Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 216


PETscan: measuring incidence of disease phenotypes to prioritize genetic studies in companion animals.

Keijser SFA, Vernooij JCM, Rothuizen J, Fieten H, Nielen M, Hesselink JW, van Steenbeek FG.

Anim Genet. 2018 Oct;49(5):492-495. doi: 10.1111/age.12707. Epub 2018 Jul 30.


Genome-wide based model predicting recovery from portosystemic shunting after liver shunt attenuation in dogs.

Van den Bossche L, van Steenbeek FG, Weber MF, Spee B, Penning LC, van Sluijs FJ, Zomerdijk F, Groot Koerkamp MJA, Rothuizen J, Burgener IA, Kummeling A.

J Vet Intern Med. 2018 Jul;32(4):1343-1352. doi: 10.1111/jvim.15140. Epub 2018 May 17.


Immunohistochemical characterisation of the hepatic stem cell niche in feline hepatic lipidosis: a preliminary morphological study.

Valtolina C, Robben JH, Favier RP, Rothuizen J, Grinwis GC, Schotanus BA, Penning LC.

J Feline Med Surg. 2018 May 1:1098612X18765922. doi: 10.1177/1098612X18765922. [Epub ahead of print]


DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells.

Kruitwagen HS, Westendorp B, Viebahn CS, Post K, van Wolferen ME, Oosterhoff LA, Egan DA, Delabar JM, Toussaint MJ, Schotanus BA, de Bruin A, Rothuizen J, Penning LC, Spee B.

Stem Cells Dev. 2018 Jan 15;27(2):133-146. doi: 10.1089/scd.2017.0139. Epub 2018 Jan 3.


Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour.

van Sprundel RG, van den Ingh TS, Schotanus BA, van Wolferen ME, Penning LC, Rothuizen J, Spee B.

Vet Rec Open. 2017 Oct 21;4(1):e000212. doi: 10.1136/vetreco-2016-000212. eCollection 2017.


Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts.

Van den Bossche L, Schoonenberg VAC, Burgener IA, Penning LC, Schrall IM, Kruitwagen HS, van Wolferen ME, Grinwis GCM, Kummeling A, Rothuizen J, van Velzen JF, Stathonikos N, Molenaar MR, Helms BJ, Brouwers JFHM, Spee B, van Steenbeek FG.

PLoS One. 2017 Oct 19;12(10):e0186491. doi: 10.1371/journal.pone.0186491. eCollection 2017.


Saline is as effective as nitrogen scavengers for treatment of hyperammonemia.

van Straten G, de Sain-van der Velden MGM, van Geijlswijk IM, Favier RP, Mesu SJ, Holwerda-Loof NE, van der Ham M, Fieten H, Rothuizen J, Spee B, Verhoeven-Duif NM.

Sci Rep. 2017 Oct 13;7(1):13112. doi: 10.1038/s41598-017-12686-9.


Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis.

Valtolina C, Vaandrager AB, Favier RP, Tuohetahuntila M, Kummeling A, Jeusette I, Rothuizen J, Robben JH.

BMC Vet Res. 2017 Aug 8;13(1):231. doi: 10.1186/s12917-017-1152-y.


Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers.

Dirksen K, Burgener IA, Rothuizen J, van den Ingh TSGAM, Penning LC, Spee B, Fieten H.

J Vet Intern Med. 2017 Jul;31(4):1017-1027. doi: 10.1111/jvim.14716. Epub 2017 May 23.


Disease burden in four populations of dog and cat breeds compared to mixed-breed dogs and European shorthair cats.

Keijser SFA, Meijndert LE, Fieten H, Carrière BJ, van Steenbeek FG, Leegwater PAJ, Rothuizen J, Nielen M.

Prev Vet Med. 2017 May 1;140:38-44. doi: 10.1016/j.prevetmed.2017.02.016. Epub 2017 Mar 2.


Gene expression patterns in the progression of canine copper-associated chronic hepatitis.

Dirksen K, Spee B, Penning LC, van den Ingh TSGAM, Burgener IA, Watson AL, Groot Koerkamp M, Rothuizen J, van Steenbeek FG, Fieten H.

PLoS One. 2017 May 1;12(5):e0176826. doi: 10.1371/journal.pone.0176826. eCollection 2017.


Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment

Otte CM, Penning LC, Rothuizen J.

J Feline Med Surg. 2017 May;19(5):514-528. doi: 10.1177/1098612X17706465. Review.


Immunohistochemical evaluation of the activation of hepatic progenitor cells and their niche in feline lymphocytic cholangitis.

Otte CM, Valtolina C, Vreman S, Hubers S, van Wolferen ME, Favier RP, Rothuizen J, Penning LC.

J Feline Med Surg. 2018 Jan;20(1):30-37. doi: 10.1177/1098612X17699723. Epub 2017 Mar 28.


Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.

Kruitwagen HS, Oosterhoff LA, Vernooij IGWH, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B.

Stem Cell Reports. 2017 Apr 11;8(4):822-830. doi: 10.1016/j.stemcr.2017.02.015. Epub 2017 Mar 23.


Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals.

Nantasanti S, de Bruin A, Rothuizen J, Penning LC, Schotanus BA.

Stem Cells Transl Med. 2016 Mar;5(3):325-30. doi: 10.5966/sctm.2015-0152. Epub 2016 Jan 21. Review.


The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.

Fieten H, Gill Y, Martin AJ, Concilli M, Dirksen K, van Steenbeek FG, Spee B, van den Ingh TS, Martens EC, Festa P, Chesi G, van de Sluis B, Houwen RH, Watson AL, Aulchenko YS, Hodgkinson VL, Zhu S, Petris MJ, Polishchuk RS, Leegwater PA, Rothuizen J.

Dis Model Mech. 2016 Jan;9(1):25-38. doi: 10.1242/dmm.020263.


No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats.

Valtolina C, Vaandrager AB, Favier RP, Robben JH, Tuohetahuntila M, Kummeling A, Jeusette I, Rothuizen J.

BMC Vet Res. 2015 Nov 9;11:280. doi: 10.1186/s12917-015-0591-6.


Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.

Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RRG, Clevers H, de Bruin A, Rothuizen J, Penning LC, Schotanus BA.

Stem Cell Reports. 2015 Nov 10;5(5):895-907. doi: 10.1016/j.stemcr.2015.09.002. Epub 2015 Oct 8.


Diagnostic value of the rectal ammonia tolerance test, fasting plasma ammonia and fasting plasma bile acids for canine portosystemic shunting.

van Straten G, Spee B, Rothuizen J, van Straten M, Favier RP.

Vet J. 2015 Jun;204(3):282-6. doi: 10.1016/j.tvjl.2015.04.020. Epub 2015 Apr 16.


Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt.

van Dongen AM, Heuving SM, Tryfonidou MA, van Steenbeek FG, Rothuizen J, Penning LC.

Vet J. 2015 May;204(2):226-8. doi: 10.1016/j.tvjl.2015.03.008. Epub 2015 Mar 11.


Dietary management of labrador retrievers with subclinical hepatic copper accumulation.

Fieten H, Biourge VC, Watson AL, Leegwater PA, van den Ingh TS, Rothuizen J.

J Vet Intern Med. 2015 May-Jun;29(3):822-7. doi: 10.1111/jvim.12574. Epub 2015 Mar 16.


Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche.

Schotanus BA, Kruitwagen HS, van den Ingh TS, van Wolferen ME, Rothuizen J, Penning LC, Spee B.

BMC Vet Res. 2014 Dec 31;10:309. doi: 10.1186/s12917-014-0309-1.


Classification of primary hepatic tumours in the cat.

van Sprundel RG, van den Ingh TS, Guscetti F, Kershaw O, van Wolferen ME, Rothuizen J, Spee B.

Vet J. 2014 Nov;202(2):255-66. doi: 10.1016/j.tvjl.2014.07.002. Epub 2014 Jul 15.


Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.

Favier RP, Spee B, Fieten H, van den Ingh TS, Schotanus BA, Brinkhof B, Rothuizen J, Penning LC.

J Trace Elem Med Biol. 2015 Jan;29:347-53. doi: 10.1016/j.jtemb.2014.06.007. Epub 2014 Jun 24.


Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts.

van Straten G, van Steenbeek FG, Grinwis GC, Favier RP, Kummeling A, van Gils IH, Fieten H, Groot Koerkamp MJ, Holstege FC, Rothuizen J, Spee B.

PLoS One. 2014 Jun 19;9(6):e100077. doi: 10.1371/journal.pone.0100077. eCollection 2014.


The canine hepatic progenitor cell niche: molecular characterisation in health and disease.

Kruitwagen HS, Spee B, Viebahn CS, Venema HB, Penning LC, Grinwis GC, Favier RP, van den Ingh TS, Rothuizen J, Schotanus BA.

Vet J. 2014 Sep;201(3):345-52. doi: 10.1016/j.tvjl.2014.05.024. Epub 2014 May 22.


Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort.

van der Laan LJ, de Ruiter PE, van Gils IM, Fieten H, Spee B, Pan Q, Rothuizen J, Penning LC.

J Viral Hepat. 2014 Dec;21(12):894-6. doi: 10.1111/jvh.12268. Epub 2014 Jun 5.


New canine models of copper toxicosis: diagnosis, treatment, and genetics.

Fieten H, Penning LC, Leegwater PA, Rothuizen J.

Ann N Y Acad Sci. 2014 May;1314:42-8. doi: 10.1111/nyas.12442. Epub 2014 Apr 23.


A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis.

Otte CM, Rothuizen J, Favier RP, Penning LC, Vreman S.

J Feline Med Surg. 2014 Oct;16(10):796-804. doi: 10.1177/1098612X14520811. Epub 2014 Feb 4.


Nutritional management of inherited copper-associated hepatitis in the Labrador retriever.

Fieten H, Biourge VC, Watson AL, Leegwater PA, van den Ingh TS, Rothuizen J.

Vet J. 2014 Mar;199(3):429-33. doi: 10.1016/j.tvjl.2013.12.017. Epub 2013 Dec 22.


Classification of primary hepatic tumours in the dog.

van Sprundel RG, van den Ingh TS, Guscetti F, Kershaw O, Kanemoto H, van Gils HM, Rothuizen J, Roskams T, Spee B.

Vet J. 2013 Sep;197(3):596-606. doi: 10.1016/j.tvjl.2013.05.027. Epub 2013 Sep 5.


A retrospective study of oral prednisolone treatment in canine chronic hepatitis.

Favier RP, Poldervaart JH, van den Ingh TS, Penning LC, Rothuizen J.

Vet Q. 2013;33(3):113-20. doi: 10.1080/01652176.2013.826881. Epub 2013 Aug 13.


American Cocker Spaniel chronic hepatitis in Japan.

Kanemoto H, Sakai M, Sakamoto Y, Spee B, van den Ingh TS, Schotanus BA, Ohno K, Rothuizen J.

J Vet Intern Med. 2013 Sep-Oct;27(5):1041-8. doi: 10.1111/jvim.12126. Epub 2013 Jun 19.


Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs.

Fieten H, Hugen S, van den Ingh TS, Hendriks WH, Vernooij JC, Bode P, Watson AL, Leegwater PA, Rothuizen J.

Vet J. 2013 Aug;197(2):468-73. doi: 10.1016/j.tvjl.2013.03.003. Epub 2013 Apr 9.


Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.

van Steenbeek FG, Spee B, Penning LC, Kummeling A, van Gils IH, Grinwis GC, Van Leenen D, Holstege FC, Vos-Loohuis M, Rothuizen J, Leegwater PA.

PLoS One. 2013;8(3):e57973. doi: 10.1371/journal.pone.0057973. Epub 2013 Mar 5.


Aberrant gene expression in dogs with portosystemic shunts.

van Steenbeek FG, Van den Bossche L, Grinwis GC, Kummeling A, van Gils IH, Koerkamp MJ, van Leenen D, Holstege FC, Penning LC, Rothuizen J, Leegwater PA, Spee B.

PLoS One. 2013;8(2):e57662. doi: 10.1371/journal.pone.0057662. Epub 2013 Feb 25. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/5cccaae3-f06c-413f-857e-46546e87fce1.


D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.

Fieten H, Dirksen K, van den Ingh TS, Winter EA, Watson AL, Leegwater PA, Rothuizen J.

Vet J. 2013 Jun;196(3):522-7. doi: 10.1016/j.tvjl.2012.12.013. Epub 2013 Jan 31.


Association of dietary copper and zinc levels with hepatic copper and zinc concentration in Labrador Retrievers.

Fieten H, Hooijer-Nouwens BD, Biourge VC, Leegwater PA, Watson AL, van den Ingh TS, Rothuizen J.

J Vet Intern Med. 2012 Nov-Dec;26(6):1274-80. doi: 10.1111/j.1939-1676.2012.01001.x. Epub 2012 Sep 24.


COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.

Favier RP, Spee B, Schotanus BA, van den Ingh TS, Fieten H, Brinkhof B, Viebahn CS, Penning LC, Rothuizen J.

PLoS One. 2012;7(8):e42158. doi: 10.1371/journal.pone.0042158. Epub 2012 Aug 6.


Retrospective comparison of prednisolone and ursodeoxycholic acid for the treatment of feline lymphocytic cholangitis.

Otte CM, Penning LC, Rothuizen J, Favier RP.

Vet J. 2013 Feb;195(2):205-9. doi: 10.1016/j.tvjl.2012.06.020. Epub 2012 Jul 25.


Distribution of extrahepatic congenital portosystemic shunt morphology in predisposed dog breeds.

Van den Bossche L, van Steenbeek FG, Favier RP, Kummeling A, Leegwater PA, Rothuizen J.

BMC Vet Res. 2012 Jul 11;8:112. doi: 10.1186/1746-6148-8-112.


Sequence-independent VIDISCA-454 technique to discover new viruses in canine livers.

van der Heijden M, de Vries M, van Steenbeek FG, Favier RP, Deijs M, Brinkhof B, Rothuizen J, van der Hoek L, Penning LC.

J Virol Methods. 2012 Oct;185(1):152-5. doi: 10.1016/j.jviromet.2012.05.019. Epub 2012 Jun 1.


Canine models of copper toxicosis for understanding mammalian copper metabolism.

Fieten H, Leegwater PA, Watson AL, Rothuizen J.

Mamm Genome. 2012 Feb;23(1-2):62-75. doi: 10.1007/s00335-011-9378-7. Epub 2011 Dec 7. Review.


Detection of bacterial DNA in bile of cats with lymphocytic cholangitis.

Otte CM, Gutiérrez OP, Favier RP, Rothuizen J, Penning LC.

Vet Microbiol. 2012 Apr 23;156(1-2):217-21. doi: 10.1016/j.vetmic.2011.10.023. Epub 2011 Nov 3.


Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein.

van Steenbeek FG, van den Bossche L, Leegwater PA, Rothuizen J.

Mamm Genome. 2012 Feb;23(1-2):76-84. doi: 10.1007/s00335-011-9364-0. Epub 2011 Nov 4. Review.


Copper-induced hepatitis: the COMMD1 deficient dog as a translational animal model for human chronic hepatitis.

Favier RP, Spee B, Penning LC, Rothuizen J.

Vet Q. 2011 Mar;31(1):49-60. doi: 10.1080/01652176.2011.563146. Review.


High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia.

Piek CJ, Brinkhof B, Teske E, Rothuizen J, Dekker A, Penning LC.

Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):346-54. doi: 10.1016/j.vetimm.2011.08.010. Epub 2011 Aug 22.


Recombinant hepatocyte growth factor treatment in a canine model of congenital liver hypoplasia.

Kruitwagen HS, Arends B, Spee B, Brinkhof B, van den Ingh TS, Rutten VP, Penning LC, Roskams T, Rothuizen J.

Liver Int. 2011 Aug;31(7):940-9. doi: 10.1111/j.1478-3231.2011.02513.x. Epub 2011 Mar 29.


Hepatic gene expression and plasma albumin concentration related to outcome after attenuation of a congenital portosystemic shunt in dogs.

Kummeling A, Penning LC, Rothuizen J, Brinkhof B, Weber MF, van Sluijs FJ.

Vet J. 2012 Mar;191(3):383-8. doi: 10.1016/j.tvjl.2011.04.022.


[Cholangitis in cats: symptoms, cause, diagnosis, treatment, and prognosis].

Otte CM, Penning LC, Rothuizen J, Favier RP.

Tijdschr Diergeneeskd. 2011 May 1;136(5):332-8. Review. Dutch.


Supplemental Content

Loading ...
Support Center