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Items: 1 to 50 of 77

1.

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA.

EMBO Rep. 2018 Nov 2. pii: e44706. doi: 10.15252/embr.201744706. [Epub ahead of print]

PMID:
30389725
2.

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.

Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, Diaz-Valdivia N, Sanhueza C, Lopez-Crisosto C, Tahbaz N, Rothermel BA, Hill JA, Cifuentes M, Simmen T, Quest AFG, Lavandero S.

Cell Death Differ. 2018 Sep 12. doi: 10.1038/s41418-018-0197-1. [Epub ahead of print]

PMID:
30209302
3.

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT2R and Akt-dependent mechanism.

Mendoza-Torres E, Riquelme JA, Vielma A, Sagredo AR, Gabrielli L, Bravo-Sagua R, Jalil JE, Rothermel BA, Sanchez G, Ocaranza MP, Lavandero S.

Pharmacol Res. 2018 Sep;135:112-121. doi: 10.1016/j.phrs.2018.07.022. Epub 2018 Jul 23.

PMID:
30048754
4.

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.

Sun Y, Yao X, Zhang QJ, Zhu M, Liu ZP, Ci B, Xie Y, Carlson D, Rothermel BA, Sun Y, Levine B, Hill JA, Wolf SE, Minei JP, Zang QS.

Circulation. 2018 May 31. pii: CIRCULATIONAHA.117.032821. doi: 10.1161/CIRCULATIONAHA.117.032821. [Epub ahead of print]

PMID:
29853517
5.

Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network.

Parra V, Altamirano F, Hernández-Fuentes CP, Tong D, Kyrychenko V, Rotter D, Pedrozo Z, Hill JA, Eisner V, Lavandero S, Schneider JW, Rothermel BA.

Circ Res. 2018 Mar 16;122(6):e20-e33. doi: 10.1161/CIRCRESAHA.117.311522. Epub 2018 Jan 23.

PMID:
29362227
6.

Mitochondria in Structural and Functional Cardiac Remodeling.

Torrealba N, Aranguiz P, Alonso C, Rothermel BA, Lavandero S.

Adv Exp Med Biol. 2017;982:277-306. doi: 10.1007/978-3-319-55330-6_15. Review.

PMID:
28551793
7.

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells.

Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ.

Angiogenesis. 2017 Aug;20(3):341-358. doi: 10.1007/s10456-017-9542-0. Epub 2017 Mar 7.

8.

Calcineurin signaling in the heart: The importance of time and place.

Parra V, Rothermel BA.

J Mol Cell Cardiol. 2017 Feb;103:121-136. doi: 10.1016/j.yjmcc.2016.12.006. Epub 2016 Dec 20. Review.

9.

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

Bravo-Sagua R, López-Crisosto C, Parra V, Rodriguez-Peña M, Rothermel BA, Quest AF, Lavandero S.

Sci Rep. 2016 Nov 3;6:36394. doi: 10.1038/srep36394.

10.

Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.

Morales CR, Li DL, Pedrozo Z, May HI, Jiang N, Kyrychenko V, Cho GW, Kim SY, Wang ZV, Rotter D, Rothermel BA, Schneider JW, Lavandero S, Gillette TG, Hill JA.

Sci Signal. 2016 Apr 5;9(422):ra34. doi: 10.1126/scisignal.aad5736.

11.

Pharmacological priming of adipose-derived stem cells promotes myocardial repair.

Burchfield JS, Paul AL, Lanka V, Tan W, Kong Y, McCallister C, Rothermel BA, Schneider JW, Gillette TG, Hill JA.

J Investig Med. 2016 Jan;64(1):50-62. doi: 10.1136/jim-2015-000018.

PMID:
26755814
12.

Mitochondrial dynamics, mitophagy and cardiovascular disease.

Vásquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA, Lavandero S.

J Physiol. 2016 Feb 1;594(3):509-25. doi: 10.1113/JP271301. Epub 2016 Jan 15. Review.

13.

ER-to-mitochondria miscommunication and metabolic diseases.

López-Crisosto C, Bravo-Sagua R, Rodriguez-Peña M, Mera C, Castro PF, Quest AF, Rothermel BA, Cifuentes M, Lavandero S.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2096-105. doi: 10.1016/j.bbadis.2015.07.011. Epub 2015 Jul 11. Review.

14.

Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability.

Pedrozo Z, Criollo A, Battiprolu PK, Morales CR, Contreras-Ferrat A, Fernández C, Jiang N, Luo X, Caplan MJ, Somlo S, Rothermel BA, Gillette TG, Lavandero S, Hill JA.

Circulation. 2015 Jun 16;131(24):2131-42. doi: 10.1161/CIRCULATIONAHA.114.013537. Epub 2015 Apr 17.

15.

Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.

Westermeier F, Navarro-Marquez M, López-Crisosto C, Bravo-Sagua R, Quiroga C, Bustamante M, Verdejo HE, Zalaquett R, Ibacache M, Parra V, Castro PF, Rothermel BA, Hill JA, Lavandero S.

Biochim Biophys Acta. 2015 May;1853(5):1113-8. doi: 10.1016/j.bbamcr.2015.02.005. Epub 2015 Feb 14. Review.

16.

Autophagy in cardiovascular biology.

Lavandero S, Chiong M, Rothermel BA, Hill JA.

J Clin Invest. 2015 Jan;125(1):55-64. doi: 10.1172/JCI73943. Epub 2015 Jan 2. Review.

17.

Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes.

Gutiérrez T, Parra V, Troncoso R, Pennanen C, Contreras-Ferrat A, Vasquez-Trincado C, Morales PE, Lopez-Crisosto C, Sotomayor-Flores C, Chiong M, Rothermel BA, Lavandero S.

Cell Commun Signal. 2014 Nov 7;12:68. doi: 10.1186/s12964-014-0068-4.

18.

An integrated mechanism of cardiomyocyte nuclear Ca(2+) signaling.

Ibarra C, Vicencio JM, Varas-Godoy M, Jaimovich E, Rothermel BA, Uhlén P, Hill JA, Lavandero S.

J Mol Cell Cardiol. 2014 Oct;75:40-8. doi: 10.1016/j.yjmcc.2014.06.015. Epub 2014 Jul 2. Review.

19.

Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.

Rotter D, Grinsfelder DB, Parra V, Pedrozo Z, Singh S, Sachan N, Rothermel BA.

J Mol Cell Cardiol. 2014 Sep;74:103-11. doi: 10.1016/j.yjmcc.2014.05.004. Epub 2014 May 15.

20.

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway.

Pennanen C, Parra V, López-Crisosto C, Morales PE, Del Campo A, Gutierrez T, Rivera-Mejías P, Kuzmicic J, Chiong M, Zorzano A, Rothermel BA, Lavandero S.

J Cell Sci. 2014 Jun 15;127(Pt 12):2659-71. doi: 10.1242/jcs.139394. Epub 2014 Apr 28.

21.

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA.

Cell. 2014 Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032. Erratum in: Cell. 2014 May 22;157(5):1243.

22.

Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.

Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette TG, Scherer PE, Hill JA.

Cell. 2014 Mar 13;156(6):1179-1192. doi: 10.1016/j.cell.2014.01.014.

23.

Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration.

Singh S, Canseco DC, Manda SM, Shelton JM, Chirumamilla RR, Goetsch SC, Ye Q, Gerard RD, Schneider JW, Richardson JA, Rothermel BA, Mammen PP.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E129-38. doi: 10.1073/pnas.1314962111. Epub 2013 Dec 23.

24.

Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment.

Hoeffer CA, Wong H, Cain P, Levenga J, Cowansage KK, Choi Y, Davy C, Majmundar N, McMillan DR, Rothermel BA, Klann E.

J Neurosci. 2013 Oct 23;33(43):16930-44. doi: 10.1523/JNEUROSCI.3513-12.2013.

25.

Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway.

Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S.

Diabetes. 2014 Jan;63(1):75-88. doi: 10.2337/db13-0340. Epub 2013 Sep 5.

26.

Cardiovascular autophagy: concepts, controversies, and perspectives.

Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA.

Autophagy. 2013 Oct;9(10):1455-66. doi: 10.4161/auto.25969. Epub 2013 Aug 14. Review.

PMID:
23959233
27.

Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death.

Parra V, Moraga F, Kuzmicic J, López-Crisosto C, Troncoso R, Torrealba N, Criollo A, Díaz-Elizondo J, Rothermel BA, Quest AF, Lavandero S.

Biochim Biophys Acta. 2013 Aug;1832(8):1334-44. doi: 10.1016/j.bbadis.2013.04.009. Epub 2013 Apr 16.

28.

Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy.

Cao DJ, Jiang N, Blagg A, Johnstone JL, Gondalia R, Oh M, Luo X, Yang KC, Shelton JM, Rothermel BA, Gillette TG, Dorn GW, Hill JA.

J Am Heart Assoc. 2013 Apr 8;2(2):e000016. doi: 10.1161/JAHA.113.000016.

29.

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.

Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, Mammen PP, Rothermel BA, Olson EN, Sadek HA.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):187-92. doi: 10.1073/pnas.1208863110. Epub 2012 Dec 17.

30.

Cell death and survival through the endoplasmic reticulum-mitochondrial axis.

Bravo-Sagua R, Rodriguez AE, Kuzmicic J, Gutierrez T, Lopez-Crisosto C, Quiroga C, Díaz-Elizondo J, Chiong M, Gillette TG, Rothermel BA, Lavandero S.

Curr Mol Med. 2013 Feb;13(2):317-29. Review.

31.

Targets, trafficking, and timing of cardiac autophagy.

Rotter D, Rothermel BA.

Pharmacol Res. 2012 Dec;66(6):494-504. doi: 10.1016/j.phrs.2012.10.001. Epub 2012 Oct 8. Review.

32.

FHL2 binds calcineurin and represses pathological cardiac growth.

Hojayev B, Rothermel BA, Gillette TG, Hill JA.

Mol Cell Biol. 2012 Oct;32(19):4025-34. doi: 10.1128/MCB.05948-11. Epub 2012 Jul 30.

33.

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.

Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA.

J Clin Invest. 2012 Mar;122(3):1109-18. doi: 10.1172/JCI60329. Epub 2012 Feb 13.

34.

STIM1-dependent store-operated Ca²⁺ entry is required for pathological cardiac hypertrophy.

Luo X, Hojayev B, Jiang N, Wang ZV, Tandan S, Rakalin A, Rothermel BA, Gillette TG, Hill JA.

J Mol Cell Cardiol. 2012 Jan;52(1):136-47. doi: 10.1016/j.yjmcc.2011.11.003. Epub 2011 Nov 13.

35.

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics.

Bravo R, Gutierrez T, Paredes F, Gatica D, Rodriguez AE, Pedrozo Z, Chiong M, Parra V, Quest AF, Rothermel BA, Lavandero S.

Int J Biochem Cell Biol. 2012 Jan;44(1):16-20. doi: 10.1016/j.biocel.2011.10.012. Epub 2011 Nov 2. Review.

36.

Reversibility of adverse, calcineurin-dependent cardiac remodeling.

Berry JM, Le V, Rotter D, Battiprolu PK, Grinsfelder B, Tannous P, Burchfield JS, Czubryt M, Backs J, Olson EN, Rothermel BA, Hill JA.

Circ Res. 2011 Aug 5;109(4):407-17. doi: 10.1161/CIRCRESAHA.110.228452. Epub 2011 Jun 23.

37.

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.

Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S.

J Cell Sci. 2011 Jul 1;124(Pt 13):2143-52. doi: 10.1242/jcs.080762. Epub 2011 May 31.

38.

Anabolic androgenic steroids and intracellular calcium signaling: a mini review on mechanisms and physiological implications.

Vicencio JM, Estrada M, Galvis D, Bravo R, Contreras AE, Rotter D, Szabadkai G, Hill JA, Rothermel BA, Jaimovich E, Lavandero S.

Mini Rev Med Chem. 2011 May;11(5):390-8. Review.

39.

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.

Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, Kong Y, Rothermel BA, Gillette TG, Hill JA.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8. doi: 10.1073/pnas.1015081108. Epub 2011 Feb 18.

40.

The complex interplay between mitochondrial dynamics and cardiac metabolism.

Parra V, Verdejo H, del Campo A, Pennanen C, Kuzmicic J, Iglewski M, Hill JA, Rothermel BA, Lavandero S.

J Bioenerg Biomembr. 2011 Feb;43(1):47-51. doi: 10.1007/s10863-011-9332-0. Review.

41.

Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.

Sachan N, Dey A, Rotter D, Grinsfelder DB, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM, Bibb JA, Hill JA, Rothermel BA.

Circ Res. 2011 Feb 18;108(4):437-45. doi: 10.1161/CIRCRESAHA.110.235309. Epub 2011 Jan 13.

42.

Mitochondrial fission and autophagy in the normal and diseased heart.

Iglewski M, Hill JA, Lavandero S, Rothermel BA.

Curr Hypertens Rep. 2010 Dec;12(6):418-25. doi: 10.1007/s11906-010-0147-x. Review.

43.

FoxO, autophagy, and cardiac remodeling.

Ferdous A, Battiprolu PK, Ni YG, Rothermel BA, Hill JA.

J Cardiovasc Transl Res. 2010 Aug;3(4):355-64. doi: 10.1007/s12265-010-9200-z. Epub 2010 Jun 25.

44.

Regulator of calcineurin 1 controls growth plasticity of adult pancreas.

Gurda GT, Crozier SJ, Ji B, Ernst SA, Logsdon CD, Rothermel BA, Williams JA.

Gastroenterology. 2010 Aug;139(2):609-19, 619.e1-6. doi: 10.1053/j.gastro.2010.04.050. Epub 2010 Jun 18.

45.

The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4.

Oh M, Dey A, Gerard RD, Hill JA, Rothermel BA.

J Biol Chem. 2010 May 28;285(22):16623-31. doi: 10.1074/jbc.M109.098236. Epub 2010 Apr 6.

46.

Autophagy in hypertensive heart disease.

Wang ZV, Rothermel BA, Hill JA.

J Biol Chem. 2010 Mar 19;285(12):8509-14. doi: 10.1074/jbc.R109.025023. Epub 2010 Jan 29. Review.

47.

Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel.

Tandan S, Wang Y, Wang TT, Jiang N, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA.

Circ Res. 2009 Jul 2;105(1):51-60. doi: 10.1161/CIRCRESAHA.109.199828. Epub 2009 May 28.

48.

Autophagy in load-induced heart disease.

Zhu H, Rothermel BA, Hill JA.

Methods Enzymol. 2009;453:343-63. doi: 10.1016/S0076-6879(08)04017-2.

49.

Calcineurin activates cytoglobin transcription in hypoxic myocytes.

Singh S, Manda SM, Sikder D, Birrer MJ, Rothermel BA, Garry DJ, Mammen PP.

J Biol Chem. 2009 Apr 17;284(16):10409-21. doi: 10.1074/jbc.M809572200. Epub 2009 Feb 9.

50.

Autophagy in load-induced heart disease.

Rothermel BA, Hill JA.

Circ Res. 2008 Dec 5;103(12):1363-9. doi: 10.1161/CIRCRESAHA.108.186551. Review.

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