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Glutaminase activity in GLS1 het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS.

Kosten L, Chowdhury GM, Mingote S, Staelens S, Rothman DL, Behar KL, Rayport S.

Neurochem Int. 2019 Jul 18:104508. doi: 10.1016/j.neuint.2019.104508. [Epub ahead of print]


Dynamic Thermal Mapping of Localized Therapeutic Hypothermia in the Brain.

Walsh JJ, Huang Y, Simmons JW, Goodrich JA, McHugh B, Rothman DL, Elefteriades JA, Hyder F, Coman D.

J Neurotrauma. 2019 Jul 16. doi: 10.1089/neu.2019.6485. [Epub ahead of print]


A Non-cognitive Behavioral Model for Interpreting Functional Neuroimaging Studies.

Shulman RG, Rothman DL.

Front Hum Neurosci. 2019 Mar 11;13:28. doi: 10.3389/fnhum.2019.00028. eCollection 2019.


Glymphatic System Function in Relation to Anesthesia and Sleep States.

Benveniste H, Heerdt PM, Fontes M, Rothman DL, Volkow ND.

Anesth Analg. 2019 Apr;128(4):747-758. doi: 10.1213/ANE.0000000000004069.


Glycemic Variability and Brain Glucose Levels in Type 1 Diabetes.

Hwang JJ, Jiang L, Sanchez Rangel E, Fan X, Ding Y, Lam W, Leventhal J, Dai F, Rothman DL, Mason GF, Sherwin RS.

Diabetes. 2019 Jan;68(1):163-171. doi: 10.2337/db18-0722. Epub 2018 Oct 16.


Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood.

Benveniste H, Dienel G, Jacob Z, Lee H, Makaryus R, Gjedde A, Hyder F, Rothman DL.

Front Neurosci. 2018 Sep 11;12:631. doi: 10.3389/fnins.2018.00631. eCollection 2018.


Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration.

Del Tufo SN, Frost SJ, Hoeft F, Cutting LE, Molfese PJ, Mason GF, Rothman DL, Fulbright RK, Pugh KR.

Front Psychol. 2018 Sep 4;9:1507. doi: 10.3389/fpsyg.2018.01507. eCollection 2018.


Functional MRS with J-edited lactate in human motor cortex at 4 T.

Koush Y, de Graaf RA, Jiang L, Rothman DL, Hyder F.

Neuroimage. 2019 Jan 1;184:101-108. doi: 10.1016/j.neuroimage.2018.09.008. Epub 2018 Sep 8.


Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo.

De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA.

Sci Adv. 2018 Aug 22;4(8):eaat7314. doi: 10.1126/sciadv.aat7314. eCollection 2018 Aug.


Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain.

Mortensen KN, Gjedde A, Thompson GJ, Herman P, Parent MJ, Rothman DL, Kupers R, Ptito M, Stender J, Laureys S, Riedl V, Alkire MT, Hyder F.

Neural Plast. 2018 Jun 12;2018:6120925. doi: 10.1155/2018/6120925. eCollection 2018.


The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.

Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF.

Neuropsychopharmacology. 2018 Sep;43(10):2154-2160. doi: 10.1038/s41386-018-0136-3. Epub 2018 Jun 28.


Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.


Cellular Origin of [18F]FDG-PET Imaging Signals During Ceftriaxone-Stimulated Glutamate Uptake: Astrocytes and Neurons.

Dienel GA, Behar KL, Rothman DL.

Neuroscientist. 2018 Aug;24(4):316-328. doi: 10.1177/1073858417749375. Epub 2017 Dec 24.


Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.

Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, Grinband J, Lieberman JA.

JAMA Psychiatry. 2018 Jan 1;75(1):11-19. doi: 10.1001/jamapsychiatry.2017.3572.


Selective proton-observed, carbon-edited (selPOCE) MRS method for measurement of glutamate and glutamine 13 C-labeling in the human frontal cortex.

De Feyter HM, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf RA.

Magn Reson Med. 2018 Jul;80(1):11-20. doi: 10.1002/mrm.27003. Epub 2017 Nov 13.


The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer.

Shulman RG, Rothman DL.

Trends Cancer. 2017 Nov;3(11):761-767. doi: 10.1016/j.trecan.2017.09.007. Epub 2017 Nov 6. Review.


In vivo detection and automatic analysis of GABA in the mouse brain with MEGA-PRESS at 9.4 T.

Guo J, Gang Z, Sun Y, Laine A, Small SA, Rothman DL.

NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3837. Epub 2017 Nov 3.


Waking Up to a New Model for Studying Neural Systems: What Emergence from Unconscious States Can Reveal about Brain Organization.

Garcia PS, Rothman DL, Fitzpatrick SM.

Front Syst Neurosci. 2017 Oct 17;11:78. doi: 10.3389/fnsys.2017.00078. eCollection 2017. No abstract available.


Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM.

Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS.

JCI Insight. 2017 Oct 19;2(20). pii: 95913. doi: 10.1172/jci.insight.95913.


Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.


Comparison of direct 13C and indirect 1H-[13C] MR detection methods for the study of dynamic metabolic turnover in the human brain.

Chen H, De Feyter HM, Brown PB, Rothman DL, Cai S, de Graaf RA.

J Magn Reson. 2017 Oct;283:33-44. doi: 10.1016/j.jmr.2017.08.004. Epub 2017 Aug 12.


Advances in Imaging Brain Metabolism.

Hyder F, Rothman DL.

Annu Rev Biomed Eng. 2017 Jun 21;19:485-515. doi: 10.1146/annurev-bioeng-071516-044450. Review.


Evaluating the gray and white matter energy budgets of human brain function.

Yu Y, Herman P, Rothman DL, Agarwal D, Hyder F.

J Cereb Blood Flow Metab. 2018 Aug;38(8):1339-1353. doi: 10.1177/0271678X17708691. Epub 2017 Jun 7.


"What to eat or what not to eat-that is still the question" - Reply.

De Feyter HM, Behar KL, de Graaf RA, Rothman DL.

Neuro Oncol. 2017 Apr 1;19(4):596-597. doi: 10.1093/neuonc/now291. No abstract available.


The human brain produces fructose from glucose.

Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS.

JCI Insight. 2017 Feb 23;2(4):e90508. doi: 10.1172/jci.insight.90508.


Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-13C2]Glucose Metabolism in Anesthetized Rats.

Patel AB, Lai JC, Chowdhury GI, Rothman DL, Behar KL.

Neurochem Res. 2017 Jan;42(1):173-190. doi: 10.1007/s11064-016-2103-x. Epub 2016 Dec 26.


Detection of cerebral NAD+ in humans at 7T.

de Graaf RA, De Feyter HM, Brown PB, Nixon TW, Rothman DL, Behar KL.

Magn Reson Med. 2017 Sep;78(3):828-835. doi: 10.1002/mrm.26465. Epub 2016 Sep 26.


Metabolic demands of neural-hemodynamic associated and disassociated areas in brain.

Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F.

J Cereb Blood Flow Metab. 2016 Oct;36(10):1695-1707. Epub 2016 Aug 25.


Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI.

Cell Metab. 2016 Jul 12;24(1):167-71. doi: 10.1016/j.cmet.2016.06.005.


Hypophosphatemia promotes lower rates of muscle ATP synthesis.

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI.

FASEB J. 2016 Oct;30(10):3378-3387. Epub 2016 Jun 23.


A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth.

De Feyter HM, Behar KL, Rao JU, Madden-Hennessey K, Ip KL, Hyder F, Drewes LR, Geschwind JF, de Graaf RA, Rothman DL.

Neuro Oncol. 2016 Aug;18(8):1079-87. doi: 10.1093/neuonc/now088. Epub 2016 May 3.


Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects.

Chowdhury GM, Zhang J, Thomas M, Banasr M, Ma X, Pittman B, Bristow L, Schaeffer E, Duman RS, Rothman DL, Behar KL, Sanacora G.

Mol Psychiatry. 2017 Jan;22(1):120-126. doi: 10.1038/mp.2016.34. Epub 2016 Apr 12.


Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI.

J Biol Chem. 2016 Jun 3;291(23):12161-70. doi: 10.1074/jbc.M116.720631. Epub 2016 Mar 21.


Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis.

Hyder F, Herman P, Bailey CJ, Møller A, Globinsky R, Fulbright RK, Rothman DL, Gjedde A.

J Cereb Blood Flow Metab. 2016 May;36(5):903-16. doi: 10.1177/0271678X15625349. Epub 2016 Jan 11.


Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas.

Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F.

NMR Biomed. 2016 Mar;29(3):309-19. doi: 10.1002/nbm.3466. Epub 2016 Jan 11.


Quantitative β mapping for calibrated fMRI.

Shu CY, Sanganahalli BG, Coman D, Herman P, Rothman DL, Hyder F.

Neuroimage. 2016 Feb 1;126:219-28. doi: 10.1016/j.neuroimage.2015.11.042. Epub 2015 Nov 24.


Response: Commentary: Chronic SSRI Stimulation of Astrocytic 5-HT2B Receptors Change Multiple Gene Expressions/Editings and Metabolism of Glutamate, Glucose and Glycogen: A Potential Paradigm Shift.

Hertz L, Rothman DL, Li B, Peng L.

Front Behav Neurosci. 2015 Nov 13;9:308. doi: 10.3389/fnbeh.2015.00308. eCollection 2015. No abstract available.


Brain region and activity-dependent properties of M for calibrated fMRI.

Shu CY, Herman P, Coman D, Sanganahalli BG, Wang H, Juchem C, Rothman DL, de Graaf RA, Hyder F.

Neuroimage. 2016 Jan 15;125:848-856. doi: 10.1016/j.neuroimage.2015.10.083. Epub 2015 Oct 31.


Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast.

Shulman RG, Rothman DL.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10902-7. doi: 10.1073/pnas.1510730112. Epub 2015 Aug 17.


Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift.

Hertz L, Rothman DL, Li B, Peng L.

Front Behav Neurosci. 2015 Feb 20;9:25. doi: 10.3389/fnbeh.2015.00025. eCollection 2015. Review.


Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized rat In vivo.

Patel AB, de Graaf RA, Rothman DL, Behar KL.

J Neurosci Res. 2015 Jul;93(7):1101-8. doi: 10.1002/jnr.23548. Epub 2015 Feb 6.


Response to burgess.

Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI.

Nat Med. 2015 Feb;21(2):109-10. doi: 10.1038/nm.3790. No abstract available.


High-sensitivity, broadband-decoupled (13) C MR spectroscopy in humans at 7T using two-dimensional heteronuclear single-quantum coherence.

de Graaf RA, De Feyter HM, Rothman DL.

Magn Reson Med. 2015 Oct;74(4):903-14. doi: 10.1002/mrm.25470. Epub 2014 Sep 29.


Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior.

Shulman RG, Hyder F, Rothman DL.

J Cereb Blood Flow Metab. 2014 Nov;34(11):1721-35. doi: 10.1038/jcbfm.2014.145. Epub 2014 Aug 27. Review.


Decreased occipital cortical glutamate levels in response to successful cognitive-behavioral therapy and pharmacotherapy for major depressive disorder.

Abdallah CG, Niciu MJ, Fenton LR, Fasula MK, Jiang L, Black A, Rothman DL, Mason GF, Sanacora G.

Psychother Psychosom. 2014;83(5):298-307. doi: 10.1159/000361078. Epub 2014 Aug 6.


Characterization of cerebral glutamine uptake from blood in the mouse brain: implications for metabolic modeling of 13C NMR data.

Bagga P, Behar KL, Mason GF, De Feyter HM, Rothman DL, Patel AB.

J Cereb Blood Flow Metab. 2014 Oct;34(10):1666-72. doi: 10.1038/jcbfm.2014.129. Epub 2014 Jul 30.

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