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ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Hecht I, Toporik A, Podojil JR, Vaknin I, Cojocaru G, Oren A, Aizman E, Liang SC, Leung L, Dicken Y, Novik A, Marbach-Bar N, Elmesmari A, Tange C, Gilmour A, McIntyre D, Kurowska-Stolarska M, McNamee K, Leitner J, Greenwald S, Dassa L, Levine Z, Steinberger P, Williams RO, Miller SD, McInnes IB, Neria E, Rotman G.

J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325. Epub 2018 Feb 5.


ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.

Podojil JR, Hecht I, Chiang MY, Vaknin I, Barbiro I, Novik A, Neria E, Rotman G, Miller SD.

J Immunol. 2018 Mar 15;200(6):2013-2024. doi: 10.4049/jimmunol.1700326. Epub 2018 Feb 5.


The role of observers' gaze behaviour when watching object manipulation tasks: predicting and evaluating the consequences of action.

Flanagan JR, Rotman G, Reichelt AF, Johansson RS.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 9;368(1628):20130063. doi: 10.1098/rstb.2013.0063. Print 2013 Oct 19.


The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats.

Savergnini SQ, Ianzer D, Carvalho MB, Ferreira AJ, Silva GA, Marques FD, Peluso AA, Beiman M, Cojocaru G, Cohen Y, Almeida AP, Rotman G, Santos RA.

PLoS One. 2013;8(3):e57757. doi: 10.1371/journal.pone.0057757. Epub 2013 Mar 1.


A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.

Palmer GM, Tiran Z, Zhou Z, Capozzi ME, Park W, Coletta C, Pyriochou A, Kliger Y, Levy O, Borukhov I, Dewhirst MW, Rotman G, Penn JS, Papapetropoulos A.

Br J Pharmacol. 2012 Mar;165(6):1891-1903. doi: 10.1111/j.1476-5381.2011.01677.x.


Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity.

Pini A, Shemesh R, Samuel CS, Bathgate RA, Zauberman A, Hermesh C, Wool A, Bani D, Rotman G.

J Pharmacol Exp Ther. 2010 Dec;335(3):589-99. doi: 10.1124/jpet.110.170977. Epub 2010 Sep 8.


Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the MAS receptor.

Savergnini SQ, Beiman M, Lautner RQ, de Paula-Carvalho V, Allahdadi K, Pessoa DC, Costa-Fraga FP, Fraga-Silva RA, Cojocaru G, Cohen Y, Bader M, de Almeida AP, Rotman G, Santos RA.

Hypertension. 2010 Jul;56(1):112-20. doi: 10.1161/HYPERTENSIONAHA.110.152942. Epub 2010 May 17.


A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects.

Hecht I, Rong J, Sampaio AL, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J, Cohen Y.

J Pharmacol Exp Ther. 2009 Feb;328(2):426-34. doi: 10.1124/jpet.108.145821. Epub 2008 Nov 20.


Discovery and validation of novel peptide agonists for G-protein-coupled receptors.

Shemesh R, Toporik A, Levine Z, Hecht I, Rotman G, Wool A, Dahary D, Gofer E, Kliger Y, Soffer MA, Rosenberg A, Eshel D, Cohen Y.

J Biol Chem. 2008 Dec 12;283(50):34643-9. doi: 10.1074/jbc.M805181200. Epub 2008 Oct 9.


A novel recombinant soluble splice variant of Met is a potent antagonist of the hepatocyte growth factor/scatter factor-Met pathway.

Tiran Z, Oren A, Hermesh C, Rotman G, Levine Z, Amitai H, Handelsman T, Beiman M, Chen A, Landesman-Milo D, Dassa L, Peres Y, Koifman C, Glezer S, Vidal-Finkelstein R, Bahat K, Pergam T, Israel C, Horev J, Tsarfaty I, Ayalon-Soffer M.

Clin Cancer Res. 2008 Jul 15;14(14):4612-21. doi: 10.1158/1078-0432.CCR-08-0108.


The role of uncertainty in the systematic spatial mislocalization of moving objects.

Brenner E, van Beers RJ, Rotman G, Smeets JB.

J Exp Psychol Hum Percept Perform. 2006 Aug;32(4):811-25.


Eye movements when observing predictable and unpredictable actions.

Rotman G, Troje NF, Johansson RS, Flanagan JR.

J Neurophysiol. 2006 Sep;96(3):1358-69. Epub 2006 May 10.


Flashes are localised as if they were moving with the eyes.

Rotman G, Brenner E, Smeets JB.

Vision Res. 2005 Feb;45(3):355-64.


hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.

Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G.

Gene. 2004 Apr 28;331:17-31.


Quickly tapping targets that are flashed during smooth pursuit reveals perceptual mislocalisations.

Rotman G, Brenner E, Smeets JB.

Exp Brain Res. 2004 Jun;156(4):409-14. Epub 2004 Feb 14.


Widespread occurrence of antisense transcription in the human genome.

Yelin R, Dahary D, Sorek R, Levanon EY, Goldstein O, Shoshan A, Diber A, Biton S, Tamir Y, Khosravi R, Nemzer S, Pinner E, Walach S, Bernstein J, Savitsky K, Rotman G.

Nat Biotechnol. 2003 Apr;21(4):379-86. Epub 2003 Mar 17.


ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage.

Barzilai A, Rotman G, Shiloh Y.

DNA Repair (Amst). 2002 Jan 22;1(1):3-25. Review.


Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.

David A, Mabjeesh N, Azar I, Biton S, Engel S, Bernstein J, Romano J, Avidor Y, Waks T, Eshhar Z, Langer SZ, Lifschitz-Mercer B, Matzkin H, Rotman G, Toporik A, Savitsky K, Mintz L.

J Biol Chem. 2002 May 17;277(20):18084-90. Epub 2002 Feb 7.


Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice.

Stern N, Hochman A, Zemach N, Weizman N, Hammel I, Shiloh Y, Rotman G, Barzilai A.

J Biol Chem. 2002 Jan 4;277(1):602-8. Epub 2001 Oct 25.


Nuclear retention of ATM at sites of DNA double strand breaks.

Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G.

J Biol Chem. 2001 Oct 12;276(41):38224-30. Epub 2001 Jul 13.


Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid.

Gatei M, Shkedy D, Khanna KK, Uziel T, Shiloh Y, Pandita TK, Lavin MF, Rotman G.

Oncogene. 2001 Jan 18;20(3):289-94.


Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.

Peter Y, Rotman G, Lotem J, Elson A, Shiloh Y, Groner Y.

EMBO J. 2001 Apr 2;20(7):1538-46.


Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.

Kamsler A, Daily D, Hochman A, Stern N, Shiloh Y, Rotman G, Barzilai A.

Cancer Res. 2001 Mar 1;61(5):1849-54.


ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.

Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G.

J Biol Chem. 2001 Mar 23;276(12):8898-903. Epub 2000 Dec 12.


Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.


ATM: a mediator of multiple responses to genotoxic stress.

Rotman G, Shiloh Y.

Oncogene. 1999 Nov 1;18(45):6135-44. Review.


Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice.

Eilam R, Peter Y, Elson A, Rotman G, Shiloh Y, Groner Y, Segal M.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12653-6.


ATM: from gene to function.

Rotman G, Shiloh Y.

Hum Mol Genet. 1998;7(10):1555-63. Review.


Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

Rotman G, Shiloh Y.

Bioessays. 1997 Oct;19(10):911-7. Review.


Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene.

Platzer M, Rotman G, Bauer D, Uziel T, Savitsky K, Bar-Shira A, Gilad S, Shiloh Y, Rosenthal A.

Genome Res. 1997 Jun;7(6):592-605.


Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression.

Savitsky K, Platzer M, Uziel T, Gilad S, Sartiel A, Rosenthal A, Elroy-Stein O, Shiloh Y, Rotman G.

Nucleic Acids Res. 1997 May 1;25(9):1678-84.


Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.

Pecker I, Avraham KB, Gilbert DJ, Savitsky K, Rotman G, Harnik R, Fukao T, Schröck E, Hirotsune S, Tagle DA, Collins FS, Wynshaw-Boris A, Ried T, Copeland NG, Jenkins NA, Shiloh Y, Ziv Y.

Genomics. 1996 Jul 1;35(1):39-45.


Genomic Organization of the ATM gene.

Uziel T, Savitsky K, Platzer M, Ziv Y, Helbitz T, Nehls M, Boehm T, Rosenthal A, Shiloh Y, Rotman G.

Genomics. 1996 Apr 15;33(2):317-20.


A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.

Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G.

Genomics. 1996 Apr 15;33(2):199-206.


Predominance of null mutations in ataxia-telangiectasia.

Gilad S, Khosravi R, Shkedy D, Uziel T, Ziv Y, Savitsky K, Rotman G, Smith S, Chessa L, Jorgensen TJ, Harnik R, Frydman M, Sanal O, Portnoi S, Goldwicz Z, Jaspers NG, Gatti RA, Lenoir G, Lavin MF, Tatsumi K, Wegner RD, Shiloh Y, Bar-Shira A.

Hum Mol Genet. 1996 Apr;5(4):433-9.


The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.

Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G.

Hum Mol Genet. 1995 Nov;4(11):2025-32.


A single ataxia telangiectasia gene with a product similar to PI-3 kinase.

Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NG, Taylor AM, Arlett CF, Miki T, Weissman SM, Lovett M, Collins FS, Shiloh Y.

Science. 1995 Jun 23;268(5218):1749-53.


A high-density microsatellite map of the ataxia-telangiectasia locus.

Vanagaite L, James MR, Rotman G, Savitsky K, Bar-Shira A, Gilad S, Ziv Y, Uchenik V, Sartiel A, Collins FS, Sheffield VC, Richard CW 3rd, Weissenbach J, Shiloh Y.

Hum Genet. 1995 Apr;95(4):451-4.


Rapid identification of polymorphic CA-repeats in YAC clones.

Rotman G, Vanagaite L, Collins FS, Shiloh Y.

Mol Biotechnol. 1995 Apr;3(2):85-92.


Physical and genetic mapping at the ATA/ATC locus on chromosome 11q22-23.

Rotman G, Savitski K, Vanagaite L, Bar-Shira A, Ziv Y, Gilad S, Uchenik V, Smith S, Shiloh Y.

Int J Radiat Biol. 1994 Dec;66(6 Suppl):S63-6.


Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an approximately 850 kb region on chromosome 11q23.1.

Gatti RA, Lange E, Rotman G, Chen X, Uhrhammer N, Liang T, Chiplunkar S, Yang L, Udar N, Dandekar S, Sheikhavandi S, Wang Z, Yang HM, Polikow J, Elashoff M, Teletar M, Sanal O, Chessa L, McConville C, Taylor M, Shiloh Y, Porras O, Borresen AL, Wegner RD, Curry C, Gerken S, Lange K, Concannon P.

Int J Radiat Biol. 1994 Dec;66(6 Suppl):S57-62.


A haplotype common to intermediate radiosensitivity variants of ataxia-telangiectasia in the UK.

Taylor AM, McConville CM, Rotman G, Shiloh Y, Byrd PJ.

Int J Radiat Biol. 1994 Dec;66(6 Suppl):S35-41.


A YAC contig spanning the ataxia-telangiectasia locus (groups A and C) at 11q22-q23.

Rotman G, Savitsky K, Ziv Y, Cole CG, Higgins MJ, Bar-Am I, Dunham I, Bar-Shira A, Vanagaite L, Qin S, Zhang J, Nowak NJ, Chandrasekharappa SC, Lehrach H, Avivi L, Shows TB, Collins FS, Bentley DR, Shiloh Y.

Genomics. 1994 Nov 15;24(2):234-42.


Three dinucleotide repeat polymorphisms at the ataxia-telangiectasia locus.

Rotman G, Vanagaite L, Collins FS, Shiloh Y.

Hum Mol Genet. 1994 Nov;3(11):2079. No abstract available.


Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23.

Vanagaite L, Savitsky K, Rotman G, Ziv Y, Gerken SC, White R, Weissenbach J, Gillett G, Benham FJ, Richard CW 3rd, James MR, Collins FS, Shiloh Y.

Genomics. 1994 Jul 1;22(1):231-3.


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