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ITS finally here! The first International Transplant Science meeting jointly organized by AST, ESOT, and TTS.

Chong AS, Rothstein DM, Issa F, Kotsch K, Leuvenink H, Tullius SG.

Transplantation. 2019 Oct;103(10):1975-1976. doi: 10.1097/TP.0000000000002940. No abstract available.


Antigen-dependent interactions between regulatory B cells and T cells at the T:B border inhibit subsequent T cell interactions with DCs.

Mohib K, Cherukuri A, Zhou Y, Ding Q, Watkins SC, Rothstein DM.

Am J Transplant. 2019 Jul 29. doi: 10.1111/ajt.15546. [Epub ahead of print]


In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease.

Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD.

Blood Adv. 2019 Jul 23;3(14):2082-2092. doi: 10.1182/bloodadvances.2019000227.


Post-transplant donor specific antibody is associated with poor kidney transplant outcomes only when combined with both T-cell-mediated rejection and non-adherence.

Cherukuri A, Mehta R, Sharma A, Sood P, Zeevi A, Tevar AD, Rothstein DM, Hariharan S.

Kidney Int. 2019 Jul;96(1):202-213. doi: 10.1016/j.kint.2019.01.033. Epub 2019 Mar 20.


Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection.

Chong AS, Rothstein DM, Safa K, Riella LV.

Am J Transplant. 2019 Aug;19(8):2155-2163. doi: 10.1111/ajt.15323. Epub 2019 Apr 10. Review.


Regulatory and Effector B Cells: A New Path Toward Biomarkers and Therapeutic Targets to Improve Transplant Outcomes?

Cherukuri A, Ding Q, Sharma A, Mohib K, Rothstein DM.

Clin Lab Med. 2019 Mar;39(1):15-29. doi: 10.1016/j.cll.2018.10.011. Epub 2018 Dec 18. Review.


Regulatory B cells and transplantation: almost prime time?

Mohib K, Cherukuri A, Rothstein DM.

Curr Opin Organ Transplant. 2018 Oct;23(5):524-532. doi: 10.1097/MOT.0000000000000559. Review.


Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection.

Fantus D, Dai H, Ono Y, Watson A, Yokota S, Mohib K, Yoshida O, Ross MA, Watkins SC, Ramaswami B, Valusjkikh A, Rothstein DM, Thomson AW.

Transplantation. 2017 Dec;101(12):2830-2840. doi: 10.1097/TP.0000000000001933.


TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.

Ding Q, Mohib K, Kuchroo VK, Rothstein DM.

J Immunol. 2017 Oct 1;199(7):2585-2595. doi: 10.4049/jimmunol.1602107. Epub 2017 Aug 28.


Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.

Dai H, Friday AJ, Abou-Daya KI, Williams AL, Mortin-Toth S, Nicotra ML, Rothstein DM, Shlomchik WD, Matozaki T, Isenberg JS, Oberbarnscheidt MH, Danska JS, Lakkis FG.

Sci Immunol. 2017 Jun 23;2(12). pii: eaam6202. doi: 10.1126/sciimmunol.aam6202.


A Mutation in the Bacillus subtilis rsbU Gene That Limits RNA Synthesis during Sporulation.

Rothstein DM, Lazinski D, Osburne MS, Sonenshein AL.

J Bacteriol. 2017 Jun 27;199(14). pii: e00212-17. doi: 10.1128/JB.00212-17. Print 2017 Jul 15.


Reduced human transitional B cell T1/T2 ratio is associated with subsequent deterioration in renal allograft function.

Cherukuri A, Salama AD, Carter CR, Landsittel D, Arumugakani G, Clark B, Rothstein DM, Baker RJ.

Kidney Int. 2017 Jan;91(1):183-195. doi: 10.1016/j.kint.2016.08.028. Epub 2016 Oct 28.


Rifamycins, Alone and in Combination.

Rothstein DM.

Cold Spring Harb Perspect Med. 2016 Jul 1;6(7). pii: a027011. doi: 10.1101/cshperspect.a027011. Review.


Erratum for Grossman et al., target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA.

Antimicrob Agents Chemother. 2015 Sep;59(9):5870. doi: 10.1128/AAC.01551-15. No abstract available.


New insights into the mechanisms of Treg function.

Rothstein DM, Camirand G.

Curr Opin Organ Transplant. 2015 Aug;20(4):376-84. doi: 10.1097/MOT.0000000000000212. Review.


Role of B cells in tolerance induction.

Kim JI, Rothstein DM, Markmann JF.

Curr Opin Organ Transplant. 2015 Aug;20(4):369-75. doi: 10.1097/MOT.0000000000000204. Review.


TIM-1 signaling is required for maintenance and induction of regulatory B cells.

Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM.

Am J Transplant. 2015 Apr;15(4):942-53. doi: 10.1111/ajt.13087. Epub 2015 Feb 2.


Clinical implications of basic science discoveries: janus resurrected--two faces of B cell and plasma cell biology.

Woodle ES, Rothstein DM.

Am J Transplant. 2015 Jan;15(1):39-43. doi: 10.1111/ajt.13028. Epub 2014 Nov 7. Review.


CD45 ligation expands Tregs by promoting interactions with DCs.

Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM.

J Clin Invest. 2014 Oct;124(10):4603-13. doi: 10.1172/JCI74087. Epub 2014 Sep 9.


A general protein purification and immobilization method on controlled porosity glass: biocatalytic applications.

Engelmark Cassimjee K, Kadow M, Wikmark Y, Svedendahl Humble M, Rothstein ML, Rothstein DM, Bäckvall JE.

Chem Commun (Camb). 2014 Aug 21;50(65):9134-7. doi: 10.1039/c4cc02605e.


Non-self recognition by monocytes initiates allograft rejection.

Oberbarnscheidt MH, Zeng Q, Li Q, Dai H, Williams AL, Shlomchik WD, Rothstein DM, Lakkis FG.

J Clin Invest. 2014 Aug;124(8):3579-89. doi: 10.1172/JCI74370. Epub 2014 Jul 1.


AST Cutting Edge of Transplantation 2013 Meeting Report: a comprehensive look at B cells and antibodies in transplantation.

Mengel M, Chong A, Rothstein DM, Zorn E, Maltzman JS.

Am J Transplant. 2014 Mar;14(3):524-30. doi: 10.1111/ajt.12593. Epub 2014 Jan 24.


TIM4 Regulates the Anti-Islet Th2 Alloimmune Response.

Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH, Fiorina P.

Cell Transplant. 2015;24(8):1599-1614. doi: 10.3727/096368914X678571. Epub 2014 Mar 7.


Immunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells.

Cherukuri A, Rothstein DM, Clark B, Carter CR, Davison A, Hernandez-Fuentes M, Hewitt E, Salama AD, Baker RJ.

J Am Soc Nephrol. 2014 Jul;25(7):1575-85. doi: 10.1681/ASN.2013080837. Epub 2014 Mar 7.


Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen.

Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein DM, Atkinson M, Kamanaka M, Flavell RA, Roncarolo MG, Battaglia M.

Am J Transplant. 2013 Aug;13(8):1963-75. doi: 10.1111/ajt.12333. Epub 2013 Jul 8.


Cognate antigen directs CD8+ T cell migration to vascularized transplants.

Walch JM, Zeng Q, Li Q, Oberbarnscheidt MH, Hoffman RA, Williams AL, Rothstein DM, Shlomchik WD, Kim JV, Camirand G, Lakkis FG.

J Clin Invest. 2013 Jun;123(6):2663-71. doi: 10.1172/JCI66722. Epub 2013 May 15.


Allograft outcomes in outbred mice.

Reichenbach DK, Li Q, Hoffman RA, Williams AL, Shlomchik WD, Rothstein DM, Demetris AJ, Lakkis FG.

Am J Transplant. 2013 Mar;13(3):580-8. doi: 10.1111/ajt.12056. Epub 2013 Jan 11.


Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction.

Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, Lakkis FG, Shlomchik WD.

J Immunol. 2012 Apr 15;188(8):3804-11. doi: 10.4049/jimmunol.1102795. Epub 2012 Mar 14.


Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA.

Antimicrob Agents Chemother. 2012 May;56(5):2559-64. doi: 10.1128/AAC.06187-11. Epub 2012 Feb 21. Erratum in: Antimicrob Agents Chemother. 2015 Sep;59(9):5870.


Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.

Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG.

Transpl Immunol. 2012 Mar;26(2-3):113-8. doi: 10.1016/j.trim.2011.12.006. Epub 2011 Dec 24.


Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

Gagliani N, Gregori S, Jofra T, Valle A, Stabilini A, Rothstein DM, Atkinson M, Roncarolo MG, Battaglia M.

PLoS One. 2011;6(12):e28434. doi: 10.1371/journal.pone.0028434. Epub 2011 Dec 9.


Multiphoton intravital microscopy of the transplanted mouse kidney.

Camirand G, Li Q, Demetris AJ, Watkins SC, Shlomchik WD, Rothstein DM, Lakkis FG.

Am J Transplant. 2011 Oct;11(10):2067-74. doi: 10.1111/j.1600-6143.2011.03671.x. Epub 2011 Aug 11.


Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.

Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM.

J Clin Invest. 2011 Sep;121(9):3645-56. doi: 10.1172/JCI46274. Epub 2011 Aug 8.


Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.

Wang Y, Camirand G, Lin Y, Froicu M, Deng S, Shlomchik WD, Lakkis FG, Rothstein DM.

J Immunol. 2011 Mar 1;186(5):2809-18. doi: 10.4049/jimmunol.0903805. Epub 2011 Jan 26.


Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells.

Skuk D, Paradis M, Goulet M, Chapdelaine P, Rothstein DM, Tremblay JP.

Mol Ther. 2010 Sep;18(9):1689-97. doi: 10.1038/mt.2010.128. Epub 2010 Jul 6.


NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.

Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG.

J Immunol. 2010 Jun 15;184(12):6649-57. doi: 10.4049/jimmunol.0903729. Epub 2010 May 14.


Type I interferons are not critical for skin allograft rejection or the generation of donor-specific CD8+ memory T cells.

Oberbarnscheidt MH, Obhrai JS, Williams AL, Rothstein DM, Shlomchik WD, Chalasani G, Lakkis FG.

Am J Transplant. 2010 Jan;10(1):162-7. doi: 10.1111/j.1600-6143.2009.02871.x. Epub 2009 Nov 24.


An innate response to allogeneic nonself mediated by monocytes.

Zecher D, van Rooijen N, Rothstein DM, Shlomchik WD, Lakkis FG.

J Immunol. 2009 Dec 15;183(12):7810-6. doi: 10.4049/jimmunol.0902194.


A case for immunosuppression for myoblast transplantation in duchenne muscular dystrophy.

Tremblay JP, Skuk D, Palmieri B, Rothstein DM.

Mol Ther. 2009 Jul;17(7):1122-4. doi: 10.1038/mt.2009.125. No abstract available.


Costimulatory pathways in transplantation: challenges and new developments.

Li XC, Rothstein DM, Sayegh MH.

Immunol Rev. 2009 May;229(1):271-93. doi: 10.1111/j.1600-065X.2009.00781.x. Review.


Rifalazil retains activity against rifampin-resistant mutants of Chlamydia pneumoniae.

Rothstein DM, Suchland RJ, Xia M, Murphy CK, Stamm WE.

J Antibiot (Tokyo). 2008 Aug;61(8):489-95. doi: 10.1038/ja.2008.65.


Rifalazil and derivative compounds show potent efficacy in a mouse model of H. pylori colonization.

Rothstein DM, Mullin S, Sirokman K, Söndergaard KL, Johnson S, Gwathmey JK, van Duzer J, Murphy CK.

J Antibiot (Tokyo). 2008 Aug;61(8):485-8. doi: 10.1038/ja.2008.64.


CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.

Tang AL, Teijaro JR, Njau MN, Chandran SS, Azimzadeh A, Nadler SG, Rothstein DM, Farber DL.

J Immunol. 2008 Aug 1;181(3):1806-13.


Central tolerance to myogenic cell transplants does not include muscle neoantigens.

Camirand G, Stéphan L, Rousseau J, Sackett MK, Caron NJ, Mills P, Kurtz J, Sykes M, Rothstein DM, Tremblay JP.

Transplantation. 2008 Jun 27;85(12):1791-801. doi: 10.1097/TP.0b013e31817726bc.


Efficacy of benzoxazinorifamycins in a mouse model of Chlamydia pneumoniae lung infection.

Campbell LA, Kuo CC, Suchland RJ, Rothstein DM.

Antimicrob Agents Chemother. 2008 May;52(5):1855-8. doi: 10.1128/AAC.01567-07. Epub 2008 Mar 10.


The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.

Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH.

J Clin Invest. 2008 Feb;118(2):742-51. doi: 10.1172/JCI32451.


In vitro activity of novel rifamycins against gram-positive clinical isolates.

Murphy CK, Karginova E, Sahm D, Rothstein DM.

J Antibiot (Tokyo). 2007 Sep;60(9):572-6.


Rifalazil and other benzoxazinorifamycins in the treatment of chlamydia-based persistent infections.

Rothstein DM, van Duzer J, Sternlicht A, Gilman SC.

Arch Pharm (Weinheim). 2007 Oct;340(10):517-29. Review.


PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.

Tanaka K, Albin MJ, Yuan X, Yamaura K, Habicht A, Murayama T, Grimm M, Waaga AM, Ueno T, Padera RF, Yagita H, Azuma M, Shin T, Blazar BR, Rothstein DM, Sayegh MH, Najafian N.

J Immunol. 2007 Oct 15;179(8):5204-10.


CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcription.

Jen KY, Campo M, He H, Makani SS, Velasco G, Rothstein DM, Perkins DL, Finn PW.

J Immunol. 2007 Sep 15;179(6):4212-8.

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