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The inflammation-reducing compatible solute ectoine does not impair the cytotoxic effect of ionizing radiation on head and neck cancer cells.

Rieckmann T, Gatzemeier F, Christiansen S, Rothkamm K, Münscher A.

Sci Rep. 2019 Apr 29;9(1):6594. doi: 10.1038/s41598-019-43040-w.


Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC.

Beizaei K, Gleißner L, Hoffer K, Bußmann L, Vu AT, Steinmeister L, Laban S, Möckelmann N, Münscher A, Petersen C, Rothkamm K, Kriegs M.

Head Neck. 2019 Jan;41(1):208-215. doi: 10.1002/hed.25440. Epub 2018 Dec 15.


A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer.

Köcher S, Beyer B, Lange T, Nordquist L, Volquardsen J, Burdak-Rothkamm S, Schlomm T, Petersen C, Rothkamm K, Mansour WY.

Int J Cancer. 2019 Apr 1;144(7):1685-1696. doi: 10.1002/ijc.32018. Epub 2019 Jan 5.


Radiation-induced bystander and systemic effects serve as a unifying model system for genotoxic stress responses.

Burdak-Rothkamm S, Rothkamm K.

Mutat Res. 2018 Oct - Dec;778:13-22. doi: 10.1016/j.mrrev.2018.08.001. Epub 2018 Aug 17. Review.


BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy.

Oing C, Tennstedt P, Simon R, Volquardsen J, Borgmann K, Bokemeyer C, Petersen C, Dikomey E, Rothkamm K, Mansour WY.

Cancer Lett. 2018 Jun 1;423:60-70. doi: 10.1016/j.canlet.2018.03.007. Epub 2018 Mar 8.


Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.

Mansour WY, Tennstedt P, Volquardsen J, Oing C, Kluth M, Hube-Magg C, Borgmann K, Simon R, Petersen C, Dikomey E, Rothkamm K.

Sci Rep. 2018 Mar 2;8(1):3947. doi: 10.1038/s41598-018-22289-7.


Analyzing the influence of kinase inhibitors on DNA repair by differential proteomics of chromatin-interacting proteins and nuclear phospho-proteins.

Gleißner L, Kwiatkowski M, Myllynen L, Steffen P, Petersen C, Rothkamm K, Schlüter H, Kriegs M.

Oncotarget. 2017 Nov 10;8(67):110983-110993. doi: 10.18632/oncotarget.22424. eCollection 2017 Dec 19.


Targeted nanoparticles for tumour radiotherapy enhancement-the long dawn of a golden era?

Gargioni E, Schulz F, Raabe A, Burdak-Rothkamm S, Rieckmann T, Rothkamm K.

Ann Transl Med. 2016 Dec;4(24):523. doi: 10.21037/atm.2016.12.46.


G2-checkpoint targeting and radiosensitization of HPV/p16-positive HNSCC cells through the inhibition of Chk1 and Wee1.

Busch CJ, Kröger MS, Jensen J, Kriegs M, Gatzemeier F, Petersen C, Münscher A, Rothkamm K, Rieckmann T.

Radiother Oncol. 2017 Feb;122(2):260-266. doi: 10.1016/j.radonc.2016.11.017. Epub 2016 Dec 9.


The RENEB operational basis: complement of established biodosimetric assays.

Wojcik A, Oestreicher U, Barrios L, Vral A, Terzoudi G, Ainsbury E, Rothkamm K, Trompier F, Kulka U.

Int J Radiat Biol. 2017 Jan;93(1):15-19. doi: 10.1080/09553002.2016.1235296. Epub 2016 Oct 25.


The second gamma-H2AX assay inter-comparison exercise carried out in the framework of the European biodosimetry network (RENEB).

Moquet J, Barnard S, Staynova A, Lindholm C, Monteiro Gil O, Martins V, Rößler U, Vral A, Vandevoorde C, Wojewódzka M, Rothkamm K.

Int J Radiat Biol. 2017 Jan;93(1):58-64. doi: 10.1080/09553002.2016.1207822. Epub 2016 Aug 15.


Uncertainty of fast biological radiation dose assessment for emergency response scenarios.

Ainsbury EA, Higueras M, Puig P, Einbeck J, Samaga D, Barquinero JF, Barrios L, Brzozowska B, Fattibene P, Gregoire E, Jaworska A, Lloyd D, Oestreicher U, Romm H, Rothkamm K, Roy L, Sommer S, Terzoudi G, Thierens H, Trompier F, Vral A, Woda C.

Int J Radiat Biol. 2017 Jan;93(1):127-135. doi: 10.1080/09553002.2016.1227106. Epub 2016 Sep 26.


Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations.

Monteiro Gil O, Vaz P, Romm H, De Angelis C, Antunes AC, Barquinero JF, Beinke C, Bortolin E, Burbidge CI, Cucu A, Della Monaca S, Domene MM, Fattibene P, Gregoire E, Hadjidekova V, Kulka U, Lindholm C, Meschini R, M'Kacher R, Moquet J, Oestreicher U, Palitti F, Pantelias G, Montoro Pastor A, Popescu IA, Quattrini MC, Ricoul M, Rothkamm K, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Trompier F, Vral A.

Int J Radiat Biol. 2017 Jan;93(1):136-141. doi: 10.1080/09553002.2016.1227107. Epub 2016 Oct 4.


Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB.

Romm H, Ainsbury EA, Barquinero JF, Barrios L, Beinke C, Cucu A, Domene MM, Filippi S, Monteiro Gil O, Gregoire E, Hadjidekova V, Hatzi V, Lindholm C, M Kacher R, Montoro A, Moquet J, Noditi M, Oestreicher U, Palitti F, Pantelias G, Prieto MJ, Popescu I, Rothkamm K, Sebastià N, Sommer S, Terzoudi G, Testa A, Wojcik A.

Int J Radiat Biol. 2017 Jan;93(1):110-117. doi: 10.1080/09553002.2016.1206228. Epub 2016 Aug 22.


Sorafenib inhibits cell growth but fails to enhance radio- and chemosensitivity of glioblastoma cell lines.

Riedel M, Struve N, Müller-Goebel J, Köcher S, Petersen C, Dikomey E, Rothkamm K, Kriegs M.

Oncotarget. 2016 Sep 20;7(38):61988-61995. doi: 10.18632/oncotarget.11328.


Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.

Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, Rothkamm K, Mansour WY.

Oncotarget. 2016 Sep 6;7(36):57679-57693. doi: 10.18632/oncotarget.11023.


DNA Repair.

Borgmann K, Köcher S, Kriegs M, Mansour WY, Parplys AC, Rieckmann T, Rothkamm K.

Recent Results Cancer Res. 2016;198:1-24. doi: 10.1007/978-3-662-49651-0_1. Review.


Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests.

Kriegs M, Kasten-Pisula U, Riepen B, Hoffer K, Struve N, Myllynen L, Braig F, Binder M, Rieckmann T, Grénman R, Petersen C, Dikomey E, Rothkamm K.

Oncotarget. 2016 Jul 19;7(29):45122-45133. doi: 10.18632/oncotarget.9161.


Erratum to "Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy" [Cancer Lett. 374/2 (2016) 324-330].

Nuta O, Somaiah N, Boyle S, Chua ML, Gothard L, Yarnold J, Rothkamm K, Herskind C.

Cancer Lett. 2016 Aug 1;378(1):68. doi: 10.1016/j.canlet.2016.05.009. Epub 2016 May 12. No abstract available.


Similar cisplatin sensitivity of HPV-positive and -negative HNSCC cell lines.

Busch CJ, Becker B, Kriegs M, Gatzemeier F, Krüger K, Möckelmann N, Fritz G, Petersen C, Knecht R, Rothkamm K, Rieckmann T.

Oncotarget. 2016 Jun 14;7(24):35832-35842. doi: 10.18632/oncotarget.9028.


Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy.

Somaiah N, Chua ML, Bourne S, Daley F, A' Hern R, Nuta O, Gothard L, Boyle S, Herskind C, Pearson A, Warrington J, Helyer S, Owen R, Rothkamm K, Yarnold J.

Radiother Oncol. 2016 May;119(2):244-9. doi: 10.1016/j.radonc.2016.04.012. Epub 2016 Apr 19.


Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells.

Möckelmann N, Rieckmann T, Busch CJ, Becker B, Gleißner L, Hoffer K, Omniczynski M, Steinmeister L, Laban S, Grénman R, Petersen C, Rothkamm K, Dikomey E, Knecht R, Kriegs M.

Oncotarget. 2016 Apr 26;7(17):23542-51. doi: 10.18632/oncotarget.8275.


Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy.

Nuta O, Somaiah N, Boyle S, Chua ML, Gothard L, Yarnold J, Rothkamm K, Herskind C.

Cancer Lett. 2016 May 1;374(2):324-30. doi: 10.1016/j.canlet.2016.02.036. Epub 2016 Mar 2.


Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.

Bakr A, Köcher S, Volquardsen J, Reimer R, Borgmann K, Dikomey E, Rothkamm K, Mansour WY.

Radiother Oncol. 2016 May;119(2):276-81. doi: 10.1016/j.radonc.2015.11.001. Epub 2015 Nov 23.


Zero-inflated regression models for radiation-induced chromosome aberration data: A comparative study.

Oliveira M, Einbeck J, Higueras M, Ainsbury E, Puig P, Rothkamm K.

Biom J. 2016 Mar;58(2):259-79. doi: 10.1002/bimj.201400233. Epub 2015 Oct 13.


Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1.

Myllynen L, Kwiatkowski M, Gleißner L, Riepen B, Hoffer K, Wurlitzer M, Petersen C, Dikomey E, Rothkamm K, Schlüter H, Kriegs M.

Radiother Oncol. 2015 Sep;116(3):423-30. doi: 10.1016/j.radonc.2015.09.018. Epub 2015 Sep 25.


EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells.

Struve N, Riedel M, Schulte A, Rieckmann T, Grob TJ, Gal A, Rothkamm K, Lamszus K, Petersen C, Dikomey E, Kriegs M.

Oncotarget. 2015 Oct 20;6(32):33867-77. doi: 10.18632/oncotarget.5293.


radir package: an R implementation for cytogenetic biodosimetry dose estimation.

Moriña D, Higueras M, Puig P, Ainsbury EA, Rothkamm K.

J Radiol Prot. 2015 Sep;35(3):557-69. doi: 10.1088/0952-4746/35/3/557. Epub 2015 Jul 10.


Where Do We Look for Markers of Radiotherapy Fraction Size Sensitivity?

Somaiah N, Rothkamm K, Yarnold J.

Clin Oncol (R Coll Radiol). 2015 Oct;27(10):570-8. doi: 10.1016/j.clon.2015.06.006. Epub 2015 Jun 21. Review.


A new Bayesian model applied to cytogenetic partial body irradiation estimation.

Higueras M, Puig P, Ainsbury EA, Vinnikov VA, Rothkamm K.

Radiat Prot Dosimetry. 2016 Mar;168(3):330-6. doi: 10.1093/rpd/ncv356. Epub 2015 Jun 11.


Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.

Markiewicz E, Barnard S, Haines J, Coster M, van Geel O, Wu W, Richards S, Ainsbury E, Rothkamm K, Bouffler S, Quinlan RA.

Open Biol. 2015 Apr;5(4):150011. doi: 10.1098/rsob.150011.


Development of a retrospective/fortuitous accident dosimetry service based on OSL of mobile phones.

Smith RW, Eakins JS, Hager LG, Rothkamm K, Tanner RJ.

Radiat Prot Dosimetry. 2015 Apr;164(1-2):89-92. doi: 10.1093/rpd/ncu370.


Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.

Cook R, Zoumpoulidou G, Luczynski MT, Rieger S, Moquet J, Spanswick VJ, Hartley JA, Rothkamm K, Huang PH, Mittnacht S.

Cell Rep. 2015 Mar 31;10(12):2006-18. doi: 10.1016/j.celrep.2015.02.059. Epub 2015 Mar 26.


The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects.

Bouffler SD, Peters S, Gilvin P, Slack K, Markiewicz E, Quinlan RA, Gillan J, Coster M, Barnard S, Rothkamm K, Ainsbury E.

Ann ICRP. 2015 Jun;44(1 Suppl):84-90. doi: 10.1177/0146645314560693. Epub 2015 Mar 10.


DNA damage foci: Meaning and significance.

Rothkamm K, Barnard S, Moquet J, Ellender M, Rana Z, Burdak-Rothkamm S.

Environ Mol Mutagen. 2015 Jul;56(6):491-504. doi: 10.1002/em.21944. Epub 2015 Mar 12. Review.


A new inverse regression model applied to radiation biodosimetry.

Higueras M, Puig P, Ainsbury EA, Rothkamm K.

Proc Math Phys Eng Sci. 2015 Feb 8;471(2174):20140588.


BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.

Burdak-Rothkamm S, Rothkamm K, McClelland K, Al Rashid ST, Prise KM.

Cancer Lett. 2015 Jan 28;356(2 Pt B):454-61. doi: 10.1016/j.canlet.2014.09.043. Epub 2014 Oct 7.


Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project.

Jaworska A, Ainsbury EA, Fattibene P, Lindholm C, Oestreicher U, Rothkamm K, Romm H, Thierens H, Trompier F, Voisin P, Vral A, Woda C, Wojcik A.

Radiat Prot Dosimetry. 2015 Apr;164(1-2):165-9. doi: 10.1093/rpd/ncu294. Epub 2014 Oct 1. Review.


Realising the European network of biodosimetry: RENEB-status quo.

Kulka U, Ainsbury L, Atkinson M, Barnard S, Smith R, Barquinero JF, Barrios L, Bassinet C, Beinke C, Cucu A, Darroudi F, Fattibene P, Bortolin E, Monaca SD, Gil O, Gregoire E, Hadjidekova V, Haghdoost S, Hatzi V, Hempel W, Herranz R, Jaworska A, Lindholm C, Lumniczky K, M'kacher R, Mörtl S, Montoro A, Moquet J, Moreno M, Noditi M, Ogbazghi A, Oestreicher U, Palitti F, Pantelias G, Popescu I, Prieto MJ, Roch-Lefevre S, Roessler U, Romm H, Rothkamm K, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Thierens H, Trompier F, Turai I, Vandevoorde C, Vaz P, Voisin P, Vral A, Ugletveit F, Wieser A, Woda C, Wojcik A.

Radiat Prot Dosimetry. 2015 Apr;164(1-2):42-5. doi: 10.1093/rpd/ncu266. Epub 2014 Sep 9.


The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB.

Barnard S, Ainsbury EA, Al-hafidh J, Hadjidekova V, Hristova R, Lindholm C, Monteiro Gil O, Moquet J, Moreno M, Rößler U, Thierens H, Vandevoorde C, Vral A, Wojewódzka M, Rothkamm K.

Radiat Prot Dosimetry. 2015 Apr;164(3):265-70. doi: 10.1093/rpd/ncu259. Epub 2014 Aug 12.


Multibiodose radiation emergency triage categorization software.

Ainsbury EA, Barnard S, Barrios L, Fattibene P, de Gelder V, Gregoire E, Lindholm C, Lloyd D, Nergaard I, Rothkamm K, Romm H, Scherthan H, Thierens H, Vandevoorde C, Woda C, Wojcik A.

Health Phys. 2014 Jul;107(1):83-9. doi: 10.1097/HP.0000000000000049.


Validation of semi-automatic scoring of dicentric chromosomes after simulation of three different irradiation scenarios.

Romm H, Ainsbury E, Barnard S, Barrios L, Barquinero JF, Beinke C, Deperas M, Gregoire E, Koivistoinen A, Lindholm C, Moquet J, Oestreicher U, Puig R, Rothkamm K, Sommer S, Thierens H, Vandersickel V, Vral A, Wojcik A.

Health Phys. 2014 Jun;106(6):764-71. doi: 10.1097/HP.0000000000000077.


Is a semi-automated approach indicated in the application of the automated micronucleus assay for triage purposes?

Thierens H, Vral A, Vandevoorde C, Vandersickel V, de Gelder V, Romm H, Oestreicher U, Rothkamm K, Barnard S, Ainsbury E, Sommer S, Beinke C, Wojcik A.

Radiat Prot Dosimetry. 2014 Jun;159(1-4):87-94. doi: 10.1093/rpd/ncu130. Epub 2014 Apr 17.


What radiation dose does the FISH translocation assay measure in cases of incorporated radionuclides for the Southern Urals populations?

Ainsbury EA, Moquet J, Rothkamm K, Darroudi F, Vozilova A, Degteva M, Azizova TV, Lloyd DC, Harrison J.

Radiat Prot Dosimetry. 2014 Jun;159(1-4):26-33. doi: 10.1093/rpd/ncu118. Epub 2014 Apr 15.


Gamma-H2AX biodosimetry for use in large scale radiation incidents: comparison of a rapid '96 well lyse/fix' protocol with a routine method.

Moquet J, Barnard S, Rothkamm K.

PeerJ. 2014 Mar 6;2:e282. doi: 10.7717/peerj.282. eCollection 2014.


DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy.

Chua ML, Horn S, Somaiah N, Davies S, Gothard L, A'Hern R, Yarnold J, Rothkamm K.

Radiat Environ Biophys. 2014 May;53(2):355-64. doi: 10.1007/s00411-014-0531-z. Epub 2014 Mar 13.


Web-based scoring of the dicentric assay, a collaborative biodosimetric scoring strategy for population triage in large scale radiation accidents.

Romm H, Ainsbury E, Bajinskis A, Barnard S, Barquinero JF, Barrios L, Beinke C, Puig-Casanovas R, Deperas-Kaminska M, Gregoire E, Oestreicher U, Lindholm C, Moquet J, Rothkamm K, Sommer S, Thierens H, Vral A, Vandersickel V, Wojcik A.

Radiat Environ Biophys. 2014 May;53(2):241-54. doi: 10.1007/s00411-014-0519-8. Epub 2014 Feb 21.


Impact of long-term exposure to sodium arsenite on cytogenetic radiation damage.

Nuta O, Moquet J, Bouffler S, Lloyd D, Sepai O, Rothkamm K.

Mutagenesis. 2014 Mar;29(2):123-9. doi: 10.1093/mutage/get070. Epub 2014 Jan 22.


Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency.

Ainsbury EA, Al-Hafidh J, Bajinskis A, Barnard S, Barquinero JF, Beinke C, de Gelder V, Gregoire E, Jaworska A, Lindholm C, Lloyd D, Moquet J, Nylund R, Oestreicher U, Roch-Lefévre S, Rothkamm K, Romm H, Scherthan H, Sommer S, Thierens H, Vandevoorde C, Vral A, Wojcik A.

Int J Radiat Biol. 2014 Feb;90(2):193-202. doi: 10.3109/09553002.2014.868616.


Review of Bayesian statistical analysis methods for cytogenetic radiation biodosimetry, with a practical example.

Ainsbury EA, Vinnikov VA, Puig P, Higueras M, Maznyk NA, Lloyd DC, Rothkamm K.

Radiat Prot Dosimetry. 2014 Dec;162(3):185-96. doi: 10.1093/rpd/nct301. Epub 2013 Nov 25. Review.


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