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Items: 1 to 50 of 109

1.

Alveolar bone protection by targeting the SH3BP2-SYK axis in osteoclasts.

Kittaka M, Yoshimoto T, Schlosser C, Rottapel R, Kajiya M, Kurihara H, Reichenberger EJ, Ueki Y.

J Bone Miner Res. 2019 Oct 15. doi: 10.1002/jbmr.3882. [Epub ahead of print]

PMID:
31613396
2.

Chromosomal instability and mTORC1 activation through PTEN loss contribute to proteotoxic stress in ovarian carcinoma.

Chui MH, Doodnauth SA, Erdmann N, Tiedemann RE, Sircoulomb F, Drapkin R, Shaw P, Rottapel R.

Cancer Res. 2019 Sep 17. pii: canres.3029.2018. doi: 10.1158/0008-5472.CAN-18-3029. [Epub ahead of print]

PMID:
31530568
3.

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.

Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandí MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G.

J Cell Biol. 2019 Sep 2;218(9):3077-3097. doi: 10.1083/jcb.201812073. Epub 2019 Aug 16.

PMID:
31420453
4.

Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer.

Jiang DM, Fyles A, Nguyen LT, Neel BG, Sacher A, Rottapel R, Wang BX, Ohashi PS, Sridhar SS.

Oncotarget. 2019 Apr 26;10(31):2947-2958. doi: 10.18632/oncotarget.26893. eCollection 2019 Apr 26.

5.

Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer.

Krzyzanowski PM, Sircoulomb F, Yousif F, Normand J, La Rose J, E Francis K, Suarez F, Beck T, McPherson JD, Stein LD, Rottapel RK.

Sci Rep. 2019 Mar 5;9(1):3590. doi: 10.1038/s41598-019-39878-9.

6.

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.

Bast RC Jr, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ Jr, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L.

Cancer. 2019 Jun 15;125(12):1963-1972. doi: 10.1002/cncr.32004. Epub 2019 Mar 5.

PMID:
30835824
7.

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R.

Cell Rep. 2018 Jul 31;24(5):1123-1135. doi: 10.1016/j.celrep.2018.06.075.

8.

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.

Gebregiworgis T, Marshall CB, Nishikawa T, Radulovich N, Sandí MJ, Fang Z, Rottapel R, Tsao MS, Ikura M.

J Am Chem Soc. 2018 Apr 4;140(13):4473-4476. doi: 10.1021/jacs.7b13703. Epub 2018 Mar 22.

PMID:
29543440
9.

Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils.

Fine N, Dimitriou ID, Rottapel R.

Small GTPases. 2017 Nov 30:1-9. doi: 10.1080/21541248.2017.1332505. [Epub ahead of print]

PMID:
29188751
10.

Enhancing yoga participation: A qualitative investigation of barriers and facilitators to yoga among predominantly racial/ethnic minority, low-income adults.

Spadola CE, Rottapel R, Khandpur N, Kontos E, Bertisch SM, Johnson DA, Quante M, Khalsa SBS, Saper RB, Redline S.

Complement Ther Clin Pract. 2017 Nov;29:97-104. doi: 10.1016/j.ctcp.2017.09.001. Epub 2017 Sep 4.

11.

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R.

Sci Signal. 2017 Oct 31;10(503). pii: eaan3286. doi: 10.1126/scisignal.aan3286.

12.

Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.

Kent OA, Sandi MJ, Rottapel R.

Small GTPases. 2019 Nov;10(6):441-448. doi: 10.1080/21541248.2017.1337545. Epub 2017 Jul 11.

13.

Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.

Matsumoto Y, La Rose J, Lim M, Adissu HA, Law N, Mao X, Cong F, Mera P, Karsenty G, Goltzman D, Changoor A, Zhang L, Stajkowski M, Grynpas MD, Bergmann C, Rottapel R.

J Clin Invest. 2017 Jun 30;127(7):2612-2625. doi: 10.1172/JCI92233. Epub 2017 Jun 5.

14.

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S.

Oncotarget. 2017 Apr 18;8(16):27380-27392. doi: 10.18632/oncotarget.16068.

15.

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

Matsumoto Y, Larose J, Kent OA, Lim M, Changoor A, Zhang L, Storozhuk Y, Mao X, Grynpas MD, Cong F, Rottapel R.

J Clin Invest. 2017 Apr 3;127(4):1303-1315. doi: 10.1172/JCI90527. Epub 2017 Mar 13.

16.

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R.

Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028.

17.

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

Kent OA, Sandí MJ, Burston HE, Brown KR, Rottapel R.

Oncotarget. 2017 Jan 17;8(3):4484-4500. doi: 10.18632/oncotarget.13152.

18.

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.

J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. Epub 2016 Oct 31.

19.

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

Fine N, Dimitriou ID, Rullo J, Sandí MJ, Petri B, Haitsma J, Ibrahim H, La Rose J, Glogauer M, Kubes P, Cybulsky M, Rottapel R.

J Cell Biol. 2016 Oct 10;215(1):107-119.

20.

Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1.

Kent OA, Mendell JT, Rottapel R.

Mol Cancer Res. 2016 Mar;14(3):267-77. doi: 10.1158/1541-7786.MCR-15-0456. Epub 2016 Jan 8.

21.

Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages.

Prod'Homme V, Boyer L, Dubois N, Mallavialle A, Munro P, Mouska X, Coste I, Rottapel R, Tartare-Deckert S, Deckert M.

J Clin Invest. 2015 Apr;125(4):1396-400. doi: 10.1172/JCI71081. Epub 2015 Feb 23.

22.

Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice.

Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y.

Arthritis Rheumatol. 2015 Mar;67(3):656-67. doi: 10.1002/art.38975.

23.

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.

Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2740-53. doi: 10.1107/S1399004714017660. Epub 2014 Sep 27.

24.

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.

Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M, Rottapel R.

Nat Commun. 2014 Sep 11;5:4857. doi: 10.1038/ncomms5857.

PMID:
25209408
25.

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity.

Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, Pereira K, Lobo N, Stewart J, Go C, Ho J, Medrano M, Hyatt E, Yuan J, Lauriault S, Meyer M, Kondratyev M, van den Beucken T, Jewett M, Dirks P, Guidos CJ, Danska J, Wang J, Wouters B, Neel B, Rottapel R, Ailles LE.

PLoS One. 2014 Aug 29;9(8):e105602. doi: 10.1371/journal.pone.0105602. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e114354. Meyer, Mona [added].

26.

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics.

Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J.

Mol Syst Biol. 2014 Jul 1;10:733. doi: 10.15252/msb.20145216.

27.

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.

Mukai T, Ishida S, Ishikawa R, Yoshitaka T, Kittaka M, Gallant R, Lin YL, Rottapel R, Brotto M, Reichenberger EJ, Ueki Y.

J Bone Miner Res. 2014 Dec;29(12):2618-35. doi: 10.1002/jbmr.2295.

28.

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.

Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D, Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel BG, Gingras AC, Tsao MS, Rottapel R.

Cancer Cell. 2014 Feb 10;25(2):181-95. doi: 10.1016/j.ccr.2014.01.025.

29.

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E.

Cancer Res. 2014 Apr 1;74(7):2119-30. doi: 10.1158/0008-5472.CAN-13-2138. Epub 2014 Jan 31.

30.

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.

Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M, Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA, Andrews B, Boone C, Moffat J.

Mol Syst Biol. 2013 Oct 8;9:696. doi: 10.1038/msb.2013.54.

31.

CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.

Borozan I, Wilson S, Blanchette P, Laflamme P, Watt SN, Krzyzanowski PM, Sircoulomb F, Rottapel R, Branton PE, Ferretti V.

BMC Bioinformatics. 2012 Aug 17;13:206. doi: 10.1186/1471-2105-13-206.

32.

The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.

Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R.

J Immunol. 2012 Sep 1;189(5):2138-50. doi: 10.4049/jimmunol.1103184. Epub 2012 Jul 18.

33.

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.

Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M.

Methods. 2012 Aug;57(4):473-85. doi: 10.1016/j.ymeth.2012.06.014. Epub 2012 Jun 28.

PMID:
22750304
34.

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JLY, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, Vizeacoumar FS, Datti A, Kasimer D, Buzina A, Mero P, Misquitta C, Normand J, Haider M, Ketela T, Wrana JL, Rottapel R, Neel BG, Moffat J.

Cancer Discov. 2012 Feb;2(2):172-189. doi: 10.1158/2159-8290.CD-11-0224. Epub 2011 Dec 29.

35.

Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.

Guerra FM, Gommerman JL, Corfe SA, Paige CJ, Rottapel R.

PLoS One. 2012;7(4):e35533. doi: 10.1371/journal.pone.0035533. Epub 2012 Apr 24.

36.

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C, Larose J, Fine N, Ikura M, Rottapel R.

Mol Cell. 2012 Mar 9;45(5):642-55. doi: 10.1016/j.molcel.2012.01.027. Erratum in: Mol Cell. 2012 Mar 30;45(6):844. Bakal, Chris [added].

37.

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.

Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F.

Cell. 2011 Dec 9;147(6):1340-54. doi: 10.1016/j.cell.2011.10.046. Erratum in: Cell. 2012 Jan 20;148(1-2):376.

38.

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.

Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La Rose J, Rottapel R.

Cell. 2011 Dec 9;147(6):1324-39. doi: 10.1016/j.cell.2011.10.045.

39.

Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.

Corfe SA, Rottapel R, Paige CJ.

J Immunol. 2011 Oct 1;187(7):3499-510. doi: 10.4049/jimmunol.1100424. Epub 2011 Aug 26.

40.

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions.

Levaot N, Simoncic PD, Dimitriou ID, Scotter A, La Rose J, Ng AH, Willett TL, Wang CJ, Janmohamed S, Grynpas M, Reichenberger E, Rottapel R.

J Clin Invest. 2011 Aug;121(8):3244-57. doi: 10.1172/JCI45843. Epub 2011 Jul 18.

41.

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens.

Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S.

J Immunol. 2010 Jul 1;185(1):357-66. doi: 10.4049/jimmunol.1000066. Epub 2010 Jun 2.

42.

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.

Jain P, Coisne C, Enzmann G, Rottapel R, Engelhardt B.

J Immunol. 2010 Jun 15;184(12):7196-206. doi: 10.4049/jimmunol.0901404. Epub 2010 May 17.

43.

3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.

GuezGuez A, Prod'homme V, Mouska X, Baudot A, Blin-Wakkach C, Rottapel R, Deckert M.

J Biol Chem. 2010 Jul 2;285(27):20952-63. doi: 10.1074/jbc.M109.091124. Epub 2010 May 3.

44.

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.

Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, Fine N, Simpson CD, Sharmeen S, Rottapel R, Schimmer AD.

Blood. 2010 Jun 10;115(23):4824-33. doi: 10.1182/blood-2009-09-243055. Epub 2010 Mar 26.

PMID:
20348394
45.

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA.

Cell Cycle. 2010 Mar 15;9(6):1143-55. Epub 2010 Mar 15.

PMID:
20237422
46.

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M.

J Biol Chem. 2010 Feb 19;285(8):5132-6. doi: 10.1074/jbc.C109.064766. Epub 2009 Dec 14.

47.

Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation.

Meiri D, Greeve MA, Brunet A, Finan D, Wells CD, LaRose J, Rottapel R.

Mol Cell Biol. 2009 Nov;29(21):5963-73. doi: 10.1128/MCB.01268-08. Epub 2009 Aug 10.

48.

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.

Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD.

Nat Neurosci. 2009 Jun;12(6):735-44. doi: 10.1038/nn.2339. Epub 2009 May 17.

PMID:
19448628
49.

Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis.

Dehlin M, Bokarewa M, Rottapel R, Foster SJ, Magnusson M, Dahlberg LE, Tarkowski A.

PLoS One. 2008;3(11):e3633. doi: 10.1371/journal.pone.0003633. Epub 2008 Nov 4.

50.

Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins.

Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R.

Immunol Rev. 2008 Aug;224:265-83. doi: 10.1111/j.1600-065X.2008.00659.x. Review.

PMID:
18759933

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