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Items: 1 to 50 of 213


Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice.

Guo B, Ludlow AV, Brightwell AS, Rothstein TL.

Cell Immunol. 2019 Dec;346:103993. doi: 10.1016/j.cellimm.2019.103993. Epub 2019 Oct 16.


SSEP retains its value as predictor of poor outcome following cardiac arrest in the era of therapeutic hypothermia.

Rothstein TL.

Crit Care. 2019 Oct 23;23(1):327. doi: 10.1186/s13054-019-2576-5. Review.


Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.

Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen A, McSkimming C, Marshall MA, Garmey JC, Taylor AM, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA.

Circ Res. 2019 Oct 25;125(10):e55-e70. doi: 10.1161/CIRCRESAHA.119.315786. Epub 2019 Sep 24.


B1 B cell progenitors.

Ghosn E, Dorshkind K, Herzenberg LA, Holodick N, Kantor A, Montecino-Rodriguez E, Rothstein TL, Silverman GJ, Yang Y, Yoder MC, Yoshimoto M.

Science. 2019 Apr 19;364(6437):248. doi: 10.1126/science.aax6784. Epub 2019 Apr 18. No abstract available.


Human B-1 Cells and B-1 Cell Antibodies Change With Advancing Age.

Rodriguez-Zhurbenko N, Quach TD, Hopkins TJ, Rothstein TL, Hernandez AM.

Front Immunol. 2019 Mar 19;10:483. doi: 10.3389/fimmu.2019.00483. eCollection 2019.


Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients.

Huang W, Quach TD, Dascalu C, Liu Z, Leung T, Byrne-Steele M, Pan W, Yang Q, Han J, Lesser M, Rothstein TL, Furie R, Mackay M, Aranow C, Davidson A.

JCI Insight. 2018 Sep 6;3(17). pii: 122525. doi: 10.1172/jci.insight.122525. eCollection 2018 Sep 6.


B-1a cells protect mice from sepsis-induced acute lung injury.

Aziz M, Ode Y, Zhou M, Ochani M, Holodick NE, Rothstein TL, Wang P.

Mol Med. 2018 May 29;24(1):26. doi: 10.1186/s10020-018-0029-2.


Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis.

Gallego JA, Blanco EA, Husain-Krautter S, Madeline Fagen E, Moreno-Merino P, Del Ojo-Jiménez JA, Ahmed A, Rothstein TL, Lencz T, Malhotra AK.

Schizophr Res. 2018 Dec;202:64-71. doi: 10.1016/j.schres.2018.07.019. Epub 2018 Jul 17.


CD25 + B-1a Cells Express Aicda.

Kaku H, Holodick NE, Tumang JR, Rothstein TL.

Front Immunol. 2017 Jun 20;8:672. doi: 10.3389/fimmu.2017.00672. eCollection 2017.


B-1a Cells Protect Mice from Sepsis: Critical Role of CREB.

Aziz M, Holodick NE, Rothstein TL, Wang P.

J Immunol. 2017 Jul 15;199(2):750-760. doi: 10.4049/jimmunol.1602056. Epub 2017 Jun 19.


Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells.

Quách TD, Hopkins TJ, Holodick NE, Vuyyuru R, Manser T, Bayer RL, Rothstein TL.

J Immunol. 2016 Nov 15;197(10):3950-3958. Epub 2016 Oct 7.


Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.

Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, Lövdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW, Tracey KJ.

Nat Biotechnol. 2016 Oct;34(10):1066-1071. doi: 10.1038/nbt.3663. Epub 2016 Sep 12.


IL-4 rescues surface IgM expression in chronic lymphocytic leukemia.

Guo B, Zhang L, Chiorazzi N, Rothstein TL.

Blood. 2016 Jul 28;128(4):553-62. doi: 10.1182/blood-2015-11-682997. Epub 2016 May 25.


Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age.

Holodick NE, Vizconde T, Hopkins TJ, Rothstein TL.

J Immunol. 2016 May 15;196(10):4348-57. doi: 10.4049/jimmunol.1600073. Epub 2016 Apr 20.


Natural Antibodies as Rheostats for Susceptibility to Chronic Diseases in the Aged.

Rothstein TL.

Front Immunol. 2016 Apr 7;7:127. doi: 10.3389/fimmu.2016.00127. eCollection 2016. Review.


Expansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice.

Holodick NE, Zeumer L, Rothstein TL, Morel L.

Front Immunol. 2016 Mar 24;7:108. doi: 10.3389/fimmu.2016.00108. eCollection 2016.


RasGRP1 Is an Essential Signaling Molecule for Development of B1a Cells with Autoantigen Receptors.

Guo B, Rothstein TL.

J Immunol. 2016 Mar 15;196(6):2583-90. doi: 10.4049/jimmunol.1502132. Epub 2016 Feb 5.


Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction.

Sharma A, Kiripolsky J, Klimatcheva E, Howell A, Fereidouni F, Levenson R, Rothstein TL, Kramer JM.

Clin Immunol. 2016 Mar;164:85-94. doi: 10.1016/j.clim.2016.01.015. Epub 2016 Jan 28.


Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood.

Quách TD, Rodríguez-Zhurbenko N, Hopkins TJ, Guo X, Hernández AM, Li W, Rothstein TL.

J Immunol. 2016 Feb 1;196(3):1060-9. doi: 10.4049/jimmunol.1501843. Epub 2016 Jan 6.


B-1 Cell Development and Function.

Rothstein TL, Herzenberg LA, Holodick NE, Ghosn E.

Ann N Y Acad Sci. 2015 Dec;1362:v-vi. doi: 10.1111/nyas.12949. No abstract available.


The role of B-1 cells in inflammation.

Aziz M, Holodick NE, Rothstein TL, Wang P.

Immunol Res. 2015 Dec;63(1-3):153-66. doi: 10.1007/s12026-015-8708-3. Review.


Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome.

Kramer JM, Holodick NE, Vizconde TC, Raman I, Yan M, Li QZ, Gaile DP, Rothstein TL.

J Leukoc Biol. 2016 Feb;99(2):321-31. doi: 10.1189/jlb.2A0715-297R. Epub 2015 Sep 17.


Low Levels of IgM Antibodies against an Advanced Glycation Endproduct-Modified Apolipoprotein B100 Peptide Predict Cardiovascular Events in Nondiabetic Subjects.

Engelbertsen D, Vallejo J, Quách TD, Fredrikson GN, Alm R, Hedblad B, Björkbacka H, Rothstein TL, Nilsson J, Bengtsson E.

J Immunol. 2015 Oct 1;195(7):3020-5. doi: 10.4049/jimmunol.1402869. Epub 2015 Aug 19.


Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability.

Cui X, Zhang L, Magli AR, Catera R, Yan XJ, Griffin DO, Rothstein TL, Barrientos J, Kolitz JE, Allen SL, Rai KR, Chiorazzi N, Chu CC.

Leukemia. 2016 Jan;30(1):74-85. doi: 10.1038/leu.2015.204. Epub 2015 Jul 29.


B cells in the aging immune system: time to consider B-1 cells.

Holodick NE, Rothstein TL.

Ann N Y Acad Sci. 2015 Dec;1362:176-87. doi: 10.1111/nyas.12825. Epub 2015 Jul 20. Review.


The human counterpart of mouse B-1 cells.

Rothstein TL, Quach TD.

Ann N Y Acad Sci. 2015 Dec;1362:143-52. doi: 10.1111/nyas.12790. Epub 2015 May 18. Review.


The osteopontin transgenic mouse is a new model for Sjögren's syndrome.

Husain-Krautter S, Kramer JM, Li W, Guo B, Rothstein TL.

Clin Immunol. 2015 Mar;157(1):30-42. doi: 10.1016/j.clim.2014.12.010. Epub 2015 Jan 5.


A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.

Kaku H, Cheng KF, Al-Abed Y, Rothstein TL.

J Immunol. 2014 Dec 15;193(12):5904-13. doi: 10.4049/jimmunol.1400336. Epub 2014 Nov 12.


Therapeutic hypothermia does not diminish the vital and necessary role of SSEP in predicting unfavorable outcome in anoxic-ischemic coma.

Rothstein TL.

Clin Neurol Neurosurg. 2014 Nov;126:205-9. doi: 10.1016/j.clineuro.2014.08.031. Epub 2014 Sep 3. Review.


Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.

Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK.

J Exp Med. 2014 Jun 2;211(6):1243-56. doi: 10.1084/jem.20131471. Epub 2014 May 12.


Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice.

Holodick NE, Vizconde T, Rothstein TL.

Front Immunol. 2014 Mar 28;5:129. doi: 10.3389/fimmu.2014.00129. eCollection 2014.


B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location.

Holodick NE, Vizconde T, Rothstein TL.

J Immunol. 2014 Mar 1;192(5):2432-41. doi: 10.4049/jimmunol.1300247. Epub 2014 Jan 29.


Atypical Response of B-1 Cells to BCR Ligation: A Speculative Model.

Holodick NE, Rothstein TL.

Front Immunol. 2013 Dec 16;4:457. doi: 10.3389/fimmu.2013.00457. Review.


Human B-1 cells are not preplasmablasts: analysis of microarray data and other issues.

Li W, Batliwalla F, Rothstein TL.

Blood. 2013 Nov 21;122(22):3691-3. doi: 10.1182/blood-2013-08-520031. No abstract available.


CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis.

Kramer JM, Klimatcheva E, Rothstein TL.

J Leukoc Biol. 2013 Nov;94(5):1079-89. doi: 10.1189/jlb.0113036. Epub 2013 Jul 31.


IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation.

Guo B, Rothstein TL.

J Immunol. 2013 Jul 15;191(2):670-7. doi: 10.4049/jimmunol.1203211. Epub 2013 Jun 17.


Human B-1 cells take the stage.

Rothstein TL, Griffin DO, Holodick NE, Quach TD, Kaku H.

Ann N Y Acad Sci. 2013 May;1285:97-114. doi: 10.1111/nyas.12137. Review.


Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling.

Chen SS, Batliwalla F, Holodick NE, Yan XJ, Yancopoulos S, Croce CM, Rothstein TL, Chiorazzi N.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1500-7. doi: 10.1073/pnas.1300616110. Epub 2013 Apr 2.


A novel Lyn-protein kinase Cδ/ε-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signaling.

Guo B, Rothstein TL.

Eur J Immunol. 2013 Jun;43(6):1643-50. doi: 10.1002/eji.201242830. Epub 2013 Apr 12.


Induction of Th17 cell differentiation by B-1 cells.

Wang Y, Rothstein TL.

Front Immunol. 2012 Sep 11;3:281. doi: 10.3389/fimmu.2012.00281. eCollection 2012.


Human b1 cell frequency: isolation and analysis of human b1 cells.

Griffin DO, Rothstein TL.

Front Immunol. 2012 May 25;3:122. doi: 10.3389/fimmu.2012.00122. eCollection 2012.


Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity.

Griffin DO, Rothstein TL.

Mol Med. 2012 Sep 7;18:1003-8. doi: 10.2119/molmed.2012.00203.


Therapeutic hypothermia and reliability of somatosensory evoked potentials in predicting outcome after cardiopulmonary arrest.

Rothstein TL.

Neurocrit Care. 2012 Aug;17(1):146-9. doi: 10.1007/s12028-012-9696-y.


Human CD11b+ B1 cells are not monocytes: A reply to "Gene profiling of CD11b+ and CD11b- B1 cell subsets reveals potential cell sorting artifacts".

Griffin DO, Quach T, Batliwalla F, Andreopoulos D, Holodick NE, Rothstein TL.

J Exp Med. 2012 Mar 12;209(3):434-6. doi: 10.1084/jem.20120403. No abstract available.


Human B1 cells are CD3-: A reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27+CD43+ B cells".

Griffin DO, Holodick NE, Rothstein TL.

J Exp Med. 2011 Dec 19;208(13):2566-9. doi: 10.1084/jem.20111761. No abstract available.


A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus.

Griffin DO, Rothstein TL.

J Exp Med. 2011 Dec 19;208(13):2591-8. doi: 10.1084/jem.20110978. Epub 2011 Nov 21.


Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-.

Griffin DO, Holodick NE, Rothstein TL.

J Exp Med. 2011 Jan 17;208(1):67-80. doi: 10.1084/jem.20101499. Epub 2011 Jan 10. Erratum in: J Exp Med. 2011 Apr 11;208(4):871. J Exp Med. 2011 Feb 14;208(2):409. J Exp Med. 2011 Jan 17;208(1):67.


A late complication of γ knife radiosurgery.

Rothstein TL.

Rev Neurol Dis. 2010;7(4):150-1; discussion 157-9.


L2pB1: a new player in autoimmunity.

Zhong X, Rothstein TL.

Mol Immunol. 2011 Jun;48(11):1292-300. doi: 10.1016/j.molimm.2010.12.006. Epub 2010 Dec 31. Review.


A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF.

Tumang JR, Holodick NE, Vizconde TC, Kaku H, Francés R, Rothstein TL.

Front Immunol. 2011 Mar 21;2:6. doi: 10.3389/fimmu.2011.00006. eCollection 2011.

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