Immunol. 2000 Aug;30(8):2372-7.

36.
37.
38.

Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii.

Levy JK, Ritchey JW, Rottman JB, Davidson MG, Liang YH, Jordan HL, Tompkins WA, Tompkins MB.

J Infect Dis. 1998 Aug;178(2):503-11.

PMID:
9697733
39.

Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239.

Sasseville VG, Rottman JB, Du Z, Veazey R, Knight HL, Caunt D, Desrosiers RC, Lackner AA.

J Invest Dermatol. 1998 Jun;110(6):894-901.

40.

Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis.

Westmoreland SV, Rottman JB, Williams KC, Lackner AA, Sasseville VG.

Am J Pathol. 1998 Mar;152(3):659-65.

41.

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, Loetscher M, Koch AE, Moser B, Mackay CR.

J Clin Invest. 1998 Feb 15;101(4):746-54.

42.

Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection.

Rottman JB, Ganley KP, Williams K, Wu L, Mackay CR, Ringler DJ.

Am J Pathol. 1997 Nov;151(5):1341-51.

43.

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro.

Wu L, Paxton WA, Kassam N, Ruffing N, Rottman JB, Sullivan N, Choe H, Sodroski J, Newman W, Koup RA, Mackay CR.

J Exp Med. 1997 May 5;185(9):1681-91.

44.

Cytologic identification of Toxoplasma gondii in bronchoalveolar lavage fluid of experimentally infected cats.

Hawkins EC, Davidson MG, Meuten DJ, Rottman JB, Kennedy-Stoskopf S, Levy JK, Ritchey JW, Cullins LD, Tompkins MB.

J Am Vet Med Assoc. 1997 Mar 1;210(5):648-50.

PMID:
9054992
45.

Pyelonephritis following inadvertent excision of the ureter during ovariohysterectomy in a bitch.

Kyles AE, Douglass JP, Rottman JB.

Vet Rec. 1996 Nov 9;139(19):471-2. No abstract available.

PMID:
8938968
47.

A reverse transcription-polymerase chain reaction technique to detect feline cytokine genes.

Rottman JB, Freeman EB, Tonkonogy S, Tompkins MB.

Vet Immunol Immunopathol. 1995 Mar;45(1-2):1-18.

PMID:
7604528
48.

Sclerosing encapsulating peritonitis in four dogs and a cat.

Hardie EM, Rottman JB, Levy JK.

Vet Surg. 1994 Mar-Apr;23(2):107-14.

PMID:
8191669
49.

Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis.

Davidson MG, Rottman JB, English RV, Lappin MR, Tompkins MB.

Am J Pathol. 1993 Nov;143(5):1486-97.

50.

Hypereosinophilia associated with transitional cell carcinoma in a cat.

Sellon RK, Rottman JB, Jordan HL, Wells MR, Simpson RM, Nelson P, Keene BW.

J Am Vet Med Assoc. 1992 Aug 15;201(4):591-3.

PMID:
1517134

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