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Golgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack.

Tiwari N, Graham M, Liu X, Yue X, Zhu L, Meshram D, Choi S, Qian Y, Rothman JE, Lee I.

Sci Rep. 2019 Aug 28;9(1):12465. doi: 10.1038/s41598-019-48875-x.


Jim's view: Why basic science?

Rothman JE.

FEBS Lett. 2019 Jul;593(14):1693-1697. doi: 10.1002/1873-3468.13510. Epub 2019 Jul 12. No abstract available.


Jim's view: What makes transformative basic science possible?

Rothman JE.

FEBS Lett. 2019 Aug;593(15):1877-1878. doi: 10.1002/1873-3468.13517. Epub 2019 Jul 12. No abstract available.


Jim's view: Patience vs urgency.

Rothman JE.

FEBS Lett. 2019 Aug;593(16):2081-2082. doi: 10.1002/1873-3468.13518. Epub 2019 Jul 12. No abstract available.


AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.

Salpietro V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S, Torti E, Hacke M, Rankin J, Tariq H, Colin E, Procaccio V, Striano P, Mankad K, Lieb A, Chen S, Pisani L, Bettencourt C, Männikkö R, Manole A, Brusco A, Grosso E, Ferrero GB, Armstrong-Moron J, Gueden S, Bar-Yosef O, Tzadok M, Monaghan KG, Santiago-Sim T, Person RE, Cho MT, Willaert R, Yoo Y, Chae JH, Quan Y, Wu H, Wang T, Bernier RA, Xia K, Blesson A, Jain M, Motazacker MM, Jaeger B, Schneider AL, Boysen K, Muir AM, Myers CT, Gavrilova RH, Gunderson L, Schultz-Rogers L, Klee EW, Dyment D, Osmond M, Parellada M, Llorente C, Gonzalez-Peñas J, Carracedo A, Van Haeringen A, Ruivenkamp C, Nava C, Heron D, Nardello R, Iacomino M, Minetti C, Skabar A, Fabretto A; SYNAPS Study Group, Raspall-Chaure M, Chez M, Tsai A, Fassi E, Shinawi M, Constantino JN, De Zorzi R, Fortuna S, Kok F, Keren B, Bonneau D, Choi M, Benzeev B, Zara F, Mefford HC, Scheffer IE, Clayton-Smith J, Macaya A, Rothman JE, Eichler EE, Kullmann DM, Houlden H.

Nat Commun. 2019 Jul 12;10(1):3094. doi: 10.1038/s41467-019-10910-w.


PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation.

Chelban V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G, Liu YT, Tribollet E, Haridy NA, Botía JA, Ryten M, Nicolaou P, Minaidou A, Christodoulou K, Kernohan KD, Eaton A, Osmond M, Ito Y, Bourque P, Jepson JEC, Bello O, Bremner F, Cordivari C, Reilly MM, Foiani M, Heslegrave A, Zetterberg H, Heales SJR, Wood NW, Rothman JE, Boycott KM, Mills PB, Clayton PT, Houlden H; Care4Rare Canada Consortium and the SYNaPS Study Group.

Ann Neurol. 2019 Aug;86(2):225-240. doi: 10.1002/ana.25524. Epub 2019 Jul 1.


Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin.

Grushin K, Wang J, Coleman J, Rothman JE, Sindelar CV, Krishnakumar SS.

Nat Commun. 2019 Jun 3;10(1):2413. doi: 10.1038/s41467-019-10391-x.


Highly Reproducible Physiological Asymmetric Membrane with Freely Diffusing Embedded Proteins in a 3D-Printed Microfluidic Setup.

Heo P, Ramakrishnan S, Coleman J, Rothman JE, Fleury JB, Pincet F.

Small. 2019 May;15(21):e1900725. doi: 10.1002/smll.201900725. Epub 2019 Apr 12.


Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment.

Salpietro V, Malintan NT, Llano-Rivas I, Spaeth CG, Efthymiou S, Striano P, Vandrovcova J, Cutrupi MC, Chimenz R, David E, Di Rosa G, Marce-Grau A, Raspall-Chaure M, Martin-Hernandez E, Zara F, Minetti C; Deciphering Developmental Disorders Study; SYNAPS Study Group, Bello OD, De Zorzi R, Fortuna S, Dauber A, Alkhawaja M, Sultan T, Mankad K, Vitobello A, Thomas Q, Mau-Them FT, Faivre L, Martinez-Azorin F, Prada CE, Macaya A, Kullmann DM, Rothman JE, Krishnakumar SS, Houlden H.

Am J Hum Genet. 2019 Apr 4;104(4):721-730. doi: 10.1016/j.ajhg.2019.02.016. Epub 2019 Mar 28.


Labeling Strategies Matter for Super-Resolution Microscopy: A Comparison between HaloTags and SNAP-tags.

Erdmann RS, Baguley SW, Richens JH, Wissner RF, Xi Z, Allgeyer ES, Zhong S, Thompson AD, Lowe N, Butler R, Bewersdorf J, Rothman JE, St Johnston D, Schepartz A, Toomre D.

Cell Chem Biol. 2019 Apr 18;26(4):584-592.e6. doi: 10.1016/j.chembiol.2019.01.003. Epub 2019 Feb 7.


SNARE machinery is optimized for ultrafast fusion.

Manca F, Pincet F, Truskinovsky L, Rothman JE, Foret L, Caruel M.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2435-2442. doi: 10.1073/pnas.1820394116. Epub 2019 Jan 30.


Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+ -sensitive fusion clamp.

Ramakrishnan S, Bera M, Coleman J, Krishnakumar SS, Pincet F, Rothman JE.

FEBS Lett. 2019 Jan;593(2):154-162. doi: 10.1002/1873-3468.13317. Epub 2019 Jan 18.


Symmetrical organization of proteins under docked synaptic vesicles.

Li X, Radhakrishnan A, Grushin K, Kasula R, Chaudhuri A, Gomathinayagam S, Krishnakumar SS, Liu J, Rothman JE.

FEBS Lett. 2019 Jan;593(2):144-153. doi: 10.1002/1873-3468.13316. Epub 2019 Jan 18.


Jim's view: analog to digital conversion in biology.

Rothman JE.

FEBS Lett. 2018 Dec;592(24):4009-4010. doi: 10.1002/1873-3468.13308. Epub 2018 Dec 15. No abstract available.


S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi.

Ernst AM, Syed SA, Zaki O, Bottanelli F, Zheng H, Hacke M, Xi Z, Rivera-Molina F, Graham M, Rebane AA, Björkholm P, Baddeley D, Toomre D, Pincet F, Rothman JE.

Dev Cell. 2018 Nov 19;47(4):479-493.e7. doi: 10.1016/j.devcel.2018.10.024.


FEBS Letters Special Issue on Exocytosis and Endocytosis.

Karatekin E, Rothman JE.

FEBS Lett. 2018 Nov;592(21):3477-3479. doi: 10.1002/1873-3468.13274. No abstract available.


Assessing photodamage in live-cell STED microscopy.

Kilian N, Goryaynov A, Lessard MD, Hooker G, Toomre D, Rothman JE, Bewersdorf J.

Nat Methods. 2018 Oct;15(10):755-756. doi: 10.1038/s41592-018-0145-5. No abstract available.


Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.

Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7624-E7631. doi: 10.1073/pnas.1808792115. Epub 2018 Jul 23.


Jim's View: "Playing Billiards with Science".

Rothman JE.

FEBS Lett. 2018 Jul;592(14):2381-2382. doi: 10.1002/1873-3468.13125. Epub 2018 Jun 19. No abstract available.


High-Throughput Monitoring of Single Vesicle Fusion Using Freestanding Membranes and Automated Analysis.

Ramakrishnan S, Gohlke A, Li F, Coleman J, Xu W, Rothman JE, Pincet F.

Langmuir. 2018 May 22;34(20):5849-5859. doi: 10.1021/acs.langmuir.8b00116. Epub 2018 May 9.


Rearrangements under confinement lead to increased binding energy of Synaptotagmin-1 with anionic membranes in Mg2+ and Ca2.

Gruget C, Coleman J, Bello O, Krishnakumar SS, Perez E, Rothman JE, Pincet F, Donaldson SH Jr.

FEBS Lett. 2018 May;592(9):1497-1506. doi: 10.1002/1873-3468.13040. Epub 2018 Apr 10.


PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly.

Coleman J, Jouannot O, Ramakrishnan SK, Zanetti MN, Wang J, Salpietro V, Houlden H, Rothman JE, Krishnakumar SS.

Cell Rep. 2018 Jan 16;22(3):820-831. doi: 10.1016/j.celrep.2017.12.056.


Jim's View: "Some Thoughts for Young Scientists".

Rothman JE.

FEBS Lett. 2018 Feb;592(4):461-462. doi: 10.1002/1873-3468.12960. Epub 2018 Jan 15. No abstract available.


Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.

Michalski N, Goutman JD, Auclair SM, Boutet de Monvel J, Tertrais M, Emptoz A, Parrin A, Nouaille S, Guillon M, Sachse M, Ciric D, Bahloul A, Hardelin JP, Sutton RB, Avan P, Krishnakumar SS, Rothman JE, Dulon D, Safieddine S, Petit C.

Elife. 2017 Nov 7;6. pii: e31013. doi: 10.7554/eLife.31013.


Two Disease-Causing SNAP-25B Mutations Selectively Impair SNARE C-terminal Assembly.

Rebane AA, Wang B, Ma L, Qu H, Coleman J, Krishnakumar S, Rothman JE, Zhang Y.

J Mol Biol. 2018 Feb 16;430(4):479-490. doi: 10.1016/j.jmb.2017.10.012. Epub 2017 Oct 19.


Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.

Rothman JE, Krishnakumar SS, Grushin K, Pincet F.

FEBS Lett. 2017 Nov;591(21):3459-3480. doi: 10.1002/1873-3468.12874. Epub 2017 Oct 31. Review.


Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity.

Praschberger R, Lowe SA, Malintan NT, Giachello CNG, Patel N, Houlden H, Kullmann DM, Baines RA, Usowicz MM, Krishnakumar SS, Hodge JJL, Rothman JE, Jepson JEC.

Cell Rep. 2017 Oct 3;21(1):97-109. doi: 10.1016/j.celrep.2017.09.004.


Correction: Re-visiting the trans insertion model for complexin clamping.

Krishnakumar SS, Li F, Coleman J, Schauder CM, Kümmel D, Pincet F, Rothman JE, Reinisch KM.

Elife. 2017 Sep 7;6. pii: e31512. doi: 10.7554/eLife.31512. No abstract available.


Land-locked mammalian Golgi reveals cargo transport between stable cisternae.

Dunlop MH, Ernst AM, Schroeder LK, Toomre DK, Lavieu G, Rothman JE.

Nat Commun. 2017 Sep 5;8(1):432. doi: 10.1038/s41467-017-00570-z.


Circular oligomerization is an intrinsic property of synaptotagmin.

Wang J, Li F, Bello OD, Sindelar CV, Pincet F, Krishnakumar SS, Rothman JE.

Elife. 2017 Aug 29;6. pii: e27441. doi: 10.7554/eLife.27441.


ACBD3 functions as a scaffold to organize the Golgi stacking proteins and a Rab33b-GAP.

Yue X, Bao M, Christiano R, Li S, Mei J, Zhu L, Mao F, Yue Q, Zhang P, Jing S, Rothman JE, Qian Y, Lee I.

FEBS Lett. 2017 Sep;591(18):2793-2802. doi: 10.1002/1873-3468.12780. Epub 2017 Aug 21.


Long time-lapse nanoscopy with spontaneously blinking membrane probes.

Takakura H, Zhang Y, Erdmann RS, Thompson AD, Lin Y, McNellis B, Rivera-Molina F, Uno SN, Kamiya M, Urano Y, Rothman JE, Bewersdorf J, Schepartz A, Toomre D.

Nat Biotechnol. 2017 Aug;35(8):773-780. doi: 10.1038/nbt.3876. Epub 2017 Jul 3.


Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.

Chelban V, Patel N, Vandrovcova J, Zanetti MN, Lynch DS, Ryten M, Botía JA, Bello O, Tribollet E, Efthymiou S, Davagnanam I; SYNAPSE Study Group, Bashiri FA, Wood NW, Rothman JE, Alkuraya FS, Houlden H.

Am J Hum Genet. 2017 Jun 1;100(6):969-977. doi: 10.1016/j.ajhg.2017.05.009.


Entropic forces drive self-organization and membrane fusion by SNARE proteins.

Mostafavi H, Thiyagarajan S, Stratton BS, Karatekin E, Warner JM, Rothman JE, O'Shaughnessy B.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5455-5460. doi: 10.1073/pnas.1611506114. Epub 2017 May 10.


A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi.

Bottanelli F, Kilian N, Ernst AM, Rivera-Molina F, Schroeder LK, Kromann EB, Lessard MD, Erdmann RS, Schepartz A, Baddeley D, Bewersdorf J, Toomre D, Rothman JE.

Mol Biol Cell. 2017 Jun 15;28(12):1676-1687. doi: 10.1091/mbc.E16-12-0863. Epub 2017 Apr 20.


Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome.

Salpietro V, Lin W, Delle Vedove A, Storbeck M, Liu Y, Efthymiou S, Manole A, Wiethoff S, Ye Q, Saggar A, McElreavey K, Krishnakumar SS; SYNAPS Study Group, Pitt M, Bello OD, Rothman JE, Basel-Vanagaite L, Hubshman MW, Aharoni S, Manzur AY, Wirth B, Houlden H.

Ann Neurol. 2017 Apr;81(4):597-603. doi: 10.1002/ana.24905. Epub 2017 Mar 29.


Low energy cost for optimal speed and control of membrane fusion.

François-Martin C, Rothman JE, Pincet F.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1238-1241. doi: 10.1073/pnas.1621309114. Epub 2017 Jan 23.


Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex.

Zhang X, Rebane AA, Ma L, Li F, Jiao J, Qu H, Pincet F, Rothman JE, Zhang Y.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8031-E8040. Epub 2016 Nov 28.


Kinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion.

Li F, Tiwari N, Rothman JE, Pincet F.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10536-41. doi: 10.1073/pnas.1604000113. Epub 2016 Sep 6.


Ring-like oligomers of Synaptotagmins and related C2 domain proteins.

Zanetti MN, Bello OD, Wang J, Coleman J, Cai Y, Sindelar CV, Rothman JE, Krishnakumar SS.

Elife. 2016 Jul 19;5. pii: e17262. doi: 10.7554/eLife.17262.


Ultra-High Resolution 3D Imaging of Whole Cells.

Huang F, Sirinakis G, Allgeyer ES, Schroeder LK, Duim WC, Kromann EB, Phan T, Rivera-Molina FE, Myers JR, Irnov I, Lessard M, Zhang Y, Handel MA, Jacobs-Wagner C, Lusk CP, Rothman JE, Toomre D, Booth MJ, Bewersdorf J.

Cell. 2016 Aug 11;166(4):1028-1040. doi: 10.1016/j.cell.2016.06.016. Epub 2016 Jul 7.


FRAP to Characterize Molecular Diffusion and Interaction in Various Membrane Environments.

Pincet F, Adrien V, Yang R, Delacotte J, Rothman JE, Urbach W, Tareste D.

PLoS One. 2016 Jul 7;11(7):e0158457. doi: 10.1371/journal.pone.0158457. eCollection 2016.


Small cargoes pass through synthetically glued Golgi stacks.

Dancourt J, Zheng H, Bottanelli F, Allgeyer ES, Bewersdorf J, Graham M, Liu X, Rothman JE, Lavieu G.

FEBS Lett. 2016 Jun;590(12):1675-86. doi: 10.1002/1873-3468.12210. Epub 2016 May 31.


Self-assembly of size-controlled liposomes on DNA nanotemplates.

Yang Y, Wang J, Shigematsu H, Xu W, Shih WM, Rothman JE, Lin C.

Nat Chem. 2016 May;8(5):476-83. doi: 10.1038/nchem.2472. Epub 2016 Mar 21.


Using ApoE Nanolipoprotein Particles To Analyze SNARE-Induced Fusion Pores.

Bello OD, Auclair SM, Rothman JE, Krishnakumar SS.

Langmuir. 2016 Mar 29;32(12):3015-23. doi: 10.1021/acs.langmuir.6b00245. Epub 2016 Mar 18.


Two-colour live-cell nanoscale imaging of intracellular targets.

Bottanelli F, Kromann EB, Allgeyer ES, Erdmann RS, Wood Baguley S, Sirinakis G, Schepartz A, Baddeley D, Toomre DK, Rothman JE, Bewersdorf J.

Nat Commun. 2016 Mar 4;7:10778. doi: 10.1038/ncomms10778.


A Programmable DNA Origami Platform to Organize SNAREs for Membrane Fusion.

Xu W, Nathwani B, Lin C, Wang J, Karatekin E, Pincet F, Shih W, Rothman JE.

J Am Chem Soc. 2016 Apr 6;138(13):4439-47. doi: 10.1021/jacs.5b13107. Epub 2016 Mar 23.


Accelerating SNARE-Mediated Membrane Fusion by DNA-Lipid Tethers.

Xu W, Wang J, Rothman JE, Pincet F.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14388-92. doi: 10.1002/anie.201506844. Epub 2015 Oct 6.


Correction to Formation of Giant Unilamellar Proteo-Liposomes by Osmotic Shock.

Motta I, Gohlke A, Adrien V, Li F, Gardavot H, Rothman JE, Pincet F.

Langmuir. 2015 Sep 1;31(34):9521. doi: 10.1021/acs.langmuir.5b02955. Epub 2015 Aug 21. No abstract available.


[The source of membrane fusion in the cell].

Rothman JE.

Biol Aujourdhui. 2015;209(1):63-85. doi: 10.1051/jbio/2015010. Epub 2015 Jun 26. French. No abstract available.


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